LT2768942T - Pristatymas į ląstelės vidų - Google Patents
Pristatymas į ląstelės vidųInfo
- Publication number
- LT2768942T LT2768942T LTEP12841329.1T LT12841329T LT2768942T LT 2768942 T LT2768942 T LT 2768942T LT 12841329 T LT12841329 T LT 12841329T LT 2768942 T LT2768942 T LT 2768942T
- Authority
- LT
- Lithuania
- Prior art keywords
- delivery
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Electromagnetism (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548013P | 2011-10-17 | 2011-10-17 | |
| US201261684301P | 2012-08-17 | 2012-08-17 | |
| PCT/US2012/060646 WO2013059343A1 (en) | 2011-10-17 | 2012-10-17 | Intracellular delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2768942T true LT2768942T (lt) | 2020-04-10 |
Family
ID=48141314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP12841329.1T LT2768942T (lt) | 2011-10-17 | 2012-10-17 | Pristatymas į ląstelės vidų |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10696944B2 (lt) |
| EP (2) | EP3608394A1 (lt) |
| JP (2) | JP6219832B2 (lt) |
| KR (1) | KR102058568B1 (lt) |
| CN (3) | CN107058101B (lt) |
| AU (1) | AU2012326203B2 (lt) |
| BR (1) | BR112014009346B1 (lt) |
| CA (1) | CA2852672C (lt) |
| DK (1) | DK2768942T3 (lt) |
| ES (1) | ES2764105T3 (lt) |
| HR (1) | HRP20200051T1 (lt) |
| HU (1) | HUE047507T2 (lt) |
| LT (1) | LT2768942T (lt) |
| PL (1) | PL2768942T3 (lt) |
| PT (1) | PT2768942T (lt) |
| RS (1) | RS59898B1 (lt) |
| RU (1) | RU2656156C2 (lt) |
| SI (1) | SI2768942T1 (lt) |
| WO (1) | WO2013059343A1 (lt) |
Families Citing this family (186)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107058101B (zh) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| US11046596B2 (en) | 2012-10-25 | 2021-06-29 | Hydrus Technology Pty. Ltd. | Electrochemical liquid treatment apparatus |
| US9725709B2 (en) * | 2013-03-12 | 2017-08-08 | OpenCell Technologies, Inc. | Intracellular delivery and transfection methods and devices |
| GB201308946D0 (en) * | 2013-05-16 | 2013-07-03 | The Technology Partnership Plc | Method and device |
| ITPD20130220A1 (it) * | 2013-08-02 | 2015-02-03 | Univ Padova | Metodo per la riprogrammazione e programmazione cellulare mediante l'impiego di tecnologia microfluidica |
| KR102386122B1 (ko) * | 2013-08-16 | 2022-04-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| EP3071515A2 (en) | 2013-11-18 | 2016-09-28 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
| RU2736495C2 (ru) | 2014-04-01 | 2020-11-17 | Рубиус Терапьютикс, Инк. | Способ и композиции для иммуномодуляции |
| CN106573801B (zh) | 2014-05-23 | 2020-12-15 | 海卓斯科技有限公司 | 电化学液体处理装置 |
| US11046595B2 (en) | 2014-05-23 | 2021-06-29 | Hydrus Technology Pty. Ltd. | Electrochemical treatment methods |
| EP3164482B1 (en) | 2014-07-03 | 2024-05-22 | Massachusetts Institute of Technology | Apparatus and method for optimization of cell electroporation |
| US10081816B1 (en) | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
| US10760040B1 (en) | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
| CA2964392A1 (en) * | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Delivery of biomolecules to immune cells |
| CA2964138C (en) * | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| EP3037517A1 (en) * | 2014-12-28 | 2016-06-29 | Femtofab Co., Ltd. | Process for modifying a cell by putting material into the cell |
| EP3037515A1 (en) * | 2014-12-28 | 2016-06-29 | Femtofab Co., Ltd. | Modified cell prepared by putting material into the cell without using delivery vehicle |
| KR102428463B1 (ko) * | 2014-12-28 | 2022-08-03 | 주식회사 펨토바이오메드 | 세포에 물질을 주입하는 장치 및 제조 방법 |
| EP3037518B1 (en) | 2014-12-28 | 2020-05-06 | Femtobiomed Inc. | Device for putting material into cell |
| HK1247241A1 (zh) | 2015-01-07 | 2018-09-21 | 英迪公司 | 一种用於机械和水动力微流体转染的方法以及用於其的设备 |
| AU2016206870B2 (en) * | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20190388469A1 (en) * | 2015-01-30 | 2019-12-26 | The Regents Of The University Of California | Protein delivery in primary hematopoietic cells |
| WO2016168680A1 (en) * | 2015-04-17 | 2016-10-20 | Exocyte Therapeutics Pte Ltd. | Method for developing exosome-based vaccines |
| CA2988996A1 (en) * | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| JP6929829B2 (ja) * | 2015-07-24 | 2021-09-01 | ソレント・セラピューティクス・インコーポレイテッド | 薬剤送達装置 |
| DK3325080T3 (da) | 2015-07-24 | 2021-10-04 | Sorrento Therapeutics Inc | Fremgangsmåder til bedre indgivelse af aktive midler til tumorer |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| WO2017040548A1 (en) | 2015-08-31 | 2017-03-09 | I Peace, Inc. | Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells |
| ES2930017T3 (es) | 2015-09-04 | 2022-12-05 | Sqz Biotechnologies Co | Suministro intracelular de biomoléculas mediado por una superficie con poros |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| WO2017070169A1 (en) * | 2015-10-19 | 2017-04-27 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
