KR101279677B1 - 사이토메갈로바이러스 인핸서 및 닭 β­액틴 프로모터를 포함하는 하이브리드 프로모터를 이용한 마이너스 가닥 ＲＮＡ 바이러스 벡터의 제조방법 - Google Patents

사이토메갈로바이러스 인핸서 및 닭 β­액틴 프로모터를 포함하는 하이브리드 프로모터를 이용한 마이너스 가닥 ＲＮＡ 바이러스 벡터의 제조방법 Download PDF

Info

Publication number
KR101279677B1
KR101279677B1 KR1020067016708A KR20067016708A KR101279677B1 KR 101279677 B1 KR101279677 B1 KR 101279677B1 KR 1020067016708 A KR1020067016708 A KR 1020067016708A KR 20067016708 A KR20067016708 A KR 20067016708A KR 101279677 B1 KR101279677 B1 KR 101279677B1
Authority
KR
South Korea
Prior art keywords
virus
dna
rna
promoter
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020067016708A
Other languages
English (en)
Korean (ko)
Other versions
KR20070004636A (ko
Inventor
아키히로 이이다
히로시 반
마코토 이노우에
다카히로 히라타
마모루 하세가와
Original Assignee
가부시키가이샤 디나벡크 겐큐쇼
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가부시키가이샤 디나벡크 겐큐쇼 filed Critical 가부시키가이샤 디나벡크 겐큐쇼
Publication of KR20070004636A publication Critical patent/KR20070004636A/ko
Application granted granted Critical
Publication of KR101279677B1 publication Critical patent/KR101279677B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
KR1020067016708A 2004-01-22 2005-01-20 사이토메갈로바이러스 인핸서 및 닭 β­액틴 프로모터를 포함하는 하이브리드 프로모터를 이용한 마이너스 가닥 ＲＮＡ 바이러스 벡터의 제조방법 Expired - Fee Related KR101279677B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2004-00014653 2004-01-22
JP2004014653 2004-01-22
PCT/JP2005/000705 WO2005071092A1 (ja) 2004-01-22 2005-01-20 サイトメガロウイルスエンハンサーおよびニワトリβ-アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法

Publications (2)

Publication Number Publication Date
KR20070004636A KR20070004636A (ko) 2007-01-09
KR101279677B1 true KR101279677B1 (ko) 2013-06-27

Family

ID=34805423

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067016708A Expired - Fee Related KR101279677B1 (ko) 2004-01-22 2005-01-20 사이토메갈로바이러스 인핸서 및 닭 β­액틴 프로모터를 포함하는 하이브리드 프로모터를 이용한 마이너스 가닥 ＲＮＡ 바이러스 벡터의 제조방법

Country Status (8)

