KR950701338A - Process for producing methanediphosphonate compound - Google Patents

Process for producing methanediphosphonate compound

Info

Publication number
KR950701338A
KR950701338A KR1019940703838A KR19940703838A KR950701338A KR 950701338 A KR950701338 A KR 950701338A KR 1019940703838 A KR1019940703838 A KR 1019940703838A KR 19940703838 A KR19940703838 A KR 19940703838A KR 950701338 A KR950701338 A KR 950701338A
Authority
KR
South Korea
Prior art keywords
straight
methanediphosphonate
alkyl
alkyl group
compound
Prior art date
Application number
KR1019940703838A
Other languages
Korean (ko)
Inventor
케이지로 다카니시
히로미 우치로
노리오 가와베
Original Assignee
마에다 가쓰노스케
토레이가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마에다 가쓰노스케, 토레이가부시키가이샤 filed Critical 마에다 가쓰노스케
Publication of KR950701338A publication Critical patent/KR950701338A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents

Abstract

금속 산화물의 존재하에서 다음 반응도식(Ⅰ)에 따른 커플링 반응을 수행함으로써 1-알킬티오-또는 1-아릴티오메탄디포스포네이드 화합물을 제조하는 방벙을 기술하였다.A method for preparing 1-alkylthio- or 1-arylthiomethanediphosphonide compounds has been described by carrying out a coupling reaction according to Scheme (I) in the presence of a metal oxide.

상기식에서, R1'는 각각 독립적으로 직쇄형 또는 측쇄형 C1-C6알킬이고, R1은 각각 독립적으로 약리학적으로 허용되는 양이온, 수소 또는 직쇄형 또는 C1-C6알킬이며, R2는 알킬 또는 아릴이다.Wherein R 1 ′ are each independently straight or branched C 1 -C 6 alkyl, each R 1 is independently a pharmacologically acceptable cation, hydrogen or straight or C 1 -C 6 alkyl, and R is 2 is alkyl or aryl.

이 방법은 수율을 크게 개선시키고, 따라서 정제공정이 통상의 공정에 비해 간단화되기 때문에 경제적인 측면 및 공업적인 측면에서 매우 유용하다.This method is very useful both economically and industrially because the yield is greatly improved, and thus the purification process is simplified compared to conventional processes.

Description

메탄디포스폰산 화합물의 제조방법(Process for producing methanediphosphonate compound)Process for producing methanediphosphonate compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

일반식(Ⅱ)의 테트라알킬 메탄디포스포네이트의 금속 유도체를 금속 산화물의 존재하에서 일반식(Ⅲ)이 디알킬디설파이드 또는 디아릴디설파이드와 반응시킴을 특징으로 하여, 일반식(Ⅰ)의 메탄디포스폰산 화합물을 제조하는 방법.The methanedipotase of formula (I) is characterized in that the metal derivative of tetraalkyl methanediphosphonate of formula (II) is reacted with dialkyldisulfide or diaryldisulfide in the presence of a metal oxide. Method for preparing a sponic acid compound. v v 상기식에서, R1은 동일하거나 상이하며, 약리학적으로 허용가능한 양이온, 수소원자 또는 탄소수 1내지 6의 직쇄형 또는 측쇄형 알킬 그룹이고, R2은 알킬 그룹 또는 아릴 그룹이며, R1'는 동일하거나 상이하고, 탄소수 1내지 6의 직쇄형 또는 측쇄형 알킬 그룹이다.Wherein R 1 is the same or different and is a pharmacologically acceptable cation, a hydrogen atom or a straight or branched chain alkyl group of 1 to 6 carbon atoms, R 2 is an alkyl group or an aryl group, and R 1 ′ is the same Or different, and is a straight or branched alkyl group having 1 to 6 carbon atoms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940703838A 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound KR950701338A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3683293 1993-02-25
JP93-036832 1993-02-25
PCT/JP1994/000283 WO1994019359A1 (en) 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound

Publications (1)

Publication Number Publication Date
KR950701338A true KR950701338A (en) 1995-03-23

Family

ID=12480724

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940703838A KR950701338A (en) 1993-02-25 1994-02-23 Process for producing methanediphosphonate compound

Country Status (7)

Country Link
JP (1) JP2546067B2 (en)
KR (1) KR950701338A (en)
CN (1) CN1038033C (en)
AU (1) AU674059B2 (en)
FI (1) FI944998A0 (en)
TW (1) TW346489B (en)
WO (1) WO1994019359A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1055476C (en) * 1994-08-24 2000-08-16 东丽株式会社 Process for producing methanediphosphonic acid compound
JP5655179B2 (en) 2008-09-03 2015-01-21 国立大学法人東北大学 [4- (Methylthio) phenylthio] methanebisphosphonic acid or a pharmaceutically acceptable salt thereof as an active ingredient

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531088B1 (en) * 1982-07-29 1987-08-28 Sanofi Sa ANTI-INFLAMMATORY PRODUCTS DERIVED FROM METHYLENEDIPHOSPHONIC ACID AND THEIR PREPARATION METHOD
CH675422A5 (en) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (en) * 1989-08-18 1991-04-03 Toray Ind Inc Methylene diphosphonic acid compound

Also Published As

Publication number Publication date
FI944998A (en) 1994-10-24
CN1038033C (en) 1998-04-15
FI944998A0 (en) 1994-10-24
TW346489B (en) 1998-12-01
AU674059B2 (en) 1996-12-05
WO1994019359A1 (en) 1994-09-01
JP2546067B2 (en) 1996-10-23
CN1102750A (en) 1995-05-17
AU6115094A (en) 1994-09-14

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