NL193065B - 4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialkyl -3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat. - Google Patents
4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialkyl -3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat.Info
- Publication number
- NL193065B NL193065B NL8502296A NL8502296A NL193065B NL 193065 B NL193065 B NL 193065B NL 8502296 A NL8502296 A NL 8502296A NL 8502296 A NL8502296 A NL 8502296A NL 193065 B NL193065 B NL 193065B
- Authority
- NL
- Netherlands
- Prior art keywords
- ortho
- dialkyl
- dihydro
- pharmaceutical composition
- dicarboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B2205/00—Fibre drawing or extruding details
- C03B2205/44—Monotoring or regulating the preform feed rate
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22383/84A IT1175620B (it) | 1984-08-22 | 1984-08-22 | Derivati piridinici |
IT2238384 | 1984-08-22 | ||
IT2146085 | 1985-07-05 | ||
IT21460/85A IT1187678B (it) | 1985-07-05 | 1985-07-05 | Procedimento di preparazione di derivati eterociclici |
Publications (3)
Publication Number | Publication Date |
---|---|
NL8502296A NL8502296A (nl) | 1986-03-17 |
NL193065B true NL193065B (nl) | 1998-05-06 |
NL193065C NL193065C (nl) | 1998-09-08 |
Family
ID=26327905
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8502296A NL193065C (nl) | 1984-08-22 | 1985-08-20 | 4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialkyl -3,5-pyridinedicarbonzuur diësterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat. |
NL980037C NL980037I2 (nl) | 1984-08-22 | 1998-11-27 | 4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialyl-3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL980037C NL980037I2 (nl) | 1984-08-22 | 1998-11-27 | 4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialyl-3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat. |
Country Status (33)
Country | Link |
---|---|
US (2) | US4801599A (nl) |
JP (2) | JPS6193162A (nl) |
KR (1) | KR920004482B1 (nl) |
AT (1) | AT394042B (nl) |
AU (1) | AU578724B2 (nl) |
BE (1) | BE903103A (nl) |
BG (1) | BG60409B2 (nl) |
CA (1) | CA1268180A (nl) |
CH (1) | CH666684A5 (nl) |
CS (1) | CS403091A3 (nl) |
CY (1) | CY1494A (nl) |
DE (1) | DE3529997C2 (nl) |
DK (1) | DK165949C (nl) |
ES (5) | ES8703839A1 (nl) |
FI (1) | FI81568C (nl) |
FR (1) | FR2569402B1 (nl) |
GB (1) | GB2164336B (nl) |
GR (1) | GR852016B (nl) |
HK (1) | HK52990A (nl) |
HU (1) | HU196754B (nl) |
IE (1) | IE58486B1 (nl) |
LU (2) | LU86047A1 (nl) |
MX (1) | MX159974A (nl) |
NL (2) | NL193065C (nl) |
NO (2) | NO167142C (nl) |
NZ (1) | NZ212895A (nl) |
PH (1) | PH22014A (nl) |
PT (1) | PT81000B (nl) |
SA (1) | SA91120277B1 (nl) |
SE (1) | SE459920B (nl) |
SG (1) | SG40889G (nl) |
SK (1) | SK278327B6 (nl) |
ZW (1) | ZW13185A1 (nl) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
EP0226271B1 (en) * | 1985-08-21 | 1990-11-22 | GLAXO S.p.A. | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
NL192385C (nl) * | 1985-08-21 | 1997-07-04 | Glaxo Spa | 6-alkyl-4-fenyl-1,4-dihydro-3,5-pyridinecarbonzuuresters, werkwijze voor de bereiding daarvan en farmaceutische preparaten die deze esters bevatten. |
IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1204462B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1204461B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1233370B (it) * | 1988-11-21 | 1992-03-27 | Glaxo Spa | Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari |
US5102709A (en) | 1989-04-27 | 1992-04-07 | Canon Kabushiki Kaisha | Optical recording medium and process for production thereof |
US5196529A (en) * | 1990-10-09 | 1993-03-23 | Merck & Co., Inc. | 2-phenanthrenyl carbapenem intermediates |
US5177202A (en) * | 1990-10-09 | 1993-01-05 | Merck & Co., Inc. | 2-phenanthrenyl-carbapenems |
US5132421A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
US5132422A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
US5144028A (en) * | 1990-10-09 | 1992-09-01 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
US5356889A (en) * | 1990-08-01 | 1994-10-18 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
