OA07507A - Produits anti-inflammatoires dérivés de l'acide méthylènediphosphodinique et leur procédé de préparation. - Google Patents
Produits anti-inflammatoires dérivés de l'acide méthylènediphosphodinique et leur procédé de préparation.Info
- Publication number
- OA07507A OA07507A OA58074A OA58074A OA07507A OA 07507 A OA07507 A OA 07507A OA 58074 A OA58074 A OA 58074A OA 58074 A OA58074 A OA 58074A OA 07507 A OA07507 A OA 07507A
- Authority
- OA
- OAPI
- Prior art keywords
- methylenediphosphodinic
- acid
- preparation process
- products derived
- inflammatory products
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8213250A FR2531088B1 (fr) | 1982-07-29 | 1982-07-29 | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
OA07507A true OA07507A (fr) | 1985-03-31 |
Family
ID=9276447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA58074A OA07507A (fr) | 1982-07-29 | 1983-07-28 | Produits anti-inflammatoires dérivés de l'acide méthylènediphosphodinique et leur procédé de préparation. |
Country Status (35)
Country | Link |
---|---|
US (2) | US4746654A (es) |
EP (1) | EP0100718B1 (es) |
JP (1) | JPS5942395A (es) |
KR (1) | KR910000726B1 (es) |
AR (2) | AR242394A1 (es) |
AT (1) | ATE30235T1 (es) |
AU (1) | AU566880B2 (es) |
CA (1) | CA1267650A (es) |
CS (1) | CS252463B2 (es) |
CZ (1) | CZ419191A3 (es) |
DD (1) | DD213670A5 (es) |
DE (1) | DE3374062D1 (es) |
DK (1) | DK170342B1 (es) |
DZ (1) | DZ562A1 (es) |
EG (1) | EG15968A (es) |
ES (1) | ES8403923A1 (es) |
FI (1) | FI75830C (es) |
FR (1) | FR2531088B1 (es) |
GR (1) | GR79597B (es) |
HU (1) | HU190454B (es) |
IE (1) | IE56343B1 (es) |
IL (1) | IL69347A (es) |
LU (1) | LU88723I2 (es) |
MA (1) | MA19858A1 (es) |
NL (1) | NL960007I2 (es) |
NO (2) | NO164712C (es) |
NZ (1) | NZ205061A (es) |
OA (1) | OA07507A (es) |
PH (1) | PH22082A (es) |
PL (2) | PL142022B1 (es) |
PT (1) | PT77122B (es) |
SG (1) | SG18588G (es) |
SU (2) | SU1333240A3 (es) |
YU (1) | YU45143B (es) |
ZA (1) | ZA835578B (es) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2558837B1 (fr) * | 1984-01-26 | 1986-06-27 | Sanofi Sa | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
US5641762A (en) * | 1985-05-02 | 1997-06-24 | Research Corporation Technologies, Inc. | Bone targeted inhibitors of carbonic anhydrase |
US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
DE3770982D1 (de) * | 1986-04-24 | 1991-08-01 | Fujisawa Pharmaceutical Co | Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel. |
IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
EP0282309A3 (en) * | 1987-03-11 | 1990-03-14 | Yamanouchi Pharmaceutical Co. Ltd. | Azole-aminomethylene bisphosphonic acid derivatives |
IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
DE3805663A1 (de) * | 1988-02-24 | 1989-09-07 | Henkel Kgaa | Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen |
CH675422A5 (es) * | 1988-03-31 | 1990-09-28 | Symphar Sa | |
FR2629716B1 (fr) * | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
ATE136870T1 (de) * | 1988-11-01 | 1996-05-15 | Arch Dev Corp | Verfahren zur abtrennung von metallischen ionen mit phosphonsäuren als complexbildner |
US5154843A (en) * | 1989-02-08 | 1992-10-13 | The Lubrizol Corporation | Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same |
PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
US5220021A (en) * | 1989-04-03 | 1993-06-15 | The Upjohn Company | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
JPH0377894A (ja) * | 1989-08-18 | 1991-04-03 | Toray Ind Inc | メチレンジホスホン酸化合物 |
DE69023844T2 (de) * | 1989-09-06 | 1996-06-20 | Merck & Co Inc | Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren. |
