KR950701534A - 의료장치용 항-미생물 코팅(anti-microbial coating for medical devices) - Google Patents

의료장치용 항-미생물 코팅(anti-microbial coating for medical devices)

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Publication number
KR950701534A
KR950701534A KR1019940704191A KR19940704191A KR950701534A KR 950701534 A KR950701534 A KR 950701534A KR 1019940704191 A KR1019940704191 A KR 1019940704191A KR 19940704191 A KR19940704191 A KR 19940704191A KR 950701534 A KR950701534 A KR 950701534A
Authority
KR
South Korea
Prior art keywords
metal
deposition
atoms
molecules
coating
Prior art date
Application number
KR1019940704191A
Other languages
English (en)
Inventor
에드워드 버렐 로버트
알. 모리스 래리
Original Assignee
아더 지. 맥뮬렌
웨스트에임 테크놀로지스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아더 지. 맥뮬렌, 웨스트에임 테크놀로지스 인코포레이티드 filed Critical 아더 지. 맥뮬렌
Publication of KR950701534A publication Critical patent/KR950701534A/ko

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    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/225—Oblique incidence of vaporised material on substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A61L17/145—Coating
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
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    • A61L29/10—Inorganic materials
    • A61L29/106—Inorganic materials other than carbon
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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    • C23C14/0036—Reactive sputtering
    • C—CHEMISTRY; METALLURGY
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    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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    • C23C14/024—Deposition of sublayers, e.g. to promote adhesion of the coating
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    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
    • C23C14/0688—Cermets, e.g. mixtures of metal and one or more of carbides, nitrides, oxides or borides
    • C—CHEMISTRY; METALLURGY
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    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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    • C—CHEMISTRY; METALLURGY
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    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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Abstract

본 발명에서는 항미생물 코팅과 그것을 의료 장치위에 형성하는 방법이 제공된다. 코팅은 증착 기법에 의하여 생체적합성 금속을 증착시킴으로써 형성되어 코팅내에 원자 무질서를 생성하여 항미생물 효과가 이루어지기에 충분한 금속이온이 방출되도록 한다. 원자 무질서를 이루기 위해 바람직한 증착 조건은 정상 기판 온도보다 낮은 온도, 하나 또는 그 이상의 정상 작업 기압보다 높은 기압 및 정상적인 코팅 플럭스 입사각보다 낮은 각도이다. 또한 본 발명에서는 원자 무질서를 생성하기 위해 기계적 가공에 의해 형성된 항미생물 분말도 제공된다. 본 발명은 증강된 용해도를 제공하기 위해 유사하게 형성된 다른 금속 코팅 및 분말에도 확대된다.

Description

의료장치용 항-미생물 코팅(ANTI-MICROBIAL COATING FOR MEDICAL DEVICES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (58)

