FR2531088B1 - Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation - Google Patents

Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Info

Publication number
FR2531088B1
FR2531088B1 FR8213250A FR8213250A FR2531088B1 FR 2531088 B1 FR2531088 B1 FR 2531088B1 FR 8213250 A FR8213250 A FR 8213250A FR 8213250 A FR8213250 A FR 8213250A FR 2531088 B1 FR2531088 B1 FR 2531088B1
Authority
FR
France
Prior art keywords
preparation
products derived
methylenediphosphonic acid
inflammatory products
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8213250A
Other languages
English (en)
French (fr)
Other versions
FR2531088A1 (fr
Inventor
Jean-Claude Breliere
Xavier Emonds-Alt
George Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8213250A priority Critical patent/FR2531088B1/fr
Priority to IE1716/83A priority patent/IE56343B1/en
Priority to DK336783A priority patent/DK170342B1/da
Priority to NO832701A priority patent/NO164712C/no
Priority to EP83401520A priority patent/EP0100718B1/fr
Priority to DE8383401520T priority patent/DE3374062D1/de
Priority to LU88723C priority patent/LU88723I2/fr
Priority to AT83401520T priority patent/ATE30235T1/de
Priority to IL69347A priority patent/IL69347A/xx
Priority to CA000433224A priority patent/CA1267650A/en
Priority to PH29310A priority patent/PH22082A/en
Priority to GR72051A priority patent/GR79597B/el
Priority to AU17324/83A priority patent/AU566880B2/en
Priority to MA20079A priority patent/MA19858A1/fr
Priority to ES524495A priority patent/ES8403923A1/es
Priority to HU832658A priority patent/HU190454B/hu
Priority to OA58074A priority patent/OA07507A/xx
Priority to PT77122A priority patent/PT77122B/pt
Priority to NZ205061A priority patent/NZ205061A/en
Priority to KR1019830003523A priority patent/KR910000726B1/ko
Priority to FI832758A priority patent/FI75830C/fi
Priority to PL1983259142A priority patent/PL142022B1/pl
Priority to YU1600/83A priority patent/YU45143B/xx
Priority to DD83253536A priority patent/DD213670A5/de
Priority to CS835688A priority patent/CS252463B2/cs
Priority to ZA835578A priority patent/ZA835578B/xx
Priority to JP58139324A priority patent/JPS5942395A/ja
Priority to SU833628775A priority patent/SU1333240A3/ru
Priority to PL1983243229A priority patent/PL141316B1/pl
Priority to EG468/83A priority patent/EG15968A/xx
Priority to DZ836911A priority patent/DZ562A1/fr
Publication of FR2531088A1 publication Critical patent/FR2531088A1/fr
Priority to SU843754451A priority patent/SU1367859A3/ru
Priority to AR85300674A priority patent/AR242393A1/es
Priority to AR85300673A priority patent/AR242394A1/es
Priority to US06/858,573 priority patent/US4746654A/en
Application granted granted Critical
Publication of FR2531088B1 publication Critical patent/FR2531088B1/fr
Priority to US07/165,080 priority patent/US4876248A/en
Priority to SG185/88A priority patent/SG18588G/en
Priority to CS914191A priority patent/CZ419191A3/cs
Priority to HR921258A priority patent/HRP921258B1/xx
Priority to LV930143A priority patent/LV5524A3/xx
Priority to NL960007C priority patent/NL960007I2/nl
Priority to NO1998011C priority patent/NO1998011I1/no
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8213250A 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation Expired FR2531088B1 (fr)

