ES8802497A1 - Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico. - Google Patents
Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico.Info
- Publication number
- ES8802497A1 ES8802497A1 ES552049A ES552049A ES8802497A1 ES 8802497 A1 ES8802497 A1 ES 8802497A1 ES 552049 A ES552049 A ES 552049A ES 552049 A ES552049 A ES 552049A ES 8802497 A1 ES8802497 A1 ES 8802497A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- straight
- formula
- independently represent
- calcium ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B2205/00—Fibre drawing or extruding details
- C03B2205/44—Monotoring or regulating the preform feed rate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LOS ESTERES DEL ACIDO 1,4-DIHIDRO-3,5-PIRIDINCARBOXILICO (I), DONDE NO EXCLUSIVAMENTE, R1 Y R4 SON ALQUILO C1-4, R2 Y R3 ALQUILO C1-6 Y R5 ALQUILO C1-13; SE OBTIENEN HACIENDO REACCIONAR EL ACIDO (II) CON EL AGENTE ALQUILANTE R5X, SIENDO X UN AGENTE SALIENTE COMO CLORO O MESILATO, EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE APROTICO POLAR Y CON APLICACION DE CALOR. REDUCEN LA CONCENTRACION INTRACELULAR DEL ION CALCIO Y LIMITAN SU INFLUJO A TRAVES DE LA MEMBRANA, POR LO QUE SON APLICABLES AL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES TALES COMO: HIPERTENSION, ANGINA DE PECHO, ISQUEMIA DE MIOCARDIO, INSUFICIENCIA CARDIACA, ETC. *FORMULA*
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22383/84A IT1175620B (it) | 1984-08-22 | 1984-08-22 | Derivati piridinici |
IT21460/85A IT1187678B (it) | 1985-07-05 | 1985-07-05 | Procedimento di preparazione di derivati eterociclici |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8802497A1 true ES8802497A1 (es) | 1988-07-01 |
ES552049A0 ES552049A0 (es) | 1988-07-01 |
Family
ID=26327905
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546324A Expired ES8703839A1 (es) | 1984-08-22 | 1985-08-21 | Un procedimiento para la preparacion de esteres de acidos 1,4-dihidro-3,5-piridin-dicarbaxolicos. |
ES552051A Expired ES8707932A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3,5, piridincarboxilico. |
ES552050A Expired ES8707930A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3, 5, piridincarboxilico. |
ES552049A Expired ES8802497A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico. |
ES552048A Expired ES8707931A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546324A Expired ES8703839A1 (es) | 1984-08-22 | 1985-08-21 | Un procedimiento para la preparacion de esteres de acidos 1,4-dihidro-3,5-piridin-dicarbaxolicos. |
ES552051A Expired ES8707932A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3,5, piridincarboxilico. |
ES552050A Expired ES8707930A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3, 5, piridincarboxilico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552048A Expired ES8707931A1 (es) | 1984-08-22 | 1986-02-14 | Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico. |
Country Status (33)
Country | Link |
---|---|
US (2) | US4801599A (es) |
JP (2) | JPS6193162A (es) |
KR (1) | KR920004482B1 (es) |
AT (1) | AT394042B (es) |
AU (1) | AU578724B2 (es) |
BE (1) | BE903103A (es) |
BG (1) | BG60409B2 (es) |
CA (1) | CA1268180A (es) |
CH (1) | CH666684A5 (es) |
CS (1) | CS403091A3 (es) |
CY (1) | CY1494A (es) |
DE (1) | DE3529997C2 (es) |
DK (1) | DK165949C (es) |
ES (5) | ES8703839A1 (es) |
FI (1) | FI81568C (es) |
FR (1) | FR2569402B1 (es) |
GB (1) | GB2164336B (es) |
