WO1999004816A1 - Proton pump inhibitor in therapeutic combination with antibacterial substances - Google Patents
Proton pump inhibitor in therapeutic combination with antibacterial substances Download PDFInfo
- Publication number
- WO1999004816A1 WO1999004816A1 PCT/EP1998/004553 EP9804553W WO9904816A1 WO 1999004816 A1 WO1999004816 A1 WO 1999004816A1 EP 9804553 W EP9804553 W EP 9804553W WO 9904816 A1 WO9904816 A1 WO 9904816A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proton pump
- pump inhibitors
- antibacterially active
- affect
- gastrointestinal tract
- Prior art date
Links
- 229940126409 proton pump inhibitor Drugs 0.000 title claims abstract description 30
- 239000000612 proton pump inhibitor Substances 0.000 title claims abstract description 30
- 239000000126 substance Substances 0.000 title description 3
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- 230000000844 anti-bacterial effect Effects 0.000 title description 2
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- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229960004621 cinoxacin Drugs 0.000 description 1
- VDUWPHTZYNWKRN-UHFFFAOYSA-N cinoxacin Chemical compound C1=C2N(CC)N=C(C(O)=O)C(=O)C2=CC2=C1OCO2 VDUWPHTZYNWKRN-UHFFFAOYSA-N 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
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- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
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- 230000000877 morphologic effect Effects 0.000 description 1
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- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 229960001914 paromomycin Drugs 0.000 description 1
- UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 description 1
- 229960004236 pefloxacin Drugs 0.000 description 1
- FHFYDNQZQSQIAI-UHFFFAOYSA-N pefloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 FHFYDNQZQSQIAI-UHFFFAOYSA-N 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 229940056367 penicillin v Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960002292 piperacillin Drugs 0.000 description 1
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229960003672 propicillin Drugs 0.000 description 1
- HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960005224 roxithromycin Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 229960001294 spiramycin Drugs 0.000 description 1
- 235000019372 spiramycin Nutrition 0.000 description 1
- 229930191512 spiramycin Natural products 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960005256 sulbactam Drugs 0.000 description 1
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 description 1
- 229960001608 teicoplanin Drugs 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 229960003053 thiamphenicol Drugs 0.000 description 1
- OTVAEFIXJLOWRX-NXEZZACHSA-N thiamphenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 OTVAEFIXJLOWRX-NXEZZACHSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Definitions
- the invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
- omeprazole EP-B 005 129
- pantoprazole EP-B 166 287
- lansoprazole EP-B 174 726)
- rabeprazole EP-B 268 956
- leminoprazole DE-A 35 31 487)
- nepaprazole EP-A 434 999
- European Patent 166 287 in which, inter alia, the compound pantoprazole (INN) is patented, states that the compounds according to the invention are suitable for the prevention and treatment of gastrointestinal diseases, such as can be caused, for example, by microorganisms, bacterial toxins, antiinflamma- tories, antirheumatics, ethanol, gastric acid or stress situations.
- gastrointestinal diseases such as can be caused, for example, by microorganisms, bacterial toxins, antiinflamma- tories, antirheumatics, ethanol, gastric acid or stress situations.
- - European Patent 544 760 describes combinations of pantoprazole with antibacterially active compounds for controlling the bacterium Heli- cobacter pylori, which populates the stomach.
- the invention therefore relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
- the invention further relates to the use of proton pump inhibitors for the production of medicaments for combined use in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
- the invention likewise relates to the combination of proton pump inhibitors with an antibacterially active substance for use in the treatment of bacterial diseases which do not affect the gastrointestinal tract.
- the invention furthermore relates to the use of proton pump inhibitors for avoiding side effects which can be caused by antibacterially active substances.
- the following compounds, designated by the INN, may be primarily mentioned as proton pump inhibitors: omeprazole, lansoprazole, rabeprazole, leminoprazole, nepaprazole and in particular pantoprazole.
- proton pump inhibitors is intended to mean both the compounds themselves and also their pharmacologically tolerable salts, in particular the salts with bases.