  1. 변형된 재료로서, 상기 재료에 대한 용매와 접촉시에 상기 재료가 1가지 이상의 금속을 함유하고 있는 원자, 이온, 분자 또는 클러스터를 자체의 정상적인 질성의 결정상태에 비해 증강된 속도로 방출할 수 있도록 원자의 무질서도가 충부난 것을 특징으로 하는 형태의 1가지 이상의 금속으로 이루어진 변형된 재료.
  2. 제1항에 있어서, 분말이나 호일 형태인 것을 특징으로 하는 재료.
  3. 제1항에 있어서, 코팅의 형태인 것을 특징으로 하는 재료.
  4. 제1항에 있어서, 재료가 원자의 무질서를 발생시키기 위해 냉간 가공되는 것을 특징으로 하는 재료.
  5. 제3항에 있어서, 상기 재료가 증착법에 의해 형성된 것을 특징으로 하는 재료.
  6. 제5항에 있어서, 상기 재료가 물리적 증착 방법에 의해 형성된 것을 특징으로 하는 재료.
  7. 제1항 내지 제3항중의 어느 한항에 있어서, 1가지 이상의 상기 금속들이 항-미생물 금속이고, 상기 재료에 충분한 원자 무질서를 갖도록 형성되어 상기 항-미생물 금속의 원자, 이온, 분자 또는 클러스터를 지속적으로 방출시키는 것을 특징으로 하는 재료.
  8. 제1항, 제4항 또는 제6항에 있어서, 상기 금속의 Ag, Au, Pt, Pd, ir, Sn, Cu, Sb, Bi 및 Zn 또는 이것들의 합금 또는 화합물로 이루어지는 군으로부터 선택되는 것을 특징으로 하는 재료.
  9. 제1항, 제4항 또는 제6항에 있어서, 금속이 Ag, Au또는 Pd또는 하나 또는 그 이상의 이들 금속의 합금 또는 화합물인 것을 특징으로 하는 재료.
  10. 확산을 제한하는 조건하에서 변형된 재료내에서 원자 무질서를 생성하여 충분한 원자 무질서가 재료내에 유지됨으로써 최소한 하나의 금속의 원자, 이온, 분자 또는 클러스터를 상기 재료에 대한 용매안으로, 그것의 정상질소의 결정상태에 비해 증강된 속도로 방출시키는 것으로 이루어지는, 하나 또는 그 이상의 금속을 함유하는 변형된 재료의 제조방법.
  11. 제10항에 있어서, 재료가 하나이상의 금속의 분말 또는 호일이고, 원자 무질서는 분말 또는 호일의 냉간 가공에 의해 형성되는 것을 특징으로 하는 방법.
  12. 제11항에 있어서, 분말 또는 호일이 원자 무질서를 유지하기 위해 분말 또는 호일에 대한 재결정화 온도아래의 온도에서 가공되는 것을 특징으로 하는 방법.
  13. 제12항에 있어서, 재료가 나노 결정성 분말인 것을 특징으로 하는 방법.
  14. 제12항에 있어서, 최소한 하나의 금속이 항-미생물 금속이고 재료는 항-미생물 금속의 원자, 이온, 분자 또는 클러스터가 지속적으로 방출되도록 충분한 원자 무질서를 갖도록 형성되는 것을 특징으로 하는 방법.
  15. 제12항에 있어서, 최소한 하나의 금속이 Ag, Au, Pd, ir, Cu, Sb, Bi 및 Zn 또는 하나 또는 그 이상의 이들 금속의 합금 또는 화합물로 이루어지는 군으로부터 선택되는 것을 특징으로 하는 방법.
  16. 제12항에 있어서, Ag, Au 또는 Pd또는 하나 이상의 이들 금속을 함유하는 합금 또는 화합물인 것을 특징으로 하는 방법.
  17. 제12항에 있어서, 최소한 하나의 금속이 은 또는 은 함유 합금 또는 화합물인 것을 특징으로 하는 방법.
  18. 제10항에 있어서, 재료가 증착동안 확산을 제한하고, 증착후에 어닐링 또는 재결정화를 제한하는 조건하에서 증착이 기판상에 코팅으로서 형성되는 것을 특징으로 하는 방법.
  19. 제18항에 있어서, 재료가 물리적 증착에 의해 형성되는 것을 특징으로 하는 방법.
  20. 제19항에 있어서, 재료가 진공 증발, 스퍼터링, 마그네트론 스퍼터링,또는 이온 도금에 의해 기판상에 형성되는 하나 이상의 금속의 코팅인 것을 특징으로 하는 방법.
  21. 제20항에 있어서, 증착이 기판 온도 대 증착될 금속 또는 금속 화합물의 비가 0.5이하로 유지되는 조건하에서 수행되는 것을 특징으로 하는 방법.
  22. 제21항에 있어서, 비가 0.3이하로 유지되는 것을 특징으로 하는 방법.
  23. 제21항에 있어서, 증착이 코팅될 기판상의 코팅 플럭스의 입사각이 75°미만이 되도록 수행되는 것을 특징으로 하는 방법.
  24. 제21항에 있어서, 증착이 0.01mT보다 큰 주변 또는 작업 기압에서 아아크 증발에 의해 수행되는 것을 특징으로 하는 방법.
