FR2531088B1 - Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation - Google Patents

Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Info

Publication number
FR2531088B1
FR2531088B1 FR8213250A FR8213250A FR2531088B1 FR 2531088 B1 FR2531088 B1 FR 2531088B1 FR 8213250 A FR8213250 A FR 8213250A FR 8213250 A FR8213250 A FR 8213250A FR 2531088 B1 FR2531088 B1 FR 2531088B1
Authority
FR
France
Prior art keywords
preparation
products derived
methylenediphosphonic acid
inflammatory products
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8213250A
Other languages
English (en)
French (fr)
Other versions
FR2531088A1 (fr
Inventor
Jean-Claude Breliere
Xavier Emonds-Alt
George Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8213250A priority Critical patent/FR2531088B1/fr
Priority to IE1716/83A priority patent/IE56343B1/en
Priority to DK336783A priority patent/DK170342B1/da
Priority to LU88723C priority patent/LU88723I2/fr
Priority to NO832701A priority patent/NO164712C/no
Priority to AT83401520T priority patent/ATE30235T1/de
Priority to DE8383401520T priority patent/DE3374062D1/de
Priority to EP83401520A priority patent/EP0100718B1/fr
Priority to CA000433224A priority patent/CA1267650A/en
Priority to IL69347A priority patent/IL69347A/xx
Priority to PH29310A priority patent/PH22082A/en
Priority to GR72051A priority patent/GR79597B/el
Priority to AU17324/83A priority patent/AU566880B2/en
Priority to NZ205061A priority patent/NZ205061A/en
Priority to PT77122A priority patent/PT77122B/pt
Priority to MA20079A priority patent/MA19858A1/fr
Priority to OA58074A priority patent/OA07507A/xx
Priority to KR1019830003523A priority patent/KR910000726B1/ko
Priority to HU832658A priority patent/HU190454B/hu
Priority to ES524495A priority patent/ES8403923A1/es
Priority to CS835688A priority patent/CS252463B2/cs
Priority to ZA835578A priority patent/ZA835578B/xx
Priority to PL1983259142A priority patent/PL142022B1/pl
Priority to FI832758A priority patent/FI75830C/fi
Priority to SU833628775A priority patent/SU1333240A3/ru
Priority to JP58139324A priority patent/JPS5942395A/ja
Priority to PL1983243229A priority patent/PL141316B1/pl
Priority to DD83253536A priority patent/DD213670A5/de
Priority to YU1600/83A priority patent/YU45143B/xx
Priority to EG468/83A priority patent/EG15968A/xx
Priority to DZ836911A priority patent/DZ562A1/fr
Publication of FR2531088A1 publication Critical patent/FR2531088A1/fr
Priority to SU843754451A priority patent/SU1367859A3/ru
Priority to AR85300673A priority patent/AR242394A1/es
Priority to AR85300674A priority patent/AR242393A1/es
Priority to US06/858,573 priority patent/US4746654A/en
Application granted granted Critical
Publication of FR2531088B1 publication Critical patent/FR2531088B1/fr
Priority to US07/165,080 priority patent/US4876248A/en
Priority to SG185/88A priority patent/SG18588G/en
Priority to CS914191A priority patent/CZ419191A3/cs
Priority to HR921258A priority patent/HRP921258B1/xx
Priority to LV930143A priority patent/LV5524A3/xx
Priority to NL960007C priority patent/NL960007I2/nl
Priority to NO1998011C priority patent/NO1998011I1/no
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8213250A 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation Expired FR2531088B1 (fr)

Priority Applications (42)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IE1716/83A IE56343B1 (en) 1982-07-29 1983-07-21 Anti-inflammatory products derived from methylene-diphosphonic acid,and process for their preparation
DK336783A DK170342B1 (da) 1982-07-29 1983-07-22 Analogifremgangsmåde til fremstilling af methylendiphosphonsyrederivater
NO832701A NO164712C (no) 1982-07-29 1983-07-25 Analogifremgangsmaate til fremstilling av metylendifosfonsyre-derivater.
AT83401520T ATE30235T1 (de) 1982-07-29 1983-07-25 Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung.
DE8383401520T DE3374062D1 (en) 1982-07-29 1983-07-25 Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation
EP83401520A EP0100718B1 (fr) 1982-07-29 1983-07-25 Produits anti-inflammatoires dérivés de l'acide méthylène-diphosphonique et leur procédé de préparation
LU88723C LU88723I2 (fr) 1982-07-29 1983-07-25 Skelid
CA000433224A CA1267650A (en) 1982-07-29 1983-07-26 Derivatives of methylene diphosphonic acid, preparation of the same pharmaceutical compositions containing the same
IL69347A IL69347A (en) 1982-07-29 1983-07-26 Methylene-diphosphonic acid derivatives,their preparation and pharmaceutical compositions containing them
PH29310A PH22082A (en) 1982-07-29 1983-07-27 Anti-inflammatory products derived from methylene-diphosphonic acid
GR72051A GR79597B (enExample) 1982-07-29 1983-07-27
AU17324/83A AU566880B2 (en) 1982-07-29 1983-07-27 Sulphur containing methylene diphosphonates
PT77122A PT77122B (fr) 1982-07-29 1983-07-28 Procede de preparation de derives de l'acide methylenediphosphonique
MA20079A MA19858A1 (fr) 1982-07-29 1983-07-28 Procede de preparation de derives de l'acide methylene disphosphonique .
