KR920002128B1 - 피리딘 유도체의 제조방법 - Google Patents
피리딘 유도체의 제조방법 Download PDFInfo
- Publication number
- KR920002128B1 KR920002128B1 KR1019850005863A KR850005863A KR920002128B1 KR 920002128 B1 KR920002128 B1 KR 920002128B1 KR 1019850005863 A KR1019850005863 A KR 1019850005863A KR 850005863 A KR850005863 A KR 850005863A KR 920002128 B1 KR920002128 B1 KR 920002128B1
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- reaction
- sodium
- hours
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 0 *[C@](C*(C*C1[N+]([O-])=O)I)[C@]1OO Chemical compound *[C@](C*(C*C1[N+]([O-])=O)I)[C@]1OO 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP171069 | 1984-08-16 | ||
| JP59171069A JPS6150978A (ja) | 1984-08-16 | 1984-08-16 | ピリジン誘導体およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR870002125A KR870002125A (ko) | 1987-03-30 |
| KR920002128B1 true KR920002128B1 (ko) | 1992-03-12 |
Family
ID=15916456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850005863A Expired KR920002128B1 (ko) | 1984-08-16 | 1985-08-14 | 피리딘 유도체의 제조방법 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US4628098A (enExample) |
| EP (1) | EP0174726B1 (enExample) |
| JP (1) | JPS6150978A (enExample) |
| KR (1) | KR920002128B1 (enExample) |
| AU (1) | AU570130B2 (enExample) |
| BG (1) | BG60415B2 (enExample) |
| CA (1) | CA1255314A (enExample) |
| DE (3) | DE19975017I2 (enExample) |
| DK (1) | DK171340B1 (enExample) |
| ES (1) | ES8607288A1 (enExample) |
| GE (1) | GEP19960313B (enExample) |
| GR (1) | GR851981B (enExample) |
| HK (1) | HK4792A (enExample) |
| HU (1) | HU195210B (enExample) |
| IE (1) | IE58363B1 (enExample) |
| MX (1) | MX9203043A (enExample) |
| NL (1) | NL930109I2 (enExample) |
| NO (2) | NO163131C (enExample) |
| PH (1) | PH20946A (enExample) |
| SG (1) | SG103291G (enExample) |
| SU (1) | SU1507211A3 (enExample) |
| UA (1) | UA7140A1 (enExample) |
| ZA (1) | ZA856117B (enExample) |
Families Citing this family (243)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3585252D1 (de) | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
| CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| US6749864B2 (en) * | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| CA1276017C (en) * | 1986-02-13 | 1990-11-06 | Takeda Chemical Industries, Ltd. | Sulfenamide derivatives and their production |
| US5433959A (en) * | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| AU3690289A (en) * | 1988-05-25 | 1989-12-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New fluoralkoxy compounds |
| JP2536173B2 (ja) * | 1988-08-18 | 1996-09-18 | 武田薬品工業株式会社 | 注射剤 |
| US5223515A (en) * | 1988-08-18 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Injectable solution containing a pyridyl methylsulfinylbenzimidazole |
| AT391693B (de) * | 1988-11-15 | 1990-11-12 | Cl Pharma | Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer |
| SE8804629D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
| EG19302A (en) * | 1988-12-22 | 1994-11-30 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
| SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| ATE114114T1 (de) * | 1989-02-10 | 1994-12-15 | Takeda Chemical Industries Ltd | Verwendung von benzimidazol-derivaten als antibakterielle mittel. |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| US5049674A (en) * | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
| CA2053527C (en) * | 1990-10-17 | 2002-03-12 | Takashi Sohda | Pyridine derivatives, their production and use |
| TW209174B (enExample) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
| NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
| ES2036948B1 (es) * | 1991-11-21 | 1994-09-01 | Genesis Para La Investigacion | Procedimiento de obtencion de compuestos derivados de piridina. |
| KR950702416A (ko) * | 1992-07-08 | 1995-07-29 | 제임스 클리프튼 보올딩 | 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine) |
