KR890001569B1 - 피리다진의 아미노 화합물의 제조방법 - Google Patents

피리다진의 아미노 화합물의 제조방법 Download PDF

Info

Publication number
KR890001569B1
KR890001569B1 KR8203557A KR820003557A KR890001569B1 KR 890001569 B1 KR890001569 B1 KR 890001569B1 KR 8203557 A KR8203557 A KR 8203557A KR 820003557 A KR820003557 A KR 820003557A KR 890001569 B1 KR890001569 B1 KR 890001569B1
Authority
KR
South Korea
Prior art keywords
pyridazine
reaction
group
phenyl
preparing amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8203557A
Other languages
English (en)
Korean (ko)
Other versions
KR840001145A (ko
Inventor
쟝-뽈 강
까스린 비지에르
까밀 죠르쥐 웨르뮈스
Original Assignee
엠.쟝.루이.드라뤼
소시에떼 아노임 사노피
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 엠.쟝.루이.드라뤼, 소시에떼 아노임 사노피 filed Critical 엠.쟝.루이.드라뤼
Publication of KR840001145A publication Critical patent/KR840001145A/ko
Application granted granted Critical
Publication of KR890001569B1 publication Critical patent/KR890001569B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR8203557A 1981-08-07 1982-08-07 피리다진의 아미노 화합물의 제조방법 Expired KR890001569B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8115380A FR2510998B1 (fr) 1981-08-07 1981-08-07 Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR87/15380 1981-08-07

Publications (2)

Publication Number Publication Date
KR840001145A KR840001145A (ko) 1984-03-28
KR890001569B1 true KR890001569B1 (ko) 1989-05-08

Family

ID=9261294

Family Applications (2)

Application Number Title Priority Date Filing Date
KR8203557A Expired KR890001569B1 (ko) 1981-08-07 1982-08-07 피리다진의 아미노 화합물의 제조방법
KR8203558A Expired KR880001624B1 (ko) 1981-08-07 1982-08-07 피리다진 치환 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR8203558A Expired KR880001624B1 (ko) 1981-08-07 1982-08-07 피리다진 치환 유도체의 제조방법

Country Status (30)

Country Link
US (1) US4508720A (https=)
EP (2) EP0074863B1 (https=)
JP (2) JPS5877867A (https=)
KR (2) KR890001569B1 (https=)
AR (2) AR231441A1 (https=)
AT (2) ATE12227T1 (https=)
AU (2) AU548931B2 (https=)
CA (2) CA1179346A (https=)
CS (2) CS229940B2 (https=)
DD (2) DD202549A5 (https=)
DE (2) DE3269383D1 (https=)
DK (2) DK148537C (https=)
EG (2) EG15788A (https=)
ES (2) ES8305738A1 (https=)
FI (2) FI72969C (https=)
FR (1) FR2510998B1 (https=)
GR (2) GR76429B (https=)
HU (2) HU189166B (https=)
IE (2) IE53388B1 (https=)
IL (2) IL66409A (https=)
MA (2) MA19560A1 (https=)
NO (2) NO157861C (https=)
NZ (2) NZ201520A (https=)
OA (2) OA07176A (https=)
PH (1) PH18545A (https=)
PL (2) PL137199B1 (https=)
PT (2) PT75351B (https=)
SU (2) SU1140685A3 (https=)
YU (2) YU172082A (https=)
ZA (2) ZA825512B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
US4565814A (en) * 1983-01-28 1986-01-21 Sanofi Pyridazine derivatives having a psychotropic action and compositions
US4628088A (en) * 1984-07-17 1986-12-09 Eli Lilly And Company Preparation of substituted pyridazines
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
FR2654727B1 (fr) * 1989-11-17 1992-03-27 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2642754B1 (fr) * 1989-02-07 1991-05-24 Sanofi Sa Nouveaux derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
WO2003018563A1 (en) * 2001-08-31 2003-03-06 Northwestern University Anti-inflammatory and protein kinase inhibitor composition and method of use
CA2495285A1 (en) * 2002-08-13 2004-02-19 Merck Sharp & Dohme Limited Phenylpyridazine derivatives as ligands for gaba receptors
CA2589102C (en) * 2004-11-02 2013-08-13 Northwestern University Pyridazine compounds and methods for using the compounds to treat inflammatory diseases
JP5337375B2 (ja) * 2004-11-02 2013-11-06 ノースウェスタン ユニバーシティ ピリダジン化合物、組成物および方法
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
US20100168120A1 (en) * 2006-04-28 2010-07-01 Neuromedix Inc. Salts of pyridazine compounds
BRPI0710938A2 (pt) * 2006-04-28 2012-06-26 Univ Northwestern formulações contendo compostos de piridazina para o tratamento de doenças neuroinflamatórias
RU2555969C1 (ru) * 2014-07-09 2015-07-10 Юлия Алексеевна Щепочкина Керамическая масса для изготовления облицовочной плитки