OA58074A OA07507A (fr) 1982-07-29 1983-07-28 Produits anti-inflammatoires dérivés de l'acide méthylènediphosphodinique et leur procédé de préparation.
KR1019830003523A KR910000726B1 (ko) 1982-07-29 1983-07-28 메틸렌-디포스폰산 유도체의 제조방법
HU832658A HU190454B (en) 1982-07-29 1983-07-28 Process for preparing methylene-diphosphonic acid derivatives
ES524495A ES8403923A1 (es) 1982-07-29 1983-07-28 Procedimiento para la preparacion de derivados del acido metilendifosfonico
NZ205061A NZ205061A (en) 1982-07-29 1983-07-28 Derivatives of methylene-diphosphonic acid and anti-inflammatory pharmaceutical compositions
CS835688A CS252463B2 (en) 1982-07-29 1983-07-29 Method of methylenediphosphonic acid's derivatives production
ZA835578A ZA835578B (en) 1982-07-29 1983-07-29 Anti-inflammatory products derived from methylene-diphosphonic acid,and process for their preparation
PL1983259142A PL142022B1 (en) 1982-07-29 1983-07-29 Method of obtaining novel derivatives of methylenediphosphonic acid
FI832758A FI75830C (fi) 1982-07-29 1983-07-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara metylendifosfonsyraderivat.
SU833628775A SU1333240A3 (ru) 1982-07-29 1983-07-29 Способ получени производных метилендифосфоновой кислоты
JP58139324A JPS5942395A (ja) 1982-07-29 1983-07-29 メチレン−ジホスホン酸から誘導された炎症抑制性生成物およびその製造方法
PL1983243229A PL141316B1 (en) 1982-07-29 1983-07-29 Method of obtaining novel derivatives of methyldiphosphonic acids
DD83253536A DD213670A5 (de) 1982-07-29 1983-07-29 Verfahren zur herstellung von methylendiphosphonsaeurederivaten
YU1600/83A YU45143B (en) 1982-07-29 1983-07-29 Methylen-diphosphonic acid derivatives
EG468/83A EG15968A (en) 1982-07-29 1983-07-30 Process for the preparation of derivatives of methylene diphosphonic acid
DZ836911A DZ562A1 (fr) 1982-07-29 1983-11-27 Produits anti-inflammatoires dérivés de l'acide méthylènedihosphonique et leur procédé de préparation.
SU843754451A SU1367859A3 (ru) 1982-07-29 1984-06-26 Способ получени производных метилендифосфоновой кислоты
AR85300673A AR242394A1 (es) 1982-07-29 1985-06-11 Procedimiento de preparacion de derivados de acido metilendifosfonico.
AR85300674A AR242393A1 (es) 1982-07-29 1985-06-11 Procedimiento de preparacion de derivados de acido metilendifosfonico.
US06/858,573 US4746654A (en) 1982-07-29 1986-04-24 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
US07/165,080 US4876248A (en) 1982-07-29 1988-03-07 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
SG185/88A SG18588G (en) 1982-07-29 1988-03-23 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
CS914191A CZ419191A3 (en) 1982-07-29 1991-12-31 Derivatives of methylenediphosphonic acid and medicaments in which said derivatives are comprised
HR921258A HRP921258B1 (en) 1982-07-29 1992-11-13 Methylenediphosphonic acid derivatives edmonds-alt, x
LV930143A LV5524A3 (lv) 1982-07-29 1993-02-25 Panemiens metilendifosfonskabes atvasinajumu iegusanai
NL960007C NL960007I2 (nl) 1982-07-29 1996-04-24 Antiflogistische produkten, die afgeleid zijn van methyleen.