Country Link
US (1) US8741650B2 (enExample)
EP (2) EP2434020B1 (enExample)
JP (2) JP4999330B2 (enExample)
KR (1) KR101279677B1 (enExample)
CN (1) CN1934260B (enExample)
AU (1) AU2005206410A1 (enExample)
CA (1) CA2553976C (enExample)
WO (1) WO2005071092A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7335296A (en) * 1995-11-01 1997-05-22 Dnavec Research Inc. Recombinant sendai virus
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
CN1665932B (zh) * 2002-04-30 2010-12-15 株式会社载体研究所 具有修饰的蛋白酶依赖向性的载体
JPWO2005042737A1 (ja) * 2003-11-04 2007-05-10 株式会社ディナベック研究所 遺伝子導入された樹状細胞の製造方法
CA2571849A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing dendritic cell having rna virus transferred thereinto
KR20080016955A (ko) * 2005-06-14 2008-02-22 디나벡크 가부시키가이샤 항체의 제작방법
KR20080094910A (ko) * 2006-01-17 2008-10-27 디나벡크 가부시키가이샤 신규 단백질 발현계
JPWO2007139178A1 (ja) 2006-05-31 2009-10-15 ディナベック株式会社 アルツハイマー病治療薬
JPWO2008007581A1 (ja) 2006-07-13 2009-12-10 ディナベック株式会社 非複製型パラミクソウイルス科ウイルスベクター
KR100725023B1 (ko) * 2006-10-16 2007-06-07 제일모직주식회사 카도계 수지를 함유한 수지 조성물 및 그에 의한 패턴의 제조방법, 이를 이용한 컬러필터
CN101646768A (zh) 2007-02-07 2010-02-10 生物载体株式会社 减毒负链rna病毒
JPWO2008136438A1 (ja) 2007-04-27 2010-07-29 国立大学法人九州大学 遺伝子治療用ウイルスベクター
DK2322611T3 (en) 2008-07-16 2016-09-05 Ip Pharma Co Ltd A process for producing reprogrammed cells using chromosomally non-integrated viral vector
US8663981B2 (en) 2008-08-07 2014-03-04 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Optimized promoter sequence
US20120088819A1 (en) 2008-10-31 2012-04-12 Makoto Inoue Method for enhancing expression of recombinant protein
CN103189508B (zh) 2010-08-30 2016-08-10 生物载体株式会社 用于诱导多能性干细胞的组合物及其用途
CN102436142B (zh) 2010-09-29 2013-11-06 第一毛织株式会社 黑色光敏树脂组合物以及使用其的光阻层
KR101367253B1 (ko) 2010-10-13 2014-03-13 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101038126B1 (ko) 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
CN102028943A (zh) * 2010-12-08 2011-04-27 中国人民解放军军事医学科学院微生物流行病研究所 一种呼吸道合胞病毒样颗粒疫苗及其制备方法
KR101486560B1 (ko) 2010-12-10 2015-01-27 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101453769B1 (ko) 2010-12-24 2014-10-22 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 컬러 필터
CN103443640B (zh) 2011-04-07 2015-10-14 惠普发展公司，有限责任合伙企业 用于确定功率相和/或相位旋转的系统和方法
KR101344786B1 (ko) 2011-12-02 2013-12-26 제일모직주식회사 컬러필터용 감광성 수지 조성물 및 이를 이용한　컬러필터
FR2986536A1 (fr) * 2012-02-08 2013-08-09 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (cho)
DK2711426T3 (en) 2012-09-24 2015-07-13 Lonza Biologics Plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
KR20140076320A (ko) 2012-12-12 2014-06-20 제일모직주식회사 감광성 수지 조성물 및 이를 이용한 블랙 스페이서
US9828609B2 (en) 2013-03-12 2017-11-28 International Park Of Creativity Biological devices and methods for increasing the production of lycopene from plants
AU2014324233B2 (en) 2013-09-24 2020-07-23 Id Pharma Co., Ltd. Method for improving efficiency of inducing pluripotent stem cell
ES2760263T3 (es) * 2014-03-21 2020-05-13 Genzyme Corp Tratamiento génico de la retinitis pigmentaria
CN104404005A (zh) * 2014-12-22 2015-03-11 天津瑞普生物技术股份有限公司 禽流感病毒ha基因重组腺病毒的制备方法
EP3542818A4 (en) 2016-11-17 2020-07-29 Japan as Represented by The Director-General of National Institute of Infectious Diseases VACCINE AGAINST INFECTIOUS DISEASES USING NON-INFECTIOUS PARAMYXOVIRUS PARTICLES
CN110892062A (zh) 2017-05-05 2020-03-17 佛罗里达大学研究基金会 表达耳畸蛋白的组合物和方法
US12215334B2 (en) 2017-07-21 2025-02-04 I'rom Group Co., Ltd. Polynucleotide for modifying target sequence and use thereof
KR20200042904A (ko) 2017-07-26 2020-04-24 온코루스, 인크. 종양용해성 바이러스 벡터 및 그의 용도
CN112135908A (zh) 2018-01-22 2020-12-25 国立传染病研究所长代表日本国 选择性cd8阳性t细胞诱导疫苗抗原