| NZ783532A (en) | 2015-12-28 | 2025-09-26 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
| JP7033535B2 (ja) * | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | 複合体の細胞内送達 |
| KR20230148844A (ko) | 2016-03-29 | 2023-10-25 | 유니버시티 오브 써던 캘리포니아 | 암을 표적하는 키메라 항원 수용체 |
| WO2017173373A1 (en) | 2016-03-31 | 2017-10-05 | Massachusetts Institute Of Technology | Flow-through microfluidic methods and devices featuring membrane-perturbing surface interactions for intracellular delivery |
| WO2017176764A1 (en) * | 2016-04-04 | 2017-10-12 | CyteQuest, Inc. | System, device and method for electroporation of cells |
| US10717083B2 (en) | 2016-04-11 | 2020-07-21 | Indian Institute Of Technology, Bombay | Microdevice for separating plasma from human blood |
| EP3452062A1 (en) * | 2016-05-03 | 2019-03-13 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| IL262677B2 (en) * | 2016-05-03 | 2025-08-01 | Sqz Biotechnologies Co | Intracellular delivery of biomolecules to suppress an immune response or to induce tolerance to an antigen in an individual |
| WO2017201378A1 (en) * | 2016-05-19 | 2017-11-23 | University Of Rochester | Micro-slits for reticulocyte maturation |
| EP3463667A1 (en) * | 2016-05-31 | 2019-04-10 | Massachusetts Institute of Technology | Hydrodynamically controlled electric fields for high throughput transformation&high throughput parallel transformation platform |
| CA3026485A1 (en) * | 2016-06-06 | 2017-12-14 | The Charles Stark Draper Laboratory, Inc. | Systems and methods for cell transduction |
| WO2018039084A1 (en) | 2016-08-20 | 2018-03-01 | The Regents Of The University Of California | High-throughput system and method for the temporary permeablization of cells |
| WO2018047149A1 (en) * | 2016-09-12 | 2018-03-15 | Texas Children's Hospital | Cell filtration as a means of introducing exogenous material into a cell |
| EP3516068B1 (en) | 2016-09-19 | 2025-04-23 | University of Southern California | Non-radioactive cytotoxicity assays |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| CN110088286B (zh) * | 2016-10-21 | 2024-01-02 | 新加坡科技研究局 | 用于细胞内递送物质的装置、系统和方法 |
| WO2018089497A1 (en) * | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
| US10011848B2 (en) | 2016-11-09 | 2018-07-03 | City University Of Hong Kong | System and method for delivery of substance into mammalian cells |
| US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| CN106525273B (zh) * | 2016-11-24 | 2018-10-30 | 哈尔滨工业大学 | 基于量子点薄膜的细胞温度传感器及其制备方法 |
| AU2017366739B2 (en) | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| GB201701946D0 (en) * | 2017-02-06 | 2017-03-22 | Univ Leeds Innovations Ltd | Fluid flow device |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| EP3868864A1 (en) | 2017-02-13 | 2021-08-25 | The Regents of University of California | Device and method for intracellular delivery of biomolecular cargo via acoustic wave exposure |
| KR20200043369A (ko) * | 2017-06-16 | 2020-04-27 | 님 싸이언티픽 인코포레이티드 | 나노 니들 및 관련된 기기 및 방법 |
| US11801364B2 (en) * | 2017-06-30 | 2023-10-31 | Avectas Limited | Electrospray catheter |
| WO2019084410A1 (en) | 2017-10-26 | 2019-05-02 | Repligen Corporation | MICRO-ALTERNATIVE TANGENTIALLY FLOWING INFUSION FILTER, TREATMENT CONTAINER, AND METHODS OF USING THE SAME |
| US20190175506A1 (en) | 2017-11-17 | 2019-06-13 | Codiak Biosciences, Inc. | Loading of Extracellular Vesicles through Imparting of Mechanical Shear |
| JP7557367B2 (ja) | 2017-11-17 | 2024-09-27 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 細針吸引及び小生検からのｔｉｌ拡大培養 |
| CA3083118A1 (en) | 2017-11-22 | 2019-05-31 | Iovance Biotherapeutics, Inc. | Expansion of peripheral blood lymphocytes (pbls) from peripheral blood |
| EP3720878A1 (en) | 2017-12-05 | 2020-10-14 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to modulate antibody production |
| WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| IL320767A (en) * | 2017-12-20 | 2025-07-01 | Stemcell Technologies Canada Inc | System for delivery of a payload into a cell |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| BR112020013848A2 (pt) | 2018-01-08 | 2020-12-01 | Iovance Biotherapeutics, Inc. | métodos para expandir linfócitos infiltrantes de tumor e para tratar um indivíduo com câncer, população de linfócitos infiltrantes de tumor, e, método para avaliar fatores de transcrição |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| US12359220B2 (en) | 2018-01-29 | 2025-07-15 | The Regents Of The University Of California | Guided magnetic nanostructures for targeted and high-throughput intracellular delivery |
| WO2019165128A1 (en) | 2018-02-21 | 2019-08-29 | Nemametrix Inc. | Transgenic animal phenotyping platform and uses thereof |
