BR112021009854A2 - heterociclos funcionalizados como agentes antivirais - Google Patents

heterociclos funcionalizados como agentes antivirais Download PDF

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Publication number
BR112021009854A2
BR112021009854A2 BR112021009854-2A BR112021009854A BR112021009854A2 BR 112021009854 A2 BR112021009854 A2 BR 112021009854A2 BR 112021009854 A BR112021009854 A BR 112021009854A BR 112021009854 A2 BR112021009854 A2 BR 112021009854A2
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BR
Brazil
Prior art keywords
optionally substituted
acid
oxo
butyl
tert
Prior art date
Application number
BR112021009854-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Joseph Panarese
Dexter Davis
Samuel Bartlett
Katherine Chong
Nathaniel Kenton
Yat Sun Or
Original Assignee
Enanta Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharmaceuticals, Inc. filed Critical Enanta Pharmaceuticals, Inc.
Publication of BR112021009854A2 publication Critical patent/BR112021009854A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112021009854-2A 2018-11-21 2019-11-20 heterociclos funcionalizados como agentes antivirais BR112021009854A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862770428P 2018-11-21 2018-11-21
US62/770,428 2018-11-21
US201962884486P 2019-08-08 2019-08-08
US62/884,486 2019-08-08
PCT/US2019/062372 WO2020106816A1 (en) 2018-11-21 2019-11-20 Functionalized heterocycles as antiviral agents

Publications (1)

Publication Number Publication Date
BR112021009854A2 true BR112021009854A2 (pt) 2021-08-17

Family

ID=70770590

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021009854-2A BR112021009854A2 (pt) 2018-11-21 2019-11-20 heterociclos funcionalizados como agentes antivirais

Country Status (17)

Country Link
US (3) US11198693B2 (https=)
EP (1) EP3883570A4 (https=)
JP (1) JP7536761B2 (https=)
KR (1) KR102819704B1 (https=)
CN (1) CN113271946A (https=)
AU (1) AU2019385477B2 (https=)
BR (1) BR112021009854A2 (https=)
CA (1) CA3119973A1 (https=)
CL (1) CL2021001288A1 (https=)
CO (1) CO2021008055A2 (https=)
IL (1) IL283190B2 (https=)
MX (1) MX2021005850A (https=)
PH (1) PH12021551116A1 (https=)
SG (1) SG11202105007TA (https=)
TW (1) TW202033524A (https=)
UY (1) UY38483A (https=)
WO (1) WO2020106816A1 (https=)

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JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
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EP3728266A1 (en) * 2017-12-20 2020-10-28 Novartis AG Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals
JP2022500466A (ja) 2018-09-21 2022-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としての官能化複素環
IL283190B2 (en) * 2018-11-21 2025-08-01 Enanta Pharm Inc Functionalized heterocycles as antiviral agents
KR102921276B1 (ko) 2018-11-21 2026-02-03 케이스 웨스턴 리저브 유니버시티 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법
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WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021018207A1 (zh) * 2019-07-30 2021-02-04 上海挚盟医药科技有限公司 一类用于治疗和/或预防乙型肝炎病毒感染的化合物及其制备方法和应用
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4320117A4 (en) * 2021-04-04 2025-02-26 Baruch S. Blumberg Institute NOVEL HEPATOSELECTIVE INHIBITORS OF POLYADENYLATION POLYMERASE AND METHOD OF USE THEREOF
WO2023230249A1 (en) * 2022-05-25 2023-11-30 Baruch S. Blumberg Institute Novel hepatoselective polyadenylating polymerases inhibitors and their method of use

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