JPS5462389A - Preparation of peptide - Google Patents
Preparation of peptideInfo
- Publication number
- JPS5462389A JPS5462389A JP12763877A JP12763877A JPS5462389A JP S5462389 A JPS5462389 A JP S5462389A JP 12763877 A JP12763877 A JP 12763877A JP 12763877 A JP12763877 A JP 12763877A JP S5462389 A JPS5462389 A JP S5462389A
- Authority
- JP
- Japan
- Prior art keywords
- inorganic salt
- neutral
- peptide
- reaction
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To improve the yield and purity of peptide synthesized using an enzyme belonging to metal protease, by adding a neutral inorganic salt to the reaction mixture.
CONSTITUTION: In the synthesis of peptide bond by the reaction of 1 mole equivalent of an amine with 1.0W1.5 mole equivalent of an acid component in the presence of 1W400 mg, pref. 10W100 mg of a metal protease, e.g. a neutral protease originated from Streptomyces, at 20W50°C, for 2W24 hours, 10W30%, based on the reaction mixture, of a neutral inorganic salt (an inorganic salt which exhibits pH6W8 in aqueous solution) such as an alkali halide, e.g. NaCl, sodium sulfate, ammonium sulfate, etc., is added to the reaction system.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12763877A JPS5831199B2 (en) | 1977-10-26 | 1977-10-26 | Method for producing peptides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12763877A JPS5831199B2 (en) | 1977-10-26 | 1977-10-26 | Method for producing peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5462389A true JPS5462389A (en) | 1979-05-19 |
JPS5831199B2 JPS5831199B2 (en) | 1983-07-04 |
Family
ID=14965037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12763877A Expired JPS5831199B2 (en) | 1977-10-26 | 1977-10-26 | Method for producing peptides |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5831199B2 (en) |
-
1977
- 1977-10-26 JP JP12763877A patent/JPS5831199B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5831199B2 (en) | 1983-07-04 |
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