CN1934260B - 利用含有巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子制造负链RNA病毒载体的方法 - Google Patents

利用含有巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子制造负链RNA病毒载体的方法 Download PDF

Info

Publication number
CN1934260B
CN1934260B CN2005800091828A CN200580009182A CN1934260B CN 1934260 B CN1934260 B CN 1934260B CN 2005800091828 A CN2005800091828 A CN 2005800091828A CN 200580009182 A CN200580009182 A CN 200580009182A CN 1934260 B CN1934260 B CN 1934260B
Authority
CN
China
Prior art keywords
virus
rna
dna
cells
minus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN2005800091828A
Other languages
English (en)
Chinese (zh)
Other versions
CN1934260A (zh
Inventor
饭田章博
伴浩志
井上诚
平田隆洋
长谷川护
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ID Pharma Co Ltd
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Publication of CN1934260A publication Critical patent/CN1934260A/zh
Application granted granted Critical
Publication of CN1934260B publication Critical patent/CN1934260B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN2005800091828A 2004-01-22 2005-01-20 利用含有巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子制造负链RNA病毒载体的方法 Expired - Lifetime CN1934260B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004014653 2004-01-22
JP014653/2004 2004-01-22
PCT/JP2005/000705 WO2005071092A1 (ja) 2004-01-22 2005-01-20 サイトメガロウイルスエンハンサーおよびニワトリβ-アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖RNAウイルスベクターの製造方法

Publications (2)

Publication Number Publication Date
CN1934260A CN1934260A (zh) 2007-03-21
CN1934260B true CN1934260B (zh) 2013-03-13

Family

ID=34805423

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800091828A Expired - Lifetime CN1934260B (zh) 2004-01-22 2005-01-20 利用含有巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子制造负链RNA病毒载体的方法

Country Status (8)

Country Link
US (1) US8741650B2 (enExample)
EP (2) EP2434020B1 (enExample)
JP (2) JP4999330B2 (enExample)
KR (1) KR101279677B1 (enExample)
CN (1) CN1934260B (enExample)
AU (1) AU2005206410A1 (enExample)
CA (1) CA2553976C (enExample)
WO (1) WO2005071092A1 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1143892C (zh) * 1995-11-01 2004-03-31 株式会社载体研究所 重组仙台病毒
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
JP4448440B2 (ja) * 2002-04-30 2010-04-07 株式会社ディナベック研究所 プロテアーゼ依存性トロピズムが改変されたベクター
CN1902312B (zh) * 2003-11-04 2011-02-23 株式会社载体研究所 制备导入了基因的树突细胞的方法
CA2571844A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand rna virus
JP4969444B2 (ja) 2005-06-14 2012-07-04 ディナベック株式会社 抗体の作製方法
EP1983048A4 (en) * 2006-01-17 2009-04-22 Dnavec Corp NEW PROTEIN EXPRESSION SYSTEM
KR20090027693A (ko) 2006-05-31 2009-03-17 디나벡크 가부시키가이샤 알츠하이머병 치료제
EP2048232A4 (en) 2006-07-13 2010-10-13 Dnavec Corp NON-REPLICATIVE PARAMYXOVIRIDAE VIRUS VECTOR
KR100725023B1 (ko) * 2006-10-16 2007-06-07 제일모직주식회사 카도계 수지를 함유한 수지 조성물 및 그에 의한 패턴의 제조방법, 이를 이용한 컬러필터
US20100323428A1 (en) 2007-02-07 2010-12-23 Dnavec Corporation Attenuated minus-stranded rna virus
US20100203027A1 (en) 2007-04-27 2010-08-12 Kyushu Univeristy National University Viral vector for gene therapy
CN102159710B (zh) 2008-07-16 2015-09-02 生物载体株式会社 使用染色体非整合型病毒载体制造经初始化的细胞的方法
NZ591439A (en) * 2008-08-07 2012-10-26 Ca Minister Health & Welfare pCAGGS VECTOR COMPRISING AN 829 BASE PAIR DELETION IN THE CHICKEN-BETA ACTIN INTRON WHICH RESULTS IN ENHANCED EXPRESSION OF A GENE OF INTEREST
JPWO2010050586A1 (ja) 2008-10-31 2012-03-29 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
JP5908838B2 (ja) 2010-08-30 2016-04-26 株式会社Ｉｄファーマ 多能性幹細胞を誘導するための組成物およびその使用
CN102436142B (zh) 2010-09-29 2013-11-06 第一毛织株式会社 黑色光敏树脂组合物以及使用其的光阻层
KR101367253B1 (ko) 2010-10-13 2014-03-13 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101038126B1 (ko) 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
CN102028943A (zh) * 2010-12-08 2011-04-27 中国人民解放军军事医学科学院微生物流行病研究所 一种呼吸道合胞病毒样颗粒疫苗及其制备方法
KR101486560B1 (ko) 2010-12-10 2015-01-27 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 차광층
KR101453769B1 (ko) 2010-12-24 2014-10-22 제일모직 주식회사 감광성 수지 조성물 및 이를 이용한 컬러 필터
WO2012138340A1 (en) 2011-04-07 2012-10-11 Hewlett-Packard Development Company, L.P. Systems and methods for determining a power phase and/or a phase rotation
KR101344786B1 (ko) 2011-12-02 2013-12-26 제일모직주식회사 컬러필터용 감광성 수지 조성물 및 이를 이용한　컬러필터
FR2986536A1 (fr) * 2012-02-08 2013-08-09 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (cho)
EP2711426B1 (en) 2012-09-24 2015-04-08 Lonza Biologics plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
KR20140076320A (ko) 2012-12-12 2014-06-20 제일모직주식회사 감광성 수지 조성물 및 이를 이용한 블랙 스페이서
US9828609B2 (en) 2013-03-12 2017-11-28 International Park Of Creativity Biological devices and methods for increasing the production of lycopene from plants
CN105916980B (zh) 2013-09-24 2025-09-16 株式会社爱迪药业 用于改进诱导多能干细胞的效率的方法
DK3628334T5 (da) 2014-03-21 2024-09-02 Genzyme Corp Genterapi til behandling af retinitis pigmentosa
CN104404005A (zh) * 2014-12-22 2015-03-11 天津瑞普生物技术股份有限公司 禽流感病毒ha基因重组腺病毒的制备方法
WO2018092887A1 (ja) 2016-11-17 2018-05-24 国立感染症研究所長が代表する日本国 非感染性パラミクソウイルス粒子を用いた感染症ワクチン
JP7240675B2 (ja) 2017-05-05 2023-03-16 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． オトフェルリンを発現させるための組成物および方法
CN111479920B (zh) 2017-07-21 2025-08-01 株式会社爱医隆集团 用于修饰靶序列的多核苷酸及其用途
RU2771110C2 (ru) 2017-07-26 2022-04-26 Онкорус, Инк. Онколитические вирусные векторы и их применение
EP3744847A4 (en) 2018-01-22 2021-12-08 Japan as Represented by The Director-General of National Institute of Infectious Diseases SELECTIVE CD8 POSITIVE T CELL INDUCING VACCINE ANTIGEN
WO2020093018A1 (en) 2018-11-01 2020-05-07 University Of Florida Research Foundation, Incorporated A codon optimized otoferlin aav dual vector gene therapy
EP3921032A4 (en) 2019-02-08 2022-11-30 Decibel Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS
CN109929847B (zh) * 2019-02-27 2023-08-15 苏州系统医学研究所 一种pex26基因、蛋白及其应用
EP3988650A4 (en) * 2019-06-21 2022-09-21 Osaka University METHOD OF PRODUCING AN ARTIFICIAL RECOMBINANT RNA VIRUS THAT KEEPS A FOREIGN GENE STABLE
EP4041902A1 (en) * 2019-10-10 2022-08-17 Oncorus, Inc. Dual viruses and dual oncolytic viruses and methods of treatment
JP7665609B2 (ja) 2019-10-30 2025-04-21 デシベル セラピューティクス インコーポレイテッド オトフェリン二重ベクター系及びそれを含む感音難聴を治療するための組成物
CA3174500A1 (en) 2020-04-01 2021-10-07 University Of Florida Research Foundation, Incorporated Dual aav-myo7a vectors with improved safety for the treatment of ush1b
JP7808298B2 (ja) 2020-09-04 2026-01-29 Ｈｅａｒｔｓｅｅｄ株式会社 ｉＰＳ細胞の品質改善剤、ｉＰＳ細胞の製造方法、ｉＰＳ細胞、及びｉＰＳ細胞製造用組成物
CA3203232A1 (en) 2020-12-25 2022-06-30 Kyoto University Method for producing naive human ips cells from somatic cells
JP7633725B2 (ja) 2021-06-30 2025-02-20 株式会社レプリテック マイナス鎖ｒｎａウイルスベクターの製造方法および製造されたマイナス鎖ｒｎａウイルスベクター
CN115772520B (zh) * 2021-09-08 2023-11-21 北京锦篮基因科技有限公司 用于治疗庞贝氏病的基因治疗构建体、药物组合物和方法
CA3243062A1 (en) 2021-12-27 2025-04-16 Repli-Tech Co.,Ltd. NEGATIVE-POLARITY RNA VIRUS OR VIRUS VECTOR AND RELATED RNA GENOME
WO2024195811A1 (ja) 2023-03-22 2024-09-26 株式会社レプリテック 温度感受性のマイナス鎖ｒｎａウイルスまたはウイルスベクターおよびそのｒｎａゲノム
CN117051040B (zh) * 2023-08-15 2024-10-01 北京百普赛斯生物科技股份有限公司 Vsv△g复制缺陷型病毒制备及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1207123A (zh) * 1995-10-31 1999-02-03 株式会社载体研究所 具有自主复制能力的负链rna病毒载体
WO2002000868A1 (en) * 2000-06-23 2002-01-03 The Uab Research Foundation Manipulation of negative stranded rna viruses by rearrangement of their genes and uses thereof
CN1355851A (zh) * 1999-05-18 2002-06-26 株式会社载体研究所 副粘病毒科的包膜基因缺陷型病毒载体

