YU45143B - Methylen-diphosphonic acid derivatives - Google Patents

Methylen-diphosphonic acid derivatives

Info

Publication number
YU45143B
YU45143B YU1600/83A YU160083A YU45143B YU 45143 B YU45143 B YU 45143B YU 1600/83 A YU1600/83 A YU 1600/83A YU 160083 A YU160083 A YU 160083A YU 45143 B YU45143 B YU 45143B
Authority
YU
Yugoslavia
Prior art keywords
methylen
acid derivatives
diphosphonic acid
diphosphonic
derivatives
Prior art date
Application number
YU1600/83A
Other languages
English (en)
Other versions
YU160083A (en
Inventor
J C Breliere
Alt X Emonds
G Garcia
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of YU160083A publication Critical patent/YU160083A/xx
Publication of YU45143B publication Critical patent/YU45143B/xx
Priority to HR921258A priority Critical patent/HRP921258B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
YU1600/83A 1982-07-29 1983-07-29 Methylen-diphosphonic acid derivatives YU45143B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR921258A HRP921258B1 (en) 1982-07-29 1992-11-13 Methylenediphosphonic acid derivatives edmonds-alt, x

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (2)

Publication Number Publication Date
YU160083A YU160083A (en) 1986-08-31
YU45143B true YU45143B (en) 1992-03-10

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1600/83A YU45143B (en) 1982-07-29 1983-07-29 Methylen-diphosphonic acid derivatives

Country Status (35)