WO2020093018A1 (en) 2018-11-01 2020-05-07 University Of Florida Research Foundation, Incorporated A codon optimized otoferlin aav dual vector gene therapy
WO2020163743A1 (en) 2019-02-08 2020-08-13 Decibel Therapeutics, Inc. Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems
CN109929847B (zh) * 2019-02-27 2023-08-15 苏州系统医学研究所 一种pex26基因、蛋白及其应用
JP7517704B2 (ja) * 2019-06-21 2024-07-17 国立大学法人大阪大学 外来遺伝子を安定的に保持する人工組換えｒｎａウイルスの作製方法
KR20220078650A (ko) * 2019-10-10 2022-06-10 온코루스, 인크. 이중 바이러스 및 이중 종양용해 바이러스 및 치료 방법
CN115666658A (zh) 2020-04-01 2023-01-31 佛罗里达州大学研究基金会 具有提高的治疗ush1b的安全性的双aav-myo7a载体
EP4209593A4 (en) 2020-09-04 2024-10-09 Heartseed Inc. IPS CELL QUALITY IMPROVING AGENT, METHOD FOR PRODUCING IPS CELLS, IPS CELLS, AND COMPOSITION FOR PRODUCING IPS CELLS
CN116802275A (zh) 2020-12-25 2023-09-22 国立大学法人京都大学 从体细胞制备幼稚型人iPS细胞的方法
CA3225564A1 (en) 2021-06-30 2023-01-05 Repli-Tech Co., Ltd. Method of producing negative-strand rna virus vector and produced negative-strand rna virus vector
CN115772520B (zh) * 2021-09-08 2023-11-21 北京锦篮基因科技有限公司 用于治疗庞贝氏病的基因治疗构建体、药物组合物和方法
WO2023127871A1 (ja) 2021-12-27 2023-07-06 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム
CN117051040B (zh) * 2023-08-15 2024-10-01 北京百普赛斯生物科技股份有限公司 Vsv△g复制缺陷型病毒制备及应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU629554B2 (en) * 1988-06-24 1992-10-08 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Exogenous gene expression vector containing chick beta-actin gene promoter
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
JP2001283451A (ja) 1992-05-13 2001-10-12 Matsushita Electric Ind Co Ltd 記録方法および再生方法
JPH06230752A (ja) 1992-09-14 1994-08-19 Hitachi Ltd 表示装置の駆動方法
JPH06230753A (ja) 1993-01-29 1994-08-19 Fuji Xerox Co Ltd 画像処理装置
JPH06233879A (ja) 1993-02-08 1994-08-23 Brother Ind Ltd ロックミシンのかがり方式変換装置
US5798100A (en) 1994-07-06 1998-08-25 Immunomedics, Inc. Multi-stage cascade boosting vaccine
DK0864645T3 (da) * 1995-10-31 2005-10-24 Dnavec Research Inc Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet
AU7335296A (en) 1995-11-01 1997-05-22 Dnavec Research Inc. Recombinant sendai virus
AU1733697A (en) 1996-02-29 1997-09-16 Takara Shuzo Co., Ltd. Method of purifying and removing viruses
US6596529B1 (en) * 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
ATE401410T1 (de) 1997-11-18 2008-08-15 Pioneer Hi Bred Int Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen
ES2245112T3 (es) 1998-08-11 2005-12-16 Dnavec Research Inc. Protector virico de rna con capacidad de infiltracion por contacto.
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
ATE367445T1 (de) * 1999-05-18 2007-08-15 Dnavec Research Inc Viraler paramyxoviridae vektor mit einem defekten hüllprotein-gen
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
HK1044175B (en) 1999-05-18 2008-11-14 Dnavec Research Inc. Ribonucleoprotein complex in paramyxovirus
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
EP1067179A1 (en) 1999-07-09 2001-01-10 Pierre Fabre Medicament Method to select attenuated paramyxoviridae useful for vaccines and therapeutics
JP3748535B2 (ja) 1999-09-06 2006-02-22 株式会社ディナベック研究所 改変された転写開始配列を有するパラミクソウイルス
JP4791651B2 (ja) 2000-05-18 2011-10-12 株式会社ディナベック研究所 外来遺伝子導入用パラミクソウイルスベクター
CN1633599A (zh) 2001-09-18 2005-06-29 株式会社载体研究所 检查和制造降低了粒子形成能力的(－)链rna载体的方法
CN1665932B (zh) * 2002-04-30 2010-12-15 株式会社载体研究所 具有修饰的蛋白酶依赖向性的载体
CA2571849A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing dendritic cell having rna virus transferred thereinto
EP1891215B1 (en) * 2005-04-20 2009-10-28 Dnavec Corporation Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
JPWO2007139178A1 (ja) * 2006-05-31 2009-10-15 ディナベック株式会社 アルツハイマー病治療薬