DE59107135D1 (de) * | 1990-01-18 | 1996-02-08 | Ciba Geigy Ag | Phoshponsäure- und Thionophosphonsäure-Derivate |
IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
EP0544812B1 (en) * | 1990-08-21 | 1995-04-05 | The Upjohn Company | Bisphosphonic acid derivatives as anti-arthritic agents |
WO1992010504A2 (en) * | 1990-12-07 | 1992-06-25 | The Upjohn Company | Phosphonic acid derivatives useful as antiinflammatory agents |
CA2058012A1 (en) * | 1990-12-19 | 1992-06-20 | Takashi Sohda | Bisphosphonic acid derivatives, their production and use |
IT1244698B (it) * | 1991-02-01 | 1994-08-08 | Gentili Ist Spa | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
JPH06508365A (ja) * | 1991-06-19 | 1994-09-22 | ジ・アップジョン・カンパニー | 抗炎症剤としてのりん酸ジアルキル(ジアルコキシホスフィニル)メチル類 |
EP0521622B1 (en) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
CA2095128C (en) * | 1991-09-05 | 1998-01-06 | Norio Kawabe | Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications |
JPH06172372A (ja) * | 1991-11-06 | 1994-06-21 | Takeda Chem Ind Ltd | スクアレン合成酵素阻害剤およびその用途 |
EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
KR950701929A (ko) * | 1992-05-29 | 1995-05-17 | 제이코버스 코넬리스 레이서 | 비정상적인 칼슘 및 인산염 대사를 치료하기 위한 황-함유 포스포네이트 화합물(sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism) |
US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
SK144694A3 (en) * | 1992-05-29 | 1995-06-07 | Procter & Gamble Pharma | Thio-substituted nitrogen containing heterocyclic phosphate compounds for treating calcium and phosphate metabolism |
CA2136825C (en) * | 1992-05-29 | 1997-10-28 | Frank H. Ebetino | Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
RU2119794C1 (ru) * | 1992-06-30 | 1998-10-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения |
US5618804A (en) * | 1992-07-10 | 1997-04-08 | Toray Industries, Inc. | Methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals |
GB9215433D0 (en) * | 1992-07-21 | 1992-09-02 | Cmb Foodcan Plc | Apparatus for stripping a drawn article from a punch |
FR2694558B1 (fr) * | 1992-08-05 | 1994-10-28 | Sanofi Elf | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant. |
EP0654035B1 (en) * | 1992-08-07 | 1997-08-20 | PHARMACIA & UPJOHN COMPANY | Phosphonoacetic esters and acids as anti-inflammatories |
WO1994009017A1 (en) * | 1992-10-09 | 1994-04-28 | The Upjohn Company | Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories |
JPH06135976A (ja) * | 1992-10-30 | 1994-05-17 | Toray Ind Inc | メタンジホスホン酸誘導体、その製造方法およびその医薬用途 |
US5332728A (en) * | 1992-11-23 | 1994-07-26 | Bristol-Myers Squibb Company | Method for treating a fungal infection |
AU670337B2 (en) | 1992-11-30 | 1996-07-11 | Novartis Ag | Use of certain methanebisphosphonic acid derivatives in fracture healing |
US6399592B1 (en) | 1992-12-23 | 2002-06-04 | Merck & Co., Inc. | Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss |
JP2546067B2 (ja) * | 1993-02-25 | 1996-10-23 | 東レ株式会社 | メタンジホスホン酸化合物の製造方法 |
FR2703590B1 (fr) * | 1993-04-05 | 1995-06-30 | Sanofi Elf | Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse . |
US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
US5886206A (en) * | 1994-08-24 | 1999-03-23 | Toray Industries, Inc. | Process for production of methanediphosphonic acid compound |
WO1996039107A1 (en) | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices |
US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
ATE290871T1 (de) * | 1995-09-29 | 2005-04-15 | Novartis Pharma Gmbh | Verfahren zur behandlung navikularer krankheiten bei pferden |
AU721320B2 (en) * | 1996-10-09 | 2000-06-29 | Elizanor Biopharmaceuticals, Inc. | Diphosphonate therapeutic compounds |
US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
