KR970074751A - Method for producing high purity 2,2-dibromo-3-nitrylpropionamide - Google Patents

Method for producing high purity 2,2-dibromo-3-nitrylpropionamide Download PDF

Info

Publication number
KR970074751A
KR970074751A KR1019960015746A KR19960015746A KR970074751A KR 970074751 A KR970074751 A KR 970074751A KR 1019960015746 A KR1019960015746 A KR 1019960015746A KR 19960015746 A KR19960015746 A KR 19960015746A KR 970074751 A KR970074751 A KR 970074751A
Authority
KR
South Korea
Prior art keywords
dibromo
acid
represented
structural formula
following structural
Prior art date
Application number
KR1019960015746A
Other languages
Korean (ko)
Other versions
KR0185280B1 (en
Inventor
소순영
장길상
송현삼
김종범
Original Assignee
김용구
주식회사 한 화
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김용구, 주식회사 한 화 filed Critical 김용구
Priority to KR1019960015746A priority Critical patent/KR0185280B1/en
Publication of KR970074751A publication Critical patent/KR970074751A/en
Application granted granted Critical
Publication of KR0185280B1 publication Critical patent/KR0185280B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 하기 구조식(Ⅰ)로 표시되는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법에 관한 것으로, 좀 더 상세하게는 원료의 효율적사용, 공정의 단순화 및 유독한 브롬화수소의 외부로의 노출을 방지항 수 있는 고순도의 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법에 관한 것이다.The present invention relates to a process for producing 2,2-dibromo-3-nitrilopropionamide represented by the following structural formula (I), more specifically, to a process for efficiently using a raw material, simplifying a process and producing toxic hydrogen bromide 2-dibromo-3-nitrilofropionamide with high purity which can prevent exposure to the outside of the reaction mixture.

Description

고순도 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법Method for producing high purity 2,2-dibromo-3-nitrylpropionamide

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (5)

하기 구조식(Ⅰ)로 표시되는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법에 있어서, 하기 구조식(Ⅲ)으로 표시되는 알킬시아노아세테이트를 물에 용해시킨 다음, 암모니아수를 적가하여 하기식(Ⅱ)로 표시되는 시아노아세트아미드를 제조한후, 무기산으로 pH를 7이하로 중화시키고, 상기 반응물에 브롬과 과산화수소를 순차적으로 적가하여 반응시킨 다음, 약산성의 무기염으로 처리하여 여과시키는 것을 특징으로 하는 하기 구조식(Ⅰ)로 표시되는 2, 2-디브로모-3-니트릴로프피온아미드의 제조방법.In the process for producing 2, 2-dibromo-3-nitrilopropionamide represented by the following structural formula (I), the alkylcyanoacetate represented by the following structural formula (III) is dissolved in water, To prepare a cyanoacetamide represented by the following formula (II), neutralizing the pH to 7 or less with an inorganic acid, adding bromine and hydrogen peroxide sequentially to the reaction, reacting with a weakly acidic inorganic salt 2-dibromo-3-nitryl ropionamide represented by the following structural formula (I). 여기서, R은 CH3또는 C2H5이다.Here, R is CH 3 or C 2 H 5. 제1항에 있어서, 상기 무기산이 황산, 염산, 질산, 인산 또는 탄산임을 특징으로 하는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법.2. The process according to claim 1, wherein the inorganic acid is sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid or carbonic acid. 제1항에 있어서, 상기 반응온도가 20∼40℃임을 특징으로 하는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법.The process according to claim 1, wherein the reaction temperature is 20 to 40 占 폚. 제1항에 있어서, 상기 약산성의 무기염이 인산나트륨, 구연산소다, 인산칼륨, 구연산나트륨, 또는 구연산칼륨인 것을 특징으로 하는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법.The process according to claim 1, wherein the weakly acidic inorganic salt is sodium phosphate, sodium citrate, potassium phosphate, sodium citrate, or potassium citrate. 제1항에 있어서, 상기 브롬과 과산화수소의 몰 당량비율이 알킬시아노아세테이트에 대하여 각각 1.0∼1.20몰인 것을 특징으로 하는 2, 2-디브로모-3-니트릴로프로피온아미드의 제조방법.The process for producing 2, 2-dibromo-3-nitrilofropionamide according to claim 1, wherein the molar equivalent ratio of bromine to hydrogen peroxide is 1.0 to 1.20 moles relative to alkylcyanoacetate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960015746A 1996-05-08 1996-05-08 Process for preparation of 2,2-dibromo-3-nitrilopropionamide KR0185280B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960015746A KR0185280B1 (en) 1996-05-08 1996-05-08 Process for preparation of 2,2-dibromo-3-nitrilopropionamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960015746A KR0185280B1 (en) 1996-05-08 1996-05-08 Process for preparation of 2,2-dibromo-3-nitrilopropionamide

Publications (2)

Publication Number Publication Date
KR970074751A true KR970074751A (en) 1997-12-10
KR0185280B1 KR0185280B1 (en) 1999-05-15

Family

ID=19458470

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960015746A KR0185280B1 (en) 1996-05-08 1996-05-08 Process for preparation of 2,2-dibromo-3-nitrilopropionamide

Country Status (1)

Country Link
KR (1) KR0185280B1 (en)

Also Published As

Publication number Publication date
KR0185280B1 (en) 1999-05-15

Similar Documents

Publication Publication Date Title
HU9601954D0 (en) Process for producing creatine and creatine-mono-hydrate
KR970074751A (en) Method for producing high purity 2,2-dibromo-3-nitrylpropionamide
US5917087A (en) Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine
US4076721A (en) Process for producing saccharin
ES8300728A1 (en) Process for the preparation of saccharin.
EP0551632A3 (en) Process for the preparation of halogenoanthranilic acid
DE3485660D1 (en) POTASSIUM MONOPERSULFATE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF.
KR970065501A (en) Method for preparing calcium pyruvate and its hydrate
KR950701338A (en) Process for producing methanediphosphonate compound
GB2251621A (en) Process for the preparation of pyrethroide derivatives
JPS54138556A (en) Preparation of hydantoin
KR840005110A (en) Method for preparing pyrazine-bis (2-oxoglycine) compound
KR960017633A (en) Method for preparing 4-aminophenyl-2-acetoxyethyl sulfone
JPS6475457A (en) Production or 2,3-dicyano-5,6-dichlorobenzoquinone
KR950018012A (en) Dehalogenation of 6,6-dihalophenic silane acid 1,1-dioxide and its derivatives
KR970010772A (en) New preparation of 7-amino-3-methoxymethyl-3-cepem-4-carboxylic acid
KR940002228A (en) Method for preparing pyridine derivative
DE3662785D1 (en) Process for the preparation of bromo-fluoro-acetic acid
ES2112550T3 (en) PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF ALPHA-ALCOXIMINOFENILACETONITRILO.
JPS5462389A (en) Preparation of peptide
KR980002010A (en) Method for preparing N- (2-carboxy-5-chloro-phenyl) glycine
JPS60252453A (en) Production of beta-chloroalanine
KR970061899A (en) Method for the preparation of 3-halomethyl-3-cephem-4-carboxylate 1-oxide
RU97121109A (en) METHOD FOR PRODUCING N-TRET-BUTYL-2-BENZTHIAZOLSULPHENAMIDE
KR830005173A (en) Method for preparing chlorinated derivatives of benzoxazolone

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20040324

Year of fee payment: 9

LAPS Lapse due to unpaid annual fee