  25. 제21항에 있어서, 증착이 20mT보다 큰 작업기압에서 기체 산란 증발에 의해 수행되는 것을 특징으로 하는 방법.
  26. 제21항에 있어서, 증착이 75mT보다 큰 작업 기압에서 스퍼터링에 의해 수행되는 것을 특징으로 하는 방법.
  27. 제21항에 있어서, 증착이 10mT보다 큰 작업 기압에서 마그네트론 스퍼터링에의해 수행되는 것을 특징으로 하는 방법.
  28. 제21항에 있어서, 증착이 200mT보다 큰 작업 기압에서 이온 도금에 의해 수행되는 것을 특징으로 하는 방법.
  29. 제20항에 있어서, 최소한 하나의 금속이 항-미생물 금속이고 재료는 항-미생물 금속의 원자, 이온, 분자 또는 클러스터가 지속적으로 방출되도록 충분한 원자 무질서를 갖도록 형성되는 것을 특징으로 하는 방법.
  30. 제21항, 23항 또는 제27항에 있어서, 최소한 하나의 금속이 항-미생물 금속이고 재료는 항-미생물 금속의 원자, 이온, 분자 또는 클러스터가 지속적으로 방출되도록 충분한 원자 무질서를 갖도록 형성되는 것을 특징으로 하는 방법.
  31. 제20항에 있어서, 혼성 코팅이 원자 무질서가 매트릭스내에 생성되도록 첫번째 금속과는 상이한 재료의 분자들의 원자와 함께 첫번째 금속을 매트릭스내에 동시에, 순차적으로 또는 반응적으로 증착시킴으로써 형성되는 것을 특징으로 하는 방법.
  32. 제31항에 있어서, 첫번째 금속이 항-미생물 금속이고 상이한 재료가 증착 과장 동안에 작업 대기로부터 매트릭스내로 반응적으로 증착된 원자 또는 분자인 것을 특징으로 하는 사용방법.
  33. 제31항에 있어서, 첫번째 금속이 항-미생물 금속이고 상이한 재료가 비활성 생체 적합한 금속의 산화물, 질화물, 탄화물, 붕소화물, 황화물 및 할로겐화물로부터 선택되는 원자 또는 분자인 것을 특징으로 하는 사용방법.
  34. 알코올 또는 물기초 전해질과 접촉시 사용하기 위해 고안된 장치위에 항미생물 코팅을 형성하는 방법으로서, 항 미생물 금속을 함유하는 코팅을 장치의 표면위에 증착에 의해 증착시켜서, 코팅이 알코올 또는 물기초 전해질과 접촉시 금속이온, 원자, 분자 또는 클러스터를 알코올 또는 물기초 전해질로, 국소화된 항미생물 효과를 제공하기에 충분한 농도에서 지속적으로 방출할 수 있도록 원자 무질서를 가지는 금속의 얇은 필름을 생성시키는 것으로 이루어지는 방법.
  35. 제34항에 있어서, 증착이 진공증바르 스퍼터링, 마그네트론 스퍼터링 또는 이온 도금으로부터 선택된 물리적 증착 기법에 의하여, 증착 과정동안 확산을 제한하고 증착후 어닐링 또는 재결정화를 제한하는 조건하에서 수행되는 것을 특징으로 하는 방법.
  36. 제35항에 있어서, 제20항에 있어서, 증착이 기판 온도 대 증착될 금속 또는 금속 화합물의 비가 0.5이하로 유지되는 조건하에서 수행되는 것을 특징으로 하는 방법.
  37. 제36항에 있어서, 증착이 코팅될 기판상의 코팅 플럭스의 입사각이 75°미만이 되도록 수행되는 것을 특징으로 하는 방법.
  38. 제36 또는 37항에 있어서, 증착이 0.01mT보다 큰 주변 또는 작업 기압에서 아아크 증발에 의해 수행되는 것을 특징으로 하는 방법.
  39. 제36 또는 37항에 있어서, 증착이 20mT보다 큰 작업기압에서 기체 산란 증발에 의해 수행되는 것을 특징으로 하는 방법.
  40. 제36 또는 37항에 있어서, 증착이 74mT보다 큰 작업 기압에서 스퍼터링에 의해 수행되는 것을 특징으로 하는 방법
  41. 제36 또는 37항에 있어서, 증착이 74mT보다 큰 작업 기압에서 마그네트론 스퍼터링에 의해 수행되는 것을 특징으로 하는 방법.
  42. 제36 또는 37항에 있어서, 증착이 200mT보다 큰 작업 기압에서 이온 도금에 의해 수행되는 것을 특징으로 하는 방법.
  43. 제36 또는 37항에 있어서, 최소한 하나의 금속이 Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Bi 및 Zn 또는 하나 또는 그 이상의 이들 금속의 합금 또는 화합물로 이루어지는 군으로부터 선택되는 것을 특징으로 하는 방법.
  44. 제36 또는 37항에 있어서, 최소한 하나의 금속이 Ag, Au 또는 Pd 또는 하나 이상의 이들 금속을 함유하는 합금 또는 화합물인 것을 특징으로 하는 방법.
