BE887574R - Derives de l'acide quinoleine-carboxylique et procede pour leur preparation - Google Patents

Derives de l'acide quinoleine-carboxylique et procede pour leur preparation

Info

Publication number
BE887574R
BE887574R BE2/59018A BE887574A BE887574R BE 887574 R BE887574 R BE 887574R BE 2/59018 A BE2/59018 A BE 2/59018A BE 887574 A BE887574 A BE 887574A BE 887574 R BE887574 R BE 887574R
Authority
BE
Belgium
Prior art keywords
quinoleine
preparation
carboxylic acid
acid derivatives
derivatives
Prior art date
Application number
BE2/59018A
Other languages
English (en)
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of BE887574R publication Critical patent/BE887574R/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
BE2/59018A 1979-08-22 1981-02-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation BE887574R (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10677679A JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
BE2059018 1981-02-19

Publications (1)

Publication Number Publication Date
BE887574R true BE887574R (fr) 1981-06-15

Family

ID=27159608

Family Applications (2)

Application Number Title Priority Date Filing Date
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
BE2/59018A BE887574R (fr) 1979-08-22 1981-02-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation

Country Status (16)

Country Link
JP (1) JPS5630964A (fr)
AU (1) AU533141B2 (fr)
BE (2) BE884824A (fr)
CA (1) CA1159454A (fr)
CH (1) CH645641A5 (fr)
DE (1) DE3031767C3 (fr)
ES (1) ES494352A0 (fr)
FR (1) FR2463771A1 (fr)
GB (1) GB2057440B (fr)
HK (1) HK98486A (fr)
HU (1) HU184817B (fr)
IT (1) IT1132392B (fr)
MY (1) MY8700155A (fr)
SE (1) SE440353B (fr)
SG (1) SG71386G (fr)
SU (2) SU978727A3 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0195135A1 (fr) * 1985-03-21 1986-09-24 Kyorin Seiyaku Kabushiki Kaisha Procédé pour la préparation de dérivés de l'acide quinoléine carboxylique
WO1986006630A1 (fr) * 1985-05-14 1986-11-20 Beecham Group P.L.C. Utilisation de derives de quinolone pour le traitement de la pneumonie mycoplasmatique chez les porcs
EP0159174A3 (en) * 1984-04-16 1987-02-04 Warner-Lambert Company Substituted naphthyridine-, quinoline- and benzoxazine- carboxylic acids as antibacterial agents and processes for their production
FR2655545A1 (fr) * 1989-12-11 1991-06-14 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
FR2656611A1 (fr) * 1990-01-04 1991-07-05 Hoechst France Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant.
FR2673426A1 (fr) * 1991-03-01 1992-09-04 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144A1 (fr) * 1991-04-10 1992-10-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US9012474B2 (en) 2006-02-17 2015-04-21 Idexx Laboratories Inc. Fluoroquinolone compositions

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS58105965A (ja) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd 置換キノリンカルボン酸誘導体
US4472405A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS59195842U (ja) * 1983-06-13 1984-12-26 クラリオン株式会社 ラジオ受信機
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
JPS61118370A (ja) * 1985-10-30 1986-06-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸とその製造方法
ZA859283B (en) * 1984-12-06 1987-07-29 Pfizer Substituted dihydroquinolone carboxylic acids and anti-bacterial compositions containing them
JPS61143364A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61143363A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
JPH01175936A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd ６．８−ジフルオロ−１−（２−フルオロエチル）−１，４−ジヒドロ−７−（４−メチル−１−ピペラジニル）−４−オキソ−３−キノリンカルボン酸を有効成分とする錠剤
JP2526128B2 (ja) * 1988-08-08 1996-08-21 エスエス製薬株式会社 キノロンカルボン酸誘導体
US5185337A (en) * 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
CA2058424A1 (fr) * 1989-07-21 1991-01-22 Akihiro Shibata Derives d'acide quinoleinecarboxylique
WO1995023787A1 (fr) * 1994-03-01 1995-09-08 Ishihara Sangyo Kaisha, Ltd. Procede de production de 5,7-dichloro-4-hydroxyquinoleine
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7101049A (fr) * 1970-01-28 1971-07-30
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS54112877A (en) 1978-02-20 1979-09-04 Sumitomo Chem Co Ltd Preparation of 1-substituted-1,4-dihydro-4-oxo-3-pyridine carboxylic acid derivatives
DE2914258A1 (de) * 1978-04-12 1979-10-25 Otsuka Pharma Co Ltd Piperazinylbenzoheterozyklische verbindungen, verfahren zu deren herstellung und mittel, welche diese enthalten
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159174A3 (en) * 1984-04-16 1987-02-04 Warner-Lambert Company Substituted naphthyridine-, quinoline- and benzoxazine- carboxylic acids as antibacterial agents and processes for their production
EP0195135A1 (fr) * 1985-03-21 1986-09-24 Kyorin Seiyaku Kabushiki Kaisha Procédé pour la préparation de dérivés de l'acide quinoléine carboxylique
WO1986006630A1 (fr) * 1985-05-14 1986-11-20 Beecham Group P.L.C. Utilisation de derives de quinolone pour le traitement de la pneumonie mycoplasmatique chez les porcs
FR2655545A1 (fr) * 1989-12-11 1991-06-14 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
EP0437128A2 (fr) 1989-12-11 1991-07-17 Rhone-Poulenc Sante Utilisation des dérivés des fluoroquinolones pour le traitement de la pneumonie à Pneumocystis carinii
FR2656611A1 (fr) * 1990-01-04 1991-07-05 Hoechst France Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant.
FR2673426A1 (fr) * 1991-03-01 1992-09-04 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144A1 (fr) * 1991-04-10 1992-10-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
WO1992018497A1 (fr) * 1991-04-10 1992-10-29 Bouchara S.A. Nouvelles quinolones difluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US9012474B2 (en) 2006-02-17 2015-04-21 Idexx Laboratories Inc. Fluoroquinolone compositions

Also Published As

Publication number Publication date
BE884824A (fr) 1980-12-16
AU533141B2 (en) 1983-11-03
DE3031767A1 (de) 1981-03-26
GB2057440A (en) 1981-04-01
ES8104233A1 (es) 1981-04-16
SE440353B (sv) 1985-07-29
GB2057440B (en) 1983-10-12
AU6112280A (en) 1981-02-26
IT1132392B (it) 1986-07-02
DE3031767C2 (fr) 1994-04-14
FR2463771A1 (fr) 1981-02-27
CH645641A5 (de) 1984-10-15
SE8005534L (sv) 1981-02-23
IT8024111A0 (it) 1980-08-11
SU978727A3 (ru) 1982-11-30
FR2463771B1 (fr) 1983-04-22
SG71386G (en) 1987-03-27
MY8700155A (en) 1987-12-31
CA1159454A (fr) 1983-12-27
SU1015827A3 (ru) 1983-04-30
DE3031767C3 (de) 1994-04-14
ES494352A0 (es) 1981-04-16
JPS5630964A (en) 1981-03-28
HK98486A (en) 1986-12-24
HU184817B (en) 1984-10-29

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Owner name: KYORIN SEIYAKU K.K.

Effective date: 20000819

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Extension date: 20050819

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Free format text: PRODUCT NAME: FLEROXACINE; NAT. REG.: 218 IS 13 F 3 19930618; FIRST REG.: DK D.SP 8655 19920915

Spc suppl protection certif: 93C0190

Filing date: 19931130

Expiry date: 20000819

Extension date: 20050819