SK286080B6 (sk) | 1998-09-09 | 2008-03-05 | Metabasis Therapeutics, Inc. | Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny |
FR2784031B1 (fr) * | 1998-10-02 | 2002-02-01 | Sanofi Elf | Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries |
EP1057488A4 (en) * | 1998-12-25 | 2003-10-22 | Toray Industries | INTERLEUKIN-6 PRODUCTION INHIBITORS |
JP4733888B2 (ja) | 1999-07-23 | 2011-07-27 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 誘導体化ポリウレタン組成物およびその製造方法 |
AR021347A1 (es) * | 1999-10-20 | 2002-07-17 | Cipla Ltd | Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma |
WO2001044257A1 (en) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Proton pump inhibitors |
CN100595204C (zh) * | 1999-12-22 | 2010-03-24 | 症变治疗公司 | 双氨基化膦酸酯前药 |
US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
US7563774B2 (en) * | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
EP1383510B1 (en) * | 2001-04-10 | 2012-10-17 | MBC Pharma, Inc. | Bisphosphonate conjugates and methods of making and using the same |
US20060269602A1 (en) * | 2001-04-13 | 2006-11-30 | Dasch James R | Method of modifying the release profile of sustained release compositions |
US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
SK2532004A3 (en) * | 2001-12-21 | 2004-11-03 | Procter & Gamble | Method for the treatment of bone disorders |
AU2002364051A1 (en) * | 2002-01-24 | 2003-09-02 | Children's Medical Center Corporation | Anti-cancer combination and use thereof |
CA2480814A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
KR20120065435A (ko) * | 2002-05-10 | 2012-06-20 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
EP1513523A1 (en) * | 2002-06-06 | 2005-03-16 | Merck Frosst Canada & Co. | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
WO2004029117A2 (en) * | 2002-09-26 | 2004-04-08 | The Children's Hospital Of Philadelphia | Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same |
US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
SG174628A1 (en) | 2002-12-20 | 2011-10-28 | Hoffmann La Roche | High dose ibandronate formulation |
WO2005007034A1 (en) * | 2003-07-08 | 2005-01-27 | The Children's Hospital Of Philadelphia | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof |
AU2004266740B2 (en) | 2003-08-21 | 2010-08-26 | Merck Frosst Canada Ltd | Cathepsin cysteine protease inhibitors |
NZ545804A (en) * | 2003-09-19 | 2009-09-25 | Wisconsin Alumni Res Found | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate |
US20050261250A1 (en) * | 2004-05-19 | 2005-11-24 | Merck & Co., Inc., | Compositions and methods for inhibiting bone resorption |
SI1753395T1 (sl) | 2004-05-24 | 2011-01-31 | Warner Chilcott Co Llc | Enterične trdne formulacije oralnih odmerkov bifosfonata, ki vsebuje kelirno sredstvo |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
CN101005847A (zh) * | 2004-08-18 | 2007-07-25 | 症变治疗公司 | 果糖1,6-双磷酸酶的新颖噻唑类抑制剂 |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
DK1855674T3 (da) | 2005-03-02 | 2014-10-20 | Merck Sharp & Dohme | Sammensætning til hæmning af cathepsin k |
CN101198316A (zh) * | 2005-03-17 | 2008-06-11 | 伊兰制药国际有限公司 | 纳米微粒双膦酸盐组合物 |
US7538163B2 (en) * | 2005-03-24 | 2009-05-26 | Medtronic, Inc. | Modification of thermoplastic polymers |
WO2009082437A2 (en) | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
EP2324041A4 (en) | 2008-08-13 | 2012-06-13 | Targanta Therapeutics Corp | PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS |
US20120100206A1 (en) | 2009-06-11 | 2012-04-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Targeted liposomes comprising n-containing bisphosphonates and uses thereof |