Country Link
US (2) US4746654A (no)
EP (1) EP0100718B1 (no)
JP (1) JPS5942395A (no)
KR (1) KR910000726B1 (no)
AR (2) AR242393A1 (no)
AT (1) ATE30235T1 (no)
AU (1) AU566880B2 (no)
CA (1) CA1267650A (no)
CS (1) CS252463B2 (no)
CZ (1) CZ419191A3 (no)
DD (1) DD213670A5 (no)
DE (1) DE3374062D1 (no)
DK (1) DK170342B1 (no)
DZ (1) DZ562A1 (no)
EG (1) EG15968A (no)
ES (1) ES8403923A1 (no)
FI (1) FI75830C (no)
FR (1) FR2531088B1 (no)
GR (1) GR79597B (no)
HU (1) HU190454B (no)
IE (1) IE56343B1 (no)
IL (1) IL69347A (no)
LU (1) LU88723I2 (no)
MA (1) MA19858A1 (no)
NL (1) NL960007I2 (no)
NO (2) NO164712C (no)
NZ (1) NZ205061A (no)
OA (1) OA07507A (no)
PH (1) PH22082A (no)
PL (2) PL142022B1 (no)
PT (1) PT77122B (no)
SG (1) SG18588G (no)
SU (2) SU1333240A3 (no)
YU (1) YU45143B (no)
ZA (1) ZA835578B (no)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US5641762A (en) * 1985-05-02 1997-06-24 Research Corporation Technologies, Inc. Bone targeted inhibitors of carbonic anhydrase
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
DE3770982D1 (de) * 1986-04-24 1991-08-01 Fujisawa Pharmaceutical Co Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
KR880011136A (ko) * 1987-03-11 1988-10-26 모리오까 시게오 아졸- 아미노메틸렌 비스포스폰산 유도체
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (no) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP3021035B2 (ja) * 1988-11-01 2000-03-15 アーク・デベロップメント・コーポレーション ホスホン酸及び分離におけるその使用
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
DE59107135D1 (de) * 1990-01-18 1996-02-08 Ciba Geigy Ag Phoshponsäure- und Thionophosphonsäure-Derivate
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
AU8495091A (en) * 1990-08-21 1992-03-17 Upjohn Company, The Bisphosphonic acid derivatives as anti-arthritic agents
WO1992010504A2 (en) * 1990-12-07 1992-06-25 The Upjohn Company Phosphonic acid derivatives useful as antiinflammatory agents
ATE133677T1 (de) * 1990-12-19 1996-02-15 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre produktion und ihre verwendung
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2102303A1 (en) * 1991-06-19 1992-12-20 Roy Allen Johnson Dialkyl (dialkoxyphosphinyl) methyl phosphates as anti-inflammatory agents
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
DK0594857T3 (da) * 1991-09-05 1998-10-07 Toray Industries Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
CZ297094A3 (en) * 1992-05-29 1995-12-13 Procter & Gamble Pharma Phosphate compounds containing quaternary nitrogen, their use and pharmaceutical compositions containing thereof
JPH07507315A (ja) * 1992-05-29 1995-08-10 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド カルシウムおよびホスフェート代謝異常治療用含硫ホスホネート化合物
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
SG47603A1 (en) * 1992-05-29 1998-04-17 Procter & Gamble Pharma Thio-substitute nitrogen containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
CA2138366C (en) * 1992-06-30 1998-09-22 Kristine Hovancik Methods for the treatment of arthritis using phosphonates and nsaids
DE69330114T2 (de) * 1992-07-10 2001-08-02 Toray Industries, Inc. Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel
GB9215433D0 (en) * 1992-07-21 1992-09-02 Cmb Foodcan Plc Apparatus for stripping a drawn article from a punch
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
AU4407493A (en) * 1992-08-07 1994-03-03 Upjohn Company, The Phosphonoacetic esters and acids as anti-inflammatories
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
AU670337B2 (en) 1992-11-30 1996-07-11 Novartis Ag Use of certain methanebisphosphonic acid derivatives in fracture healing
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
AU674059B2 (en) * 1993-02-25 1996-12-05 Toray Industries, Inc. Process for producing methanediphosphonate compound
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
ATE235499T1 (de) * 1994-08-24 2003-04-15 Toray Industries Verfahren zur herstellung einer methanphosphonsäureverbindung
EP0831756A1 (en) 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
EP0854724B1 (en) * 1995-09-29 2005-03-16 Novartis AG Method of treating the navicular disease in horses
AU721320B2 (en) * 1996-10-09 2000-06-29 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
AU761267C (en) * 1998-09-09 2007-08-09 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
CA2321864A1 (en) * 1998-12-25 2000-07-06 Toray Industries, Inc. Interleukin-6 production inhibitor
EP1208129B1 (en) * 1999-07-23 2009-03-25 The Children's Hospital of Philadelphia Derivatized polyurethane compositions and methods of making
US6900282B2 (en) * 1999-07-23 2005-05-31 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
US6420384B2 (en) 1999-12-17 2002-07-16 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
JP2003519154A (ja) * 1999-12-22 2003-06-17 メタバシス・セラピューティクス・インコーポレイテッド 新規なビスアミダートホスホネートプロドラッグ
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
WO2002083150A1 (en) * 2001-04-10 2002-10-24 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TWI315982B (en) 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
WO2003055496A1 (en) * 2001-12-21 2003-07-10 The Procter & Gamble Company Method for the treatment of bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
CA2472578A1 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
WO2003086415A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
KR20120065435A (ko) 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
BR0309691A (pt) * 2002-12-20 2005-08-02 Hoffmann La Roche Formulação de ibandronato em alta dose
US7408014B2 (en) 2003-07-08 2008-08-05 The Children's Hospital Of Philadelphia Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
EP1673336B1 (en) 2003-08-21 2014-06-04 Merck Canada Inc. Cathepsin cysteine protease inhibitors
CA2539359A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
KR20080083068A (ko) 2004-05-24 2008-09-12 더 프록터 앤드 갬블 캄파니 킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용 경구 투여 형태
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CN101005847A (zh) * 2004-08-18 2007-07-25 症变治疗公司 果糖1,6－双磷酸酶的新颖噻唑类抑制剂
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP1855674B1 (en) 2005-03-02 2014-07-16 Merck Sharp & Dohme Corp. Composition for inhibition of cathepsin k
BRPI0606280A2 (pt) * 2005-03-17 2009-06-09 Elan Pharma Int Ltd composições de bisfosfonato nanoparticulado
WO2006102603A2 (en) * 2005-03-24 2006-09-28 Medtronic, Inc. Modification of thermoplastic polymers
EP2489656A1 (en) 2007-12-21 2012-08-22 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (sarms) and uses thereof
US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL2731591T3 (pl) 2011-07-13 2021-05-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomy zawierające bisfosfonian i środek amfipatyczny w wyniku ko-enkapsulacji
AU2012290089B2 (en) 2011-08-01 2016-09-29 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
CN105593230B (zh) 2013-10-08 2018-07-06 默沙东公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302557B (no) * 1963-04-09 1971-08-26
US3654151A (en) * 1970-04-13 1972-04-04 Monsanto Co Deflocculation of solid materials in aqueous medium
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3705191A (en) * 1970-04-13 1972-12-05 Monsanto Co Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US4171373A (en) * 1974-01-07 1979-10-16 William H. Rorer, Inc. Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation
US4071584A (en) * 1977-01-03 1978-01-31 Monsanto Company Hydroxyphenylthiophosphoranylidene organophosphorus compounds
US4264582A (en) * 1978-07-31 1981-04-28 The Procter & Gamble Company Isobutylphenylacetate anti-inflammatory composition
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4330530A (en) * 1980-12-22 1982-05-18 The Procter & Gamble Company Anti-arthritic compositions and method using gold salts and organophosphonates
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
ES524495A0 (es) 1984-04-16
FR2531088B1 (fr) 1987-08-28
AR242394A1 (es) 1993-03-31
IL69347A (en) 1987-02-27
CS568883A2 (en) 1987-01-15
YU160083A (en) 1986-08-31
FI832758A0 (fi) 1983-07-29
DZ562A1 (fr) 2004-09-13
PL141316B1 (en) 1987-07-31
EG15968A (en) 1989-01-30
FI75830B (fi) 1988-04-29
FR2531088A1 (fr) 1984-02-03
PH22082A (en) 1988-05-20
PL142022B1 (en) 1987-09-30
MA19858A1 (fr) 1984-04-01
JPH0429676B2 (no) 1992-05-19
NO164712B (no) 1990-07-30
IE831716L (en) 1984-01-29
SG18588G (en) 1988-09-30
NO164712C (no) 1990-11-07
CA1267650A (en) 1990-04-10
DK336783D0 (da) 1983-07-22
LU88723I2 (fr) 1996-08-23
ZA835578B (en) 1984-04-25
FI75830C (fi) 1988-08-08
NL960007I1 (nl) 1996-09-02
FI832758A (fi) 1984-01-30
DD213670A5 (de) 1984-09-19
ES8403923A1 (es) 1984-04-16
PL243229A1 (en) 1984-07-16
KR910000726B1 (ko) 1991-01-31
ATE30235T1 (de) 1987-10-15
HU190454B (en) 1986-09-29
OA07507A (fr) 1985-03-31
PT77122A (fr) 1983-08-01
CZ419191A3 (en) 1993-10-13
EP0100718B1 (fr) 1987-10-14
GR79597B (no) 1984-10-31
CS252463B2 (en) 1987-09-17
KR840005459A (ko) 1984-11-12
NZ205061A (en) 1987-08-31
DK336783A (da) 1984-01-30
IE56343B1 (en) 1991-07-03
NL960007I2 (nl) 1997-03-03
IL69347A0 (en) 1983-11-30
AU1732483A (en) 1984-02-02
JPS5942395A (ja) 1984-03-08
SU1367859A3 (ru) 1988-01-15
DK170342B1 (da) 1995-08-07
AR242393A1 (es) 1993-03-31
US4876248A (en) 1989-10-24
NO1998011I1 (no) 1998-03-06
SU1333240A3 (ru) 1987-08-23
NO832701L (no) 1984-01-30
US4746654A (en) 1988-05-24
DE3374062D1 (en) 1987-11-19
PT77122B (fr) 1986-01-24
AU566880B2 (en) 1987-11-05
EP0100718A1 (fr) 1984-02-15