- pantoprazole additionally includes the pharmacologically tolerable salts of pantoprazole, especially the salts with bases, such as are described in European Patent 166 287, in particular the sodium salt.
- Antibacterially active compounds which may be mentioned are ⁇ -lactam antibiotics, for example penicillins (such as benzylpenicillin, phenoxymethylpenicillin, propicillin, azidocillin, dicloxacillin, flucloxacillin, oxacillin, amoxicillin, bacampicillin, ampicillin, mezlocillin, piperacillin or azlocillin), cephalosporins (such as cefadroxil, cefaclor, cefalexin, cefixim, cefuroxim, cefetamet, cefadroxil, ceftibuten, cefpodoxim, ce- fotetan, cefazolin, cefoperazon, ceftizoxim, cefotaxim, ceftazidim, cefamandol, cefepim, cefoxitin, cefo- dizim, cefsulodin, ceftriaxon, cefotiam or cefmenoxim)
- enzyme inhibitors for example sulbactam, tetracyclines, for example tetra- cycline, oxytetracycline, minocycline or doxycycline; aminoglycosides, for example tobramycin, genta- macn, neomycin, streptomycin, amikacin, netilmicin, paromomycin or spectinomycin; amphenicols, for example chloramphenicol or thiamphenicol; lincomycins and macrolide antibiotics, for example clinda- mycin, lincomycin, erythromycin, clarithromycin, spiramycin, roxithromycin or azithromycin; polypeptide antibiotics, for example colistin, polymixin B, teicoplanin or vancomycin; gyrase inhibitors, for example norfloxacin, cinoxacin, ciprofloxacin
- Combination therapeutic or “combination” in the sense of the present invention is thus to be understood as meaning that the individual components (i.e. the proton pump inhibitor on the one hand and the antibacterially active substance or active substances on the other hand) can be administered in a manner which is known and customary per se simultaneously (in the form of a combination medicament), more or less at the same time (from separate pack units) or successively (directly one after the other or else with a relatively large time interval).
- one component can be orally administered, while the other component is intravenously administered.
- the dosage of the antibacterially active substance(s) is carried out in the customary order of magnitude for the respective substance and the respective purpose, in the case of clarithromycin, for example, with a daily dose of 500 to 1000 mg.
- a lower dosage of the combination components in each case is carried out.
- the proton pump inhibitors are administered in the dose customary for them, but preferably in a lower dosage.
- Pantoprazole is administered in the customary daily dose of 40 mg, but preferably in a lower dosage (for example 10 to 20 mg/day).
- the proton pump inhibitors can be administered as combination therapeutics in the prophylactic sense in antibiotic therapy.
- proton pump inhibitors such as, for example, pantoprazole
- pantoprazole are able to compensate deep-seated and serious morphological alterations to the mucous membrane, which are obviously caused by antibiotics (in this case the combination clarithromycin and metronidazole).
- antibiotics in this case the combination clarithromycin and metronidazole.
- proton pump inhibitors should also be able in antibiotic therapy in man to decrease or to prevent the gastrointestinal side effects caused by the antibiotic.
Abstract
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
Description
PROTON PUMP INHIBITOR IN THERAPEUTIC COMBINAΗON WITH ANTIBACTERIAL SUBSTANCES
Field of application of the invention
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
Known technical background
A large number of patent applications and patents describe variously substituted 2-(2- pyridinylmethylsulfinyl)-1 H-benzimidazoles. This class of compound is able to specifically inhibit gastric acid production and is therefore also described as the proton pump inhibitors class. A whole series of proton pump inhibitors are in an advanced stage of clinical testing or already on the market. The following compounds, designated by the INN, which may be mentioned as examples are: omeprazole (EP-B 005 129), pantoprazole (EP-B 166 287), lansoprazole (EP-B 174 726), rabeprazole (EP-B 268 956), leminoprazole (DE-A 35 31 487) and nepaprazole (EP-A 434 999).