| CA2140347C (en) * | 1992-07-28 | 2001-03-27 | Shigeo Nakanishi | Injection and injection kit containing omeprazole and its analogs |
| WO1994019346A1 (de) * | 1993-02-17 | 1994-09-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituierte heteroarylalkylthiopyridine zur bekämpfung von helicobacter bakterien |
| ES2060541B1 (es) * | 1993-02-26 | 1995-11-16 | Vinas Lab | Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo. |
| ES2063705B1 (es) * | 1993-06-14 | 1995-07-16 | S A L V A T Lab Sa | Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion. |
| NZ268891A (en) * | 1993-06-29 | 1996-08-27 | Byk Gulden Lomberg Chem Fab | Arylthioalkylthiopyridines; compounds, preparation and medicaments |
| TW280770B (enExample) * | 1993-10-15 | 1996-07-11 | Takeda Pharm Industry Co Ltd | |
| US5502195A (en) * | 1993-11-04 | 1996-03-26 | Slemon; Clarke | Sulfoxide-carboxylate intermediates of omeprazole and lansoprazole |
| US5374730A (en) * | 1993-11-04 | 1994-12-20 | Torcan Chemical Ltd. | Preparation of omeprazole and lansoprazole |
| CN1048980C (zh) * | 1994-03-29 | 2000-02-02 | 广东汕头鮀滨化学药业总公司 | 一种新的吡啶衍生物及其制备方法和应用 |
| SK283268B6 (sk) * | 1994-06-10 | 2003-04-01 | Altana Pharma Ag | Tiopyridíny, spôsob ich výroby a ich použitie |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
| GB9423968D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Resolution |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| HRP960232A2 (en) * | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| PT854718E (pt) * | 1995-09-21 | 2004-08-31 | Pharma Pass Ii Llc | Composicao farmaceutica contendo um benzimidazole acido-labil e processo para a sua preparacao |
| SE521100C2 (sv) * | 1995-12-15 | 2003-09-30 | Astra Ab | Förfarande för framställning av en bensimidazolförening |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US6380222B2 (en) | 1996-10-11 | 2002-04-30 | Astrazeneca Ab | Use of an H+, K+-atpase inhibitor in the treatment of nasal polyps |
| TW385306B (en) * | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| AU6551198A (en) * | 1997-05-30 | 1998-12-30 | Dr. Reddy's Research Foundation | Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them |
| AU9067198A (en) | 1997-07-25 | 1999-02-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Proton pump inhibitor in therapeutic combination with antibacterial substances |
| SE9704870D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulation I |
| WO1999059544A2 (en) | 1998-05-18 | 1999-11-25 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
| WO2000000474A1 (en) * | 1998-06-26 | 2000-01-06 | Russinsky Limited | Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds |
| SI20019A (sl) * | 1998-07-13 | 2000-02-29 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola |
| JP2002521336A (ja) * | 1998-07-22 | 2002-07-16 | セプラコール, インク. | ヒドロキシランソプラゾールを含む医薬組成物及びその使用 |
| EP1105387B1 (en) * | 1998-08-10 | 2003-01-29 | Winston Pharmateuticals LLC | Prodrugs of proton pump inhibitors |
| US6093734A (en) * | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| SI1105105T1 (sl) | 1998-08-12 | 2006-08-31 | Altana Pharma Ag | Oralna dajalna oblika za piridin-2-ilmetilsulfinil-1J-benzimidazole |
| DE19843413C1 (de) * | 1998-08-18 | 2000-03-30 | Byk Gulden Lomberg Chem Fab | Neue Salzform von Pantoprazol |
| JP3926936B2 (ja) | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
| US20040224989A1 (en) * | 1999-01-29 | 2004-11-11 | Barberich Timothy J. | S-lansoprazole compositions and methods |
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
| JP4980527B2 (ja) | 1999-06-07 | 2012-07-18 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸に不安定な活性化合物を含有する新規の製剤および投与形 |
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| EP1191025B1 (en) * | 1999-06-30 | 2005-06-22 | Takeda Pharmaceutical Company Limited | Crystals of lansoprazole |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