Similar Documents

Publication Publication Date Title
YU45143B (en) Methylen-diphosphonic acid derivatives
EP0103647A4 (en) DERIVATIVES OF 4-CHLORO-2-PHENYLIMIDAZOLE-5-ACETIC ACID.
GB2118184B (en) Phenoxyalkylcarboxylic acid derivatives
GB8328784D0 (en) 4-oxo-1 4-dihydronicotinic acid derivatives
IE802177L (en) Imidazol-5-ylacetic acid derivatives
GB2092575B (en) 7-acylaminocephalosporanic acid derivatives
ZA834307B (en) Oxazoleacetic acid derivatives
GB2145411B (en) Gametocidal pyridazinylcarboxylic acid derivatives
GB2123817B (en) 4-hydroxy-3-quinoline-carboxylic acid derivatives
DE3371070D1 (en) 4-amino-tetrahydro-2-naphthoic acid derivatives
GB8301926D0 (en) N-methanesulfonic acid derivatives
GB8419279D0 (en) Octahydroindolizine-propanoic acid derivatives
GB8318345D0 (en) Isocarbostyryl-3-carboxylic acid derivatives
GB2124214B (en) Apovincaminic acid derivatives
GB2121408B (en) Tetrazolylalkanohydroxamic acid derivatives
GB8320494D0 (en) Aminolactonecarboxylic acid
GB8507908D0 (en) Acid derivatives
ZA846843B (en) 3-benzoyl-2-mercaptopropionic acid derivatives
GB2134111B (en) Pyrrole-2-acetylamino acid derivatives
GB2080796B (en) 2-hydroxy-5-phenylazobenzoic acid derivatives
NZ199488A (en) Cephalosporinic acid derivatives
ZA848377B (en) 4-pentinoic acid derivatives
ZA831846B (en) Phenoyxyalkylcarboxylic acid derivatives
AU1142083A (en) Lisergic acid derivatives
GB2151615B (en) Malonyl-oxacephemcarboxylic acid derivatives