NO1998011C NO1998011I1 (no) 1982-07-29 1998-03-06 Tiludronsyre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2531088A1 FR2531088A1 (fr) 1984-02-03
FR2531088B1 true FR2531088B1 (fr) 1987-08-28

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8213250A Expired FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Country Status (35)

Country Link
US (2) US4746654A (enExample)
EP (1) EP0100718B1 (enExample)
JP (1) JPS5942395A (enExample)
KR (1) KR910000726B1 (enExample)
AR (2) AR242393A1 (enExample)
AT (1) ATE30235T1 (enExample)
AU (1) AU566880B2 (enExample)
CA (1) CA1267650A (enExample)
CS (1) CS252463B2 (enExample)
CZ (1) CZ419191A3 (enExample)
DD (1) DD213670A5 (enExample)
DE (1) DE3374062D1 (enExample)
DK (1) DK170342B1 (enExample)
DZ (1) DZ562A1 (enExample)
EG (1) EG15968A (enExample)
ES (1) ES8403923A1 (enExample)
FI (1) FI75830C (enExample)
FR (1) FR2531088B1 (enExample)
GR (1) GR79597B (enExample)
HU (1) HU190454B (enExample)
IE (1) IE56343B1 (enExample)
IL (1) IL69347A (enExample)
LU (1) LU88723I2 (enExample)
MA (1) MA19858A1 (enExample)
NL (1) NL960007I2 (enExample)
NO (2) NO164712C (enExample)
NZ (1) NZ205061A (enExample)
OA (1) OA07507A (enExample)
PH (1) PH22082A (enExample)
PL (2) PL141316B1 (enExample)
PT (1) PT77122B (enExample)
SG (1) SG18588G (enExample)
SU (2) SU1333240A3 (enExample)
YU (1) YU45143B (enExample)
ZA (1) ZA835578B (enExample)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US5641762A (en) * 1985-05-02 1997-06-24 Research Corporation Technologies, Inc. Bone targeted inhibitors of carbonic anhydrase
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
EP0243173B1 (en) * 1986-04-24 1991-06-26 Fujisawa Pharmaceutical Co., Ltd. New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
EP0282309A3 (en) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (enExample) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE68926310T2 (de) * 1988-11-01 1996-10-24 Arch Dev Corp Verfahren zur abtrennung von metallischen ionen mit phosphonsäuren als complexbildner
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
EP0416689B1 (en) * 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
DE59107135D1 (de) * 1990-01-18 1996-02-08 Ciba Geigy Ag Phoshponsäure- und Thionophosphonsäure-Derivate
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
DE69108733T2 (de) * 1990-08-21 1995-09-14 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
JPH06503329A (ja) * 1990-12-07 1994-04-14 ジ・アップジョン・カンパニー 抗炎症剤として有用なホスホン酸誘導体
US5280022A (en) * 1990-12-19 1994-01-18 Takeda Chemical Industries, Ltd. Bisphosphonic acid derivatives, their production and use
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
JPH06508365A (ja) * 1991-06-19 1994-09-22 ジ・アップジョン・カンパニー 抗炎症剤としてのりん酸ジアルキル（ジアルコキシホスフィニル）メチル類
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
ES2114946T3 (es) * 1991-09-05 1998-06-16 Toray Industries Derivado de acido metanodifosfonico, su produccion y uso medicinal.
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
ES2118967T3 (es) * 1992-05-29 1998-10-01 Procter & Gamble Pharma Compuestos de fosfonato que contienen nitrogeno cuaternario para tratar un metabolismo anormal del calcio y fosfato asi como el calculo y la placa dentales.
PL175475B1 (pl) * 1992-05-29 1999-01-29 Procter & Gamble Pharma Nowe zawierające siarkę związki fosfonianowe
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
FI945595A7 (fi) * 1992-05-29 1994-11-28 Procter & Gamble Pharmaceuticals Inc Tiosubstituoituja typpipitoisia heterosyklisiä fosfonaattiyhdisteitä e pänormaalin kalsium- ja fosfaattiaineenvaihdunnan hoitamiseksi
JPH07508279A (ja) * 1992-06-30 1995-09-14 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド ホスホネート類及びｎｓａｉｄを含有した関節炎の治療用組成物
WO1994001442A1 (fr) * 1992-07-10 1994-01-20 Toray Industries, Inc. Derive de methanediphosphonate, sa production, et son usage pharmaceutique
GB9215433D0 (en) * 1992-07-21 1992-09-02 Cmb Foodcan Plc Apparatus for stripping a drawn article from a punch
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
ATE157097T1 (de) * 1992-08-07 1997-09-15 Upjohn Co Phosphonoessigsäure und ester als antientzündungsmittel
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸
JPH06135976A (ja) * 1992-10-30 1994-05-17 Toray Ind Inc メタンジホスホン酸誘導体、その製造方法およびその医薬用途
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
AU670337B2 (en) 1992-11-30 1996-07-11 Novartis Ag Use of certain methanebisphosphonic acid derivatives in fracture healing
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
AU674059B2 (en) * 1993-02-25 1996-12-05 Toray Industries, Inc. Process for producing methanediphosphonate compound
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
ATE235499T1 (de) * 1994-08-24 2003-04-15 Toray Industries Verfahren zur herstellung einer methanphosphonsäureverbindung
EP0831756A1 (en) 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
ES2239774T3 (es) * 1995-09-29 2005-10-01 Novartis Ag Metodo de tratamiento de la enfermedad navicular en caballos.