| IL277188B2 (en) | 2018-03-12 | 2025-05-01 | Sqz Biotechnologies Co | Intracellular delivery of biomolecules to modify the immune response |
| CA3093826A1 (en) | 2018-03-12 | 2019-09-19 | Sqz Biotechnologies Company | Methods for treating hpv-associated diseases |
| JP2019154314A (ja) * | 2018-03-13 | 2019-09-19 | 国立大学法人九州大学 | キャピラリーチップ及びこれを備える装置、並びに細胞への外来物質の導入方法 |
| US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| WO2019178420A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| AU2019247412B2 (en) * | 2018-04-04 | 2023-07-06 | The General Hospital Corporation | Microfluidic systems and methods to denude mammalian oocytes |
| EP3556845A1 (en) | 2018-04-20 | 2019-10-23 | Cellix Limited | A method and device for transfecting cells |
| WO2019217964A1 (en) | 2018-05-11 | 2019-11-14 | Lupagen, Inc. | Systems and methods for closed loop, real-time modifications of patient cells |
| CN113286879B (zh) | 2018-06-01 | 2025-06-13 | 安吉勒斯治疗公司 | 用于细胞疗法之多样化抗原结合域、新颖平台及其他增强子 |
| WO2020005802A1 (en) * | 2018-06-24 | 2020-01-02 | University Of Oregon | Microinjection chip, device, system and uses thereof for unicellular or multicellular organisms |
| US12440839B2 (en) * | 2018-08-21 | 2025-10-14 | The Regents Of The University Of California | High-throughput system and method for the temporary permeabilization of cells using lipid bilayers |
| CA3110750A1 (en) | 2018-09-10 | 2020-03-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against cd33 and constructs thereof |
| CA3115245A1 (en) | 2018-10-04 | 2020-04-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to enhance antigen presenting cell function |
| CN113677392B (zh) * | 2018-10-26 | 2024-09-17 | 凯拓盘公司 | 用于电穿孔的装置、系统和套件及其使用方法 |
| WO2020096927A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
| JOP20210094A1 (ar) | 2018-11-05 | 2023-01-30 | Iovance Biotherapeutics Inc | عمليات لإنتاج الخلايا الليمفاوية للورم الارتشاحي واستخداماتها في العلاج المناعي |
| BR112021008549A2 (pt) | 2018-11-05 | 2022-01-04 | Iovance Biotherapeutics Inc | Método de tratamento de carcinoma pulmonar de células não pequenas com uma população de linfócitos infiltrantes de tumor |
| EP3877512A2 (en) | 2018-11-05 | 2021-09-15 | Iovance Biotherapeutics, Inc. | Selection of improved tumor reactive t-cells |
| US10731012B2 (en) * | 2018-11-06 | 2020-08-04 | President And Fellows Of Harvard College | Anti-clogging microfluidic multichannel device |
| KR102232757B1 (ko) * | 2018-11-22 | 2021-03-26 | (주)엑솔런스바이오테크놀로지 | 체외충격파를 이용한 표적물질 전달 장치 |
| WO2020117856A1 (en) * | 2018-12-04 | 2020-06-11 | Cellfe, Inc. | Methods and systems for intracellular delivery |
| EP3898949A1 (en) | 2018-12-19 | 2021-10-27 | Iovance Biotherapeutics, Inc. | Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof |
| AU2020212601A1 (en) * | 2019-01-25 | 2021-09-09 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| EP3931309A4 (en) | 2019-02-28 | 2022-12-21 | SQZ Biotechnologies Company | ADMINISTRATION OF BIOMOLECULES TO PBMC TO MODIFY AN IMMUNE RESPONSE |
| AU2020233284A1 (en) | 2019-03-01 | 2021-09-16 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| WO2020184992A1 (ko) | 2019-03-12 | 2020-09-17 | 고려대학교 산학협력단 | 세포 내 물질 전달을 위한 미세유체 시스템 및 방법 |
| KR102354673B1 (ko) | 2019-03-12 | 2022-01-25 | 고려대학교 산학협력단 | 관성을 기반으로 한 세포 내 전달 미세 유체 플랫폼 |
| CN113631575A (zh) | 2019-03-15 | 2021-11-09 | 笛卡尔疗法股份有限公司 | 抗bcma嵌合抗原受体 |
| CN113840906B (zh) * | 2019-04-08 | 2024-09-06 | Sqz生物技术公司 | 用于在将有效载荷递送至细胞中的系统中使用的试剂盒 |
| WO2020207456A1 (en) * | 2019-04-11 | 2020-10-15 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| US20220249559A1 (en) | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| WO2020232418A1 (en) * | 2019-05-15 | 2020-11-19 | Cellfe, Inc. | Intracellular delivery |
| WO2020252215A1 (en) * | 2019-06-12 | 2020-12-17 | Cellfe, Inc. | Methods and systems for cell labeling and imaging |
| WO2020264016A1 (en) | 2019-06-25 | 2020-12-30 | Inari Agriculture, Inc. | Improved homology dependent repair genome editing |
| CN110272810A (zh) * | 2019-07-01 | 2019-09-24 | 广州世赛生物科技有限公司 | 外源物质递送至真核细胞内的装置和方法及其应用 |
| JP2022540797A (ja) * | 2019-07-02 | 2022-09-20 | カイトペン コーポレイション | 電気機械的送達のためのデバイス、システム、及びキット、ならびにそれらの使用方法 |
| KR102483442B1 (ko) | 2019-11-06 | 2022-12-30 | 고려대학교 산학협력단 | 액적 기반 미세유체 세포내 물질전달 방법 및 플랫폼 |
| AU2020380721B2 (en) * | 2019-11-06 | 2023-11-09 | Korea University Research And Business Foundation | Droplet deformation-based method of transferring material into cells and chip for same |
| KR102499546B1 (ko) * | 2020-10-07 | 2023-02-14 | 고려대학교 산학협력단 | 액적 변형에 기반한 세포내 물질 전달방법 및 이를 위한 칩 |
| CA3161104A1 (en) | 2019-12-11 | 2021-06-17 | Cecile Chartier-Courtaud | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