| US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
| US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
| US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
| US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
| US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
| US6228400B1 (en) | 1999-09-28 | 2001-05-08 | Carlsbad Technology, Inc. | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
| KR100359256B1 (ko) * | 1999-10-06 | 2002-11-04 | 한미약품공업 주식회사 | 란소프라졸의 개선된 제조방법 |
| SE9903831D0 (sv) * | 1999-10-22 | 1999-10-22 | Astra Ab | Formulation of substituted benzimidazoles |
| US20060034937A1 (en) * | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| ES2171116B1 (es) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
| CN100562318C (zh) * | 2000-05-15 | 2009-11-25 | 武田药品工业株式会社 | 晶体的制备方法 |
| AU2001276721A1 (en) | 2000-08-04 | 2002-02-18 | Takeda Chemical Industries Ltd. | Salts of benzimidazole compound and use thereof |
| US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
| AU2001296908A1 (en) * | 2000-09-29 | 2002-04-08 | Geneva Pharmaceuticals, Inc. | Proton pump inhibitor formulation |
| TWI290922B (en) | 2000-12-01 | 2007-12-11 | Takeda Chemical Industries Ltd | Production method of crystals |
| JP5009482B2 (ja) | 2000-12-07 | 2012-08-22 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸に不安定な活性成分を含有する懸濁液の形の製薬製剤 |
| DK1341528T3 (da) | 2000-12-07 | 2012-03-26 | Nycomed Gmbh | Hurtigtopløsende tablet omfattende en syrelabil aktiv bestanddel |
| US7988999B2 (en) | 2000-12-07 | 2011-08-02 | Nycomed Gmbh | Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient |
| KR100430575B1 (ko) * | 2001-02-21 | 2004-05-10 | 주식회사 씨트리 | 란소프라졸 및 그 중간체의 제조방법 |
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| SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
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| SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
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| WO2003027098A1 (en) * | 2001-09-25 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Benzimidazole compound, process for producing the same, and use thereof |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| ES2426723T3 (es) | 2001-10-17 | 2013-10-24 | Takeda Pharmaceutical Company Limited | Gránulos que contienen gran cantidad de compuesto químico inestable en medio ácido |
| SE0104295D0 (sv) * | 2001-12-18 | 2001-12-18 | Astrazeneca Ab | New process |
| RU2215739C1 (ru) * | 2002-04-03 | 2003-11-10 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 5-метокси-2-(4-метокси-3,5-диметил-2-пиридилметилтио)бензимидазола |
| WO2003084518A2 (fr) | 2002-04-09 | 2003-10-16 | Flamel Technologies | Suspension orale de microcapsules de principes actifs |
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- 1985-08-14 UA UA3947161A patent/UA7140A1/uk unknown
- 1985-08-14 CA CA000488662A patent/CA1255314A/en not_active Expired
- 1985-08-14 ES ES546152A patent/ES8607288A1/es not_active Expired
- 1985-08-14 SU SU3947161A patent/SU1507211A3/ru active
- 1985-08-15 HU HU853151A patent/HU195210B/hu unknown
- 1985-08-15 NO NO853226A patent/NO163131C/no not_active IP Right Cessation
-
1986
- 1986-12-02 US US06/937,193 patent/US4689333A/en not_active Expired - Lifetime
-
1991
- 1991-12-04 SG SG1032/91A patent/SG103291G/en unknown
-
1992
- 1992-01-16 HK HK47/92A patent/HK4792A/en not_active IP Right Cessation
- 1992-06-19 MX MX9203043A patent/MX9203043A/es unknown
-
1993
- 1993-03-11 GE GEAP1993601A patent/GEP19960313B/en unknown
- 1993-06-29 NL NL930109C patent/NL930109I2/nl unknown
-
1994
- 1994-02-11 BG BG098459A patent/BG60415B2/bg unknown
-
1995
- 1995-03-31 NO NO1995002C patent/NO1995002I1/no unknown
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