KR101173510B1 - 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 - Google Patents

에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 Download PDF

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KR101173510B1
KR101173510B1 KR1020057003043A KR20057003043A KR101173510B1 KR 101173510 B1 KR101173510 B1 KR 101173510B1 KR 1020057003043 A KR1020057003043 A KR 1020057003043A KR 20057003043 A KR20057003043 A KR 20057003043A KR 101173510 B1 KR101173510 B1 KR 101173510B1
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heteroatoms selected
heteroaryl
alkyl
aryl
compound
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Korean (ko)
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KR20050083652A (ko
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사무엘 제이. 다니쉐프스키
알렉세이 리브킨
후미히코 요시무라
아나 에스테르 가바르다 오르테가
영신 조
팅-차오 추
후아진 돈짐
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슬로안-케테링인스티튜트퍼캔서리서치
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Priority claimed from US10/402,004 external-priority patent/US6921769B2/en
Priority claimed from US10/435,408 external-priority patent/US7649006B2/en
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Publication of KR20050083652A publication Critical patent/KR20050083652A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020057003043A 2002-08-23 2003-08-22 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 Expired - Fee Related KR101173510B1 (ko)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US40582302P 2002-08-23 2002-08-23
US60/405,823 2002-08-23
US40858902P 2002-09-06 2002-09-06
US60/408,589 2002-09-06
US42312902P 2002-11-01 2002-11-01
US60/423,129 2002-11-01
US45615903P 2003-03-20 2003-03-20
US60/456,159 2003-03-20
US10/402,004 2003-03-28
US10/402,004 US6921769B2 (en) 2002-08-23 2003-03-28 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 US7649006B2 (en) 2002-08-23 2003-05-09 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 2003-05-09
US49674103P 2003-08-21 2003-08-21
US60/496,741 2003-08-21

Publications (2)

Publication Number Publication Date
KR20050083652A KR20050083652A (ko) 2005-08-26
KR101173510B1 true KR101173510B1 (ko) 2012-08-21

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KR1020057003043A Expired - Fee Related KR101173510B1 (ko) 2002-08-23 2003-08-22 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도

Country Status (18)

Country Link
US (1) US7875638B2 (enExample)
EP (3) EP1506203B1 (enExample)
JP (2) JP4791183B2 (enExample)
KR (1) KR101173510B1 (enExample)
CN (2) CN102532120A (enExample)
AT (2) ATE350383T1 (enExample)
AU (1) AU2003260002B2 (enExample)
CA (1) CA2496477C (enExample)
DE (2) DE60330407D1 (enExample)
DK (2) DK1767535T3 (enExample)
ES (2) ES2336937T3 (enExample)
IL (1) IL167046A (enExample)
MX (1) MXPA05002113A (enExample)
NZ (1) NZ538522A (enExample)
PH (1) PH12012501351A1 (enExample)
PT (2) PT1506203E (enExample)
SI (1) SI1767535T1 (enExample)
WO (1) WO2004018478A2 (enExample)

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WO2012033601A1 (en) 2010-08-20 2012-03-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Thiosemicarbazones with mdr1 - inverse activity
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US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
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MX2023012608A (es) 2021-04-30 2023-11-03 Kalivir Immunotherapeutics Inc Virus oncoliticos para la expresion modificada del mhc.
WO2023123986A1 (zh) * 2021-12-31 2023-07-06 成都华昊中天药业有限公司 优替德隆脂质体组合物及其制备方法和用途
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IL167046A (en) 2012-06-28
MXPA05002113A (es) 2005-06-03
CA2496477C (en) 2012-10-16
EP1506203B1 (en) 2007-01-03
DE60310916T2 (de) 2007-11-15
ES2281692T3 (es) 2007-10-01
EP1506203A2 (en) 2005-02-16
DE60310916D1 (de) 2007-02-15
KR20050083652A (ko) 2005-08-26
ATE350383T1 (de) 2007-01-15
ATE450534T1 (de) 2009-12-15
PT1506203E (pt) 2007-04-30

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