Priority Applications (42)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IE1716/83A IE56343B1 (en) 1982-07-29 1983-07-21 Anti-inflammatory products derived from methylene-diphosphonic acid,and process for their preparation
DK336783A DK170342B1 (da) 1982-07-29 1983-07-22 Analogifremgangsmåde til fremstilling af methylendiphosphonsyrederivater
EP83401520A EP0100718B1 (fr) 1982-07-29 1983-07-25 Produits anti-inflammatoires dérivés de l'acide méthylène-diphosphonique et leur procédé de préparation
DE8383401520T DE3374062D1 (en) 1982-07-29 1983-07-25 Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation
LU88723C LU88723I2 (fr) 1982-07-29 1983-07-25 Skelid
AT83401520T ATE30235T1 (de) 1982-07-29 1983-07-25 Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung.
NO832701A NO164712C (no) 1982-07-29 1983-07-25 Analogifremgangsmaate til fremstilling av metylendifosfonsyre-derivater.
IL69347A IL69347A (en) 1982-07-29 1983-07-26 Methylene-diphosphonic acid derivatives,their preparation and pharmaceutical compositions containing them
CA000433224A CA1267650A (en) 1982-07-29 1983-07-26 Derivatives of methylene diphosphonic acid, preparation of the same pharmaceutical compositions containing the same
PH29310A PH22082A (en) 1982-07-29 1983-07-27 Anti-inflammatory products derived from methylene-diphosphonic acid
GR72051A GR79597B (enExample) 1982-07-29 1983-07-27
AU17324/83A AU566880B2 (en) 1982-07-29 1983-07-27 Sulphur containing methylene diphosphonates
ES524495A ES8403923A1 (es) 1982-07-29 1983-07-28 Procedimiento para la preparacion de derivados del acido metilendifosfonico
HU832658A HU190454B (en) 1982-07-29 1983-07-28 Process for preparing methylene-diphosphonic acid derivatives
OA58074A OA07507A (fr) 1982-07-29 1983-07-28 Produits anti-inflammatoires dérivés de l'acide méthylènediphosphodinique et leur procédé de préparation.
PT77122A PT77122B (fr) 1982-07-29 1983-07-28 Procede de preparation de derives de l'acide methylenediphosphonique
NZ205061A NZ205061A (en) 1982-07-29 1983-07-28 Derivatives of methylene-diphosphonic acid and anti-inflammatory pharmaceutical compositions
KR1019830003523A KR910000726B1 (ko) 1982-07-29 1983-07-28 메틸렌-디포스폰산 유도체의 제조방법
MA20079A MA19858A1 (fr) 1982-07-29 1983-07-28 Procede de preparation de derives de l'acide methylene disphosphonique .
FI832758A FI75830C (fi) 1982-07-29 1983-07-29 Foerfarande foer framstaellning av terapeutiskt anvaendbara metylendifosfonsyraderivat.
PL1983259142A PL142022B1 (en) 1982-07-29 1983-07-29 Method of obtaining novel derivatives of methylenediphosphonic acid
YU1600/83A YU45143B (en) 1982-07-29 1983-07-29 Methylen-diphosphonic acid derivatives
DD83253536A DD213670A5 (de) 1982-07-29 1983-07-29 Verfahren zur herstellung von methylendiphosphonsaeurederivaten
CS835688A CS252463B2 (en) 1982-07-29 1983-07-29 Method of methylenediphosphonic acid's derivatives production
ZA835578A ZA835578B (en) 1982-07-29 1983-07-29 Anti-inflammatory products derived from methylene-diphosphonic acid,and process for their preparation
JP58139324A JPS5942395A (ja) 1982-07-29 1983-07-29 メチレン−ジホスホン酸から誘導された炎症抑制性生成物およびその製造方法
SU833628775A SU1333240A3 (ru) 1982-07-29 1983-07-29 Способ получени производных метилендифосфоновой кислоты
PL1983243229A PL141316B1 (en) 1982-07-29 1983-07-29 Method of obtaining novel derivatives of methyldiphosphonic acids
EG468/83A EG15968A (en) 1982-07-29 1983-07-30 Process for the preparation of derivatives of methylene diphosphonic acid
DZ836911A DZ562A1 (fr) 1982-07-29 1983-11-27 Produits anti-inflammatoires dérivés de l'acide méthylènedihosphonique et leur procédé de préparation.
SU843754451A SU1367859A3 (ru) 1982-07-29 1984-06-26 Способ получени производных метилендифосфоновой кислоты
AR85300674A AR242393A1 (es) 1982-07-29 1985-06-11 Procedimiento de preparacion de derivados de acido metilendifosfonico.
AR85300673A AR242394A1 (es) 1982-07-29 1985-06-11 Procedimiento de preparacion de derivados de acido metilendifosfonico.
US06/858,573 US4746654A (en) 1982-07-29 1986-04-24 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
US07/165,080 US4876248A (en) 1982-07-29 1988-03-07 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
SG185/88A SG18588G (en) 1982-07-29 1988-03-23 Anti-inflammatory products derived from methylene-diphosphonic acid, and process for their preparation
CS914191A CZ419191A3 (en) 1982-07-29 1991-12-31 Derivatives of methylenediphosphonic acid and medicaments in which said derivatives are comprised
HR921258A HRP921258B1 (en) 1982-07-29 1992-11-13 Methylenediphosphonic acid derivatives edmonds-alt, x
LV930143A LV5524A3 (lv) 1982-07-29 1993-02-25 Panemiens metilendifosfonskabes atvasinajumu iegusanai
NL960007C NL960007I2 (nl) 1982-07-29 1996-04-24 Antiflogistische produkten, die afgeleid zijn van methyleen.
NO1998011C NO1998011I1 (no) 1982-07-29 1998-03-06 Tiludronsyre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2531088A1 FR2531088A1 (fr) 1984-02-03
FR2531088B1 true FR2531088B1 (fr) 1987-08-28

