KR910000726B1 - 메틸렌-디포스폰산 유도체의 제조방법 - Google Patents

메틸렌-디포스폰산 유도체의 제조방법 Download PDF

Info

Publication number
KR910000726B1
KR910000726B1 KR1019830003523A KR830003523A KR910000726B1 KR 910000726 B1 KR910000726 B1 KR 910000726B1 KR 1019830003523 A KR1019830003523 A KR 1019830003523A KR 830003523 A KR830003523 A KR 830003523A KR 910000726 B1 KR910000726 B1 KR 910000726B1
Authority
KR
South Korea
Prior art keywords
group
hydrogen
alkyl group
carbon atoms
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830003523A
Other languages
English (en)
Korean (ko)
Other versions
KR840005459A (ko
Inventor
브레리에르 쟝-끌로드
에몽드-알뜨 싸비에
갸르씨아 죠르쥐
Original Assignee
소시에떼아노님 사노피
미셀 드 아스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 소시에떼아노님 사노피, 미셀 드 아스 filed Critical 소시에떼아노님 사노피
Publication of KR840005459A publication Critical patent/KR840005459A/ko
Application granted granted Critical
Publication of KR910000726B1 publication Critical patent/KR910000726B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019830003523A 1982-07-29 1983-07-28 메틸렌-디포스폰산 유도체의 제조방법 Expired KR910000726B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8213250 1982-07-29
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (2)

Publication Number Publication Date
KR840005459A KR840005459A (ko) 1984-11-12
KR910000726B1 true KR910000726B1 (ko) 1991-01-31

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003523A Expired KR910000726B1 (ko) 1982-07-29 1983-07-28 메틸렌-디포스폰산 유도체의 제조방법

Country Status (35)

