IL69175A - 3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives - Google Patents

3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives

Info

Publication number
IL69175A
IL69175A IL69175A IL6917583A IL69175A IL 69175 A IL69175 A IL 69175A IL 69175 A IL69175 A IL 69175A IL 6917583 A IL6917583 A IL 6917583A IL 69175 A IL69175 A IL 69175A
Authority
IL
Israel
Prior art keywords
preparation
intermediates
oxides
dimethyl
omeprazole
Prior art date
Application number
IL69175A
Other languages
English (en)
Other versions
IL69175A0 (en
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20347627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL69175(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IL69175A0 publication Critical patent/IL69175A0/xx
Publication of IL69175A publication Critical patent/IL69175A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL69175A 1982-08-26 1983-07-06 3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives IL69175A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8204879A SE8204879D0 (sv) 1982-08-26 1982-08-26 Novel chemical intermediates

Publications (2)

Publication Number Publication Date
IL69175A0 IL69175A0 (en) 1983-11-30
IL69175A true IL69175A (en) 1987-01-30

Family

ID=20347627

Family Applications (1)

Application Number Title Priority Date Filing Date
IL69175A IL69175A (en) 1982-08-26 1983-07-06 3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives

Country Status (28)

Country Link
US (2) US4544750A (fr)
EP (1) EP0103553B1 (fr)
JP (1) JPS5959662A (fr)
KR (1) KR880000091B1 (fr)
AT (1) ATE40884T1 (fr)
AU (1) AU560028B2 (fr)
CA (1) CA1234118A (fr)
CY (1) CY1328A (fr)
DD (1) DD233126A5 (fr)
DE (2) DE103553T1 (fr)
DK (1) DK381583A (fr)
ES (1) ES525122A0 (fr)
FI (1) FI79701C (fr)
GB (1) GB2126226B (fr)
GR (1) GR79374B (fr)
HK (1) HK19486A (fr)
HU (1) HU189738B (fr)
IE (1) IE55865B1 (fr)
IL (1) IL69175A (fr)
IS (1) IS1438B6 (fr)
MY (1) MY8600503A (fr)
NO (1) NO164093C (fr)
NZ (1) NZ204959A (fr)
OA (1) OA07498A (fr)
PH (1) PH17786A (fr)
PT (1) PT77249B (fr)
SE (1) SE8204879D0 (fr)
ZA (1) ZA835143B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
SE8504409D0 (sv) * 1985-09-24 1985-09-24 Haessle Ab Novel chemical intermediates
ES2053533T3 (es) * 1986-04-17 1994-08-01 Ici Plc Derivados de esteres de acido piridil-acrilico, un proceso para su preparacion y su uso como fungicidas.
US5221316A (en) * 1986-04-17 1993-06-22 Imperial Chemical Industries Plc Fungicides
US4920230A (en) * 1987-06-29 1990-04-24 Takeda Chemical Industries, Ltd. Method of producing nitrogen-containing heteroaromatic compounds having an alkoxy group
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
ES2026761A6 (es) * 1990-10-31 1992-05-01 Genesis Para La Investigacion Procedimiento de obtencion del omeprazol.
ES2036948B1 (es) * 1991-11-21 1994-09-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
ES2060541B1 (es) * 1993-02-26 1995-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
ES2097089B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
WO1999033807A2 (fr) * 1997-12-24 1999-07-08 Pdi-Research Laboratories, Inc. Synthese de derives de pyridine d'interet pharmaceutique
CA2204580A1 (fr) * 1997-05-06 1998-11-06 Michel Zoghbi Synthese de derives de la pyridine utiles en pharmacie
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
GB9717849D0 (en) * 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
KR100396431B1 (ko) * 1998-01-26 2003-09-02 가부시키가이샤 구라레 2-술포닐피리딘 유도체 및 2-[((2-피리딜)메틸)티오]-1ｈ-벤즈이
US6350876B2 (en) 1998-01-26 2002-02-26 Kuraray Co., Ltd. 4-chloro-3,5-dimethyl-2-sulfonyl pyridines
US6303787B1 (en) 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
IE990506A1 (en) * 1998-06-26 2000-11-15 Russinsky Ltd Pyridine Building Blocks
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
GB9921578D0 (en) * 1999-09-13 1999-11-17 Cipla Limited Omeprazole synthesis
ES2171116B1 (es) * 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
WO2003097606A1 (fr) * 2000-07-28 2003-11-27 Herbex, Produtos Químicos, Sa Nouveau procede de preparation des composes antiulcereux omeprazole, lansoprazole et pantoprazole
PT1387842E (pt) 2001-05-11 2009-07-20 Tibotec Pharm Ltd 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv
CA2472103A1 (fr) * 2002-01-25 2003-08-07 Santarus, Inc. Administration par voie muqueuse d'inhibiteurs de la pompe a protons
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CN100376574C (zh) * 2006-06-14 2008-03-26 浙江大学 泰妥拉唑的制备方法
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
CN101648912B (zh) * 2009-09-14 2012-07-04 南京第一农药集团有限公司 一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN102603620B (zh) * 2012-01-13 2014-10-29 江苏中邦制药有限公司 一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法
CN112142653B (zh) * 2020-10-22 2022-02-11 成都百泉生物医药科技有限公司 奥美拉唑中间体的制备方法
CN113307773A (zh) * 2021-06-17 2021-08-27 上海毕得医药科技股份有限公司 6-溴-3-甲氧基-1-苯基-1h-吲唑及其合成方法和应用
CN114805193B (zh) * 2022-04-19 2023-06-20 南京红太阳医药研究院有限公司 一种奥美拉唑中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2735851A (en) * 1956-02-21 Alkanolpykroine-n-oxides
US2663711A (en) * 1951-12-08 1953-12-22 Du Pont Process for the preparation of pyridine alcohols from pyridine n-oxides
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
JPS58135881A (ja) * 1981-11-05 1983-08-12 ビク−グルデン・ロムベルク・ヘミツシエ・フアブリク・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング 置換ベンズイミダゾ−ル類、その製造方法と利用、およびこれを含む医薬

