JPS5569591A - Azetidinone derivative and its preparation - Google Patents

Azetidinone derivative and its preparation

Info

Publication number
JPS5569591A
JPS5569591A JP14269278A JP14269278A JPS5569591A JP S5569591 A JPS5569591 A JP S5569591A JP 14269278 A JP14269278 A JP 14269278A JP 14269278 A JP14269278 A JP 14269278A JP S5569591 A JPS5569591 A JP S5569591A
Authority
JP
Japan
Prior art keywords
formula
compound
group
protecting group
eliminated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14269278A
Other languages
Japanese (ja)
Inventor
Bunji Shimizu
Akio Saito
Takuzo Nishimura
Masaki Nakahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP14269278A priority Critical patent/JPS5569591A/en
Publication of JPS5569591A publication Critical patent/JPS5569591A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An azetidinone derivative of formula I: (R1 is H or acyl group; R2 is H, alkyl, halogenoalkyl group, etc.; n is an integer 2-5), and a 2-ketopenicillin ester derivative of formula II: (R3 is R2 except H).
EXAMPLE: 5R-3-(2'-Hydroxy)ethoxy-7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene-2- carboxylic acid.
USE: Antibacterials, β-lactamase inhibitors, and intermediates for their synthesis, effective against β-lactam antibiotic-resistant bacteria.
PROCESS: The compound of formula II, obtained from a compound of formula III: (X is halogen), is reacted with a compound of formula IV (R4 is OH-protecting group), and the protecting group is eliminated to give a compound of formula V. The group R1 is changed into an acyl group, or the carboxyl-protecting group is eliminated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14269278A 1978-11-17 1978-11-17 Azetidinone derivative and its preparation Pending JPS5569591A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14269278A JPS5569591A (en) 1978-11-17 1978-11-17 Azetidinone derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14269278A JPS5569591A (en) 1978-11-17 1978-11-17 Azetidinone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5569591A true JPS5569591A (en) 1980-05-26

Family

ID=15321302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14269278A Pending JPS5569591A (en) 1978-11-17 1978-11-17 Azetidinone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5569591A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial

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