Country Link
US (2) US4746654A (enExample)
EP (1) EP0100718B1 (enExample)
JP (1) JPS5942395A (enExample)
KR (1) KR910000726B1 (enExample)
AR (2) AR242394A1 (enExample)
AT (1) ATE30235T1 (enExample)
AU (1) AU566880B2 (enExample)
CA (1) CA1267650A (enExample)
CS (1) CS252463B2 (enExample)
CZ (1) CZ419191A3 (enExample)
DD (1) DD213670A5 (enExample)
DE (1) DE3374062D1 (enExample)
DK (1) DK170342B1 (enExample)
DZ (1) DZ562A1 (enExample)
EG (1) EG15968A (enExample)
ES (1) ES524495A0 (enExample)
FI (1) FI75830C (enExample)
FR (1) FR2531088B1 (enExample)
GR (1) GR79597B (enExample)
HU (1) HU190454B (enExample)
IE (1) IE56343B1 (enExample)
IL (1) IL69347A (enExample)
LU (1) LU88723I2 (enExample)
MA (1) MA19858A1 (enExample)
NL (1) NL960007I2 (enExample)
NO (2) NO164712C (enExample)
NZ (1) NZ205061A (enExample)
OA (1) OA07507A (enExample)
PH (1) PH22082A (enExample)
PL (2) PL142022B1 (enExample)
PT (1) PT77122B (enExample)
SG (1) SG18588G (enExample)
SU (2) SU1333240A3 (enExample)
YU (1) YU45143B (enExample)
ZA (1) ZA835578B (enExample)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US5641762A (en) * 1985-05-02 1997-06-24 Research Corporation Technologies, Inc. Bone targeted inhibitors of carbonic anhydrase
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
KR880011136A (ko) * 1987-03-11 1988-10-26 모리오까 시게오 아졸- 아미노메틸렌 비스포스폰산 유도체
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (enExample) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP3021035B2 (ja) * 1988-11-01 2000-03-15 アーク・デベロップメント・コーポレーション ホスホン酸及び分離におけるその使用
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
EP0416689B1 (en) * 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
EP0438375B1 (de) * 1990-01-18 1995-12-27 Ciba-Geigy Ag Phoshponsäure- und Thionophosphonsäure-Derivate
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
DE69108733T2 (de) * 1990-08-21 1995-09-14 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
CA2094123A1 (en) * 1990-12-07 1992-06-08 Pharmacia & Upjohn Company Llc Phosphonic acid derivatives useful as antiinflammatory agents
ATE133677T1 (de) * 1990-12-19 1996-02-15 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre produktion und ihre verwendung
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2102303A1 (en) * 1991-06-19 1992-12-20 Roy Allen Johnson Dialkyl (dialkoxyphosphinyl) methyl phosphates as anti-inflammatory agents
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
ATE165603T1 (de) * 1991-09-05 1998-05-15 Toray Industries Methandiphosphonsäurederivat, herstellung davon und verwendung davon als arzneimittel
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
JPH07507317A (ja) * 1992-05-29 1995-08-10 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド 異常なカルシウムおよびホスフェート代謝を治療するためのチオ置換窒素含有複素環式ホスホネート化合物
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
DK0646119T3 (da) * 1992-05-29 1998-12-14 Procter & Gamble Pharma Phosphonatforbindelser indeholdende kvaternært nitrogen til behandling af unormalt calcium- og phosphatstofskifte samt tan
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
DE69329199D1 (de) * 1992-05-29 2000-09-14 Procter & Gamble Pharma Schwefel-enthaltende phosphonat-verbindungen zur behandlung von abnormalem calzium- und phosphat- metabolismus
DK0650361T3 (da) * 1992-06-30 1999-06-23 Procter & Gamble Pharma Sammensætninger til behandling af arthritis, hvilke sammensætninger indeholder phosphonater og NSAID'er
EP0603401B1 (en) * 1992-07-10 2001-04-11 Toray Industries, Inc. Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof
GB9215433D0 (en) * 1992-07-21 1992-09-02 Cmb Foodcan Plc Apparatus for stripping a drawn article from a punch
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
ATE157097T1 (de) * 1992-08-07 1997-09-15 Upjohn Co Phosphonoessigsäure und ester als antientzündungsmittel
AU4859493A (en) * 1992-10-09 1994-05-09 Upjohn Company, The Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
AU670337B2 (en) 1992-11-30 1996-07-11 Novartis Ag Use of certain methanebisphosphonic acid derivatives in fracture healing
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
FI944998A0 (fi) * 1993-02-25 1994-10-24 Toray Industries Menetelmä metaanidifosfonihappoyhdisteen valmistamiseksi
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
ATE235499T1 (de) * 1994-08-24 2003-04-15 Toray Industries Verfahren zur herstellung einer methanphosphonsäureverbindung
JPH11511041A (ja) 1995-06-06 1999-09-28 メルク エンド カンパニー インコーポレーテッド 整形外科的埋め込み装置の無菌性動揺を防止するビスホスホネートセメント組成物
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
JPH11513383A (ja) * 1995-09-29 1999-11-16 ノバルティス アクチェンゲゼルシャフト ウマの舟状骨病を治療する方法
US6333424B1 (en) * 1996-10-09 2001-12-25 Eliza Nor Biopharmaceuticals, Inc. Therapeutic derivatives of diphosphonates
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
DE69910045T2 (de) 1998-09-09 2004-04-22 Metabasis Therapeutics Inc., San Diego Neue heteroaromatische fructose 1,6-bisphosphatase inhibitoren
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
EP1057488A4 (en) * 1998-12-25 2003-10-22 Toray Industries INTERLEUKIN-6 PRODUCTION INHIBITORS
US6320011B1 (en) 1999-07-23 2001-11-20 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
US6900282B2 (en) * 1999-07-23 2005-05-31 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
WO2001044257A1 (en) * 1999-12-17 2001-06-21 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
