JPS5630964A - Novel substituted quinolinecarboxylic acid and its preparation - Google Patents

Novel substituted quinolinecarboxylic acid and its preparation

Info

Publication number
JPS5630964A
JPS5630964A JP10677679A JP10677679A JPS5630964A JP S5630964 A JPS5630964 A JP S5630964A JP 10677679 A JP10677679 A JP 10677679A JP 10677679 A JP10677679 A JP 10677679A JP S5630964 A JPS5630964 A JP S5630964A
Authority
JP
Japan
Prior art keywords
lower alkyl
halogen
formula
substituted
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10677679A
Other languages
English (en)
Inventor
Tsutomu Irikura
Hiroshi Koga
Satoru Murayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to JP10677679A priority Critical patent/JPS5630964A/ja
Priority to SE8005534A priority patent/SE440353B/sv
Priority to AU61122/80A priority patent/AU533141B2/en
Priority to IT24111/80A priority patent/IT1132392B/it
Priority to CH614680A priority patent/CH645641A5/de
Priority to ES494352A priority patent/ES8104233A1/es
Priority to BE2/58706A priority patent/BE884824A/fr
Priority to HU802072A priority patent/HU184817B/hu
Priority to CA000358778A priority patent/CA1159454A/en
Priority to SU802968349A priority patent/SU978727A3/ru
Priority to FR8018279A priority patent/FR2463771A1/fr
Priority to DE3031767A priority patent/DE3031767C3/de
Priority to GB8027372A priority patent/GB2057440B/en
Priority to BE2/59018A priority patent/BE887574R/fr
Priority to GB8105514A priority patent/GB2093018B/en
Priority to SU813254244A priority patent/SU1015827A3/ru
Publication of JPS5630964A publication Critical patent/JPS5630964A/ja
Priority to SG713/86A priority patent/SG71386G/en
Priority to HK984/86A priority patent/HK98486A/xx
Priority to MY155/87A priority patent/MY8700155A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
JP10677679A 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation Pending JPS5630964A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP10677679A JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation
SE8005534A SE440353B (sv) 1979-08-22 1980-08-04 Kinolinkarboxylsyraderivat och sett for framstellning derav
AU61122/80A AU533141B2 (en) 1979-08-22 1980-08-06 Quinoline carboxylic acid derivatives
IT24111/80A IT1132392B (it) 1979-08-22 1980-08-11 Derivati di acidi chinolincarbossilici e relativo procedimento di preparazione
CH614680A CH645641A5 (de) 1979-08-22 1980-08-14 Chinolin- und chinolizincarbonsaeurederivate.
ES494352A ES8104233A1 (es) 1979-08-22 1980-08-19 Procedimiento para preparar derivados de acidos quinolina- carboxilicos
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
SU802968349A SU978727A3 (ru) 1979-08-22 1980-08-21 Способ получени производных хинолинкарбоновой кислоты
CA000358778A CA1159454A (en) 1979-08-22 1980-08-21 Quinoline carboxylic acid derivatives and the process for the preparation
HU802072A HU184817B (en) 1979-08-22 1980-08-21 Process for producing quinoline-carboxylic acid derivatives
FR8018279A FR2463771A1 (fr) 1979-08-22 1980-08-21 Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne
DE3031767A DE3031767C3 (de) 1979-08-22 1980-08-22 Chinolincarbonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
GB8027372A GB2057440B (en) 1979-08-22 1980-08-22 Quinoline carboxylic acid derivatives
BE2/59018A BE887574R (fr) 1979-08-22 1981-02-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
GB8105514A GB2093018B (en) 1979-08-22 1981-02-20 6,8-difluoro-quinoline carboxylic acid derivatives
SU813254244A SU1015827A3 (ru) 1979-08-22 1981-03-03 Способ получени производных хинолинкарбоновой кислоты или их гидратов
SG713/86A SG71386G (en) 1979-08-22 1986-09-04 Quinoline carboxylic acid derivatives and their preparation
HK984/86A HK98486A (en) 1979-08-22 1986-12-18 Quinoline carboxylic acid derivatives and their preparation
MY155/87A MY8700155A (en) 1979-08-22 1987-12-30 Quinoline carboxylic acid derivatives and their preparation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10677679A JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
BE2059018 1981-02-19

Publications (1)

Publication Number Publication Date
JPS5630964A true JPS5630964A (en) 1981-03-28

Family

ID=27159608

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10677679A Pending JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation

Country Status (16)