FR2954320B1 (fr) | 2009-12-17 | 2012-06-15 | Cll Pharma | Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels |
US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
LT2731591T (lt) | 2011-07-13 | 2020-12-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Liposomos, kuriose kartu inkapsuliuotas bisfosfonatas ir amfipatinis agentas |
WO2013019874A1 (en) | 2011-08-01 | 2013-02-07 | Mbc Pharma, Inc. | Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
CA2923272A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
KR20160147007A (ko) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체 |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302557B (es) * | 1963-04-09 | 1971-08-26 | ||
US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
US3654151A (en) * | 1970-04-13 | 1972-04-04 | Monsanto Co | Deflocculation of solid materials in aqueous medium |
US3705191A (en) * | 1970-04-13 | 1972-12-05 | Monsanto Co | Substituted ethane diphosphonic acids and salts and esters thereof |
US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
US4171373A (en) * | 1974-01-07 | 1979-10-16 | William H. Rorer, Inc. | Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation |
US4071584A (en) * | 1977-01-03 | 1978-01-31 | Monsanto Company | Hydroxyphenylthiophosphoranylidene organophosphorus compounds |
US4264582A (en) * | 1978-07-31 | 1981-04-28 | The Procter & Gamble Company | Isobutylphenylacetate anti-inflammatory composition |
JPS5598193A (en) * | 1979-01-22 | 1980-07-25 | Nissan Chem Ind Ltd | Methylenediphosphonic acid derivative and herbicide comprising it as active constituent |
GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
US4330530A (en) * | 1980-12-22 | 1982-05-18 | The Procter & Gamble Company | Anti-arthritic compositions and method using gold salts and organophosphonates |
DE3365492D1 (en) * | 1982-01-27 | 1986-10-02 | Schering Ag | Diphosphonic acid derivatives and pharmaceutical preparations containing them |
-
1982
- 1982-07-29 FR FR8213250A patent/FR2531088B1/fr not_active Expired
-
1983
- 1983-07-21 IE IE1716/83A patent/IE56343B1/en not_active IP Right Cessation
- 1983-07-22 DK DK336783A patent/DK170342B1/da not_active IP Right Cessation
- 1983-07-25 NO NO832701A patent/NO164712C/no not_active IP Right Cessation
- 1983-07-25 AT AT83401520T patent/ATE30235T1/de active
- 1983-07-25 LU LU88723C patent/LU88723I2/fr unknown
- 1983-07-25 DE DE8383401520T patent/DE3374062D1/de not_active Expired
- 1983-07-25 EP EP83401520A patent/EP0100718B1/fr not_active Expired
- 1983-07-26 CA CA000433224A patent/CA1267650A/en not_active Expired - Lifetime
- 1983-07-26 IL IL69347A patent/IL69347A/xx not_active IP Right Cessation
- 1983-07-27 GR GR72051A patent/GR79597B/el unknown
- 1983-07-27 AU AU17324/83A patent/AU566880B2/en not_active Expired
- 1983-07-27 PH PH29310A patent/PH22082A/en unknown
- 1983-07-28 ES ES524495A patent/ES8403923A1/es not_active Expired
- 1983-07-28 HU HU832658A patent/HU190454B/hu unknown
- 1983-07-28 MA MA20079A patent/MA19858A1/fr unknown
- 1983-07-28 OA OA58074A patent/OA07507A/xx unknown
- 1983-07-28 PT PT77122A patent/PT77122B/pt unknown
- 1983-07-28 KR KR1019830003523A patent/KR910000726B1/ko not_active IP Right Cessation
- 1983-07-28 NZ NZ205061A patent/NZ205061A/en unknown
- 1983-07-29 ZA ZA835578A patent/ZA835578B/xx unknown
- 1983-07-29 PL PL1983259142A patent/PL142022B1/pl unknown
- 1983-07-29 FI FI832758A patent/FI75830C/fi not_active IP Right Cessation
- 1983-07-29 SU SU833628775A patent/SU1333240A3/ru active
- 1983-07-29 DD DD83253536A patent/DD213670A5/de not_active IP Right Cessation
- 1983-07-29 PL PL1983243229A patent/PL141316B1/pl unknown
- 1983-07-29 YU YU1600/83A patent/YU45143B/xx unknown