MXPA02006156A (es) * 1999-12-22 2003-09-22 Metabasis Therapeutics Inc Nuevos profarmacos de bisamidato fosfonato.
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
EP1383510B1 (en) * 2001-04-10 2012-10-17 MBC Pharma, Inc. Bisphosphonate conjugates and methods of making and using the same
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
CA2469779C (en) * 2001-12-21 2008-02-12 The Procter & Gamble Company Method for the treatment of bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
JP4502641B2 (ja) * 2002-01-24 2010-07-14 ティルタン ファーマ リミテッド 抗癌組み合わせおよびその使用方法
US20050176685A1 (en) * 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
CN1939314A (zh) * 2002-05-10 2007-04-04 弗·哈夫曼-拉罗切有限公司 用于治疗和预防骨质疏松症的二膦酸
US20060258726A1 (en) * 2002-06-06 2006-11-16 Xavier Billot 1,5-Disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
SI1596870T2 (sl) * 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
WO2005007034A1 (en) 2003-07-08 2005-01-27 The Children's Hospital Of Philadelphia Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
AU2004266740B2 (en) 2003-08-21 2010-08-26 Merck Frosst Canada Ltd Cathepsin cysteine protease inhibitors
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
PT2269584T (pt) 2004-05-24 2022-07-01 Theramex Hq Uk Ltd Forma de dosagem oral entérica sólida de um bisfosfonato contendo um agente quelante
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP2008510018A (ja) * 2004-08-18 2008-04-03 メタバシス・セラピューティクス・インコーポレイテッド フルクトース−１，６−ビスホスファターゼの新規チアゾール阻害物質
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
SI1855674T1 (sl) 2005-03-02 2014-10-30 Merck Sharp & Dohme Corp. Sestavek za inhibicijo katepsina k
EA200701997A1 (ru) * 2005-03-17 2008-02-28 Элан Фарма Интернэшнл Лтд. Композиция из наночастиц бисфосфоната
DE602006006663D1 (de) * 2005-03-24 2009-06-18 Medtronic Inc Modifizierung von thermoplastischen polymeren
PT2222636E (pt) 2007-12-21 2013-07-16 Ligand Pharm Inc Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações
WO2010019511A2 (en) 2008-08-13 2010-02-18 Targanta Therapeutics Corp. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
EP2440250A1 (en) 2009-06-11 2012-04-18 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
ES2819059T3 (es) 2011-07-13 2021-04-14 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Liposomas que encapsulan conjuntamente un bifosfonato y un agente anfipático
WO2013019874A1 (en) 2011-08-01 2013-02-07 Mbc Pharma, Inc. Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
EP3055314B1 (en) 2013-10-08 2018-09-12 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
MX2021012690A (es) 2019-04-19 2022-01-31 Ligand Pharm Inc Formas cristalinas y metodos para producir formas cristalinas de un compuesto.
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302557B (enExample) * 1963-04-09 1971-08-26
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3705191A (en) * 1970-04-13 1972-12-05 Monsanto Co Substituted ethane diphosphonic acids and salts and esters thereof
US3654151A (en) * 1970-04-13 1972-04-04 Monsanto Co Deflocculation of solid materials in aqueous medium
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US4171373A (en) * 1974-01-07 1979-10-16 William H. Rorer, Inc. Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation
US4071584A (en) * 1977-01-03 1978-01-31 Monsanto Company Hydroxyphenylthiophosphoranylidene organophosphorus compounds
US4264582A (en) * 1978-07-31 1981-04-28 The Procter & Gamble Company Isobutylphenylacetate anti-inflammatory composition
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4330530A (en) * 1980-12-22 1982-05-18 The Procter & Gamble Company Anti-arthritic compositions and method using gold salts and organophosphonates
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
SU1333240A3 (ru) 1987-08-23
YU45143B (en) 1992-03-10
DK336783D0 (da) 1983-07-22
AU566880B2 (en) 1987-11-05
IE831716L (en) 1984-01-29
HU190454B (en) 1986-09-29
CZ419191A3 (en) 1993-10-13
PT77122B (fr) 1986-01-24
AR242393A1 (es) 1993-03-31
OA07507A (fr) 1985-03-31
KR840005459A (ko) 1984-11-12
AU1732483A (en) 1984-02-02
FI832758A0 (fi) 1983-07-29
JPS5942395A (ja) 1984-03-08
NL960007I1 (nl) 1996-09-02
SU1367859A3 (ru) 1988-01-15
ES8403923A1 (es) 1984-04-16
EG15968A (en) 1989-01-30
AR242394A1 (es) 1993-03-31
NO832701L (no) 1984-01-30
MA19858A1 (fr) 1984-04-01
PT77122A (fr) 1983-08-01
SG18588G (en) 1988-09-30
NZ205061A (en) 1987-08-31
US4746654A (en) 1988-05-24
DK336783A (da) 1984-01-30
DD213670A5 (de) 1984-09-19
JPH0429676B2 (enExample) 1992-05-19
LU88723I2 (fr) 1996-08-23
CS252463B2 (en) 1987-09-17
CA1267650A (en) 1990-04-10
FR2531088A1 (fr) 1984-02-03
ATE30235T1 (de) 1987-10-15
PL142022B1 (en) 1987-09-30
NO164712B (no) 1990-07-30
ES524495A0 (es) 1984-04-16
EP0100718B1 (fr) 1987-10-14
PL141316B1 (en) 1987-07-31
US4876248A (en) 1989-10-24
NO164712C (no) 1990-11-07
GR79597B (enExample) 1984-10-31
YU160083A (en) 1986-08-31
FR2531088B1 (fr) 1987-08-28
DK170342B1 (da) 1995-08-07
EP0100718A1 (fr) 1984-02-15
PH22082A (en) 1988-05-20
NO1998011I1 (no) 1998-03-06
DZ562A1 (fr) 2004-09-13
IL69347A0 (en) 1983-11-30
IL69347A (en) 1987-02-27
IE56343B1 (en) 1991-07-03
CS568883A2 (en) 1987-01-15
FI75830B (fi) 1988-04-29
FI75830C (fi) 1988-08-08
ZA835578B (en) 1984-04-25
PL243229A1 (en) 1984-07-16
NL960007I2 (nl) 1997-03-03
FI832758L (fi) 1984-01-30
DE3374062D1 (en) 1987-11-19

