KR880000091B1 - 오메프라졸 중간체의 제조방법 - Google Patents

오메프라졸 중간체의 제조방법 Download PDF

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Publication number
KR880000091B1
KR880000091B1 KR1019830004003A KR830004003A KR880000091B1 KR 880000091 B1 KR880000091 B1 KR 880000091B1 KR 1019830004003 A KR1019830004003 A KR 1019830004003A KR 830004003 A KR830004003 A KR 830004003A KR 880000091 B1 KR880000091 B1 KR 880000091B1
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KR
South Korea
Prior art keywords
solution
formula
compound
oxide
added
Prior art date
Application number
KR1019830004003A
Other languages
English (en)
Korean (ko)
Other versions
KR840005718A (ko
Inventor
엘로프 브랜드스트룀 아른
보로베르트람
Original Assignee
악티볼라게트 헤슬레
키엘 호름키스트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20347627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR880000091(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 악티볼라게트 헤슬레, 키엘 호름키스트 filed Critical 악티볼라게트 헤슬레
Publication of KR840005718A publication Critical patent/KR840005718A/ko
Application granted granted Critical
Publication of KR880000091B1 publication Critical patent/KR880000091B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019830004003A 1982-08-26 1983-08-26 오메프라졸 중간체의 제조방법 KR880000091B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8204879-4 1982-08-26
SE8204879A SE8204879D0 (sv) 1982-08-26 1982-08-26 Novel chemical intermediates

Publications (2)

Publication Number Publication Date
KR840005718A KR840005718A (ko) 1984-11-15
KR880000091B1 true KR880000091B1 (ko) 1988-02-23

Family

ID=20347627

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830004003A KR880000091B1 (ko) 1982-08-26 1983-08-26 오메프라졸 중간체의 제조방법

Country Status (28)

Country Link
US (2) US4544750A (fr)
EP (1) EP0103553B1 (fr)
JP (1) JPS5959662A (fr)
KR (1) KR880000091B1 (fr)
AT (1) ATE40884T1 (fr)
AU (1) AU560028B2 (fr)
CA (1) CA1234118A (fr)
CY (1) CY1328A (fr)
DD (1) DD233126A5 (fr)
DE (2) DE3379222D1 (fr)
DK (1) DK381583A (fr)
ES (1) ES525122A0 (fr)
FI (1) FI79701C (fr)
GB (1) GB2126226B (fr)
GR (1) GR79374B (fr)
HK (1) HK19486A (fr)
HU (1) HU189738B (fr)
IE (1) IE55865B1 (fr)
IL (1) IL69175A (fr)
IS (1) IS1438B6 (fr)
MY (1) MY8600503A (fr)
NO (1) NO164093C (fr)
NZ (1) NZ204959A (fr)
OA (1) OA07498A (fr)
PH (1) PH17786A (fr)
PT (1) PT77249B (fr)
SE (1) SE8204879D0 (fr)
ZA (1) ZA835143B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
SE8504409D0 (sv) * 1985-09-24 1985-09-24 Haessle Ab Novel chemical intermediates
US5221316A (en) * 1986-04-17 1993-06-22 Imperial Chemical Industries Plc Fungicides
DE3783503T2 (de) * 1986-04-17 1993-05-13 Ici Plc Pyridylacrylsaeureester-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
US4920230A (en) * 1987-06-29 1990-04-24 Takeda Chemical Industries, Ltd. Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
ES2036948B1 (es) * 1991-11-21 1994-09-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
ES2060541B1 (es) * 1993-02-26 1995-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
ES2097089B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
WO1999033807A2 (fr) * 1997-12-24 1999-07-08 Pdi-Research Laboratories, Inc. Synthese de derives de pyridine d'interet pharmaceutique
CA2204580A1 (fr) * 1997-05-06 1998-11-06 Michel Zoghbi Synthese de derives de la pyridine utiles en pharmacie
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
GB9717849D0 (en) * 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
KR100396431B1 (ko) * 1998-01-26 2003-09-02 가부시키가이샤 구라레 2-술포닐피리딘 유도체 및 2-[((2-피리딜)메틸)티오]-1ｈ-벤즈이
US6350876B2 (en) 1998-01-26 2002-02-26 Kuraray Co., Ltd. 4-chloro-3,5-dimethyl-2-sulfonyl pyridines
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
IE990506A1 (en) * 1998-06-26 2000-11-15 Russinsky Ltd Pyridine Building Blocks
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis
ES2171116B1 (es) * 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
WO2003097606A1 (fr) * 2000-07-28 2003-11-27 Herbex, Produtos Químicos, Sa Nouveau procede de preparation des composes antiulcereux omeprazole, lansoprazole et pantoprazole
AU2002310818B2 (en) 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN100376574C (zh) * 2006-06-14 2008-03-26 浙江大学 泰妥拉唑的制备方法
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN101648912B (zh) * 2009-09-14 2012-07-04 南京第一农药集团有限公司 一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN102603620B (zh) * 2012-01-13 2014-10-29 江苏中邦制药有限公司 一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
BR112022005578A2 (pt) 2019-09-24 2022-09-20 Prolacta Bioscience Inc Composições e métodos para tratamento de doenças inflamatórias e imunes
CN112142653B (zh) * 2020-10-22 2022-02-11 成都百泉生物医药科技有限公司 奥美拉唑中间体的制备方法
CN113307773A (zh) * 2021-06-17 2021-08-27 上海毕得医药科技股份有限公司 6-溴-3-甲氧基-1-苯基-1h-吲唑及其合成方法和应用
CN114805193B (zh) * 2022-04-19 2023-06-20 南京红太阳医药研究院有限公司 一种奥美拉唑中间体的制备方法