Country Link
JP (1) JPS5630964A (ja)
AU (1) AU533141B2 (ja)
BE (2) BE884824A (ja)
CA (1) CA1159454A (ja)
CH (1) CH645641A5 (ja)
DE (1) DE3031767C3 (ja)
ES (1) ES8104233A1 (ja)
FR (1) FR2463771A1 (ja)
GB (1) GB2057440B (ja)
HK (1) HK98486A (ja)
HU (1) HU184817B (ja)
IT (1) IT1132392B (ja)
MY (1) MY8700155A (ja)
SE (1) SE440353B (ja)
SG (1) SG71386G (ja)
SU (2) SU978727A3 (ja)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58105965A (ja) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd 置換キノリンカルボン酸誘導体
JPS59212474A (ja) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト ７−アミノ−１−シクロプロピル−６，８−ジフルオロ−１，４−ジヒドロ−４−オキソキノリンカルボン酸
JPS59195842U (ja) * 1983-06-13 1984-12-26 クラリオン株式会社 ラジオ受信機
JPS60246370A (ja) * 1984-05-11 1985-12-06 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） キノリン誘導体、その製造法及びそれを含有する医薬組成物
JPS61118370A (ja) * 1985-10-30 1986-06-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸とその製造方法
JPS61143363A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61143365A (ja) * 1984-12-06 1986-07-01 フアイザー・インコーポレーテツド 置換ジヒドロキノロンカルボン酸
JPS61143364A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
JPS63264461A (ja) * 1986-02-25 1988-11-01 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
JPH01125371A (ja) * 1987-08-21 1989-05-17 Warner Lambert Co ナフチリジン抗菌剤
JPH01175936A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd ６．８−ジフルオロ−１−（２−フルオロエチル）−１，４−ジヒドロ−７−（４−メチル−１−ピペラジニル）−４−オキソ−３−キノリンカルボン酸を有効成分とする錠剤
JPH02138261A (ja) * 1988-08-08 1990-05-28 Ss Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5185337A (en) * 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives
WO1995023787A1 (fr) * 1994-03-01 1995-09-08 Ishihara Sangyo Kaisha, Ltd. Procede de production de 5,7-dichloro-4-hydroxyquinoleine

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
US4472405A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
EP0195135B1 (en) * 1985-03-21 1992-06-17 Kyorin Seiyaku Kabushiki Kaisha A process for the preparation of quinoline carboxylic acid derivatives
GB8512143D0 (en) * 1985-05-14 1985-06-19 Beecham Group Plc Method of treatment
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
FR2656611B1 (fr) * 1990-01-04 1992-05-07 Hoechst France Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant.
FR2673426B1 (fr) * 1991-03-01 1993-07-16 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7101049A (ja) * 1970-01-28 1971-07-30
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS54112877A (en) 1978-02-20 1979-09-04 Sumitomo Chem Co Ltd Preparation of 1-substituted-1,4-dihydro-4-oxo-3-pyridine carboxylic acid derivatives
DE2953973C2 (ja) * 1978-04-12 1989-02-02 Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58105965A (ja) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd 置換キノリンカルボン酸誘導体
JPH0312061B2 (ja) * 1981-12-15 1991-02-19 Nippon Shinyaku Co Ltd
JPS59212474A (ja) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト ７−アミノ−１−シクロプロピル−６，８−ジフルオロ−１，４−ジヒドロ−４−オキソキノリンカルボン酸
JPH0592922A (ja) * 1983-05-18 1993-04-16 Bayer Ag 抗バクテリア剤
JPH0559007A (ja) * 1983-05-18 1993-03-09 Bayer Ag １−シクロプロピル−６，７，８−トリフルオロ−１，４−ジヒドロ−４−オキソキノリン−３−カルボン酸
JPH0227639Y2 (ja) * 1983-06-13 1990-07-25
JPS59195842U (ja) * 1983-06-13 1984-12-26 クラリオン株式会社 ラジオ受信機
JPS60246370A (ja) * 1984-05-11 1985-12-06 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） キノリン誘導体、その製造法及びそれを含有する医薬組成物
JPH0354936B2 (ja) * 1984-05-11 1991-08-21
JPH0366301B2 (ja) * 1984-12-06 1991-10-16 Pfizer
JPS61143365A (ja) * 1984-12-06 1986-07-01 フアイザー・インコーポレーテツド 置換ジヒドロキノロンカルボン酸
JPS61143364A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61143363A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPH056543B2 (ja) * 1984-12-17 1993-01-26 Kyorin Seiyaku Kk
JPS61118370A (ja) * 1985-10-30 1986-06-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸とその製造方法
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
JPS63264461A (ja) * 1986-02-25 1988-11-01 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH01125371A (ja) * 1987-08-21 1989-05-17 Warner Lambert Co ナフチリジン抗菌剤
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
JPH01175936A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd ６．８−ジフルオロ−１−（２−フルオロエチル）−１，４−ジヒドロ−７−（４−メチル−１−ピペラジニル）−４−オキソ−３−キノリンカルボン酸を有効成分とする錠剤
JPH02138261A (ja) * 1988-08-08 1990-05-28 Ss Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5185337A (en) * 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives
WO1995023787A1 (fr) * 1994-03-01 1995-09-08 Ishihara Sangyo Kaisha, Ltd. Procede de production de 5,7-dichloro-4-hydroxyquinoleine

Also Published As

Publication number Publication date
SU1015827A3 (ru) 1983-04-30
GB2057440B (en) 1983-10-12
MY8700155A (en) 1987-12-31
CA1159454A (en) 1983-12-27
FR2463771A1 (fr) 1981-02-27
DE3031767C2 (ja) 1994-04-14
AU6112280A (en) 1981-02-26
SG71386G (en) 1987-03-27
SU978727A3 (ru) 1982-11-30
ES494352A0 (es) 1981-04-16
DE3031767C3 (de) 1994-04-14
HU184817B (en) 1984-10-29
IT8024111A0 (it) 1980-08-11
SE8005534L (sv) 1981-02-23
GB2057440A (en) 1981-04-01
DE3031767A1 (de) 1981-03-26
IT1132392B (it) 1986-07-02
FR2463771B1 (ja) 1983-04-22
SE440353B (sv) 1985-07-29
BE884824A (fr) 1980-12-16
AU533141B2 (en) 1983-11-03
ES8104233A1 (es) 1981-04-16
HK98486A (en) 1986-12-24
BE887574R (fr) 1981-06-15
CH645641A5 (de) 1984-10-15

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