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Frederic Iseni 등. The EMBO Journal. 2002. Vol. 21, No. 19, 페이지 5141-5150. *
Frederic Iseni 등. The EMBO Journal. 2002. Vol. 21, No. 19, 페이지 5141-5150.*
Makoto Inoue 등. JOURNAL OF VIROLOGY. 2003. Vol. 77, No. 11, 페이지 6419-6429. *
Makoto Inoue 등. JOURNAL OF VIROLOGY. 2003. Vol. 77, No. 11, 페이지 6419-6429.*

Also Published As

Publication number Publication date
EP1717317A1 (en) 2006-11-02
KR20070004636A (ko) 2007-01-09
CA2553976A1 (en) 2005-08-04
CA2553976C (en) 2013-09-24
CN1934260A (zh) 2007-03-21
US20070161110A1 (en) 2007-07-12
JPWO2005071092A1 (ja) 2007-09-06
JP5438149B2 (ja) 2014-03-12
US8741650B2 (en) 2014-06-03
EP2434020A2 (en) 2012-03-28
AU2005206410A1 (en) 2005-08-04
EP1717317A4 (en) 2009-02-11
EP2434020B1 (en) 2014-11-05
CN1934260B (zh) 2013-03-13
JP2012130346A (ja) 2012-07-12
EP2434020A3 (en) 2012-07-25
JP4999330B2 (ja) 2012-08-15
WO2005071092A1 (ja) 2005-08-04

Similar Documents

Publication Publication Date Title
KR101279677B1 (ko) 사이토메갈로바이러스 인핸서 및 닭 β­액틴 프로모터를 포함하는 하이브리드 프로모터를 이용한 마이너스 가닥 ＲＮＡ 바이러스 벡터의 제조방법
US7144579B2 (en) Paramyxoviruses comprising modified transcription start sequence
JP3602058B2 (ja) エンベロープ遺伝子欠損パラミクソ科ウイルスベクター
ES2307509T3 (es) Complejo ribonucleoproteico en paramixovirus.
US6746860B1 (en) Paramyxovirus vectors used for transfer of foreign genes
KR20050062634A (ko) Ｔ 세포에 유전자를 도입하는 방법
JPWO2000070070A1 (ja) エンベロープ遺伝子欠損パラミクソ科ウイルスベクター
KR20090052857A (ko) 비복제형 파라믹소바이러스과 바이러스 벡터
WO2002031138A1 (en) Paramyxovirus vector for transferring foreign gene into skeletal muscle
KR20070004637A (ko) 바이러스 벡터의 제조방법
KR20090114431A (ko) 약독화 마이너스 가닥 ｒｎａ 바이러스
KR20050100379A (ko) 리보자임을 코드하는 파라믹소바이러스 벡터 및 그의 이용
JP4791651B2 (ja) 外来遺伝子導入用パラミクソウイルスベクター
KR20060028432A (ko) 고변이영역이 개변된 유전자를 탑재하는 마이너스가닥 ｒｎａ 바이러스 벡터
WO2006137517A1 (ja) 幼少個体への遺伝子導入用ベクター
HK1094898A (en) Methods for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken beta-actin promoter
HK1083110A (en) Paramyxovirus vector encoding ribozyme and utilization thereof
HK1106793A (en) Anticancer agent containing minus-strand rna virus
HK1133675A (en) Non-replicating paramyxoviridae virus vector

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20160622

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20160622