European Patent 166 287, in which, inter alia, the compound pantoprazole (INN) is patented, states that the compounds according to the invention are suitable for the prevention and treatment of gastrointestinal diseases, such as can be caused, for example, by microorganisms, bacterial toxins, antiinflamma- tories, antirheumatics, ethanol, gastric acid or stress situations. - European Patent 544 760 describes combinations of pantoprazole with antibacterially active compounds for controlling the bacterium Heli- cobacter pylori, which populates the stomach.
Description of the invention
Surprisingly, it has now been found that, using proton pump inhibitors as combination components, side effects caused by antibacterially active compounds can be avoided.
The invention therefore relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
The invention further relates to the use of proton pump inhibitors for the production of medicaments for combined use in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
The invention likewise relates to the combination of proton pump inhibitors with an antibacterially active substance for use in the treatment of bacterial diseases which do not affect the gastrointestinal tract.
The invention furthermore relates to the use of proton pump inhibitors for avoiding side effects which can be caused by antibacterially active substances.
The following compounds, designated by the INN, may be primarily mentioned as proton pump inhibitors: omeprazole, lansoprazole, rabeprazole, leminoprazole, nepaprazole and in particular pantoprazole. The designation "proton pump inhibitors" is intended to mean both the compounds themselves and also their pharmacologically tolerable salts, in particular the salts with bases. Thus the designation "pantoprazole" additionally includes the pharmacologically tolerable salts of pantoprazole, especially the salts with bases, such as are described in European Patent 166 287, in particular the sodium salt.
Examples which may be mentioned of bacterial diseases which do not affect the gastrointestinal tract are infections of the bones and joints, the soft parts, the skin and mucous membranes, the kidneys and the renal pelvis, the efferent ureters, the sex organs and the CNS, in particular infections of the ENT region and of the respiratory tract, such as, for example, bronchitis or pneumonia.
Antibacterially active compounds which may be mentioned are β-lactam antibiotics, for example penicillins (such as benzylpenicillin, phenoxymethylpenicillin, propicillin, azidocillin, dicloxacillin, flucloxacillin, oxacillin, amoxicillin, bacampicillin, ampicillin, mezlocillin, piperacillin or azlocillin), cephalosporins (such as cefadroxil, cefaclor, cefalexin, cefixim, cefuroxim, cefetamet, cefadroxil, ceftibuten, cefpodoxim, ce- fotetan, cefazolin, cefoperazon, ceftizoxim, cefotaxim, ceftazidim, cefamandol, cefepim, cefoxitin, cefo- dizim, cefsulodin, ceftriaxon, cefotiam or cefmenoxim) or other β-lactam antibiotics (e.g. aztreonam, loracarbef or meropenem); enzyme inhibitors, for example sulbactam, tetracyclines, for example tetra- cycline, oxytetracycline, minocycline or doxycycline; aminoglycosides, for example tobramycin, genta- micin, neomycin, streptomycin, amikacin, netilmicin, paromomycin or spectinomycin; amphenicols, for example chloramphenicol or thiamphenicol; lincomycins and macrolide antibiotics, for example clinda- mycin, lincomycin, erythromycin, clarithromycin, spiramycin, roxithromycin or azithromycin; polypeptide antibiotics, for example colistin, polymixin B, teicoplanin or vancomycin; gyrase inhibitors, for example norfloxacin, cinoxacin, ciprofloxacin, pipemidic acid, enoxacin, nalidixic acid, pefloxacin, fleroxacin or ofloxacin; nitroimidazoles, for example metronidazole; or other antibiotics, for example fosfomycin or fucidic acid, where these antibacterially active substances are administered on their own or alternatively can be combined with one another.
Side effects of the antibacterially active substances which may be mentioned, which can be avoided by the administration of proton pump inhibitors, are, in particular, atrophic gastritis.
"Combination therapeutic" or "combination" in the sense of the present invention is thus to be understood as meaning that the individual components (i.e. the proton pump inhibitor on the one hand and the antibacterially active substance or active substances on the other hand) can be administered in a manner which is known and customary per se simultaneously (in the form of a combination medicament), more or less at the same time (from separate pack units) or successively (directly one after the other or else with a relatively large time interval).