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339413C (en) * 1988-06-24 1997-09-02 Junichi Miyazaki Exogenous gene expression vector containing chick .beta.-actin gene promoter
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
JP2001283451A (ja) 1992-05-13 2001-10-12 Matsushita Electric Ind Co Ltd 記録方法および再生方法
JPH06230752A (ja) 1992-09-14 1994-08-19 Hitachi Ltd 表示装置の駆動方法
JPH06230753A (ja) 1993-01-29 1994-08-19 Fuji Xerox Co Ltd 画像処理装置
JPH06233879A (ja) 1993-02-08 1994-08-23 Brother Ind Ltd ロックミシンのかがり方式変換装置
US5798100A (en) 1994-07-06 1998-08-25 Immunomedics, Inc. Multi-stage cascade boosting vaccine
CN1143892C (zh) * 1995-11-01 2004-03-31 株式会社载体研究所 重组仙台病毒
JP4223550B2 (ja) 1996-02-29 2009-02-12 タカラバイオ株式会社 ウイルスの精製および除去方法
NZ503859A (en) 1997-11-18 2003-02-28 Pioneer Hi Bred Int Non-identical minimal recombination sites (FRT) which are non-identical for targeted integration of nucleotide sequences into transformed plants
WO2000009700A1 (fr) 1998-08-11 2000-02-24 Dnavec Research Inc. Vecteur de virus d'arn ayant la capacite de s'infiltrer par contact
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
CA2368944C (en) 1999-05-18 2010-07-27 Dnavec Research Inc. Paramyxovirus-derived rnp
EP1067179A1 (en) 1999-07-09 2001-01-10 Pierre Fabre Medicament Method to select attenuated paramyxoviridae useful for vaccines and therapeutics
CA2376106A1 (en) 1999-09-06 2001-03-15 Dnavec Research Inc. Paramyxoviruses comprising modified transcription start sequence
JP4791651B2 (ja) 2000-05-18 2011-10-12 株式会社ディナベック研究所 外来遺伝子導入用パラミクソウイルスベクター
CN1633599A (zh) 2001-09-18 2005-06-29 株式会社载体研究所 检查和制造降低了粒子形成能力的(－)链rna载体的方法
JP4448440B2 (ja) * 2002-04-30 2010-04-07 株式会社ディナベック研究所 プロテアーゼ依存性トロピズムが改変されたベクター
CA2571844A1 (en) * 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing minus-strand rna virus
EP1891215B1 (en) * 2005-04-20 2009-10-28 Dnavec Corporation Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
KR20090027693A (ko) * 2006-05-31 2009-03-17 디나벡크 가부시키가이샤 알츠하이머병 치료제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1207123A (zh) * 1995-10-31 1999-02-03 株式会社载体研究所 具有自主复制能力的负链rna病毒载体
CN1355851A (zh) * 1999-05-18 2002-06-26 株式会社载体研究所 副粘病毒科的包膜基因缺陷型病毒载体
WO2002000868A1 (en) * 2000-06-23 2002-01-03 The Uab Research Foundation Manipulation of negative stranded rna viruses by rearrangement of their genes and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Frederic Iseni, Dominique Garcin,et al.Sendai virus trailer RNA binds TIAR, a cellular proteininvolvedin virus-induced apoptosis.The EMBO Journal21 19.2002,21(19),5141-5150.
Frederic Iseni, Dominique Garcin,et al.Sendai virus trailer RNA binds TIAR, a cellular proteininvolvedin virus-induced apoptosis.The EMBO Journal21 19.2002,21(19),5141-5150. *
Makoto Inoue et al.A New Sendai Virus Vector Deficient in the Matrix Gene DoesNot Form Virus Particles and Shows Extensive Cell-to-CellSpreading.JOURNAL OF VIROLOGY77 11.2003,77(11),6419-6429.
Makoto Inoue et al.A New Sendai Virus Vector Deficient in the Matrix Gene DoesNot Form Virus Particles and Shows Extensive Cell-to-CellSpreading.JOURNAL OF VIROLOGY77 11.2003,77(11),6419-6429. *
WO 0200868 A1,全文.