| EP4077676A1 (en) | 2019-12-18 | 2022-10-26 | Novartis AG | Compositions and methods for the treatment of hemoglobinopathies |
| EP4121079A4 (en) | 2020-03-16 | 2024-10-30 | Angeles Therapeutics, Inc. | NEW ANTIGEN-BINDING DOMAINS AND SYNTHETIC ANTIGEN RECEPTORS |
| CN115516101A (zh) * | 2020-03-26 | 2022-12-23 | 新加坡科技研究局 | 将一种或多种外源物质引入免疫细胞的方法和系统 |
| EP4048779A4 (en) * | 2020-03-26 | 2022-11-16 | Hewlett-Packard Development Company, L.P. | CELL PREPARATION WITH A SERIES OF DETECTION DEVICES |
| TW202208616A (zh) | 2020-05-04 | 2022-03-01 | 美商艾歐凡斯生物治療公司 | 改良之腫瘤反應性ｔ細胞的選擇 |
| US20230172987A1 (en) | 2020-05-04 | 2023-06-08 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| AU2021268007A1 (en) * | 2020-05-05 | 2022-11-24 | 3D Systems, Inc. | Microcosm bio-scaffold and applications thereof |
| CA3177288A1 (en) | 2020-05-11 | 2021-11-18 | F.Hoffmann-La Roche Ag | Combination therapy with modified pbmcs and an immunoconjugate |
| AU2021273985A1 (en) * | 2020-05-22 | 2022-12-22 | Sqz Biotechnologies Company | Point of care system for automatically processing cells |
| EP4158039A4 (en) * | 2020-05-26 | 2024-11-13 | Transcytos, LLC | DEVICES AND METHODS FOR TRANSFECTION |
| KR20230058388A (ko) | 2020-07-29 | 2023-05-03 | 에스큐지 바이오테크놀로지스 컴퍼니 | 무핵 세포를 사용해 돌연변이체 ras에 대한 면역 반응을 자극하는 방법 |
| US20250255961A1 (en) | 2020-07-29 | 2025-08-14 | Stemcell Technologies Canada Inc. | Methods to stimulate immune responses to mutant ras using nucleated cells |
| CN112268934B (zh) * | 2020-09-16 | 2022-06-28 | 东南大学 | 一种针对循环肿瘤细胞的检测芯片及其检测方法 |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| CN112275337B (zh) * | 2020-10-29 | 2022-03-18 | 上海荧辉医疗器械有限公司 | 一种微流控芯片及细胞筛选装置和方法 |
| EP4232554A1 (en) | 2020-11-18 | 2023-08-30 | Cellfe, Inc. | Methods and systems for mechanoporation-based payload delivery into biological cells |
| TW202241468A (zh) | 2020-12-11 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 用腫瘤浸潤性淋巴球療法與ｂｒａｆ抑制劑及／或ｍｅｋ抑制劑組合治療癌症患者 |
| EP4262827A1 (en) | 2020-12-17 | 2023-10-25 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocytes |
| WO2022133140A1 (en) | 2020-12-17 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| US12227729B2 (en) | 2020-12-24 | 2025-02-18 | Cellfe, Inc. | Methods and systems for high-throughput cell processing |
| WO2022147026A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | METHODS FOR TREATING CANCERS WITH MODIFIED PBMCs |
| JP2024502791A (ja) | 2020-12-29 | 2024-01-23 | スクイーズ バイオテクノロジーズ カンパニー | 細胞膜を摂動させるための並列化された狭窄部を有する高スループットマイクロ流体チップ |
| CA3203356A1 (en) | 2020-12-29 | 2022-07-07 | Oliver Rosen | Methods for treating cancers with activating antigen carriers |
| JP2024503277A (ja) | 2020-12-29 | 2024-01-25 | スクイーズ バイオテクノロジーズ カンパニー | 活性化抗原担体の製剤 |
| WO2022147428A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Microfluidic chip having increased throughput for use in a system for delivery of a payload into a cell |
| US12150982B2 (en) | 2020-12-29 | 2024-11-26 | Stemcell Technologies Canada Inc. | Formulations of PBMCs |
| US20240067910A1 (en) * | 2021-01-13 | 2024-02-29 | The General Hospital Corporation | Viscoelastic mechanoporation systems and methods of use thereof |
| CA3206549A1 (en) | 2021-01-29 | 2022-08-04 | Frederick G. Vogt | Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy |
| US20240173717A1 (en) | 2021-04-01 | 2024-05-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Multistage device and method for intracellular delivery |
| US20240182851A1 (en) | 2021-04-02 | 2024-06-06 | Sqz Biotechnologies Company | Reprogramming of cells and uses thereof |
| WO2022220539A1 (ko) | 2021-04-12 | 2022-10-20 | ㈜엠엑스티바이오텍 | 세포 내 물질 전달 플랫폼 |
| JP2024515189A (ja) | 2021-04-19 | 2024-04-05 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 細胞免疫療法におけるキメラ共刺激受容体、ケモカイン受容体、及びそれらの使用 |
| EP4337769A1 (en) | 2021-05-10 | 2024-03-20 | SQZ Biotechnologies Company | Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof |
| EP4359527A2 (en) | 2021-06-23 | 2024-05-01 | Novartis AG | Compositions and methods for the treatment of hemoglobinopathies |
| EP4373270A2 (en) | 2021-07-22 | 2024-05-29 | Iovance Biotherapeutics, Inc. | Method for cryopreservation of solid tumor fragments |
| WO2023009716A1 (en) | 2021-07-28 | 2023-02-02 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| EP4377447A1 (en) | 2021-07-29 | 2024-06-05 | SQZ Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
| CN113862112B (zh) * | 2021-09-03 | 2023-08-15 | 南昌大学 | 微流控离心式挤压的细胞转染系统及细胞转染方法 |
| US20230130686A1 (en) * | 2021-10-25 | 2023-04-27 | Massachusetts Institute Of Technology | Devices and systems for delivery of materials to cells |
| CA3235824A1 (en) | 2021-10-27 | 2023-05-04 | Frederick G. Vogt | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| EP4430167A1 (en) | 2021-11-10 | 2024-09-18 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| JP2024545582A (ja) | 2021-11-11 | 2024-12-10 | ステムセル テクノロジーズ カナダ インコーポレイテッド | マイクロ流体送達による増強された腫瘍浸潤リンパ球を作製する方法 |