In the case of administration of the individual components more or less at the same time from separate pack units and in the case of the administration of the individual components which takes place one after the other, it is possible, if desired, to select a different administration form. For example, one component can be orally administered, while the other component is intravenously administered.
The dosage of the antibacterially active substance(s) is carried out in the customary order of magnitude for the respective substance and the respective purpose, in the case of clarithromycin, for example, with a daily dose of 500 to 1000 mg. In the case of the combined use of a number of.antibacterially active substances simultaneously, if appropriate, a lower dosage of the combination components in each case is carried out.
The proton pump inhibitors are administered in the dose customary for them, but preferably in a lower dosage.
Pantoprazole is administered in the customary daily dose of 40 mg, but preferably in a lower dosage (for example 10 to 20 mg/day). In particular in the case of a lower dosage, the proton pump inhibitors can be administered as combination therapeutics in the prophylactic sense in antibiotic therapy.
Investigation results
In the investigation on dogs described in detail below, it was possible to show that the atrophic gastritis caused by administration of antibacterially active substances can be avoided by the simultaneous administration of proton pump inhibitors:
Material and methodology
Animal material 22 dogs (beagles, CPB Harlan, Netherlands)
Age/weight male: 12 months/13.8 kg female: 12.6 months/10.8 kg
Number of animals per group 3m / 3f Experimental period 30 days Recovery time 4 weeks (group 4)
Treatment
The conclusion is drawn from this investigation that proton pump inhibitors, such as, for example, pantoprazole, are able to compensate deep-seated and serious morphological alterations to the mucous membrane, which are obviously caused by antibiotics (in this case the combination clarithromycin and metronidazole). Thus proton pump inhibitors should also be able in antibiotic therapy in man to decrease or to prevent the gastrointestinal side effects caused by the antibiotic.
Claims
1. The use of proton pump inhibitors and/or their salts as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
2. The use of proton pump inhibitors and/or their salts for the production of medicaments for combined use in the treatment of bacterial diseases which do not affect the gastrointestinal tract using antibacterially active compounds.
3. The combination of proton pump inhibitors and/or their salts with an antibacterially active substance for use in the treatment of bacterial diseases which do not affect the gastrointestinal tract.
4. The use of proton pump inhibitors and/or their salts for avoiding side effects which can be caused by antibacterially active compounds.
5. The use as claimed in one of claims 1 , 2 or 3, wherein the bacterial diseases which do not affect the gastrointestinal tract are infections of the bones and joints, the soft parts, the skin and mucous membranes, the kidneys and the renal pelvis, the efferent ureters, the sex organs and the CNS, the ENT region and the respiratory tract.
6. The use as claimed in claim 4, wherein the side effects of the antibacterially active substances which can be avoided by the administration of proton pump inhibitors are atrophic gastritis.
7. The use as claimed in one of claims 1 , 2 or 3, wherein the proton pump inhibitor is pantoprazole.
8. The use as claimed in one of claims 1 , 2 or 3, wherein the proton pump inhibitor is omeprazole, lansoprazole, leminoprazole, rabeprazole or nepaprazole.