GR (1) | GR852016B (es) |
HK (1) | HK52990A (es) |
HU (1) | HU196754B (es) |
IE (1) | IE58486B1 (es) |
LU (2) | LU88267I2 (es) |
MX (1) | MX159974A (es) |
NL (2) | NL193065C (es) |
NO (2) | NO167142C (es) |
NZ (1) | NZ212895A (es) |
PH (1) | PH22014A (es) |
PT (1) | PT81000B (es) |
SA (1) | SA91120277B1 (es) |
SE (1) | SE459920B (es) |
SG (1) | SG40889G (es) |
SK (1) | SK278327B6 (es) |
ZW (1) | ZW13185A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
CA1337295C (en) * | 1985-08-21 | 1995-10-10 | Claudio Semeraro | Dihydropyridine derivatives and their preparation and pharmaceutical formulation |
EP0226271B1 (en) * | 1985-08-21 | 1990-11-22 | GLAXO S.p.A. | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1204461B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1204462B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1233370B (it) * | 1988-11-21 | 1992-03-27 | Glaxo Spa | Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari |
DE69030982T2 (de) | 1989-04-27 | 1997-11-13 | Canon Kk | Optisches Aufzeichnungsmedium und Verfahren zu seiner Herstellung |
US5177202A (en) * | 1990-10-09 | 1993-01-05 | Merck & Co., Inc. | 2-phenanthrenyl-carbapenems |
US5196529A (en) * | 1990-10-09 | 1993-03-23 | Merck & Co., Inc. | 2-phenanthrenyl carbapenem intermediates |
US5132421A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
US5132422A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
US5144028A (en) * | 1990-10-09 | 1992-09-01 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
US5356889A (en) * | 1990-08-01 | 1994-10-18 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
US5208329A (en) * | 1990-10-09 | 1993-05-04 | Merck & Co., Inc. | 2-biphenyl carbapenem intermediates |
IT1244728B (it) * | 1991-02-13 | 1994-08-08 | Glaxo Spa | Impiego medicamentoso di derivati diidropiridinici |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
AU1042199A (en) * | 1998-11-06 | 2000-05-29 | Boehringer Ingelheim International Gmbh | Antihypertensive medicaments containing lacidipine and telmisartan |
RS20050106A (en) | 2002-08-19 | 2007-11-15 | Pfizer Products Inc., | Combination therapy for hyperproliferative diseases |
SG141430A1 (en) * | 2003-05-30 | 2008-04-28 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
US20060147520A1 (en) * | 2004-07-26 | 2006-07-06 | Curtis Ruegg | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
WO2006113309A1 (en) | 2005-04-15 | 2006-10-26 | Dr. Reddy's Laboratories Ltd. | Lacidipine particles |
US20070043088A1 (en) * | 2005-08-16 | 2007-02-22 | Eswaraiah Sajja | Process for preparing lacidipine |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
EP1951253A2 (en) * | 2005-10-26 | 2008-08-06 | Cotherix, Inc. | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
BRPI0618379A2 (pt) * | 2005-11-08 | 2011-08-30 | Ranbaxy Lab Ltd | processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
TW200744583A (en) * | 2006-03-14 | 2007-12-16 | Ranbaxy Lab Ltd | Statin stabilizing dosage formulations |
US20080153896A1 (en) * | 2006-07-14 | 2008-06-26 | Gyan Chand Yadav | Polymorphic Forms of an HMG-CoA Reductase Inhibitor and Uses Thereof |
US20080089947A1 (en) * | 2006-08-18 | 2008-04-17 | Knox Clayton D | Calcium Influx Inhibitors in the Treatment of Ischemia |
ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
LT2705839T (lt) | 2012-09-10 | 2018-06-11 | Rivopharm Sa | Farmacinė kompozicija, apimanti lacidipiną ir jos gavimo būdas |
