KR970010772A - New preparation of 7-amino-3-methoxymethyl-3-cepem-4-carboxylic acid - Google Patents

New preparation of 7-amino-3-methoxymethyl-3-cepem-4-carboxylic acid Download PDF

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Publication number
KR970010772A
KR970010772A KR1019950025313A KR19950025313A KR970010772A KR 970010772 A KR970010772 A KR 970010772A KR 1019950025313 A KR1019950025313 A KR 1019950025313A KR 19950025313 A KR19950025313 A KR 19950025313A KR 970010772 A KR970010772 A KR 970010772A
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KR
South Korea
Prior art keywords
cepem
methoxymethyl
amino
carboxylic acid
new preparation
Prior art date
Application number
KR1019950025313A
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Korean (ko)
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KR0164947B1 (en
Inventor
김맹섭
Original Assignee
이웅열
주식회사 코오롱
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Publication date
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Priority to KR1019950025313A priority Critical patent/KR0164947B1/en
Publication of KR970010772A publication Critical patent/KR970010772A/en
Application granted granted Critical
Publication of KR0164947B1 publication Critical patent/KR0164947B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

본 발명은 7-아미노-3-메톡시메틸-3-세펨-4-카르복실산의 개량된 제조방법에 관한 것이며, 7-ACA 또는 그 염을 메탄술폰산과 염화수소메탄올 용액과 반응시켜서 간단하게 높은 수율과 순도로 목적화합물을 제조할 수 있다.The present invention relates to an improved process for the preparation of 7-amino-3-methoxymethyl-3-cepem-4-carboxylic acid, wherein 7-ACA or a salt thereof is reacted with a solution of methanesulfonic acid and hydrogen chloride The desired compound can be prepared in yield and purity.

Description

7-아미노-3-메톡시메틸-3-세펨-4-카르복실산의 신규 제조방법New preparation of 7-amino-3-methoxymethyl-3-cepem-4-carboxylic acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

구조식(Ⅱ)화합물 또는 그의 염을 메탄술폰산과 염화수소 메탄올 용액과 반응시켜서 구조식(Ⅰ)화합물을 제조하는 방법.A method for preparing a compound of formula (I) by reacting a compound of formula (II) or a salt thereof with methanesulfonic acid and methanol solution of hydrogen chloride. 제1항에 있어서, 구조식(Ⅱ)화합물에 대하여 메탄술폰산 1 내지 30당량, 메탄올 1 내지 30당량을 사용하여 반응을 행하는 방법.The method according to claim 1, wherein the reaction is carried out using 1 to 30 equivalents of methanesulfonic acid and 1 to 30 equivalents of methanol to the compound of formula II. 제1항에 있어서, 구조식(Ⅱ)화합물에 대하여 염화수소메탄올 용액의 조성이 0.01 내지 5N-염화수소를 포함하는 메탄올을 사용하여 반응을 행하는 방법.The process according to claim 1, wherein the composition of the hydrogen chloride methanol solution is reacted with methanol containing 0.01 to 5 N-hydrogen chloride. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950025313A 1995-08-17 1995-08-17 Process for the preparation of 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acids KR0164947B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950025313A KR0164947B1 (en) 1995-08-17 1995-08-17 Process for the preparation of 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950025313A KR0164947B1 (en) 1995-08-17 1995-08-17 Process for the preparation of 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acids

Publications (2)

Publication Number Publication Date
KR970010772A true KR970010772A (en) 1997-03-27
KR0164947B1 KR0164947B1 (en) 1999-01-15

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ID=19423670

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950025313A KR0164947B1 (en) 1995-08-17 1995-08-17 Process for the preparation of 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acids

Country Status (1)

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KR (1) KR0164947B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8477568B2 (en) 2009-03-11 2013-07-02 Jae-Chun Go Alarm clock which operates in conjunction with a gradually fading-in lamp

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8477568B2 (en) 2009-03-11 2013-07-02 Jae-Chun Go Alarm clock which operates in conjunction with a gradually fading-in lamp

Also Published As

Publication number Publication date
KR0164947B1 (en) 1999-01-15

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