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives

Also Published As

Publication number Publication date
US4508720A (en) 1985-04-02
SU1140685A3 (ru) 1985-02-15
AR231441A1 (es) 1984-11-30
HU190028B (en) 1986-08-28
FI72968B (fi) 1987-04-30
PT75350A (fr) 1982-08-01
ZA825512B (en) 1983-06-29
CA1179346A (en) 1984-12-11
OA07175A (fr) 1984-04-30
HU189166B (en) 1986-06-30
NO157861B (no) 1988-02-22
FI822747A0 (fi) 1982-08-06
DK148795B (da) 1985-09-30
AU548930B2 (en) 1986-01-09
DD202549A5 (de) 1983-09-21
PT75351B (fr) 1984-08-01
ES514794A0 (es) 1983-04-16
ATE12227T1 (de) 1985-04-15
EP0074863A1 (fr) 1983-03-23
AU548931B2 (en) 1986-01-09
OA07176A (fr) 1984-04-30
ATE18216T1 (de) 1986-03-15
DK148537B (da) 1985-07-29
DK354482A (da) 1983-02-08
KR840001145A (ko) 1984-03-28
IL66408A0 (en) 1982-11-30
ES514795A0 (es) 1983-04-16
CS229941B2 (en) 1984-07-16
ES8305737A1 (es) 1983-04-16
FI822747L (fi) 1983-02-08
ES8305738A1 (es) 1983-04-16
AR231637A1 (es) 1985-01-31
DE3269383D1 (en) 1986-04-03
EG15788A (en) 1986-09-30
IL66409A0 (en) 1982-11-30
FI822748A0 (fi) 1982-08-06
NO157861C (no) 1988-06-01
FR2510998A1 (fr) 1983-02-11
AU8655482A (en) 1983-02-10
PL237809A1 (en) 1983-02-28
FR2510998B1 (fr) 1986-01-10
CA1174240A (en) 1984-09-11
NZ201518A (en) 1985-04-30
NO822509L (no) 1983-02-08
NO822510L (no) 1983-02-08
PT75351A (fr) 1982-08-01
FI72968C (fi) 1987-08-10
IL66409A (en) 1985-09-29
DK148537C (da) 1986-01-13
GR76429B (https=) 1984-08-10
EG15747A (en) 1986-06-30
MA19562A1 (fr) 1983-04-01
DK354382A (da) 1983-02-08
KR840001159A (ko) 1984-03-28
NO157102B (no) 1987-10-12
JPS5877867A (ja) 1983-05-11
DE3262671D1 (en) 1985-04-25
IE53388B1 (en) 1988-10-26
FI822748L (fi) 1983-02-08
AU8655382A (en) 1983-02-10
FI72969C (fi) 1987-08-10
IE821779L (en) 1983-02-07
NZ201520A (en) 1985-04-30
NO157102C (no) 1988-01-20
YU171882A (en) 1985-03-20
PT75350B (fr) 1984-08-01
EP0072726A1 (fr) 1983-02-23
DD202715A5 (de) 1983-09-28
IE821778L (en) 1983-02-07
CS229940B2 (en) 1984-07-16
EP0072726B1 (fr) 1985-03-20
FI72969B (fi) 1987-04-30
KR880001624B1 (ko) 1988-09-02
JPH0459312B2 (https=) 1992-09-21
MA19560A1 (fr) 1983-04-01
JPS5877868A (ja) 1983-05-11
ZA825513B (en) 1983-06-29
PL237808A1 (en) 1983-02-28
GR76430B (https=) 1984-08-10
PH18545A (en) 1985-08-09
PL130647B1 (en) 1984-08-31
YU172082A (en) 1985-03-20
PL137199B1 (en) 1986-05-31
SU1138024A3 (ru) 1985-01-30
IL66408A (en) 1985-12-31
DK148795C (da) 1986-03-10
IE53387B1 (en) 1988-10-26
EP0074863B1 (fr) 1986-02-26

Similar Documents

Publication Publication Date Title
KR890001569B1 (ko) 피리다진의 아미노 화합물의 제조방법
KR880002710B1 (ko) 4-메틸 6-페닐 피리다진 유도체의 제조방법
FI72970B (fi) Foerfarande foer framstaellning av 2-aminosubstituerade pyridazinderivat med inverkan pao det centrala nervsystemet.
PL95166B1 (https=)
FR2601952A1 (fr) Nouveaux derives amino alkyl thio de triazolopyridine ou triazoloquinoline, leurs procedes de preparation, medicaments les contenant, utiles notamment comme antalgiques
WO1984000546A1 (fr) Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
KR900003301B1 (ko) 2-피페라지닐-4-페닐 퀴나졸린 유도체 및 그의 산염의 제조 방법
EP0079810A1 (fr) Nouveaux dérivés de la phényl-4 quinazoline actifs sur le système nerveux central
PL94923B1 (https=)
JPH11506470A (ja) 新規複素環式化合物
NZ204072A (en) Pharmaceutical compositions which contain theophylline as active ingredient
JPS6185370A (ja) ４ｈ‐１，２，４‐トリアゾール誘導体の新製造法、得られる新トリアゾール、それらの薬剤としての使用及びそれらを含む製薬組成物
FR2572074A1 (fr) Derives du thiadiazole actifs sur le systeme nerveux central, procede d'obtention et compositions pharmaceutiques les contenant
JPS59141565A (ja) 向精神性活性を有するピリダジン誘導体，その製造方法および該誘導体を含有する薬剤
KR830000772B1 (ko) 이소퀴놀린 유도체의 제조방법
JPS6022711B2 (ja) トランス−デカハイドロキノリン誘導体，その製造法，及びそれを含む医薬
JPS615076A (ja) 新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0221820A1 (fr) Dérivés de l'imino-3 pyridazine, procédé d'obtention et compositions pharmaceutiques en contenant
CH420198A (fr) Procédé de préparation de dérivés de benzodioxane-1,4
EP0755680A2 (en) Use of piperazine compounds as narcotic antagonists
FR2539739A1 (fr) Nouveaux derives de la naphtyl pyridazine actifs sur le systeme nerveux central, procede de preparation de ces derives et medicaments en contenant
JPH04261121A (ja) 肺高血圧症の予防または治療剤
JPS61178979A (ja) ３−アミノ−２，３−ジヒドロ−１−ベンゾキセピン化合物、その製造法及び該化合物を含有する、抗抑圧作用を有する医薬調剤
CS245789B2 (cs) Způsob výroby derivátů pyridazinu substituovaných v poloze 3 substituovanou aminoskupinou

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19920509

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19920509