KR20170066628A - Ror-감마의 디히드로피롤로피리딘 억제제 - Google Patents
Ror-감마의 디히드로피롤로피리딘 억제제 Download PDFInfo
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- KR20170066628A KR20170066628A KR1020177012650A KR20177012650A KR20170066628A KR 20170066628 A KR20170066628 A KR 20170066628A KR 1020177012650 A KR1020177012650 A KR 1020177012650A KR 20177012650 A KR20177012650 A KR 20177012650A KR 20170066628 A KR20170066628 A KR 20170066628A
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- 0 *CN(Cc1c2)C(*)c1ncc2C(NC(*)(*)C(*)O)=O Chemical compound *CN(Cc1c2)C(*)c1ncc2C(NC(*)(*)C(*)O)=O 0.000 description 1
- QBKWZYVJKOMWIW-BJKOFHAPSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(CC(F)(F)F)[C@@H]3Cc4ccccc4)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(CC(F)(F)F)[C@@H]3Cc4ccccc4)c3nc2)=O)cc1)(=O)=O QBKWZYVJKOMWIW-BJKOFHAPSA-N 0.000 description 1
- SDRZCTCQNVFEEV-AWBNTJMESA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(CC(F)(F)F)[C@H]3Cc4ccc(CCS(c5ccc([C@H](CO)NC(c6cc(CN(C[C@@H](CC7)OC[C@@H]7C(F)(F)F)[C@H]7C(C)C)c7nc6)=O)cc5)(=O)=O)cc4)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(CC(F)(F)F)[C@H]3Cc4ccc(CCS(c5ccc([C@H](CO)NC(c6cc(CN(C[C@@H](CC7)OC[C@@H]7C(F)(F)F)[C@H]7C(C)C)c7nc6)=O)cc5)(=O)=O)cc4)c3nc2)=O)cc1)(=O)=O SDRZCTCQNVFEEV-AWBNTJMESA-N 0.000 description 1
- QVDGHCSMKMJNNS-VAJMTYMLSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@@H](CC3)OC[C@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@@H](CC3)OC[C@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O QVDGHCSMKMJNNS-VAJMTYMLSA-N 0.000 description 1
- ZXVZCOMEQJNJTR-VQONDCLZSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@@H]3CO)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@@H]3CO)c3nc2)=O)cc1)(=O)=O ZXVZCOMEQJNJTR-VQONDCLZSA-N 0.000 description 1
- ZXVZCOMEQJNJTR-OXMFBNLJSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@H]3CO)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@H]3CO)c3nc2)=O)cc1)(=O)=O ZXVZCOMEQJNJTR-OXMFBNLJSA-N 0.000 description 1
- HAKPHDIDDRHSLW-DMGDPNCRSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@H]3COC)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)CC[C@@H]3C(F)(F)F)[C@H]3COC)c3nc2)=O)cc1)(=O)=O HAKPHDIDDRHSLW-DMGDPNCRSA-N 0.000 description 1
- QVDGHCSMKMJNNS-MXRVMPPXSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)OC[C@@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)OC[C@@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O QVDGHCSMKMJNNS-MXRVMPPXSA-N 0.000 description 1
- QVDGHCSMKMJNNS-AAXIEHDTSA-N CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)OC[C@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O Chemical compound CCS(c1ccc([C@H](CO)NC(c2cc(CN(C[C@H](CC3)OC[C@H]3C(F)(F)F)[C@H]3C(C)C)c3nc2)=O)cc1)(=O)=O QVDGHCSMKMJNNS-AAXIEHDTSA-N 0.000 description 1
- LVKGENXUCJIVHC-CQOCVSQPSA-N CC[C@@H]1N(C[C@H](CC2)CC[C@@H]2C(F)(F)F)Cc2c1ncc(C(N[C@@H](CO)c(nc1)ccc1S(C)(=O)=O)=O)c2 Chemical compound CC[C@@H]1N(C[C@H](CC2)CC[C@@H]2C(F)(F)F)Cc2c1ncc(C(N[C@@H](CO)c(nc1)ccc1S(C)(=O)=O)=O)c2 LVKGENXUCJIVHC-CQOCVSQPSA-N 0.000 description 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462063912P | 2014-10-14 | 2014-10-14 | |
| US62/063,912 | 2014-10-14 | ||
| US201462074406P | 2014-11-03 | 2014-11-03 | |
| US62/074,406 | 2014-11-03 | ||
| PCT/US2015/055420 WO2016061160A1 (en) | 2014-10-14 | 2015-10-14 | Dihydropyrrolopyridine inhibitors of ror-gamma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20170066628A true KR20170066628A (ko) | 2017-06-14 |
Family
ID=54352515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177012650A Withdrawn KR20170066628A (ko) | 2014-10-14 | 2015-10-14 | Ror-감마의 디히드로피롤로피리딘 억제제 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US9796710B2 (https=) |
| EP (1) | EP3207043B3 (https=) |
| JP (1) | JP6564029B2 (https=) |
| KR (1) | KR20170066628A (https=) |
| CN (1) | CN107074852B (https=) |
| AU (1) | AU2015333610B2 (https=) |
| BR (1) | BR112017007460A2 (https=) |
| CA (1) | CA2963140A1 (https=) |
| CL (1) | CL2017000902A1 (https=) |
| CO (1) | CO2017004525A2 (https=) |
| CY (1) | CY1121413T1 (https=) |
| DK (1) | DK3207043T6 (https=) |
| EA (1) | EA031967B1 (https=) |
| EC (1) | ECSP17029371A (https=) |
| ES (1) | ES2715458T7 (https=) |
| HU (1) | HUE042335T2 (https=) |
| IL (1) | IL251584B (https=) |
| MX (1) | MX371304B (https=) |
| MY (1) | MY182454A (https=) |
| PH (1) | PH12017500583B1 (https=) |
| PL (1) | PL3207043T6 (https=) |
| PT (1) | PT3207043T (https=) |
| SG (1) | SG11201702362SA (https=) |
| SI (1) | SI3207043T1 (https=) |
| TW (1) | TWI675032B (https=) |
| UA (1) | UA118989C2 (https=) |
| WO (1) | WO2016061160A1 (https=) |
| ZA (1) | ZA201702237B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3927329A4 (en) * | 2019-02-20 | 2022-11-23 | The Regents of the University of California | TREATMENT OF RETINIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR-Y(RORY)-DEPENDENT CANCER |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3927329A4 (en) * | 2019-02-20 | 2022-11-23 | The Regents of the University of California | TREATMENT OF RETINIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR-Y(RORY)-DEPENDENT CANCER |
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