AU2014255381A1 (en) | 2013-04-17 | 2015-10-08 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
JOP20210193A1 (ar) | 2019-01-18 | 2023-01-30 | Astrazeneca Ab | مثبطات pcsk9 وطرق استخدامها |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3455945A (en) * | 1967-06-07 | 1969-07-15 | Smithkline Corp | 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines |
DE2228363A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
-
1985
- 1985-07-29 NZ NZ212895A patent/NZ212895A/xx unknown
- 1985-08-20 SE SE8503888A patent/SE459920B/sv not_active IP Right Cessation
- 1985-08-20 ZW ZW131/85A patent/ZW13185A1/xx unknown
- 1985-08-20 US US06/767,593 patent/US4801599A/en not_active Expired - Lifetime
- 1985-08-20 GR GR852016A patent/GR852016B/el unknown
- 1985-08-20 DK DK378085A patent/DK165949C/da not_active IP Right Cessation
- 1985-08-20 NL NL8502296A patent/NL193065C/nl not_active IP Right Cessation
- 1985-08-21 GB GB08520924A patent/GB2164336B/en not_active Expired
- 1985-08-21 IE IE205485A patent/IE58486B1/en not_active IP Right Cessation
- 1985-08-21 NO NO853293A patent/NO167142C/no not_active IP Right Cessation
- 1985-08-21 FI FI853206A patent/FI81568C/fi not_active IP Right Cessation
- 1985-08-21 LU LU88267C patent/LU88267I2/xx unknown
- 1985-08-21 CH CH3593/85A patent/CH666684A5/de not_active IP Right Cessation
- 1985-08-21 LU LU86047A patent/LU86047A1/fr active Protection Beyond IP Right Term
- 1985-08-21 MX MX206376A patent/MX159974A/es unknown
- 1985-08-21 JP JP60181934A patent/JPS6193162A/ja active Granted
- 1985-08-21 CY CY1494A patent/CY1494A/xx unknown
- 1985-08-21 ES ES546324A patent/ES8703839A1/es not_active Expired
- 1985-08-22 AT AT0245485A patent/AT394042B/de not_active IP Right Cessation
- 1985-08-22 DE DE3529997A patent/DE3529997C2/de not_active Expired - Lifetime
- 1985-08-22 PT PT81000A patent/PT81000B/pt unknown
- 1985-08-22 BE BE0/215493A patent/BE903103A/fr not_active IP Right Cessation
- 1985-08-22 KR KR1019850006044A patent/KR920004482B1/ko not_active IP Right Cessation
- 1985-08-22 AU AU46576/85A patent/AU578724B2/en not_active Expired
- 1985-08-22 FR FR8512631A patent/FR2569402B1/fr not_active Expired
- 1985-08-22 CA CA000489261A patent/CA1268180A/en not_active Expired - Lifetime
- 1985-08-22 HU HU853202A patent/HU196754B/hu unknown
- 1985-08-22 PH PH32680A patent/PH22014A/en unknown
-
1986
- 1986-02-14 ES ES552051A patent/ES8707932A1/es not_active Expired
- 1986-02-14 ES ES552050A patent/ES8707930A1/es not_active Expired
- 1986-02-14 ES ES552049A patent/ES8802497A1/es not_active Expired
- 1986-02-14 ES ES552048A patent/ES8707931A1/es not_active Expired
-
1988
- 1988-07-27 JP JP63185661A patent/JPH0686430B2/ja not_active Expired - Lifetime
-
1989
- 1989-01-23 US US07/300,022 patent/US5011848A/en not_active Expired - Lifetime
- 1989-07-06 SG SG40889A patent/SG40889G/en unknown
-
1990
- 1990-07-12 HK HK529/90A patent/HK52990A/xx not_active IP Right Cessation
-
1991
- 1991-12-16 SA SA91120277A patent/SA91120277B1/ar unknown
- 1991-12-23 SK SK4030-91A patent/SK278327B6/sk unknown
- 1991-12-23 CS CS914030A patent/CS403091A3/cs unknown
-
1993
- 1993-08-20 BG BG98061A patent/BG60409B2/bg unknown
-
1998
- 1998-11-27 NL NL980037C patent/NL980037I2/nl unknown
-
1999
- 1999-04-23 NO NO1999007C patent/NO1999007I1/no unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20080416 |