| CN114181825B (zh) * | 2021-11-29 | 2024-05-03 | 南昌大学 | 一种外加电场作用下微流控离心式挤压的细胞转染系统 |
| DE102021214276A1 (de) * | 2021-12-14 | 2023-06-15 | Robert Bosch Gesellschaft mit beschränkter Haftung | Vorrichtung und Verfahren zum Splitten dreidimensionaler Agglomerate |
| US20250257322A1 (en) | 2022-01-05 | 2025-08-14 | Stemcell Technologies Canada Inc. | Modified hematopoietic stem cells and uses thereof |
| CN114316950B (zh) * | 2022-01-12 | 2022-08-26 | 广东粤港澳大湾区国家纳米科技创新研究院 | 通过前体胶囊制备量子点材料的方法和量子点材料、量子点组合物以及量子点器件 |
| US20250101380A1 (en) | 2022-01-28 | 2025-03-27 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
| JP2025504908A (ja) | 2022-01-28 | 2025-02-19 | アイオバンス バイオセラピューティクス，インコーポレイテッド | サイトカイン関連腫瘍浸潤リンパ球組成物及び方法 |
| CA3244717A1 (en) | 2022-02-23 | 2023-08-31 | Stemcell Technologies Canada Inc. | GLIAL CELL PRODUCTION PROCESSES AND THEIR USES |
| EP4504220A1 (en) | 2022-04-06 | 2025-02-12 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| EP4522202A1 (en) | 2022-05-10 | 2025-03-19 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist |
| CN119487180A (zh) | 2022-05-24 | 2025-02-18 | 加拿大干细胞技术公司 | 使用自扩增rna对细胞进行重编程 |
| JP2025517524A (ja) | 2022-05-27 | 2025-06-05 | ステムセル テクノロジーズ カナダ インコーポレイテッド | 細胞内にペイロードを送達するためのシステムで使用するカートリッジ及びデバイス |
| WO2024005863A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| WO2024005864A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| EP4299733A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| EP4299739A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
| CA3262748A1 (en) | 2022-07-28 | 2024-02-01 | Stemcell Technologies Canada Inc. | IMPROVED ANTIGEN-PRESENTING CELL FORMULATIONS |
| CN119866224A (zh) | 2022-07-28 | 2025-04-22 | 加拿大干细胞技术公司 | 编码连接抗原的多核苷酸以及其用途 |
| WO2024026492A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Methods for treating cancer with enhanced antigen presenting cells |
| EP4565683A1 (en) | 2022-08-01 | 2025-06-11 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| WO2024068996A1 (en) | 2022-09-30 | 2024-04-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| WO2024098024A1 (en) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| JP2025539816A (ja) | 2022-11-21 | 2025-12-09 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球の増幅のための２次元プロセス及びそれからの治療法 |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2024218295A1 (en) | 2023-04-21 | 2024-10-24 | Vib Vzw | Allelic combinations in crops for yield increase |
| AU2024277678A1 (en) | 2023-05-25 | 2025-11-27 | Dispatch Biotherapeutics, Inc. | Synthetic cancer antigens as targets for treating cancers |
| WO2025007073A2 (en) | 2023-06-29 | 2025-01-02 | Dispatch Biotherapeutics, Inc. | Synthetic cytokine receptors |
| WO2025076141A1 (en) | 2023-10-03 | 2025-04-10 | Inari Agriculture Technology, Inc. | Viral delivery of grna to the scion |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
| WO2025168705A1 (en) | 2024-02-08 | 2025-08-14 | Vib Vzw | Means and methods for the production of saponins with endosomal escape-enhancing properties |
| WO2025171383A2 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens and related methods and uses |
| WO2025171388A1 (en) | 2024-02-09 | 2025-08-14 | Dispatch Biotherapeutics, Inc. | Engineered cancer antigens with modified domains and related methods and uses |
| WO2025240518A1 (en) | 2024-05-14 | 2025-11-20 | Dispatch Biotherapeutics, Inc. | Modified lentiviral transfer plasmids |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2502621C3 (de) * | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
| US4478824A (en) | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| FR2569477B1 (fr) * | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | Appareil et procede pour la determination de la deformabilite des globules rouges du sang |
| JP2720161B2 (ja) | 1988-02-01 | 1998-02-25 | 株式会社アドバンス | 細胞変形能測定装置 |
| JP2685544B2 (ja) * | 1988-11-11 | 1997-12-03 | 株式会社日立製作所 | 血液フィルタおよび血液検査方法並びに血液検査装置 |
| JP2532707B2 (ja) | 1990-03-08 | 1996-09-11 | 佑二 菊池 | 血液回路及びこれを用いた血液測定装置及び血液測定方法 |
| DK0528859T3 (da) | 1990-04-24 | 1998-09-14 | Flustat Pty Ltd | Oral vaccine, som omfatter antigen knyttet til overfladen af røde blodlegemer |
| US5658892A (en) | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
| US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| DK0814838T3 (da) | 1995-03-08 | 2003-09-15 | Scripps Research Inst | Antigenpræsenterende system og aktivering af T-celler |
| US6051409A (en) | 1995-09-25 | 2000-04-18 | Novartis Finance Corporation | Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells |
| DE69626853T2 (de) | 1995-12-04 | 2004-02-19 | Puget Sound Blood Center And Programm, Seattle | Nicht-immunogene Blutplättchen und rote Blutzellen enthaltende Zubereitungen |