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US2735851A (en) * 1956-02-21 Alkanolpykroine-n-oxides
US2663711A (en) * 1951-12-08 1953-12-22 Du Pont Process for the preparation of pyridine alcohols from pyridine n-oxides
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
KR840002371A (ko) * 1981-11-05 1984-06-25 귄터 미카엘, 헤르페르트 수키 치환된 벤즈 이미다졸의 제조방법

Also Published As

Publication number Publication date
AU1710183A (en) 1984-03-01
KR840005718A (ko) 1984-11-15
SE8204879D0 (sv) 1982-08-26
US4544750A (en) 1985-10-01
ES8404993A1 (es) 1984-05-16
ATE40884T1 (de) 1989-03-15
NZ204959A (en) 1985-12-13
AU560028B2 (en) 1987-03-26
GB8322866D0 (en) 1983-09-28
FI79701B (fi) 1989-10-31
NO164093C (no) 1990-08-29
OA07498A (en) 1985-03-31
FI833047A0 (fi) 1983-08-25
PT77249A (en) 1983-09-01
GB2126226B (en) 1985-09-18
IL69175A0 (en) 1983-11-30
NO164093B (no) 1990-05-21
IS1438B6 (is) 1990-09-25
FI833047A (fi) 1984-02-27
IS2845A7 (is) 1984-02-27
DE3379222D1 (en) 1989-03-30
DK381583D0 (da) 1983-08-19
CA1234118A (fr) 1988-03-15
JPS6353987B2 (fr) 1988-10-26
EP0103553B1 (fr) 1989-02-22
ZA835143B (en) 1984-04-25
EP0103553A1 (fr) 1984-03-21
DK381583A (da) 1984-02-27
CY1328A (en) 1986-06-27
HK19486A (en) 1986-03-27
JPS5959662A (ja) 1984-04-05
PT77249B (en) 1986-07-14
IL69175A (en) 1987-01-30
GB2126226A (en) 1984-03-21
DD233126A5 (de) 1986-02-19
GR79374B (fr) 1984-10-22
IE831787L (en) 1984-02-26
PH17786A (en) 1984-12-13
IE55865B1 (en) 1991-01-30
NO832794L (no) 1984-02-27
ES525122A0 (es) 1984-05-16
HU189738B (en) 1986-07-28
US4620008A (en) 1986-10-28
DE103553T1 (de) 1984-09-27
FI79701C (fi) 1990-02-12
MY8600503A (en) 1986-12-31

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