  45. 알코올 또는 물기초 전해질과 접촉시 사용하기 위해 계획된, 표면에 항-미생물 코팅을 가지고 있는 의료 장치로서, 실제로 생체비활성 구조의 재료로 형성된 의료용 장치; 및 하나 또는 그 이상의, 항 미생물 금속으로부터 형성되며, 코팅이 알코올 또는 물기초 전해질과 접촉시 금속이온, 원자, 분자 또는 클러스터를국소화된 항미생물 효과를 제공하기에 충분한 농도로 알코올 또는 물기초 전해질안으로 지속적으로 방출하도록충분한 원자 무질서를 가지는, 상기 의료 장치의 표면에 형성된 항미생물 코팅으로 이루어지는 의료 장치.
  46. 제45항에 있어서, 증착이 진공증발, 스퍼터링, 마그네트론 스퍼터링 또는 이온 도금으로부터 선택된 물리적 증착 기법에 의해 수행되는 것을 특징으로 하는 방법.
  47. 제46항에 있어서, 금속이 Ag, Au,Pt, Pd, Ir, Sn, Cu, Sb, Bi 및 Zn 또는 이들 금속의 하나 이상을 함유하는 합금 또는 화합물로 이루어지는 군으로부터 선택되는 것을 특징으로 하는 의료 장치.
  48. 제46항에 있어서, 금속이 Ag, Au 또는 Pd또는 하나 이상의 이들 금속을 함유하는 합금 또는 화합물인 것을 특징으로 하는 의료 장치.
  49. 제6항에 있어서, 코팅이 최소한 하나의 첫번째 금속으로부터 형성된 혼성 코팅이고, 이 금속은 첫번째 금속과 상이한 재료의 원자 또는 분자를 함유하는 매트릭스내에서 방출되며, 상이한 재료의 원자 또는 분자는 매트릭스내에 원자 무질서를 생성하는 것을 특징으로 하는 재료.
  50. 제49항에 있어서, 상이한 재료가 첫번째 금속 또는 금속화합물의 반응된 핵종; 산소, 질소, 수소, 붕소, 황 및 할로겐의 흡수된 또는 포획된 원자 또는 분자들; 및 제2금속으로부터 선택되는 것을 특징으로 하는 재료.
  51. 제50항에 있어서, 첫번째 금속이 항 미생물 금속이고, 상이한 재료가 항 미생물 또는 제2금속의 산화물, 질화물, 수소화물, 할로겐화물, 붕소화물, 및 탄화물; 및 산소, 질소, 수소, 붕소, 황 및 할로겐을 함유하는흡수된 또는 포획된 원자 또는 분자들로부터 선택되는 것을 특징으로 하는 재료.
  52. 제49항에 있어서, 첫번째 금속이 항 미생물 금속이고, 상이한 재료가 Ta, Ti, Nb, V, Hf, Zn, Mo, Si및 Al로부터 선택된 비활성 금속의 산화물, 질화물, 붕소화물, 황화물, 할로겐화물 또는 수소화물인 것을 특징으로 하는 재료.
  53. 제49항에 있어서, 산화 은, 은 금속 및 임의로 산소, 질소, 수소, 붕소, 황 및 할로겐을 함유하는 흡수된 또는 포획된 원자 또는 분자들을 포함하는 재료.
  54. 제18항에 있어서, 변형된 재료가, 첫번째 금속을 원자 무질서가 매트릭스내에 생성되도록 첫번째 금속과 상이한 재료의 원자 또는 분자들과 함께 매트릭스내에 동시에, 순차적으로 또는 반응적으로 증착시킴에 의해 형성된 혼성 코팅인 것을 특징으로 하는 장치.
  55. 제53항에 있어서, 첫번째 금속이 항 미생물 금속이고, 상이한 재료가 증착 대기로부터 매트릭스에 흡수된 또는 포획된 산소, 질소, 수소, 붕소, 황 및 할로겐을 함유하는 원자 또는 분자들로부터 선택되는 것을 특징으로 하는 재료.
  56. 제54항에 있어서, 첫번째 금속이 은이고, 상이한 재료가 산소, 질소, 수소, 붕소, 황 및 할로겐을 함유하는 원자 또는 분자들로부터 선택되는 것을 특징으로 하는 재료.
  57. 제55항에 있어서, 첫번째 금속이 항 미생물 금속이고, 상이한 재료가 Ta, Ti, Nb, V, Hf, Zn, Mo, Si및 Al로부터 선택된 비활성 금속의 산화물, 질화물, 붕소화물, 황화물, 할로겐화물 또는 수소화물인 것을 특징으로 하는 방법.
  58. 제57항에 있어서, 첫번째 금속이 은이고, 상이한 재료가 Ta, Ti또는 Nb의 산화물인 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940704191A 1992-05-19 1993-05-19 의료장치용 항-미생물 코팅(anti-microbial coating for medical devices) KR950701534A (ko)

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