US5208329A (en) * | 1990-10-09 | 1993-05-04 | Merck & Co., Inc. | 2-biphenyl carbapenem intermediates |
IT1244728B (it) * | 1991-02-13 | 1994-08-08 | Glaxo Spa | Impiego medicamentoso di derivati diidropiridinici |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
WO2000027397A1 (en) * | 1998-11-06 | 2000-05-18 | Glaxo Group Limited | Antihypertensive medicaments containing lacidipine and telmisartan |
AP2005003232A0 (en) | 2002-08-19 | 2005-03-31 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases. |
GEP20084406B (en) * | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
CN101090714A (zh) * | 2004-07-26 | 2007-12-19 | 康泽里克斯公司 | 通过吸入伊洛前列素和微粒制剂治疗肺动脉高血压症 |
EP1868577A4 (en) | 2005-04-15 | 2009-12-09 | Reddys Lab Inc Dr | Lacidipine PARTICLE |
US20070043088A1 (en) * | 2005-08-16 | 2007-02-22 | Eswaraiah Sajja | Process for preparing lacidipine |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7893050B2 (en) * | 2005-10-26 | 2011-02-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
WO2008020314A2 (en) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Statin stabilizing dosage formulations |
AU2007274724B2 (en) * | 2006-07-14 | 2012-07-26 | Ranbaxy Laboratories Limited | Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof |
US20080089947A1 (en) * | 2006-08-18 | 2008-04-17 | Knox Clayton D | Calcium Influx Inhibitors in the Treatment of Ischemia |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
US8883844B2 (en) | 2010-09-24 | 2014-11-11 | Nitrogenix Inc. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
ITMI20131485A1 (it) | 2012-09-10 | 2014-03-11 | Rivopharm Sa | Composizione farmaceutica comprendente lacipidina e processo di preparazione |
BR112015026513A2 (pt) | 2013-04-17 | 2017-07-25 | Pfizer | derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
MX2021008533A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3455945A (en) * | 1967-06-07 | 1969-07-15 | Smithkline Corp | 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines |
DE2228363A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
-
1985
- 1985-07-29 NZ NZ212895A patent/NZ212895A/xx unknown
- 1985-08-20 DK DK378085A patent/DK165949C/da not_active IP Right Cessation
- 1985-08-20 GR GR852016A patent/GR852016B/el unknown
- 1985-08-20 SE SE8503888A patent/SE459920B/sv not_active IP Right Cessation
- 1985-08-20 NL NL8502296A patent/NL193065C/nl not_active IP Right Cessation
- 1985-08-20 US US06/767,593 patent/US4801599A/en not_active Expired - Lifetime
- 1985-08-20 ZW ZW131/85A patent/ZW13185A1/xx unknown
- 1985-08-21 GB GB08520924A patent/GB2164336B/en not_active Expired
- 1985-08-21 ES ES546324A patent/ES8703839A1/es not_active Expired
- 1985-08-21 MX MX206376A patent/MX159974A/es unknown
- 1985-08-21 NO NO853293A patent/NO167142C/no not_active IP Right Cessation
- 1985-08-21 LU LU86047A patent/LU86047A1/fr active Protection Beyond IP Right Term
- 1985-08-21 CY CY1494A patent/CY1494A/xx unknown
- 1985-08-21 IE IE205485A patent/IE58486B1/en not_active IP Right Cessation
- 1985-08-21 FI FI853206A patent/FI81568C/fi not_active IP Right Cessation
- 1985-08-21 CH CH3593/85A patent/CH666684A5/de not_active IP Right Cessation
- 1985-08-21 LU LU88267C patent/LU88267I2/xx unknown
- 1985-08-21 JP JP60181934A patent/JPS6193162A/ja active Granted
- 1985-08-22 DE DE3529997A patent/DE3529997C2/de not_active Expired - Lifetime
- 1985-08-22 AT AT0245485A patent/AT394042B/de not_active IP Right Cessation
- 1985-08-22 HU HU853202A patent/HU196754B/hu unknown
- 1985-08-22 BE BE0/215493A patent/BE903103A/fr not_active IP Right Cessation
- 1985-08-22 CA CA000489261A patent/CA1268180A/en not_active Expired - Lifetime
- 1985-08-22 PH PH32680A patent/PH22014A/en unknown
- 1985-08-22 KR KR1019850006044A patent/KR920004482B1/ko not_active IP Right Cessation
- 1985-08-22 PT PT81000A patent/PT81000B/pt unknown
- 1985-08-22 FR FR8512631A patent/FR2569402B1/fr not_active Expired
- 1985-08-22 AU AU46576/85A patent/AU578724B2/en not_active Expired
-
1986
- 1986-02-14 ES ES552048A patent/ES8707931A1/es not_active Expired
- 1986-02-14 ES ES552049A patent/ES8802497A1/es not_active Expired
- 1986-02-14 ES ES552050A patent/ES8707930A1/es not_active Expired