9. The use as claimed in claim 4, wherein the proton pump inhibitor is pantoprazole.
10. The use as claimed in claim 4, wherein the side effects of the antibacterially active compounds which can be avoided by the administration of proton pump inhibitors are atrophic gastritis and the proton pump inhibitor is pantoprazole.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9830734T SI1003554T1 (en) | 1997-07-25 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial substances |
| DK98942585T DK1003554T3 (en) | 1998-07-21 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial agents |
| US09/463,390 US6303644B1 (en) | 1997-07-25 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial substances |
| AT98942585T ATE281178T1 (en) | 1997-07-25 | 1998-07-21 | PROTON PUMP INHIBITORS AS COMBINATION THERAPEUTICS WITH ANTIBACTERIAL SUBSTANCES |
| PT98942585T PT1003554E (en) | 1997-07-25 | 1998-07-21 | PUMP INHIBITOR IN THERAPEUTIC COMBINATION WITH ANTIBACTERIAL SUBSTANCES |
| AU90671/98A AU9067198A (en) | 1997-07-25 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial substances |
| EP98942585A EP1003554B1 (en) | 1997-07-25 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial substances |
| DE69827392T DE69827392T2 (en) | 1997-07-25 | 1998-07-21 | PROTEIN PUMP DISORDERS AS COMBINATION THERAPEUTICS WITH ANTIBACTERIAL ACTIVE SUBSTANCES |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112795.6 | 1997-07-25 | ||
| EP97112795 | 1997-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1999004816A1 true WO1999004816A1 (en) | 1999-02-04 |
Family
ID=8227119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1998/004553 WO1999004816A1 (en) | 1997-07-25 | 1998-07-21 | Proton pump inhibitor in therapeutic combination with antibacterial substances |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6303644B1 (en) |
| EP (1) | EP1003554B1 (en) |
| AT (1) | ATE281178T1 (en) |
| AU (1) | AU9067198A (en) |
| DE (1) | DE69827392T2 (en) |
| ES (1) | ES2232015T3 (en) |
| PT (1) | PT1003554E (en) |
| SI (1) | SI1003554T1 (en) |
| WO (1) | WO1999004816A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094968A2 (en) * | 2002-05-07 | 2003-11-20 | Altana Pharma Ag | Combination of a proton pump inhibitor and a respiratory agent for the treatment of respiratory diseases |
| WO2003094967A2 (en) * | 2002-05-07 | 2003-11-20 | Altana Pharma Ag | New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders |
| DE112011101062T5 (en) | 2010-03-26 | 2013-01-03 | Cambridge Display Technology Limited | Organic electroluminescent device |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| US20060194748A1 (en) * | 2005-02-28 | 2006-08-31 | National University Corporation Nagoya University | Methods for treating disorders induced by H. pylori infections and pharmaceutical compositions for the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002021A1 (en) * | 1995-07-05 | 1997-01-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical compositions with delayed release of reversible proton pump inhibitors |
| JPH09188624A (en) * | 1996-01-06 | 1997-07-22 | Takeshi Azuma | Medicine for treating hepatic encephalopathy or medicine for preventing hepatic encephalopathy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (en) | 1978-04-14 | 1979-10-15 | Haessle Ab | Gastric acid secretion |
| IL75400A (en) | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| JPS6150978A (en) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | Pyridine derivative and preparation thereof |
| AU4640985A (en) | 1984-08-31 | 1986-03-06 | Nippon Chemiphar Co. Ltd. | Benzimidazole derivatives |
| FI90544C (en) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Process for Preparation as Drug Useful 2-Pyridin-2-yl-methylthio- and sulfinyl-1H-benzimidazole derivatives |
| DE69011645T2 (en) | 1989-11-29 | 1995-01-12 | Toa Eiyo Ltd | Cycloheptenopyridine derivatives, process for their preparation and antiulcer agents containing them. |
| GB9018603D0 (en) | 1990-08-24 | 1990-10-10 | Smith Kline French Lab | Compositions |