| JP2000516911A (ja) | 1996-03-28 | 2000-12-19 | ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ | オプソニン強化細胞、および抗原に対する免疫応答を調節する方法 |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| EP0882448B1 (en) | 1997-05-05 | 2005-01-12 | DIDECO S.r.l. | Method of encapsulating biologically active agents within erythrocytes and apparatus therefor |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilisation of cell structures and use thereof |
| GB9816583D0 (en) | 1998-07-31 | 1998-09-30 | Univ Ulster | Nucleic acid carrier |
| WO2000078920A1 (en) | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
| JP2002325572A (ja) | 2000-12-25 | 2002-11-12 | Univ Osaka | 外来物質の導入方法 |
| AU2002252073A1 (en) | 2001-02-22 | 2002-09-12 | The Scepens Eye Research Institute, Inc. | Tolerogenic antigen presenting cells and in treating immune-inflammatory conditions |
| WO2003020039A1 (en) | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Immune tolerance to predetermined antigens |
| CA2468424A1 (en) | 2001-11-27 | 2003-06-05 | Cecilia Farre | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
| US20030133922A1 (en) | 2002-01-15 | 2003-07-17 | Kasha John R. | Oral tolerance using allogeneic platelets in ITP |
| EP2365325A1 (en) | 2002-06-05 | 2011-09-14 | Panasonic Corporation | Device for measuring extracellular potential and method of manufacturing the device |
| GB0214528D0 (en) | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
| EP1587908A4 (en) | 2003-01-09 | 2008-02-20 | Invitrogen Corp | RELEASE AND ACTIVATION OF COMPLEX CELLS OF POLYPEPTIDES AND NUCLEIC ACIDS |
| US20060134067A1 (en) * | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| ES2967961T3 (es) * | 2004-05-03 | 2024-05-06 | Ipsen Biopharm Ltd | Liposomas útiles en la administración de fármacos |
| EP1780266A4 (en) * | 2004-06-17 | 2009-09-09 | Ken Nakata | CELL CULTIVATION PROCESS WITH BIOMECHANICAL LOAD TREATMENT AND ITS DEVICE |
| CA2574128C (en) | 2004-07-27 | 2012-10-09 | Dsm Ip Assets B.V. | Process for making a carbon nanotubes / ultra-high molar mass polyethylene composite fibre |
| US20060134772A1 (en) * | 2004-11-18 | 2006-06-22 | The Regents Of The University Of California | System for locating cells and for cellular analysis |
| WO2006095330A2 (en) | 2005-03-10 | 2006-09-14 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
| US7704743B2 (en) | 2005-03-30 | 2010-04-27 | Georgia Tech Research Corporation | Electrosonic cell manipulation device and method of use thereof |
| US7993821B2 (en) | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| WO2007097934A2 (en) | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Methods and compositions for using erythrocytes as carriers for delivery of drugs |
| US8293524B2 (en) * | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
| US20070249038A1 (en) | 2006-04-21 | 2007-10-25 | Andrea Adamo | Microfluidic device for single cell targeted operations |
| EP2054499A2 (en) | 2006-08-17 | 2009-05-06 | Massachusetts Institute of Technology | Method and apparatus for microfluidic injection |
| US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
| US8841135B2 (en) | 2007-06-20 | 2014-09-23 | University Of Washington | Biochip for high-throughput screening of circulating tumor cells |
| US8420891B2 (en) | 2007-06-21 | 2013-04-16 | National University Corporation Nagoya University | Method for introducing foreign substance into cell having cell wall |
| FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
| GB0718160D0 (en) | 2007-09-18 | 2007-10-24 | Medical Res Council | Methods |
| EP2057998A1 (en) | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Use of modified cells for the treatment of multiple sclerosis |
| CN101874201B (zh) * | 2007-11-28 | 2012-08-15 | 柯尼卡美能达精密光学株式会社 | 血液流动性测量装置及血液流动性测量方法 |
| US20090280518A1 (en) * | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
| JP2010002582A (ja) | 2008-06-19 | 2010-01-07 | Konica Minolta Business Technologies Inc | 画像形成装置 |
| WO2010010513A2 (en) | 2008-07-21 | 2010-01-28 | Trium Investments (Pty) Limited | Solar panel mounting arrangement |
| JP5137129B2 (ja) * | 2008-07-23 | 2013-02-06 | 国立大学法人山口大学 | 血液細胞の力学的特性測定装置 |
| EP2321405A4 (en) * | 2008-08-08 | 2012-09-12 | Agency Science Tech & Res | Microfluidic continuous flow device |
| US8211656B2 (en) | 2008-08-13 | 2012-07-03 | The Invention Science Fund I, Llc | Biological targeting compositions and methods of using the same |
| US20110091973A1 (en) | 2008-12-09 | 2011-04-21 | Glaser Larry F | Modified and fusion enhanced erythrocytes, cells and uses thereof |
| US9157550B2 (en) | 2009-01-05 | 2015-10-13 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and methods |