WO1998015560A1 (en) * 1996-10-09 1998-04-16 Elizanor Biopharmaceuticals, Inc. Diphosphonate therapeutic compounds
US8586781B2 (en) 1998-04-02 2013-11-19 Mbc Pharma, Inc. Bone targeted therapeutics and methods of making and using the same
US6489476B1 (en) * 1998-09-09 2002-12-03 Metabasis Therapeutics, Inc. Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase
FR2784031B1 (fr) * 1998-10-02 2002-02-01 Sanofi Elf Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
US6579860B1 (en) * 1998-12-25 2003-06-17 Toray Industries, Inc. Interleukin-6 production inhibitors
AU6362100A (en) * 1999-07-23 2001-02-13 Children's Hospital Of Philadelphia, The Derivatized polyurethane compositions and methods of making
AR021347A1 (es) * 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
AU2583901A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
CZ301401B6 (cs) * 1999-12-22 2010-02-17 Metabasis Therapeutics, Inc. Bisamidátfosfonátová predléciva a farmaceutické prostredky s jejich obsahem
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
CA2443857C (en) * 2001-04-10 2012-06-26 Mbc Research, Inc. Bisphosphonate conjugates and methods of making and using the same
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
EP1455796A1 (en) * 2001-12-21 2004-09-15 The Procter & Gamble Company Method for the treatment of bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
JP4502641B2 (ja) * 2002-01-24 2010-07-14 ティルタン ファーマ リミテッド 抗癌組み合わせおよびその使用方法
US20050176685A1 (en) * 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
RU2387451C2 (ru) * 2002-05-10 2010-04-27 Ф.Хоффманн-Ля Рош Аг Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза
AU2003233731A1 (en) * 2002-06-06 2003-12-22 Xavier Billot 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
WO2004029117A2 (en) * 2002-09-26 2004-04-08 The Children's Hospital Of Philadelphia Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
EP1790347B1 (en) * 2002-12-20 2014-12-24 F. Hoffmann-La Roche AG High dose ibandronate formulation
US7408014B2 (en) * 2003-07-08 2008-08-05 The Children's Hospital Of Philadelphia Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
AU2004266740B2 (en) 2003-08-21 2010-08-26 Merck Frosst Canada Ltd Cathepsin cysteine protease inhibitors
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
CN1956706A (zh) 2004-05-24 2007-05-02 宝洁公司 包含一种螯合剂的双膦酸酯肠溶固体口服剂型
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CN101005847A (zh) * 2004-08-18 2007-07-25 症变治疗公司 果糖1,6－双磷酸酶的新颖噻唑类抑制剂
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
DK1855674T3 (da) 2005-03-02 2014-10-20 Merck Sharp & Dohme Sammensætning til hæmning af cathepsin k
JP2008533173A (ja) * 2005-03-17 2008-08-21 エラン ファーマ インターナショナル リミテッド ナノ粒子ビスホスホネート組成物
DE602006006663D1 (de) * 2005-03-24 2009-06-18 Medtronic Inc Modifizierung von thermoplastischen polymeren
ES2413504T3 (es) 2007-12-21 2013-07-16 Ligand Pharmaceuticals Inc. Moduladores selectivos del receptor de andrógeno (SARM) y usos de los mismos
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
HUE051570T2 (hu) 2011-07-13 2021-03-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Liposzómák biszfoszfonát és amfipatikus szer együtt kapszulázásához
US9334300B2 (en) 2011-08-01 2016-05-10 Mbc Pharma, Inc. Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
EP3055314B1 (en) 2013-10-08 2018-09-12 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
WO2015181676A1 (en) 2014-05-30 2015-12-03 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
BR112021020864A2 (pt) 2019-04-19 2021-12-14 Ligand Pharm Inc Formas cristalinas e métodos de produção de formas cristalinas de um composto
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302557B (enExample) * 1963-04-09 1971-08-26
US3654151A (en) * 1970-04-13 1972-04-04 Monsanto Co Deflocculation of solid materials in aqueous medium
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3705191A (en) * 1970-04-13 1972-12-05 Monsanto Co Substituted ethane diphosphonic acids and salts and esters thereof
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US4171373A (en) * 1974-01-07 1979-10-16 William H. Rorer, Inc. Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation
US4071584A (en) * 1977-01-03 1978-01-31 Monsanto Company Hydroxyphenylthiophosphoranylidene organophosphorus compounds
US4264582A (en) * 1978-07-31 1981-04-28 The Procter & Gamble Company Isobutylphenylacetate anti-inflammatory composition
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
US4330530A (en) * 1980-12-22 1982-05-18 The Procter & Gamble Company Anti-arthritic compositions and method using gold salts and organophosphonates
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them

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