Also Published As

Publication number Publication date
JP4999330B2 (ja) 2012-08-15
US8741650B2 (en) 2014-06-03
EP2434020A2 (en) 2012-03-28
EP2434020B1 (en) 2014-11-05
CA2553976A1 (en) 2005-08-04
EP2434020A3 (en) 2012-07-25
EP1717317A1 (en) 2006-11-02
KR101279677B1 (ko) 2013-06-27
CA2553976C (en) 2013-09-24
WO2005071092A1 (ja) 2005-08-04
JPWO2005071092A1 (ja) 2007-09-06
AU2005206410A1 (en) 2005-08-04
CN1934260A (zh) 2007-03-21
JP5438149B2 (ja) 2014-03-12
KR20070004636A (ko) 2007-01-09
JP2012130346A (ja) 2012-07-12
US20070161110A1 (en) 2007-07-12
EP1717317A4 (en) 2009-02-11

Similar Documents

Publication Publication Date Title
JP5438149B2 (ja) サイトメガロウイルスエンハンサーおよびニワトリβ−アクチンプロモーターを含むハイブリッドプロモーターを利用したマイナス鎖ＲＮＡウイルスベクターの製造方法
JP3602058B2 (ja) エンベロープ遺伝子欠損パラミクソ科ウイルスベクター
US7144579B2 (en) Paramyxoviruses comprising modified transcription start sequence
JPWO2000070070A1 (ja) エンベロープ遺伝子欠損パラミクソ科ウイルスベクター
KR20050062634A (ko) Ｔ 세포에 유전자를 도입하는 방법
JPWO2008007581A1 (ja) 非複製型パラミクソウイルス科ウイルスベクター
JPWO2008096811A1 (ja) 弱毒化マイナス鎖ｒｎａウイルス
EP1642966B1 (en) Minus strand rna viral vectors carrying a gene with altered hypermutable regions
JP4791651B2 (ja) 外来遺伝子導入用パラミクソウイルスベクター
US20060216824A1 (en) Paramyxovirus vector encoding ribozyme and utilization thereof
WO2006137517A1 (ja) 幼少個体への遺伝子導入用ベクター
HK1094898A (en) Methods for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken beta-actin promoter
HK1088038A (en) Minus strand rna viral vectors carrying a gene with altered hypermutable regions
HK1083110A (en) Paramyxovirus vector encoding ribozyme and utilization thereof
HK1133675A (en) Non-replicating paramyxoviridae virus vector

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20230921

Address after: Tokyo, Japan

Patentee after: ID PHARMA Co.,Ltd.

Address before: Ibaraki

Patentee before: DNAVEC RESEARCH Inc.

TR01 Transfer of patent right
CX01 Expiry of patent term

Granted publication date: 20130313

CX01 Expiry of patent term