DE69108739T2 - Phosphonsäurederivate als entzündungshemmende mittel. - Google Patents

Phosphonsäurederivate als entzündungshemmende mittel.

Info

Publication number
DE69108739T2
DE69108739T2 DE69108739T DE69108739T DE69108739T2 DE 69108739 T2 DE69108739 T2 DE 69108739T2 DE 69108739 T DE69108739 T DE 69108739T DE 69108739 T DE69108739 T DE 69108739T DE 69108739 T2 DE69108739 T2 DE 69108739T2
Authority
DE
Germany
Prior art keywords
flamming
agents
acid derivatives
phosphonic acid
phosphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108739T
Other languages
English (en)
Other versions
DE69108739D1 (de
Inventor
Roy Johnson
Herman Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE69108739D1 publication Critical patent/DE69108739D1/de
Publication of DE69108739T2 publication Critical patent/DE69108739T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69108739T 1990-12-07 1991-12-03 Phosphonsäurederivate als entzündungshemmende mittel. Expired - Fee Related DE69108739T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62411990A 1990-12-07 1990-12-07
PCT/US1991/008817 WO1992010504A2 (en) 1990-12-07 1991-12-03 Phosphonic acid derivatives useful as antiinflammatory agents

Publications (2)

Publication Number Publication Date
DE69108739D1 DE69108739D1 (de) 1995-05-11
DE69108739T2 true DE69108739T2 (de) 1995-09-14

Family

ID=24500731

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108739T Expired - Fee Related DE69108739T2 (de) 1990-12-07 1991-12-03 Phosphonsäurederivate als entzündungshemmende mittel.

Country Status (8)

Country Link
US (2) US5298498A (de)
EP (2) EP0622373A1 (de)
JP (1) JPH06503329A (de)
AU (1) AU9097791A (de)
CA (1) CA2094123A1 (de)
DE (1) DE69108739T2 (de)
DK (1) DK0561948T3 (de)
WO (1) WO1992010504A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69108739T2 (de) * 1990-12-07 1995-09-14 Upjohn Co Phosphonsäurederivate als entzündungshemmende mittel.
EP0661978A1 (de) * 1992-09-23 1995-07-12 PHARMACIA & UPJOHN COMPANY Arylmethylphosphonate und -phosphonsaeuren als antiinflammatorische wirkstoffe
JP3951367B2 (ja) * 1996-11-28 2007-08-01 住友化学株式会社 ５価のリン系化合物を有効成分とする熱可塑性樹脂用安定剤、その製造方法およびその用途
GB2326369B (en) * 1997-06-20 2001-06-27 Aea Technology Plc Double lid system
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
US5932563A (en) * 1998-10-23 1999-08-03 Ohio State Research Foundation Methods for treating spinal cord injury
US20020032164A1 (en) * 1998-12-30 2002-03-14 Dale Roderic M. K. Antimicrobial compounds and methods for their use
US6627215B1 (en) * 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
US7868162B2 (en) * 1998-12-30 2011-01-11 Lakewood-Amedex, Inc. Antimicrobial and antiviral compounds and methods for their use
DK1175433T3 (da) 1999-05-04 2005-09-19 Strakan Int Ltd Androgenglycosider og androgen aktivitet deraf
JP4164718B2 (ja) * 1999-10-06 2008-10-15 ソニー株式会社 ビス（アミノスチリル）ナフタレン化合物及びその合成中間体、これらの製造方法、並びに有機電界発光素子
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
CN101511170B (zh) * 2005-12-22 2014-03-26 奥克伍德药业有限公司 可升华持续释放传递系统和其制造方法
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
EP2060639B1 (de) 2007-11-14 2019-01-30 Fresenius Kabi Austria GmbH Kontinuierliches Verfahren zur Herstellung von kristallisierter Lactulose
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124949B (de) * 1960-03-04 1962-03-08 Basf Ag Verfahren zur Herstellung von Verbindungen der 1,2-Bis-(vinyl)-benzolreihe
FR1541025A (fr) * 1967-08-01 1968-10-04 Prec Mecanique Labinal Perfectionnements apportés aux filtres, notamment du type remplaçable, et plus spécialement en matière plastique
CH558424A (de) * 1968-01-15 1975-01-31 Ciba Geigy Ag Waschmittel.
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
JPS5038861A (de) * 1973-08-11 1975-04-10
JPS53105716A (en) * 1977-02-25 1978-09-14 Daicel Chem Ind Ltd Hose or tube for solvent
JPS5677474A (en) * 1979-11-28 1981-06-25 Ishikawajima Harima Heavy Ind Method of constructing multiple shell tank
JPS57209424A (en) * 1981-06-17 1982-12-22 Nissan Motor Co Ltd Holder for fuel strainer
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3346177A1 (de) * 1983-12-21 1985-07-04 Hoechst Ag, 6230 Frankfurt Neue 2,3-bis(arylethenyl)-chinoxaline, verfahren zu ihrer herstellung und ihre verwendung als photoleitfaehige verbindungen
JPS618102A (ja) * 1984-06-21 1986-01-14 Asahi Chem Ind Co Ltd 導電性ミクロフイルタ−
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
JPS6291317A (ja) * 1985-10-18 1987-04-25 Showa Denko Kk 合成樹脂製フイラ−パイプ
GB8621044D0 (en) * 1986-08-30 1986-10-08 British Petroleum Co Plc Cyclic phosphonic monoesters
US5196409A (en) * 1989-08-20 1993-03-23 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Bisphosphonates, pharmaceutical compositions, and process for the treatment of irregularities in calcium metabolism
DE69108739T2 (de) * 1990-12-07 1995-09-14 Upjohn Co Phosphonsäurederivate als entzündungshemmende mittel.

Also Published As

Publication number Publication date
DK0561948T3 (da) 1995-08-21
WO1992010504A3 (en) 1992-09-17
WO1992010504A2 (en) 1992-06-25
EP0561948B1 (de) 1995-04-05
AU9097791A (en) 1992-07-08
JPH06503329A (ja) 1994-04-14
US5360797A (en) 1994-11-01
EP0561948A1 (de) 1993-09-29
DE69108739D1 (de) 1995-05-11
EP0622373A1 (de) 1994-11-02
US5298498A (en) 1994-03-29
CA2094123A1 (en) 1992-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee