AU2005206410A1 - Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter - Google Patents

Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter Download PDF

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Publication number
AU2005206410A1
AU2005206410A1 AU2005206410A AU2005206410A AU2005206410A1 AU 2005206410 A1 AU2005206410 A1 AU 2005206410A1 AU 2005206410 A AU2005206410 A AU 2005206410A AU 2005206410 A AU2005206410 A AU 2005206410A AU 2005206410 A1 AU2005206410 A1 AU 2005206410A1
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AU
Australia
Prior art keywords
rna
virus
dna
minus
cells
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Abandoned
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AU2005206410A
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English (en)
Inventor
Hiroshi Ban
Mamoru Hasegawa
Takahiro Hirata
Akihiro Iida
Makoto Inoue
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Dnavec Research Inc
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Dnavec Research Inc
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Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Publication of AU2005206410A1 publication Critical patent/AU2005206410A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
AU2005206410A 2004-01-22 2005-01-20 Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter Abandoned AU2005206410A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004014653 2004-01-22
JP2004-014653 2004-01-22
PCT/JP2005/000705 WO2005071092A1 (ja) 2004-01-22 2005-01-20 サイトメガロウイルスエンハンサーおよびニワトリβ-アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法

Publications (1)

Publication Number Publication Date
AU2005206410A1 true AU2005206410A1 (en) 2005-08-04

Family

ID=34805423

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Application Number Title Priority Date Filing Date
AU2005206410A Abandoned AU2005206410A1 (en) 2004-01-22 2005-01-20 Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter

Country Status (8)

Country Link
US (1) US8741650B2 (enExample)
EP (2) EP1717317A4 (enExample)
JP (2) JP4999330B2 (enExample)
KR (1) KR101279677B1 (enExample)
CN (1) CN1934260B (enExample)
AU (1) AU2005206410A1 (enExample)
CA (1) CA2553976C (enExample)
WO (1) WO2005071092A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
JP4448440B2 (ja) * 2002-04-30 2010-04-07 株式会社ディナベック研究所 プロテアーゼ依存性トロピズムが改変されたベクター
EP1690937B1 (en) * 2003-11-04 2012-10-17 Dnavec Research Inc. Method of constructing transgenic dendritic cell
AU2005257105A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
KR20080016955A (ko) * 2005-06-14 2008-02-22 디나벡크 가부시키가이샤 항체의 제작방법
KR20080094910A (ko) * 2006-01-17 2008-10-27 디나벡크 가부시키가이샤 신규 단백질 발현계
CA2654033A1 (en) 2006-05-31 2007-12-06 Dnavec Corporation Therapeutic agent for alzheimer's disease
JPWO2008007581A1 (ja) 2006-07-13 2009-12-10 ディナベック株式会社 非複製型パラミクソウイルス科ウイルスベクター
KR100725023B1 (ko) * 2006-10-16 2007-06-07 제일모직주식회사 카도계 수지를 함유한 수지 조성물 및 그에 의한 패턴의 제조방법, 이를 이용한 컬러필터
CA2677659A1 (en) 2007-02-07 2008-08-14 Dnavec Corporation Attenuated minus-stranded rna virus
JPWO2008136438A1 (ja) 2007-04-27 2010-07-29 国立大学法人九州大学 遺伝子治療用ウイルスベクター
CN102159710B (zh) 2008-07-16 2015-09-02 生物载体株式会社 使用染色体非整合型病毒载体制造经初始化的细胞的方法
JP5670330B2 (ja) * 2008-08-07 2015-02-18 ハー マジェスティ ザ クイーン イン ライト オブ カナダ アズ リプリゼンテド バイ ザ ミニスター オブ ヘルスＨＥＲ ＭＡＪＥＳＴＹ ＴＨＥ ＱＵＥＥＮ ＩＮ ＲＩＧＨＴＯＦ ＣＡＮＡＤＡ ａｓ ｒｅｐｒｅｓｅｎｔｅｄ ｂｙ ＴＨＥ ＭＩＮＩＳＴＥＲ ＯＦ ＨＥＡＬＴＨ 最適化したプロモーター配列
EP2363472B1 (en) 2008-10-31 2014-12-10 Dnavec Corporation Method for enhancing expression of recombinant protein
WO2012029770A1 (ja) 2010-08-30 2012-03-08 ディナベック株式会社 多能性幹細胞を誘導するための組成物およびその使用
CN102436142B (zh) 2010-09-29 2013-11-06 第一毛织株式会社 黑色光敏树脂组合物以及使用其的光阻层
KR101367253B1 (ko) 2010-10-13 2014-03-13 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101038126B1 (ko) 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
CN102028943A (zh) * 2010-12-08 2011-04-27 中国人民解放军军事医学科学院微生物流行病研究所 一种呼吸道合胞病毒样颗粒疫苗及其制备方法
KR101486560B1 (ko) 2010-12-10 2015-01-27 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101453769B1 (ko) 2010-12-24 2014-10-22 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 컬러 필터
WO2012138340A1 (en) 2011-04-07 2012-10-11 Hewlett-Packard Development Company, L.P. Systems and methods for determining a power phase and/or a phase rotation
KR101344786B1 (ko) 2011-12-02 2013-12-26 제일모직주식회사 컬러필터용 감광성 수지 조성물 및 이를 이용한　컬러필터
FR2986536A1 (fr) * 2012-02-08 2013-08-09 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (cho)
DK2711426T3 (en) 2012-09-24 2015-07-13 Lonza Biologics Plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
KR20140076320A (ko) 2012-12-12 2014-06-20 제일모직주식회사 감광성 수지 조성물 및 이를 이용한 블랙 스페이서
US9828609B2 (en) 2013-03-12 2017-11-28 International Park Of Creativity Biological devices and methods for increasing the production of lycopene from plants
US10975358B2 (en) 2013-09-24 2021-04-13 Id Pharma Co., Ltd. Method for improving efficiency of inducing pluripotent stem cell
SI3119437T1 (sl) * 2014-03-21 2020-01-31 Genzyme Corporation Genska terapija za retinitis pigmentoza
CN104404005A (zh) * 2014-12-22 2015-03-11 天津瑞普生物技术股份有限公司 禽流感病毒ha基因重组腺病毒的制备方法
CN110234347A (zh) 2016-11-17 2019-09-13 国立传染病研究所长代表日本国 使用了非感染性副粘病毒粒子的传染病疫苗
US12359221B2 (en) 2017-05-05 2025-07-15 The Regents Of The University Of California Compositions and methods for expressing otoferlin
EP3656858A4 (en) 2017-07-21 2021-04-21 I'rom Group Co., Ltd. Polynucleotide for modifying target sequence and use thereof
WO2019023483A1 (en) 2017-07-26 2019-01-31 Oncorus, Inc. ONCOLYTIC VIRAL VECTORS AND USES THEREOF
CN112135908A (zh) 2018-01-22 2020-12-25 国立传染病研究所长代表日本国 选择性cd8阳性t细胞诱导疫苗抗原
WO2020093018A1 (en) 2018-11-01 2020-05-07 University Of Florida Research Foundation, Incorporated A codon optimized otoferlin aav dual vector gene therapy
EP3921032A4 (en) 2019-02-08 2022-11-30 Decibel Therapeutics, Inc. Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems
CN109929847B (zh) * 2019-02-27 2023-08-15 苏州系统医学研究所 一种pex26基因、蛋白及其应用
JP7517704B2 (ja) * 2019-06-21 2024-07-17 国立大学法人大阪大学 外来遺伝子を安定的に保持する人工組換えｒｎａウイルスの作製方法
KR20220078650A (ko) * 2019-10-10 2022-06-10 온코루스, 인크. 이중 바이러스 및 이중 종양용해 바이러스 및 치료 방법
CA3174500A1 (en) 2020-04-01 2021-10-07 University Of Florida Research Foundation, Incorporated Dual aav-myo7a vectors with improved safety for the treatment of ush1b
JPWO2022050419A1 (enExample) 2020-09-04 2022-03-10
WO2022138964A1 (ja) 2020-12-25 2022-06-30 国立大学法人京都大学 体細胞からのナイーブ型ヒトｉＰＳ細胞製造方法
WO2023277069A1 (ja) * 2021-06-30 2023-01-05 株式会社レプリテック マイナス鎖ｒｎａウイルスベクターの製造方法および製造されたマイナス鎖ｒｎａウイルスベクター
CN117535291A (zh) * 2021-09-08 2024-02-09 北京锦篮基因科技有限公司 一种高表达活性的组成型启动子及其应用
WO2023127871A1 (ja) 2021-12-27 2023-07-06 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム
WO2024195811A1 (ja) 2023-03-22 2024-09-26 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム
CN117051040B (zh) * 2023-08-15 2024-10-01 北京百普赛斯生物科技股份有限公司 Vsv△g复制缺陷型病毒制备及应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU629554B2 (en) 1988-06-24 1992-10-08 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Exogenous gene expression vector containing chick beta-actin gene promoter
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
JP2001283451A (ja) 1992-05-13 2001-10-12 Matsushita Electric Ind Co Ltd 記録方法および再生方法
JPH06230752A (ja) 1992-09-14 1994-08-19 Hitachi Ltd 表示装置の駆動方法
JPH06230753A (ja) 1993-01-29 1994-08-19 Fuji Xerox Co Ltd 画像処理装置
JPH06233879A (ja) 1993-02-08 1994-08-23 Brother Ind Ltd ロックミシンのかがり方式変換装置
US5798100A (en) 1994-07-06 1998-08-25 Immunomedics, Inc. Multi-stage cascade boosting vaccine
ATE298789T1 (de) 1995-10-31 2005-07-15 Dnavec Research Inc Negativstrand rna virus mit selbständiger replikationsaktivität
DK0863202T3 (da) 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
JP4223550B2 (ja) 1996-02-29 2009-02-12 タカラバイオ株式会社 ウイルスの精製および除去方法
US6596529B1 (en) * 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
ES2245487T3 (es) 1997-11-18 2006-01-01 Pioneer Hi-Bred International, Inc. Composiciones y metodos para la modificacion genetica de plantas.
DK1106692T3 (da) 1998-08-11 2005-10-17 Dnavec Research Inc RNA-virusvektor med kontaktinfiltrationsevne
US7226786B2 (en) 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030166252A1 (en) 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
CA2368948C (en) 1999-05-18 2013-12-24 Dnavec Research Inc. Envelope gene-deficient virus vector of paramyxoviridae
HK1044175B (en) 1999-05-18 2008-11-14 Dnavec Research Inc. Ribonucleoprotein complex in paramyxovirus
US20030022376A1 (en) 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20020169306A1 (en) 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
WO2003025570A1 (fr) 2001-09-18 2003-03-27 Dnavec Research Inc. Methode permettant d'examiner un vecteur de virus a arn a brin negatif
EP1067179A1 (en) 1999-07-09 2001-01-10 Pierre Fabre Medicament Method to select attenuated paramyxoviridae useful for vaccines and therapeutics
CA2376106A1 (en) 1999-09-06 2001-03-15 Dnavec Research Inc. Paramyxoviruses comprising modified transcription start sequence
JP4791651B2 (ja) 2000-05-18 2011-10-12 株式会社ディナベック研究所 外来遺伝子導入用パラミクソウイルスベクター
JP4448440B2 (ja) 2002-04-30 2010-04-07 株式会社ディナベック研究所 プロテアーゼ依存性トロピズムが改変されたベクター
AU2005257105A1 (en) 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand RNA virus
CA2605957A1 (en) 2005-04-20 2006-10-26 Dnavec Corporation Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
CA2654033A1 (en) 2006-05-31 2007-12-06 Dnavec Corporation Therapeutic agent for alzheimer's disease

Also Published As

Publication number Publication date
KR101279677B1 (ko) 2013-06-27
EP1717317A4 (en) 2009-02-11
EP2434020B1 (en) 2014-11-05
CA2553976C (en) 2013-09-24
CN1934260A (zh) 2007-03-21
EP2434020A3 (en) 2012-07-25
WO2005071092A1 (ja) 2005-08-04
US20070161110A1 (en) 2007-07-12
US8741650B2 (en) 2014-06-03
JP4999330B2 (ja) 2012-08-15
KR20070004636A (ko) 2007-01-09
JP5438149B2 (ja) 2014-03-12
JP2012130346A (ja) 2012-07-12
EP2434020A2 (en) 2012-03-28
CN1934260B (zh) 2013-03-13
EP1717317A1 (en) 2006-11-02
CA2553976A1 (en) 2005-08-04
JPWO2005071092A1 (ja) 2007-09-06

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