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8213250A Expired FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Country Status (35)

Country Link
US (2) US4746654A (enExample)
EP (1) EP0100718B1 (enExample)
JP (1) JPS5942395A (enExample)
KR (1) KR910000726B1 (enExample)
AR (2) AR242394A1 (enExample)
AT (1) ATE30235T1 (enExample)
AU (1) AU566880B2 (enExample)
CA (1) CA1267650A (enExample)
CS (1) CS252463B2 (enExample)
CZ (1) CZ419191A3 (enExample)
DD (1) DD213670A5 (enExample)
DE (1) DE3374062D1 (enExample)
DK (1) DK170342B1 (enExample)
DZ (1) DZ562A1 (enExample)
EG (1) EG15968A (enExample)
ES (1) ES8403923A1 (enExample)
FI (1) FI75830C (enExample)
FR (1) FR2531088B1 (enExample)
GR (1) GR79597B (enExample)
HU (1) HU190454B (enExample)
IE (1) IE56343B1 (enExample)
IL (1) IL69347A (enExample)
LU (1) LU88723I2 (enExample)
MA (1) MA19858A1 (enExample)
NL (1) NL960007I2 (enExample)
NO (2) NO164712C (enExample)
NZ (1) NZ205061A (enExample)
OA (1) OA07507A (enExample)
PH (1) PH22082A (enExample)
PL (2) PL142022B1 (enExample)
PT (1) PT77122B (enExample)
SG (1) SG18588G (enExample)
SU (2) SU1333240A3 (enExample)
YU (1) YU45143B (enExample)
ZA (1) ZA835578B (enExample)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
US5641762A (en) * 1985-05-02 1997-06-24 Research Corporation Technologies, Inc. Bone targeted inhibitors of carbonic anhydrase
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
ES2039237T3 (es) * 1986-04-24 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Procedimiento para preparar nuevos compuestos de acido difosfonico.
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
EP0282309A3 (en) * 1987-03-11 1990-03-14 Yamanouchi Pharmaceutical Co. Ltd. Azole-aminomethylene bisphosphonic acid derivatives
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (enExample) * 1988-03-31 1990-09-28 Symphar Sa
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP3021035B2 (ja) * 1988-11-01 2000-03-15 アーク・デベロップメント・コーポレーション ホスホン酸及び分離におけるその使用
US5154843A (en) * 1989-02-08 1992-10-13 The Lubrizol Corporation Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
EP0416689B1 (en) * 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
DE59107135D1 (de) * 1990-01-18 1996-02-08 Ciba Geigy Ag Phoshponsäure- und Thionophosphonsäure-Derivate
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
ES2072015T3 (es) * 1990-08-21 1995-07-01 Upjohn Co Derivados del acido bisfosfonico como agente anti-artritico.
EP0561948B1 (en) * 1990-12-07 1995-04-05 The Upjohn Company Phosphonic acid derivatives useful as antiinflammatory agents
EP0491374B1 (en) * 1990-12-19 1996-01-31 Takeda Chemical Industries, Ltd. Bisphosphonic acid derivatives, their production and use
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
EP0590009B1 (en) * 1991-06-19 1998-03-18 PHARMACIA & UPJOHN COMPANY Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
DK0594857T3 (da) * 1991-09-05 1998-10-07 Toray Industries Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
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