WO1994019359A1 - Process for producing methanediphosphonate compound - Google Patents

Process for producing methanediphosphonate compound Download PDF

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Publication number
WO1994019359A1
WO1994019359A1 PCT/JP1994/000283 JP9400283W WO9419359A1 WO 1994019359 A1 WO1994019359 A1 WO 1994019359A1 JP 9400283 W JP9400283 W JP 9400283W WO 9419359 A1 WO9419359 A1 WO 9419359A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
producing
null
methanediphosphonate
independently
Prior art date
Application number
PCT/JP1994/000283
Other languages
French (fr)
Inventor
Keijiro Takanishi
Hiromi Uchiro
Norio Kawabe
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to AU61150/94A priority Critical patent/AU674059B2/en
Priority to KR1019940703838A priority patent/KR950701338A/en
Publication of WO1994019359A1 publication Critical patent/WO1994019359A1/en
Priority to NO944038A priority patent/NO300547B1/en
Priority to FI944998A priority patent/FI944998A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents

Definitions

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  • V ri * ⁇ > ri rt t ⁇ V ⁇ ⁇ sr sr e 4 rv 1 impart V v_oL ⁇ t ll -S r ⁇ .
  • V. 94- 4 ⁇ ⁇ v. rv a* *J Sv SN W 4 * vjlfl.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)

Abstract

A process for producing a 1-alkylthio- or 1-arylthiomethanediphosphonate compound by conducting the coupling reaction represented by formula (I) in the presence of a metallic oxide, wherein four R'1 groups represent each independently C1-C6 linear or branched alkyl; four R1 groups represent each independently a pharmacologically acceptable cation, hydrogen or C1-C6 linear or branched alkyl; and R2 represents alkyl or aryl. This process is extremely useful from the economic and industrial points of view, because the yield is remarkably improved and accordingly the purification procedure is simplified as compared with the conventional ones.

Description

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Claims

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PCT/JP1994/000283 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound WO1994019359A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU61150/94A AU674059B2 (en) 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound
KR1019940703838A KR950701338A (en) 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound
NO944038A NO300547B1 (en) 1993-02-25 1994-10-24 Process for preparing a methane diphosphonate compound
FI944998A FI944998A (en) 1993-02-25 1994-10-24 A process for preparing a methanediphosphonic acid compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3683293 1993-02-25
JP5/36832 1993-02-25

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WO1994019359A1 true WO1994019359A1 (en) 1994-09-01

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JP (1) JP2546067B2 (en)
KR (1) KR950701338A (en)
CN (1) CN1038033C (en)
AU (1) AU674059B2 (en)
FI (1) FI944998A (en)
TW (1) TW346489B (en)
WO (1) WO1994019359A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725070A1 (en) * 1994-08-24 1996-08-07 Toray Industries, Inc. Process for producing methanediphosphonic acid compound
WO2010026701A1 (en) * 2008-09-03 2010-03-11 国立大学法人東北大学 Osteogenesis promoter comprising [4-(methylthio)phenylthio]methanebisphosphonic acid or pharmaceutically acceptable salt thereof as active ingredient

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942395A (en) * 1982-07-29 1984-03-08 サノフイ Antiinflammatory product derived from methylene-diphosphonic acid
JPH0222285A (en) * 1988-03-31 1990-01-25 Symphar Sa Phenol substituted diem-diphosphonate derivative and preparation thereof and pharmaceutical composition containing the same
JPH0377894A (en) * 1989-08-18 1991-04-03 Toray Ind Inc Methylene diphosphonic acid compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5942395A (en) * 1982-07-29 1984-03-08 サノフイ Antiinflammatory product derived from methylene-diphosphonic acid
JPH0222285A (en) * 1988-03-31 1990-01-25 Symphar Sa Phenol substituted diem-diphosphonate derivative and preparation thereof and pharmaceutical composition containing the same
JPH0377894A (en) * 1989-08-18 1991-04-03 Toray Ind Inc Methylene diphosphonic acid compound

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725070A1 (en) * 1994-08-24 1996-08-07 Toray Industries, Inc. Process for producing methanediphosphonic acid compound
EP0725070A4 (en) * 1994-08-24 1997-10-22 Toray Industries Process for producing methanediphosphonic acid compound
WO2010026701A1 (en) * 2008-09-03 2010-03-11 国立大学法人東北大学 Osteogenesis promoter comprising [4-(methylthio)phenylthio]methanebisphosphonic acid or pharmaceutically acceptable salt thereof as active ingredient

Also Published As

Publication number Publication date
AU674059B2 (en) 1996-12-05
CN1038033C (en) 1998-04-15
CN1102750A (en) 1995-05-17
TW346489B (en) 1998-12-01
FI944998A0 (en) 1994-10-24
KR950701338A (en) 1995-03-23
JP2546067B2 (en) 1996-10-23
AU6115094A (en) 1994-09-14
FI944998A (en) 1994-10-24

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