| EP2405959A4 (en) | 2009-03-13 | 2013-10-16 | Univ Tufts | METHODS, DEVICES AND KITS FOR INTRODUCING GENETIC MATERIAL IN LIVING CELLS |
| US9017991B2 (en) | 2009-03-13 | 2015-04-28 | Tufts University | Methods tip assemblies and kits for introducing material into cells |
| WO2010107399A1 (en) | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Devices for separating cells and methods of using them |
| WO2010129671A2 (en) | 2009-05-08 | 2010-11-11 | Chauncey Sayre | Method of and apparatus for changing one type of cell into another type of cell |
| GB0909754D0 (en) | 2009-06-05 | 2009-07-22 | Magnani Mauro | Drug delivery systems |
| US20110300205A1 (en) | 2009-07-06 | 2011-12-08 | Novartis Ag | Self replicating rna molecules and uses thereof |
| US9364831B2 (en) * | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
| JP5944318B2 (ja) | 2009-10-27 | 2016-07-05 | エリテック・ファルマ | 特異的免疫寛容を誘導するための組成物 |
| CN102791865B (zh) | 2009-12-21 | 2015-07-01 | 凯津公司 | 用于转染原生质体的改进技术 |
| WO2011084882A2 (en) | 2010-01-05 | 2011-07-14 | Contrafect Corporation | Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria |
| US8844570B2 (en) | 2010-02-01 | 2014-09-30 | California Institute Of Technology | Generating binary states using a microfluidic channel |
| JP5704590B2 (ja) | 2010-02-05 | 2015-04-22 | 国立大学法人東京農工大学 | サイズ選択マイクロキャビティアレイを用いた循環腫瘍細胞の検出 |
| US20110287948A1 (en) | 2010-03-22 | 2011-11-24 | Massachusetts Institute Of Technology | Measurement of material properties and related methods and compositions based on cytoadherence |
| WO2015061458A1 (en) | 2013-10-22 | 2015-04-30 | Cellanyx Diagnostics, Inc. | Systems, devices and methods for microfluidic culturing, manipulation and analysis of tissues and cells |
| EP2665540A1 (en) | 2011-01-19 | 2013-11-27 | The University of British Columbia | Apparatus and method for particle separation |
| CN103502426B (zh) | 2011-02-28 | 2018-03-13 | 哈佛大学校长及研究员协会 | 细胞培养系统 |
| CA2836608C (en) | 2011-05-27 | 2016-10-11 | The University Of British Columbia | Microfluidic cell trap and assay apparatus for high-throughput analysis |
| MX2013013243A (es) | 2011-07-05 | 2014-05-30 | Sotio As | Medios y metodos para activar la inmunoterapia celular del cancer utilizando celulas cancerosas destruidas mediante presion hidrostatica y celulas dendriticas. |
| US20130065314A1 (en) | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
| CN107058101B (zh) * | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| JP2015520194A (ja) | 2012-06-07 | 2015-07-16 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 薬物標的指向化のためのナノ療法 |
| US9255245B2 (en) | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
| CN102925337B (zh) | 2012-11-08 | 2014-06-18 | 武汉友芝友生物制药有限公司 | 一种微流体细胞捕获芯片及其制备方法 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| GB201300052D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-suppressive dendritic cells |
| GB201300049D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
| WO2014120956A1 (en) | 2013-01-30 | 2014-08-07 | Asta Fluidic Technologies, Inc. | Microfluidic-based fetal red blood cell detection |
| US9725709B2 (en) | 2013-03-12 | 2017-08-08 | OpenCell Technologies, Inc. | Intracellular delivery and transfection methods and devices |
| CN105452471A (zh) | 2013-03-15 | 2016-03-30 | 加利福尼亚大学董事会 | 使用光热平台向活细胞中的高通量运输物递送 |
| KR20140115560A (ko) | 2013-03-21 | 2014-10-01 | 인하대학교 산학협력단 | 기계적 스트레스를 이용한 단세포 생물체 개질 방법 및 이에 사용되는 장치 |
| WO2014165707A2 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| KR102386122B1 (ko) | 2013-08-16 | 2022-04-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| WO2015103331A1 (en) | 2013-12-31 | 2015-07-09 | Canon U.S. Life Sciences, Inc. | Methods and systems for continuous flow cell lysis in a microfluidic device |
| RU2736495C2 (ru) | 2014-04-01 | 2020-11-17 | Рубиус Терапьютикс, Инк. | Способ и композиции для иммуномодуляции |
| EP3800248A3 (en) | 2014-04-18 | 2021-08-04 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| EP3164482B1 (en) | 2014-07-03 | 2024-05-22 | Massachusetts Institute of Technology | Apparatus and method for optimization of cell electroporation |
| CA2964392A1 (en) * | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Delivery of biomolecules to immune cells |
| CA2964138C (en) | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| US9744533B2 (en) | 2014-12-10 | 2017-08-29 | Berkeley Lights, Inc. | Movement and selection of micro-objects in a microfluidic apparatus |
| HK1247241A1 (zh) | 2015-01-07 | 2018-09-21 | 英迪公司 | 一种用於机械和水动力微流体转染的方法以及用於其的设备 |
| AU2016206870B2 (en) | 2015-01-12 | 2022-02-17 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
| GB201513278D0 (en) | 2015-07-03 | 2015-09-09 | Transimmune Ag And Yale University | Device and method for obtaining immunostimulatory antigen-presenting cells |