- 1983-07-29 CS CS835688A patent/CS252463B2/cs unknown
- 1983-07-29 JP JP58139324A patent/JPS5942395A/ja active Granted
- 1983-07-30 EG EG468/83A patent/EG15968A/xx active
- 1983-11-27 DZ DZ836911A patent/DZ562A1/fr active
-
1984
- 1984-06-26 SU SU843754451A patent/SU1367859A3/ru active
-
1985
- 1985-06-11 AR AR85300673A patent/AR242394A1/es active
- 1985-06-11 AR AR85300674A patent/AR242393A1/es active
-
1986
- 1986-04-24 US US06/858,573 patent/US4746654A/en not_active Expired - Lifetime
-
1988
- 1988-03-07 US US07/165,080 patent/US4876248A/en not_active Expired - Lifetime
- 1988-03-23 SG SG185/88A patent/SG18588G/en unknown
-
1991
- 1991-12-31 CZ CS914191A patent/CZ419191A3/cs unknown
-
1996
- 1996-04-24 NL NL960007C patent/NL960007I2/nl unknown
-
1998
- 1998-03-06 NO NO1998011C patent/NO1998011I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DZ562A1 (fr) | Produits anti-inflammatoires dérivés de l'acide méthylènedihosphonique et leur procédé de préparation. | |
RO76614A (ro) | Procedeu de preparare a unor derivati de 3,4dehidroprolina si deaacid4,5-dehidropipecelic | |
DZ473A1 (fr) | Dérivés de l'acide cis-endo-2-azabicyclo/3,3,o/-octane-3-carboxylique, procédé pour leur préparation, agents contenant ces dérivés et leur utilisation. | |
FR2448524B1 (fr) | Procede de preparation d'esters de l'acide glyoxylique | |
FR2515182B1 (fr) | Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation | |
OA08544A (fr) | Procédé continu de préparation d'acide phosphorique et de calcium. | |
BE870268A (fr) | Procede de preparation de diester d'acide oxalique et produits ainsi obtenus | |
BE883067A (fr) | Procede de preparation d'acide levulinique et de ses esters et produits obtenus | |
OA07001A (fr) | Procédé de préparation d'acide phosphorique. | |
OA04805A (fr) | Nouveaux esters de pyrimidine d'acide thionothiol-phosphorique, leur procédé de préparation et leur application comme insecticides et acaricides. | |
OA06248A (fr) | Composés dérivés de l'acide cyclohexylcarboxylique et leur procédé de préparation. | |
OA07984A (fr) | Procédé stéréocontrolé de préparation d'acetoxyazetidione. | |
BE879830A (fr) | Procede de preparation de 1,2,3-thiadiazol-5-yl-urees et produits obtenus | |
OA05091A (fr) | Nouveaux esters de pyrimidinyle d'acide thionophosphonique, leur procédé de préparation et leur application comme insecticides, acaricides et nématicides. | |
FR2570073B1 (fr) | Procede de preparation d'acide 2,6-naphtalene-dicarboxylique | |
OA06258A (fr) | Procédé de préparation de nouveaux dérivés acétyléniques de l'androst-4-ène. | |
OA05233A (fr) | Procédé de préparation d'acides (7-acétamido Disubstitue)-3- substitue-3- cephem-4-carboxyliques et nouveaux produits industriels. | |
OA07728A (fr) | Dérivés de l'acide bicyclo (3.2.1.) octane carboxylique, leur procédé de préparation et leur application thérapeutique. | |
BE880420A (fr) | Nouvelles beta-lactones derivees de l'acide 2-hydroxy cyclopentane carboxylique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant | |
OA06748A (fr) | Procédé de préparation de sulfone d'acide 2-chlorométhyl-2méthylpéname-3-carboxylique et produits industriels nouveaux. | |
BE896868A (fr) | Procede de preparation d'acide acetique. | |
FR2513638B1 (fr) | Procede de preparation d'esters d'acides vincaminiques | |
FR2537137B1 (fr) | Procede de preparation de derives de l'acide 2-thiophene acetique et produits intermediaires necessaires pour leur preparation | |
FR2546889B1 (fr) | Procede de preparation d'un acide aminolactonecarboxylique | |
BE889805A (fr) | Procede de preparation d'esters d'acide 3-acylazo-propionique et produits ainsi obtenus |