NO832701L - Fremgangsmaate til fremstilling av metylen-difosfonsyre-derivater. - Google Patents

Fremgangsmaate til fremstilling av metylen-difosfonsyre-derivater.

Info

Publication number
NO832701L
NO832701L NO832701A NO832701A NO832701L NO 832701 L NO832701 L NO 832701L NO 832701 A NO832701 A NO 832701A NO 832701 A NO832701 A NO 832701A NO 832701 L NO832701 L NO 832701L
Authority
NO
Norway
Prior art keywords
dyphosphonic
methylene
procedure
preparation
acid derivatives
Prior art date
Application number
NO832701A
Other languages
English (en)
Other versions
NO164712C (no
NO164712B (no
Inventor
Jean-Claude Breliere
Xavier Edmonds-Alt
George Garcia
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO832701L publication Critical patent/NO832701L/no
Publication of NO164712B publication Critical patent/NO164712B/no
Publication of NO164712C publication Critical patent/NO164712C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO832701A 1982-07-29 1983-07-25 Analogifremgangsmaate til fremstilling av metylendifosfonsyre-derivater. NO164712C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (3)

Publication Number Publication Date
NO832701L true NO832701L (no) 1984-01-30
NO164712B NO164712B (no) 1990-07-30
NO164712C NO164712C (no) 1990-11-07

Family

ID=9276447

Family Applications (2)

Application Number Title Priority Date Filing Date
NO832701A NO164712C (no) 1982-07-29 1983-07-25 Analogifremgangsmaate til fremstilling av metylendifosfonsyre-derivater.
NO1998011C NO1998011I1 (no) 1982-07-29 1998-03-06 Tiludronsyre

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998011C NO1998011I1 (no) 1982-07-29 1998-03-06 Tiludronsyre

Country Status (35)

Country Link
US (2) US4746654A (no)
EP (1) EP0100718B1 (no)
JP (1) JPS5942395A (no)
KR (1) KR910000726B1 (no)
AR (2) AR242394A1 (no)
AT (1) ATE30235T1 (no)
AU (1) AU566880B2 (no)
CA (1) CA1267650A (no)
CS (1) CS252463B2 (no)
CZ (1) CZ419191A3 (no)
DD (1) DD213670A5 (no)
DE (1) DE3374062D1 (no)
DK (1) DK170342B1 (no)
DZ (1) DZ562A1 (no)
EG (1) EG15968A (no)
ES (1) ES8403923A1 (no)
FI (1) FI75830C (no)
FR (1) FR2531088B1 (no)
GR (1) GR79597B (no)
HU (1) HU190454B (no)
IE (1) IE56343B1 (no)
IL (1) IL69347A (no)
LU (1) LU88723I2 (no)
MA (1) MA19858A1 (no)
NL (1) NL960007I2 (no)
NO (2) NO164712C (no)
NZ (1) NZ205061A (no)
OA (1) OA07507A (no)
PH (1) PH22082A (no)
PL (2) PL141316B1 (no)
PT (1) PT77122B (no)
SG (1) SG18588G (no)
SU (2) SU1333240A3 (no)
YU (1) YU45143B (no)
ZA (1) ZA835578B (no)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
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IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
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US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
EP0282309A3 (en) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (no) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
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EP0100718B1 (fr) 1987-10-14
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EP0100718A1 (fr) 1984-02-15
DK170342B1 (da) 1995-08-07
NZ205061A (en) 1987-08-31
IE831716L (en) 1984-01-29
FI832758A0 (fi) 1983-07-29
MA19858A1 (fr) 1984-04-01
AU1732483A (en) 1984-02-02
PL142022B1 (en) 1987-09-30
KR840005459A (ko) 1984-11-12
NL960007I2 (nl) 1997-03-03
NO164712C (no) 1990-11-07
EG15968A (en) 1989-01-30
FR2531088A1 (fr) 1984-02-03
US4876248A (en) 1989-10-24
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YU160083A (en) 1986-08-31
PL243229A1 (en) 1984-07-16
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SG18588G (en) 1988-09-30
NL960007I1 (nl) 1996-09-02
CS568883A2 (en) 1987-01-15
DK336783D0 (da) 1983-07-22
AR242394A1 (es) 1993-03-31
CA1267650A (en) 1990-04-10
YU45143B (en) 1992-03-10
US4746654A (en) 1988-05-24
FR2531088B1 (fr) 1987-08-28
JPS5942395A (ja) 1984-03-08
DD213670A5 (de) 1984-09-19
PT77122B (fr) 1986-01-24
FI75830C (fi) 1988-08-08
NO164712B (no) 1990-07-30
FI832758A (fi) 1984-01-30
NO1998011I1 (no) 1998-03-06
PT77122A (fr) 1983-08-01
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ATE30235T1 (de) 1987-10-15

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