| CA2988996A1 (en) * | 2015-07-09 | 2017-01-12 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| ES2930017T3 (es) | 2015-09-04 | 2022-12-05 | Sqz Biotechnologies Co | Suministro intracelular de biomoléculas mediado por una superficie con poros |
| EP3393482A4 (en) | 2015-12-22 | 2019-08-21 | Sangui Bio Pty. Ltd | THERAPEUTIC PROCEDURES USING ERYTHROCYTES |
| RS62939B1 (sr) | 2016-01-11 | 2022-03-31 | Rubius Therapeutics Inc | Kompozicije i metode u vezi sa multimodalnim terapijskim ćelijskim sistemima u indikacijama kancera |
| JP7033535B2 (ja) | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | 複合体の細胞内送達 |
| IL262677B2 (en) | 2016-05-03 | 2025-08-01 | Sqz Biotechnologies Co | Intracellular delivery of biomolecules to suppress an immune response or to induce tolerance to an antigen in an individual |
| EP3452062A1 (en) | 2016-05-03 | 2019-03-13 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| US20170326213A1 (en) | 2016-05-16 | 2017-11-16 | Augusta University Research Institute, Inc. | Protein-Coupled Red Blood Cell Compositions and Methods of Their Use |
| CN106244543A (zh) | 2016-07-29 | 2016-12-21 | 北京时合生物科技有限公司 | 一种pbmc体外诱导分化成为树突状细胞的方法 |
| WO2018089497A1 (en) | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
| US12440839B2 (en) * | 2018-08-21 | 2025-10-14 | The Regents Of The University Of California | High-throughput system and method for the temporary permeabilization of cells using lipid bilayers |
| AU2020380721B2 (en) * | 2019-11-06 | 2023-11-09 | Korea University Research And Business Foundation | Droplet deformation-based method of transferring material into cells and chip for same |
| US20240067910A1 (en) * | 2021-01-13 | 2024-02-29 | The General Hospital Corporation | Viscoelastic mechanoporation systems and methods of use thereof |
| US20240173717A1 (en) * | 2021-04-01 | 2024-05-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Multistage device and method for intracellular delivery |
| CN116964210A (zh) * | 2021-04-12 | 2023-10-27 | 明新特生物科技公司 | 细胞内物质递送平台 |
-
2012
- 2012-10-17 CN CN201710109954.XA patent/CN107058101B/zh active Active
- 2012-10-17 DK DK12841329.1T patent/DK2768942T3/da active
- 2012-10-17 CA CA2852672A patent/CA2852672C/en active Active
- 2012-10-17 RU RU2014119926A patent/RU2656156C2/ru active
- 2012-10-17 CN CN201280060689.6A patent/CN103987836B/zh active Active
- 2012-10-17 RS RS20200038A patent/RS59898B1/sr unknown
- 2012-10-17 AU AU2012326203A patent/AU2012326203B2/en active Active
- 2012-10-17 US US14/352,354 patent/US10696944B2/en active Active
- 2012-10-17 HR HRP20200051TT patent/HRP20200051T1/hr unknown
- 2012-10-17 PL PL12841329T patent/PL2768942T3/pl unknown
- 2012-10-17 ES ES12841329T patent/ES2764105T3/es active Active
- 2012-10-17 WO PCT/US2012/060646 patent/WO2013059343A1/en not_active Ceased
- 2012-10-17 BR BR112014009346-6A patent/BR112014009346B1/pt active IP Right Grant
- 2012-10-17 EP EP19187758.8A patent/EP3608394A1/en active Pending
- 2012-10-17 LT LTEP12841329.1T patent/LT2768942T/lt unknown
- 2012-10-17 PT PT128413291T patent/PT2768942T/pt unknown
- 2012-10-17 KR KR1020147013150A patent/KR102058568B1/ko active Active
- 2012-10-17 HU HUE12841329A patent/HUE047507T2/hu unknown
- 2012-10-17 CN CN202110519751.4A patent/CN113337402B/zh active Active
- 2012-10-17 JP JP2014537184A patent/JP6219832B2/ja active Active
- 2012-10-17 SI SI201231714T patent/SI2768942T1/sl unknown
- 2012-10-17 EP EP12841329.1A patent/EP2768942B1/en active Active
-
2017
- 2017-09-28 JP JP2017187368A patent/JP6629272B2/ja active Active
-
2018
- 2018-09-25 US US16/141,107 patent/US20190093073A1/en not_active Abandoned
-
2020
- 2020-03-13 US US16/818,021 patent/US20200277566A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LT2768942T (lt) | Pristatymas į ląstelės vidų | |
| BR112014002399A2 (pt) | conjunto | |
| EP2667915A4 (en) | INJEKTOR | |
| EP2688642A4 (en) | neurostimulator | |
| DK2775557T3 (da) | Brændselscelle | |
| EP2752667A4 (en) | AUTO ANALYZER | |
| EP2673344A4 (en) | STABLE BIO OIL | |
| EP2713945A4 (en) | ÖSOPHAGEAL STENT | |
| IL231616A0 (en) | Tropicalizing agent | |
| DK2731571T3 (da) | Forbedringer vedrørende leveringsanordninger | |
| BR112013015345A2 (pt) | nacela | |
| IL231640A (en) | Propulsion bay | |
| EP2700534A4 (en) | Charging apparatus | |
| EP2720045A4 (en) | Autoanalyzer | |
| EP2757623A4 (en) | FUEL CELL | |
| DK2681530T3 (da) | Gennemstrømmelig målecelle | |
| DE112011105455T8 (de) | Brennstoffzelle | |
| EP2768053A4 (en) | FUEL CELL | |
| EP2696415A4 (en) | FUEL CELL | |
| FI20116111L (fi) | Mikromanipulaattorijärjestely | |
| DK2500470T3 (da) | Hoved-arbejdsvogn | |
| DE112011102608T8 (de) | Cetanzahl-Bestimmungsvorrrichtung | |
| FR2976466B1 (fr) | Etui range-piolet | |
| EP2708238A4 (en) | CYTOLYTIC CELL INDUCTION AGENT | |
| ES2396651B2 (es) | Material biosanitario antiulcera. |