| US5352688A (en) | 1991-02-14 | 1994-10-04 | The Mount Sinai School Of Medicine Of The City University Of New York | Methods for the treatment of bradyphrenia in parkinson's disease |
| WO1993012817A1 (en) | 1991-12-20 | 1993-07-08 | Warner-Lambert Company | Therapeutic combinations useful in the treatment of gastroesophageal reflux disease |
| TW276996B (en) * | 1992-04-24 | 1996-06-01 | Astra Ab | |
| US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
| US6134344A (en) * | 1997-06-26 | 2000-10-17 | Lucent Technologies Inc. | Method and apparatus for improving the efficiency of support vector machines |
-
1998
- 1998-07-21 SI SI9830734T patent/SI1003554T1/en unknown
- 1998-07-21 AT AT98942585T patent/ATE281178T1/en active
- 1998-07-21 DE DE69827392T patent/DE69827392T2/en not_active Expired - Lifetime
- 1998-07-21 US US09/463,390 patent/US6303644B1/en not_active Expired - Lifetime
- 1998-07-21 ES ES98942585T patent/ES2232015T3/en not_active Expired - Lifetime
- 1998-07-21 WO PCT/EP1998/004553 patent/WO1999004816A1/en active IP Right Grant
- 1998-07-21 EP EP98942585A patent/EP1003554B1/en not_active Expired - Lifetime
- 1998-07-21 AU AU90671/98A patent/AU9067198A/en not_active Abandoned
- 1998-07-21 PT PT98942585T patent/PT1003554E/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997002021A1 (en) * | 1995-07-05 | 1997-01-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical compositions with delayed release of reversible proton pump inhibitors |
| JPH09188624A (en) * | 1996-01-06 | 1997-07-22 | Takeshi Azuma | Medicine for treating hepatic encephalopathy or medicine for preventing hepatic encephalopathy |
Non-Patent Citations (7)
| Title |
|---|
| GRECO S. ET AL: "Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics (1)", ANNALS OF PHARMACOTHERAPY, 1997, 31/12 (1548), United States, XP002081783 * |
| JONKERS D ET AL: "Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro.", J ANTIMICROB CHEMOTHER, JAN 1996, 37 (1) P145-50, ENGLAND, XP002082027 * |
| KALAS D ET AL: "[Connection between Helicobacter pylori infection and chronic gastrointestinal urticaria]", ORV HETIL, SEP 8 1996, 137 (36) P1969-72, HUNGARY, XP002051214 * |
| MALFERTHEINER P.: "Current European concepts in the management of Helicobacter pylori infection. The Maastricht consensus report", GUT, 1997, 41/1 (8-13), UNITED KINGDOM, XP002051216 * |
| MURAKAMI K ET AL: "Atopic dermatitis successfully treated by eradication of Helicobacter pylori.", J GASTROENTEROL, NOV 1996, 31 SUPPL 9 P77-82, JAPAN, XP002051213 * |
| PATENT ABSTRACTS OF JAPAN vol. 097, no. 011 28 November 1997 (1997-11-28) * |
| REINAUER S ET AL: "Schonlein-Henoch purpura associated with gastric Helicobacter pylori infection.", J AM ACAD DERMATOL, NOV 1995, 33 (5 PT 2) P876-9, UNITED STATES, XP002051215 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094968A2 (en) * | 2002-05-07 | 2003-11-20 | Altana Pharma Ag | Combination of a proton pump inhibitor and a respiratory agent for the treatment of respiratory diseases |
| WO2003094967A2 (en) * | 2002-05-07 | 2003-11-20 | Altana Pharma Ag | New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders |
| WO2003094967A3 (en) * | 2002-05-07 | 2004-04-01 | Altana Pharma Ag | New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders |
| WO2003094968A3 (en) * | 2002-05-07 | 2004-04-01 | Altana Pharma Ag | Combination of a proton pump inhibitor and a respiratory agent for the treatment of respiratory diseases |
| DE112011101062T5 (en) | 2010-03-26 | 2013-01-03 | Cambridge Display Technology Limited | Organic electroluminescent device |
Also Published As
| Publication number | Publication date |
|---|---|
| US6303644B1 (en) | 2001-10-16 |
| DE69827392D1 (en) | 2004-12-09 |
| ES2232015T3 (en) | 2005-05-16 |
| DE69827392T2 (en) | 2005-10-27 |
| PT1003554E (en) | 2005-03-31 |
| ATE281178T1 (en) | 2004-11-15 |
| EP1003554B1 (en) | 2004-11-03 |
| AU9067198A (en) | 1999-02-16 |
| SI1003554T1 (en) | 2005-04-30 |
| EP1003554A1 (en) | 2000-05-31 |
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