KR101198571B1 - 포스포라미데이트 알킬화기 전구 약물 - Google Patents

포스포라미데이트 알킬화기 전구 약물 Download PDF

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KR101198571B1
KR101198571B1 KR1020087002436A KR20087002436A KR101198571B1 KR 101198571 B1 KR101198571 B1 KR 101198571B1 KR 1020087002436 A KR1020087002436 A KR 1020087002436A KR 20087002436 A KR20087002436 A KR 20087002436A KR 101198571 B1 KR101198571 B1 KR 101198571B1
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phosphoramidate
compound
cancer
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alkyl
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KR20080027901A (ko
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마크 마테우치
지안-씬 듀안
해일롱 지아오
자코브 카이제르맨
스티브 아몬즈
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쓰레솔드 파마슈티컬스, 인코포레이티드
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
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  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020087002436A 2005-06-29 2006-06-29 포스포라미데이트 알킬화기 전구 약물 Active KR101198571B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69575505P 2005-06-29 2005-06-29
US60/695,755 2005-06-29
PCT/US2006/025881 WO2007002931A2 (en) 2005-06-29 2006-06-29 Phosphoramidate alkylator prodrugs

Publications (2)

Publication Number Publication Date
KR20080027901A KR20080027901A (ko) 2008-03-28
KR101198571B1 true KR101198571B1 (ko) 2012-11-07

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US (4) US8003625B2 (enExample)
EP (2) EP2336141B1 (enExample)
JP (2) JP5180824B2 (enExample)
KR (1) KR101198571B1 (enExample)
CN (2) CN101501054B (enExample)
AU (2) AU2006263433B8 (enExample)
BR (1) BRPI0612845A8 (enExample)
CA (1) CA2613312C (enExample)
CY (1) CY1113250T1 (enExample)
DK (1) DK1896040T3 (enExample)
ES (2) ES2389532T3 (enExample)
HR (1) HRP20120803T1 (enExample)
IL (1) IL188236A (enExample)
NO (1) NO334420B1 (enExample)
NZ (1) NZ565378A (enExample)
PL (1) PL1896040T3 (enExample)
PT (1) PT1896040E (enExample)
RS (1) RS52505B (enExample)
RU (1) RU2414475C2 (enExample)
SI (1) SI1896040T1 (enExample)
TW (1) TWI384989B (enExample)
WO (1) WO2007002931A2 (enExample)
ZA (1) ZA200800314B (enExample)

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EP2114157B1 (en) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
WO2008124691A1 (en) 2007-04-05 2008-10-16 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
WO2009018163A1 (en) * 2007-07-27 2009-02-05 Threshold Pharmaceuticals, Inc. Hypoxia activated prodrugs of anthracyclines
UA104579C2 (uk) * 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
WO2010044885A2 (en) 2008-10-17 2010-04-22 Whitehead Institute For Biomedical Research Soluble mtor complexes and modulators thereof
US8946275B2 (en) * 2008-10-21 2015-02-03 Threshold Pharmaceuticals, Inc. Treatment of cancer using hypoxia activated prodrugs
AU2011276590A1 (en) * 2010-06-28 2013-01-31 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
ES2877629T3 (es) * 2010-07-12 2021-11-17 Immunogenesis Inc Administración de profármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer
CN103458896B (zh) * 2011-04-01 2016-02-10 施瑞修德制药公司 用于治疗癌症的方法
US20140072624A1 (en) * 2011-04-15 2014-03-13 Threshold Pharmaceuticals, Inc. Unit dose form for oral administration
US9402820B2 (en) * 2011-04-22 2016-08-02 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
CN102850397B (zh) * 2011-06-29 2015-02-18 北京大学 多靶点抗肿瘤化合物及其制备方法和应用
CN102924507A (zh) * 2011-11-10 2013-02-13 安徽四维药业有限公司 一种抗肿瘤化合物及其制备方法与应用、药物组合物
US9254299B2 (en) 2011-12-22 2016-02-09 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer
JP2015500884A (ja) * 2011-12-22 2015-01-08 スレッショルド ファーマシューティカルズ，インコーポレイテッド 癌を治療するための低酸素活性化プロドラッグおよびｍＴＯＲ阻害剤
ES2909741T3 (es) * 2012-02-21 2022-05-10 Immunogenesis Inc Tratamiento del cáncer
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
CN104583224A (zh) * 2012-07-03 2015-04-29 百时美施贵宝公司 制备用于治疗病毒感染的核苷化合物的富含非对映体的氨基磷酸酯衍生物的方法
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US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
WO2014069063A1 (ja) 2012-10-29 2014-05-08 京セラ株式会社 弾性表面波センサ
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