- 1986-02-14 ES ES552051A patent/ES8707932A1/es not_active Expired
-
1988
- 1988-07-27 JP JP63185661A patent/JPH0686430B2/ja not_active Expired - Lifetime
-
1989
- 1989-01-23 US US07/300,022 patent/US5011848A/en not_active Expired - Lifetime
- 1989-07-06 SG SG40889A patent/SG40889G/en unknown
-
1990
- 1990-07-12 HK HK529/90A patent/HK52990A/xx not_active IP Right Cessation
-
1991
- 1991-12-16 SA SA91120277A patent/SA91120277B1/ar unknown
- 1991-12-23 CS CS914030A patent/CS403091A3/cs unknown
- 1991-12-23 SK SK4030-91A patent/SK278327B6/sk unknown
-
1993
- 1993-08-20 BG BG98061A patent/BG60409B2/bg unknown
-
1998
- 1998-11-27 NL NL980037C patent/NL980037I2/nl unknown
-
1999
- 1999-04-23 NO NO1999007C patent/NO1999007I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL193065B (nl) | 4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialkyl -3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat. | |
ATE52772T1 (de) | Asymmetrische diester von 1,4-dihydro-2,6dimethylpyridine-3,5-dicarboxylsaeure. | |
DE3677316D1 (de) | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate. | |
NL190757C (nl) | 4-(3-Chloorfenyl)-1-piperazinylpropyl gesubstitueerde-1,2,4-triazool-3-on verbindingen met antidepressieve werking en farmaceutische preparaten daarvan. | |
IT8047730A0 (it) | Composti di acidi 1-(aciltio)-e (mercapto)-1-ossoalchil-1,2,3,4-te traidrochinolin-2-carbossilici dotati di attivita' anti-ipertensiva | |
DE3684410D1 (de) | Heterocyclische oxophthalazinylessigsaeure. | |
NL190581C (nl) | 7beta-(D-2-amino-2-fenylaceetamido)-3-(propenyl)-3-cefem-4-carbonzuur verbinding en farmaceutisch preparaat dat deze verbinding omvat. | |
NL990014I1 (nl) | Methyl, isopropyl-4-(2,1,3-benzoxadiazool-4-yl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylaat en farmaceutisch preparaat dat deze verbinding bevat. | |
DK135884D0 (da) | 1,4-dihydropyridin-forbindelser og farmaceutisk acceptable syreadditionssalte deraf og deres anvendelse som anti-ischaemiske og antihypertensive midler | |
DE3576335D1 (de) | Chinolincarbonsaeure-derivate. | |
DE3880227D1 (de) | Vorbeugung der nachoxidaton von methacrolein. | |
DK253785A (da) | 2-(heterocyclisk substituerede)-1,4-dihydropyridinderivater samt farmaceutiske praeparater indeholdende disse | |
IT8520433A0 (it) | Trinciaforaggi. | |
DK253585D0 (da) | Heterocyclisk substituerede 1,4-dihydropyridin-derivater og farmaceutiske praeparater indeholdende disse derivater | |
ES556082A0 (es) | Procedimiento para preparar derivados de 1,4-dihidropiridina con actividad cardiovascular | |
DK165686A (da) | 1,4-dihydropyridin-3,5-dicarboxylatderivater | |
IS3179A7 (is) | Nýjar 16,17 asetalsúbstitúeraðar pregnan-21-karboxýlsýruafleiður | |
DK269885D0 (da) | 4-(aryl eller heteroaryl)-2-(heteroarylalkoxymethyl)-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere og farmaceutiske praeparater indeholdende disse | |
ATE60600T1 (de) | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate | |
ZA817774B (en) | New 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridine derivatives, their production and pharmaceutical compositions containing them | |
IT8541600A0 (it) | Esteri alcossi- e fenossi-alchilici dell'acido 2,6-dimetil-4-(2-difluorometossifenil)-1,4diipropiridin-3,5-dicarbonico ad attivita' farmaceutica. | |
DE3877957T2 (de) | 2-nitro-5-(substituierte phenoxy)-benzohydroximsaeure-derivate. | |
ATE35258T1 (de) | 2,6-dimethyl-3-(alkoxycarbonyl oder alkoxyalkoxycarbonyl)-4-(substituiertes phenyl)1,4-dihydropyridin-5-carbons|ureester. | |
DE3889897T2 (de) | 4-Heteropentacyclic-4-N-(phenyl)amido piperidin-Derivate. | |
IT8522107A0 (it) | Trinciaforaggi. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BA | A request for search or an international-type search has been filed | ||
BB | A search report has been drawn up | ||
BC | A request for examination has been filed | ||
AC1 | Application for a supplementary protection certificate |
Free format text: 980037, 981127 |
|
KC1 | Grant of a supplementary protection certificate |
Free format text: 980037, 20050820, EXPIRES: 20051106 |
|
V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20050820 |