ES524495A0 - Procedimiento para la preparacion de derivados del acido metilendifosfonico - Google Patents

Procedimiento para la preparacion de derivados del acido metilendifosfonico

Info

Publication number
ES524495A0
ES524495A0 ES524495A ES524495A ES524495A0 ES 524495 A0 ES524495 A0 ES 524495A0 ES 524495 A ES524495 A ES 524495A ES 524495 A ES524495 A ES 524495A ES 524495 A0 ES524495 A0 ES 524495A0
Authority
ES
Spain
Prior art keywords
methylendyphosphonic
derivatives
procedure
preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES524495A
Other languages
English (en)
Other versions
ES8403923A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8403923A1 publication Critical patent/ES8403923A1/es
Publication of ES524495A0 publication Critical patent/ES524495A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES524495A 1982-07-29 1983-07-28 Procedimiento para la preparacion de derivados del acido metilendifosfonico Granted ES524495A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (2)

Publication Number Publication Date
ES8403923A1 ES8403923A1 (es) 1984-04-16
ES524495A0 true ES524495A0 (es) 1984-04-16

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524495A Granted ES524495A0 (es) 1982-07-29 1983-07-28 Procedimiento para la preparacion de derivados del acido metilendifosfonico

Country Status (35)

Country Link
US (2) US4746654A (es)
EP (1) EP0100718B1 (es)
JP (1) JPS5942395A (es)
KR (1) KR910000726B1 (es)
AR (2) AR242394A1 (es)
AT (1) ATE30235T1 (es)
AU (1) AU566880B2 (es)
CA (1) CA1267650A (es)
CS (1) CS252463B2 (es)
CZ (1) CZ419191A3 (es)
DD (1) DD213670A5 (es)
DE (1) DE3374062D1 (es)
DK (1) DK170342B1 (es)
DZ (1) DZ562A1 (es)
EG (1) EG15968A (es)
ES (1) ES524495A0 (es)
FI (1) FI75830C (es)
FR (1) FR2531088B1 (es)
GR (1) GR79597B (es)
HU (1) HU190454B (es)
IE (1) IE56343B1 (es)
IL (1) IL69347A (es)
LU (1) LU88723I2 (es)
MA (1) MA19858A1 (es)
NL (1) NL960007I2 (es)
NO (2) NO164712C (es)
NZ (1) NZ205061A (es)
OA (1) OA07507A (es)
PH (1) PH22082A (es)
PL (2) PL141316B1 (es)
PT (1) PT77122B (es)
SG (1) SG18588G (es)
SU (2) SU1333240A3 (es)
YU (1) YU45143B (es)
ZA (1) ZA835578B (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
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KR880011136A (ko) * 1987-03-11 1988-10-26 모리오까 시게오 아졸- 아미노메틸렌 비스포스폰산 유도체
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DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (es) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
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FI75830C (fi) 1988-08-08
AU1732483A (en) 1984-02-02
PT77122B (fr) 1986-01-24
IE56343B1 (en) 1991-07-03
YU45143B (en) 1992-03-10
DK336783D0 (da) 1983-07-22
NZ205061A (en) 1987-08-31
FI832758A (fi) 1984-01-30
PL141316B1 (en) 1987-07-31
FR2531088B1 (fr) 1987-08-28
AR242393A1 (es) 1993-03-31
EG15968A (en) 1989-01-30
EP0100718B1 (fr) 1987-10-14
SG18588G (en) 1988-09-30
EP0100718A1 (fr) 1984-02-15
ES8403923A1 (es) 1984-04-16
LU88723I2 (fr) 1996-08-23
NO832701L (no) 1984-01-30
NL960007I1 (nl) 1996-09-02
US4876248A (en) 1989-10-24
HU190454B (en) 1986-09-29
SU1367859A3 (ru) 1988-01-15
DZ562A1 (fr) 2004-09-13
NO164712B (no) 1990-07-30
DK336783A (da) 1984-01-30
KR910000726B1 (ko) 1991-01-31
AU566880B2 (en) 1987-11-05
FR2531088A1 (fr) 1984-02-03
DE3374062D1 (en) 1987-11-19
NO1998011I1 (no) 1998-03-06
ZA835578B (en) 1984-04-25
YU160083A (en) 1986-08-31
GR79597B (es) 1984-10-31
FI75830B (fi) 1988-04-29
US4746654A (en) 1988-05-24
NO164712C (no) 1990-11-07
JPS5942395A (ja) 1984-03-08
IL69347A (en) 1987-02-27
PL243229A1 (en) 1984-07-16
IE831716L (en) 1984-01-29
NL960007I2 (nl) 1997-03-03
PL142022B1 (en) 1987-09-30
IL69347A0 (en) 1983-11-30
MA19858A1 (fr) 1984-04-01
PT77122A (fr) 1983-08-01
FI832758A0 (fi) 1983-07-29
JPH0429676B2 (es) 1992-05-19
CS568883A2 (en) 1987-01-15
DK170342B1 (da) 1995-08-07
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CS252463B2 (en) 1987-09-17
DD213670A5 (de) 1984-09-19
SU1333240A3 (ru) 1987-08-23
CA1267650A (en) 1990-04-10
OA07507A (fr) 1985-03-31
AR242394A1 (es) 1993-03-31
ATE30235T1 (de) 1987-10-15
KR840005459A (ko) 1984-11-12
CZ419191A3 (en) 1993-10-13

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