Similar Documents

Publication Publication Date Title
KR910000726B1 (ko) 메틸렌-디포스폰산 유도체의 제조방법
CA1296739C (en) Diphosphonic acid derivatives, processes for the preparation thereofand pharmaceutical compositions containing them
CA1202635A (en) Diphosphonic acid derivatives, process for their preparation and pharmaceutical preparations containing them
CA1334409C (en) Diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5393748A (en) Methylenebisphosphonic acid derivatives
US4732998A (en) Bisphosphonic acids and esters
HU198078B (en) Process for producing new diphosphonic ancid derivatives and pharmaceutical compositions comprising same
KR20020093824A (ko) 포스포네이트 뉴클레오티드 화합물
PL144353B1 (en) Method of obtaining novel derivatives of methylenediophosphonic acid
US3449365A (en) 2-imino-4-alkalidene-1,3-dithiolanes and their preparation
US5364846A (en) N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the treatment of osteoporosis and degenerative joint disease
KR100246809B1 (ko) 비고리형 아미딘기 함유 디포스폰산유도체, 이들의 제조방법 및 이들을 포함하는 의약조성물
JP2965167B2 (ja) 新規のアミド基含有ジホスホン酸誘導体、その製法及びこの化合物を含有する医薬品
CA2058012A1 (en) Bisphosphonic acid derivatives, their production and use
IE54136B1 (en) Diphosphonic acid derivatives, process for their preparation and pharmaceutical preparations containing them
US3293328A (en) Acylsulfamoylphenyl phosphates and method of preparing the same
NZ280149A (en) Imidobisphosphoric acid derivatives and pharmaceutical compositions
CZ282524B6 (cs) Deriváty kyseliny methylendifosfonové, způsob jejich přípravy a protizánětový a protirevmatický farmaceutický prostředek
GB2113688A (en) Diphosphonic acid derivatives, process for their preparation and pharmaceutical preparations containing them.

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19830728

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19880727

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19830728

Comment text: Patent Application

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19910104

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19910411

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19910419

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19910419

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 19931224

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 19941221

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 19951222

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 19970103

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 19971222

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 19981229

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20000104

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20001228

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20020123

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20030123

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20030123

Start annual number: 13

End annual number: 13

EXPY Expiration of term
PC1801 Expiration of term