DK0561948T3 - Phosphonsyrederivater, der kan anvendes som antiinflammatoriske midler - Google Patents

Phosphonsyrederivater, der kan anvendes som antiinflammatoriske midler

Info

Publication number
DK0561948T3
DK0561948T3 DK92901352.2T DK92901352T DK0561948T3 DK 0561948 T3 DK0561948 T3 DK 0561948T3 DK 92901352 T DK92901352 T DK 92901352T DK 0561948 T3 DK0561948 T3 DK 0561948T3
Authority
DK
Denmark
Prior art keywords
acid derivatives
phosphonic acid
inflammatory agents
inflammatory
agents
Prior art date
Application number
DK92901352.2T
Other languages
English (en)
Inventor
Roy Allen Johnson
Herman Walden Smith
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0561948T3 publication Critical patent/DK0561948T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92901352.2T 1990-12-07 1991-12-03 Phosphonsyrederivater, der kan anvendes som antiinflammatoriske midler DK0561948T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62411990A 1990-12-07 1990-12-07

Publications (1)

Publication Number Publication Date
DK0561948T3 true DK0561948T3 (da) 1995-08-21

Family

ID=24500731

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92901352.2T DK0561948T3 (da) 1990-12-07 1991-12-03 Phosphonsyrederivater, der kan anvendes som antiinflammatoriske midler

Country Status (8)

Country Link
US (2) US5298498A (da)
EP (2) EP0561948B1 (da)
JP (1) JPH06503329A (da)
AU (1) AU9097791A (da)
CA (1) CA2094123A1 (da)
DE (1) DE69108739T2 (da)
DK (1) DK0561948T3 (da)
WO (1) WO1992010504A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010504A2 (en) * 1990-12-07 1992-06-25 The Upjohn Company Phosphonic acid derivatives useful as antiinflammatory agents
AU4848193A (en) * 1992-09-23 1994-04-26 Upjohn Company, The Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents
JP3951367B2 (ja) * 1996-11-28 2007-08-01 住友化学株式会社 ５価のリン系化合物を有効成分とする熱可塑性樹脂用安定剤、その製造方法およびその用途
GB2326369B (en) * 1997-06-20 2001-06-27 Aea Technology Plc Double lid system
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
US5932563A (en) * 1998-10-23 1999-08-03 Ohio State Research Foundation Methods for treating spinal cord injury
US20020032164A1 (en) * 1998-12-30 2002-03-14 Dale Roderic M. K. Antimicrobial compounds and methods for their use
US6627215B1 (en) * 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
US7868162B2 (en) * 1998-12-30 2011-01-11 Lakewood-Amedex, Inc. Antimicrobial and antiviral compounds and methods for their use
ES2246234T3 (es) 1999-05-04 2006-02-16 Strakan International Limited Glicosidos de androgenos y actividad androgenica de los mismos.
JP4164718B2 (ja) * 1999-10-06 2008-10-15 ソニー株式会社 ビス（アミノスチリル）ナフタレン化合物及びその合成中間体、これらの製造方法、並びに有機電界発光素子
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
CN101511170B (zh) * 2005-12-22 2014-03-26 奥克伍德药业有限公司 可升华持续释放传递系统和其制造方法
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2720080T3 (es) 2007-11-14 2019-07-17 Fresenius Kabi Austria Gmbh Procedimiento continúo para la preparación de lactulosa cristalina
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124949B (de) * 1960-03-04 1962-03-08 Basf Ag Verfahren zur Herstellung von Verbindungen der 1,2-Bis-(vinyl)-benzolreihe
FR1541025A (fr) * 1967-08-01 1968-10-04 Prec Mecanique Labinal Perfectionnements apportés aux filtres, notamment du type remplaçable, et plus spécialement en matière plastique
CH558424A (de) * 1968-01-15 1975-01-31 Ciba Geigy Ag Waschmittel.
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
JPS5038861A (da) * 1973-08-11 1975-04-10
JPS53105716A (en) * 1977-02-25 1978-09-14 Daicel Chem Ind Ltd Hose or tube for solvent
JPS5677474A (en) * 1979-11-28 1981-06-25 Ishikawajima Harima Heavy Ind Method of constructing multiple shell tank
JPS57209424A (en) * 1981-06-17 1982-12-22 Nissan Motor Co Ltd Holder for fuel strainer
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3346177A1 (de) * 1983-12-21 1985-07-04 Hoechst Ag, 6230 Frankfurt Neue 2,3-bis(arylethenyl)-chinoxaline, verfahren zu ihrer herstellung und ihre verwendung als photoleitfaehige verbindungen
JPS618102A (ja) * 1984-06-21 1986-01-14 Asahi Chem Ind Co Ltd 導電性ミクロフイルタ−
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
JPS6291317A (ja) * 1985-10-18 1987-04-25 Showa Denko Kk 合成樹脂製フイラ−パイプ
GB8621044D0 (en) * 1986-08-30 1986-10-08 British Petroleum Co Plc Cyclic phosphonic monoesters
US5196409A (en) * 1989-08-20 1993-03-23 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism
WO1992010504A2 (en) * 1990-12-07 1992-06-25 The Upjohn Company Phosphonic acid derivatives useful as antiinflammatory agents

Also Published As

Publication number Publication date
AU9097791A (en) 1992-07-08
CA2094123A1 (en) 1992-06-08
EP0561948B1 (en) 1995-04-05
US5360797A (en) 1994-11-01
JPH06503329A (ja) 1994-04-14
WO1992010504A2 (en) 1992-06-25
WO1992010504A3 (en) 1992-09-17
EP0622373A1 (en) 1994-11-02
DE69108739T2 (de) 1995-09-14
US5298498A (en) 1994-03-29
DE69108739D1 (de) 1995-05-11
EP0561948A1 (en) 1993-09-29

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