KR102819704B1 - 항바이러스제로서의 작용화된 헤테로사이클 - Google Patents

항바이러스제로서의 작용화된 헤테로사이클 Download PDF

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KR102819704B1
KR102819704B1 KR1020217018258A KR20217018258A KR102819704B1 KR 102819704 B1 KR102819704 B1 KR 102819704B1 KR 1020217018258 A KR1020217018258 A KR 1020217018258A KR 20217018258 A KR20217018258 A KR 20217018258A KR 102819704 B1 KR102819704 B1 KR 102819704B1
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oxo
butyl
tert
pyrido
pyrazine
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KR20210093951A (ko
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조셉 파나레세
덱스터 데이비스
사무엘 바르틀렛
캐서린 총
나다니엘 켄톤
야트 썬 오어
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이난타 파마슈티칼스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217018258A 2018-11-21 2019-11-20 항바이러스제로서의 작용화된 헤테로사이클 Active KR102819704B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862770428P 2018-11-21 2018-11-21
US62/770,428 2018-11-21
US201962884486P 2019-08-08 2019-08-08
US62/884,486 2019-08-08
PCT/US2019/062372 WO2020106816A1 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Publications (2)

Publication Number Publication Date
KR20210093951A KR20210093951A (ko) 2021-07-28
KR102819704B1 true KR102819704B1 (ko) 2025-06-11

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KR1020217018258A Active KR102819704B1 (ko) 2018-11-21 2019-11-20 항바이러스제로서의 작용화된 헤테로사이클

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US (3) US11198693B2 (https=)
EP (1) EP3883570A4 (https=)
JP (1) JP7536761B2 (https=)
KR (1) KR102819704B1 (https=)
CN (1) CN113271946A (https=)
AU (1) AU2019385477B2 (https=)
BR (1) BR112021009854A2 (https=)
CA (1) CA3119973A1 (https=)
CL (1) CL2021001288A1 (https=)
CO (1) CO2021008055A2 (https=)
IL (1) IL283190B2 (https=)
MX (1) MX2021005850A (https=)
PH (1) PH12021551116A1 (https=)
SG (1) SG11202105007TA (https=)
TW (1) TW202033524A (https=)
UY (1) UY38483A (https=)
WO (1) WO2020106816A1 (https=)

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KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
EP3548035A4 (en) * 2016-11-30 2020-07-22 Case Western Reserve University COMBINATIONS OF 15-PGDH INHIBITORS WITH CORCOSTEROIDS AND / OR TNF INHIBITORS AND THEIR USES
JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
EP3728266A1 (en) * 2017-12-20 2020-10-28 Novartis AG Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals
JP2022500466A (ja) 2018-09-21 2022-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としての官能化複素環
IL283190B2 (en) * 2018-11-21 2025-08-01 Enanta Pharm Inc Functionalized heterocycles as antiviral agents
KR102921276B1 (ko) 2018-11-21 2026-02-03 케이스 웨스턴 리저브 유니버시티 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
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WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021018207A1 (zh) * 2019-07-30 2021-02-04 上海挚盟医药科技有限公司 一类用于治疗和/或预防乙型肝炎病毒感染的化合物及其制备方法和应用
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4320117A4 (en) * 2021-04-04 2025-02-26 Baruch S. Blumberg Institute NOVEL HEPATOSELECTIVE INHIBITORS OF POLYADENYLATION POLYMERASE AND METHOD OF USE THEREOF
WO2023230249A1 (en) * 2022-05-25 2023-11-30 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

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CN108530449A (zh) * 2017-05-22 2018-09-14 河南春风医药科技有限公司 用于治疗或预防乙型肝炎病毒感染的化合物及其制备方法与应用

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