Also Published As

Publication number Publication date
NO164093C (no) 1990-08-29
ATE40884T1 (de) 1989-03-15
OA07498A (en) 1985-03-31
DE103553T1 (de) 1984-09-27
NO832794L (no) 1984-02-27
NO164093B (no) 1990-05-21
GB2126226B (en) 1985-09-18
CA1234118A (fr) 1988-03-15
US4620008A (en) 1986-10-28
HU189738B (en) 1986-07-28
JPS6353987B2 (fr) 1988-10-26
FI833047A (fi) 1984-02-27
AU560028B2 (en) 1987-03-26
IS1438B6 (is) 1990-09-25
IS2845A7 (is) 1984-02-27
CY1328A (en) 1986-06-27
IE55865B1 (en) 1991-01-30
PT77249B (en) 1986-07-14
US4544750A (en) 1985-10-01
NZ204959A (en) 1985-12-13
HK19486A (en) 1986-03-27
DK381583D0 (da) 1983-08-19
FI79701C (fi) 1990-02-12
FI79701B (fi) 1989-10-31
EP0103553A1 (fr) 1984-03-21
GR79374B (fr) 1984-10-22
ES8404993A1 (es) 1984-05-16
JPS5959662A (ja) 1984-04-05
EP0103553B1 (fr) 1989-02-22
SE8204879D0 (sv) 1982-08-26
ZA835143B (en) 1984-04-25
GB8322866D0 (en) 1983-09-28
DD233126A5 (de) 1986-02-19
IE831787L (en) 1984-02-26
PH17786A (en) 1984-12-13
DE3379222D1 (en) 1989-03-30
KR880000091B1 (ko) 1988-02-23
DK381583A (da) 1984-02-27
KR840005718A (ko) 1984-11-15
FI833047A0 (fi) 1983-08-25
AU1710183A (en) 1984-03-01
MY8600503A (en) 1986-12-31
IL69175A0 (en) 1983-11-30
ES525122A0 (es) 1984-05-16
PT77249A (en) 1983-09-01
GB2126226A (en) 1984-03-21

Similar Documents

Publication Publication Date Title
IL69175A (en) 3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives
FI853625L (fi) Tetralinderivat, deras framstaellning och anvaendning.
FI812635L (fi) Piperidylidenderivat deras framstaellning och dessa innehaollande farmaceutiska blandningar
BG41821A3 (en) Method for preparing pyridyl derivatives
PT75074A (en) Process for preparing cestain pyrimidone derivatives and composition containing their
EG17287A (en) Process for preparing of tricyclic oxindole antiinflammatory agents
GR1002384B (el) Μεθοδος παρασκευης παραγωγων υποκατεστημενου στυρολιου.
ES8604520A1 (es) Procedimiento para preparar derivados de 2(1h)-piridona
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
CA1268468C (fr) Analogues des prostaglandines avec groupement thiabicycloheptane substitue
JPS5795966A (en) Novel 2(1h)-quinazolinone derivative
ES8506301A1 (es) Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas
MY103521A (en) Bicyclocatechol derivatives
ES8203380A1 (es) Un procedimiento de preparacion de 4-(1-piperazinil)-fu- ro(3,2-c)piridinas
JPS5283532A (en) Novel aromatic compounds
CS902588A2 (en) Method of 2-aminotetrahydroisoquinoline derivatives production
PT84061A (en) Process for the preparation of monosulfactams

Legal Events

Date Code Title Description
KB Patent renewed
EXP Patent expired