JPS5462389A - Preparation of peptide - Google Patents

Preparation of peptide

Info

Publication number
JPS5462389A
JPS5462389A JP12763877A JP12763877A JPS5462389A JP S5462389 A JPS5462389 A JP S5462389A JP 12763877 A JP12763877 A JP 12763877A JP 12763877 A JP12763877 A JP 12763877A JP S5462389 A JPS5462389 A JP S5462389A
Authority
JP
Japan
Prior art keywords
inorganic salt
neutral
peptide
reaction
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12763877A
Other languages
Japanese (ja)
Other versions
JPS5831199B2 (en
Inventor
Yoshikazu Isowa
Tetsuya Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP12763877A priority Critical patent/JPS5831199B2/en
Publication of JPS5462389A publication Critical patent/JPS5462389A/en
Publication of JPS5831199B2 publication Critical patent/JPS5831199B2/en
Expired legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To improve the yield and purity of peptide synthesized using an enzyme belonging to metal protease, by adding a neutral inorganic salt to the reaction mixture.
CONSTITUTION: In the synthesis of peptide bond by the reaction of 1 mole equivalent of an amine with 1.0W1.5 mole equivalent of an acid component in the presence of 1W400 mg, pref. 10W100 mg of a metal protease, e.g. a neutral protease originated from Streptomyces, at 20W50°C, for 2W24 hours, 10W30%, based on the reaction mixture, of a neutral inorganic salt (an inorganic salt which exhibits pH6W8 in aqueous solution) such as an alkali halide, e.g. NaCl, sodium sulfate, ammonium sulfate, etc., is added to the reaction system.
COPYRIGHT: (C)1979,JPO&Japio
JP12763877A 1977-10-26 1977-10-26 Method for producing peptides Expired JPS5831199B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12763877A JPS5831199B2 (en) 1977-10-26 1977-10-26 Method for producing peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12763877A JPS5831199B2 (en) 1977-10-26 1977-10-26 Method for producing peptides

Publications (2)

Publication Number Publication Date
JPS5462389A true JPS5462389A (en) 1979-05-19
JPS5831199B2 JPS5831199B2 (en) 1983-07-04

Family

ID=14965037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12763877A Expired JPS5831199B2 (en) 1977-10-26 1977-10-26 Method for producing peptides

Country Status (1)

Country Link
JP (1) JPS5831199B2 (en)

Also Published As

Publication number Publication date
JPS5831199B2 (en) 1983-07-04

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