ATE30235T1 - Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung. - Google Patents
Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung.Info
- Publication number
- ATE30235T1 ATE30235T1 AT83401520T AT83401520T ATE30235T1 AT E30235 T1 ATE30235 T1 AT E30235T1 AT 83401520 T AT83401520 T AT 83401520T AT 83401520 T AT83401520 T AT 83401520T AT E30235 T1 ATE30235 T1 AT E30235T1
- Authority
- AT
- Austria
- Prior art keywords
- methylene
- manufacture
- products derived
- inflammatory products
- diphosphone acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8213250A FR2531088B1 (fr) | 1982-07-29 | 1982-07-29 | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
EP83401520A EP0100718B1 (de) | 1982-07-29 | 1983-07-25 | Antiinflammatorische Produkte von Methylendiphosphonsäure abgeleitet und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE30235T1 true ATE30235T1 (de) | 1987-10-15 |
Family
ID=9276447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83401520T ATE30235T1 (de) | 1982-07-29 | 1983-07-25 | Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung. |
Country Status (35)
Country | Link |
---|---|
US (2) | US4746654A (de) |
EP (1) | EP0100718B1 (de) |
JP (1) | JPS5942395A (de) |
KR (1) | KR910000726B1 (de) |
AR (2) | AR242394A1 (de) |
AT (1) | ATE30235T1 (de) |
AU (1) | AU566880B2 (de) |
CA (1) | CA1267650A (de) |
CS (1) | CS252463B2 (de) |
CZ (1) | CZ419191A3 (de) |
DD (1) | DD213670A5 (de) |
DE (1) | DE3374062D1 (de) |
DK (1) | DK170342B1 (de) |
DZ (1) | DZ562A1 (de) |
EG (1) | EG15968A (de) |
ES (1) | ES524495A0 (de) |
FI (1) | FI75830C (de) |
FR (1) | FR2531088B1 (de) |
GR (1) | GR79597B (de) |
HU (1) | HU190454B (de) |
IE (1) | IE56343B1 (de) |
IL (1) | IL69347A (de) |
LU (1) | LU88723I2 (de) |
MA (1) | MA19858A1 (de) |
NL (1) | NL960007I2 (de) |
NO (2) | NO164712C (de) |
NZ (1) | NZ205061A (de) |
OA (1) | OA07507A (de) |
PH (1) | PH22082A (de) |
PL (2) | PL141316B1 (de) |
PT (1) | PT77122B (de) |
SG (1) | SG18588G (de) |
SU (2) | SU1333240A3 (de) |
YU (1) | YU45143B (de) |
ZA (1) | ZA835578B (de) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2558837B1 (fr) * | 1984-01-26 | 1986-06-27 | Sanofi Sa | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
US5641762A (en) * | 1985-05-02 | 1997-06-24 | Research Corporation Technologies, Inc. | Bone targeted inhibitors of carbonic anhydrase |
US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
ES2039237T3 (es) * | 1986-04-24 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Procedimiento para preparar nuevos compuestos de acido difosfonico. |
IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
KR880011136A (ko) * | 1987-03-11 | 1988-10-26 | 모리오까 시게오 | 아졸- 아미노메틸렌 비스포스폰산 유도체 |
IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
DE3805663A1 (de) * | 1988-02-24 | 1989-09-07 | Henkel Kgaa | Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen |
CH675422A5 (de) * | 1988-03-31 | 1990-09-28 | Symphar Sa | |
FR2629716B1 (fr) * | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
ATE136870T1 (de) * | 1988-11-01 | 1996-05-15 | Arch Dev Corp | Verfahren zur abtrennung von metallischen ionen mit phosphonsäuren als complexbildner |
US5154843A (en) * | 1989-02-08 | 1992-10-13 | The Lubrizol Corporation | Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same |
PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
US5220021A (en) * | 1989-04-03 | 1993-06-15 | The Upjohn Company | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
JPH0377894A (ja) * | 1989-08-18 | 1991-04-03 | Toray Ind Inc | メチレンジホスホン酸化合物 |
DE69023844T2 (de) * | 1989-09-06 | 1996-06-20 | Merck & Co Inc | Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren. |
EP0438375B1 (de) * | 1990-01-18 | 1995-12-27 | Ciba-Geigy Ag | Phoshponsäure- und Thionophosphonsäure-Derivate |
IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
WO1992003451A1 (en) * | 1990-08-21 | 1992-03-05 | The Upjohn Company | Bisphosphonic acid derivatives as anti-arthritic agents |
JPH06503329A (ja) * | 1990-12-07 | 1994-04-14 | ジ・アップジョン・カンパニー | 抗炎症剤として有用なホスホン酸誘導体 |
CA2058012A1 (en) * | 1990-12-19 | 1992-06-20 | Takashi Sohda | Bisphosphonic acid derivatives, their production and use |
IT1244698B (it) * | 1991-02-01 | 1994-08-08 | Gentili Ist Spa | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
WO1992022559A1 (en) * | 1991-06-19 | 1992-12-23 | The Upjohn Company | Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents |
EP0521622B1 (de) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimiden- und Pyrimidinylbisphosphonsäureester als entzündungshemmende Mittel |
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US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
CA2188066C (en) * | 1992-05-29 | 2000-12-05 | Susan Mary Kaas | Thio-substituted phosphonate compounds |
CA2136825C (en) * | 1992-05-29 | 1997-10-28 | Frank H. Ebetino | Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
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PL2731591T3 (pl) | 2011-07-13 | 2021-05-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Liposomy zawierające bisfosfonian i środek amfipatyczny w wyniku ko-enkapsulacji |
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DE1302557B (de) * | 1963-04-09 | 1971-08-26 | ||
US3654151A (en) * | 1970-04-13 | 1972-04-04 | Monsanto Co | Deflocculation of solid materials in aqueous medium |
US3705191A (en) * | 1970-04-13 | 1972-12-05 | Monsanto Co | Substituted ethane diphosphonic acids and salts and esters thereof |
US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
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US4071584A (en) * | 1977-01-03 | 1978-01-31 | Monsanto Company | Hydroxyphenylthiophosphoranylidene organophosphorus compounds |
US4264582A (en) * | 1978-07-31 | 1981-04-28 | The Procter & Gamble Company | Isobutylphenylacetate anti-inflammatory composition |
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GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
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-
1982
- 1982-07-29 FR FR8213250A patent/FR2531088B1/fr not_active Expired
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1983
- 1983-07-21 IE IE1716/83A patent/IE56343B1/en not_active IP Right Cessation
- 1983-07-22 DK DK336783A patent/DK170342B1/da not_active IP Right Cessation
- 1983-07-25 AT AT83401520T patent/ATE30235T1/de active
- 1983-07-25 EP EP83401520A patent/EP0100718B1/de not_active Expired
- 1983-07-25 NO NO832701A patent/NO164712C/no not_active IP Right Cessation
- 1983-07-25 DE DE8383401520T patent/DE3374062D1/de not_active Expired
- 1983-07-25 LU LU88723C patent/LU88723I2/fr unknown
- 1983-07-26 IL IL69347A patent/IL69347A/xx not_active IP Right Cessation
- 1983-07-26 CA CA000433224A patent/CA1267650A/en not_active Expired - Lifetime
- 1983-07-27 AU AU17324/83A patent/AU566880B2/en not_active Expired
- 1983-07-27 GR GR72051A patent/GR79597B/el unknown
- 1983-07-27 PH PH29310A patent/PH22082A/en unknown
- 1983-07-28 HU HU832658A patent/HU190454B/hu unknown
- 1983-07-28 NZ NZ205061A patent/NZ205061A/en unknown
- 1983-07-28 ES ES524495A patent/ES524495A0/es active Granted
- 1983-07-28 KR KR1019830003523A patent/KR910000726B1/ko not_active IP Right Cessation
- 1983-07-28 PT PT77122A patent/PT77122B/pt unknown
- 1983-07-28 OA OA58074A patent/OA07507A/xx unknown
- 1983-07-28 MA MA20079A patent/MA19858A1/fr unknown
- 1983-07-29 FI FI832758A patent/FI75830C/fi not_active IP Right Cessation
- 1983-07-29 ZA ZA835578A patent/ZA835578B/xx unknown
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- 1983-07-29 JP JP58139324A patent/JPS5942395A/ja active Granted
- 1983-07-29 PL PL1983243229A patent/PL141316B1/pl unknown
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- 1983-07-29 CS CS835688A patent/CS252463B2/cs unknown
- 1983-07-29 SU SU833628775A patent/SU1333240A3/ru active
- 1983-07-29 YU YU1600/83A patent/YU45143B/xx unknown
- 1983-07-30 EG EG468/83A patent/EG15968A/xx active
- 1983-11-27 DZ DZ836911A patent/DZ562A1/fr active
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1984
- 1984-06-26 SU SU843754451A patent/SU1367859A3/ru active
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1985
- 1985-06-11 AR AR85300673A patent/AR242394A1/es active
- 1985-06-11 AR AR85300674A patent/AR242393A1/es active
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1986
- 1986-04-24 US US06/858,573 patent/US4746654A/en not_active Expired - Lifetime
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1988
- 1988-03-07 US US07/165,080 patent/US4876248A/en not_active Expired - Lifetime
- 1988-03-23 SG SG185/88A patent/SG18588G/en unknown
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1991
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1996
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1998
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