KR102921163B1 - 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 - Google Patents

다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진

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KR102921163B1
KR102921163B1 KR1020237037794A KR20237037794A KR102921163B1 KR 102921163 B1 KR102921163 B1 KR 102921163B1 KR 1020237037794 A KR1020237037794 A KR 1020237037794A KR 20237037794 A KR20237037794 A KR 20237037794A KR 102921163 B1 KR102921163 B1 KR 102921163B1
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cycloalkyl
heterocycle
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KR20230156174A (ko
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아수토시 조갈레카르
월터 원
엘리나 에스. 콜턴
아드리안 길
케빈 멜렘
나잉 아아이
안드레아스 버클
크리스토퍼 셈코
거트 키스
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레볼루션 메디슨즈, 인크.
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D477/26—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 4
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Pyridine Compounds (AREA)
KR1020237037794A 2016-07-12 2017-07-11 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진 Active KR102921163B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662361249P 2016-07-12 2016-07-12
US62/361,249 2016-07-12
US201762449523P 2017-01-23 2017-01-23
US62/449,523 2017-01-23
PCT/US2017/041577 WO2018013597A1 (en) 2016-07-12 2017-07-11 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
KR1020197004088A KR102598895B1 (ko) 2016-07-12 2017-07-11 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진

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KR20230156174A KR20230156174A (ko) 2023-11-13
KR102921163B1 true KR102921163B1 (ko) 2026-02-03

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KR1020197004088A Active KR102598895B1 (ko) 2016-07-12 2017-07-11 다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진

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US (3) US10590090B2 (enExample)
EP (2) EP4302834A3 (enExample)
JP (3) JP6916279B2 (enExample)
KR (2) KR102921163B1 (enExample)
CN (3) CN116478131A (enExample)
AU (3) AU2017296289A1 (enExample)
CA (1) CA3030167A1 (enExample)
CL (1) CL2019000090A1 (enExample)
CO (1) CO2019000613A2 (enExample)
CR (1) CR20190063A (enExample)
DO (1) DOP2019000005A (enExample)
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