PH12012501351A1 - Synthesis of eporthilones, intermediates thereto, analogues and uses thereof - Google Patents

Synthesis of eporthilones, intermediates thereto, analogues and uses thereof

Info

Publication number
PH12012501351A1
PH12012501351A1 PH12012501351A PH12012501351A PH12012501351A1 PH 12012501351 A1 PH12012501351 A1 PH 12012501351A1 PH 12012501351 A PH12012501351 A PH 12012501351A PH 12012501351 A PH12012501351 A PH 12012501351A PH 12012501351 A1 PH12012501351 A1 PH 12012501351A1
Authority
PH
Philippines
Prior art keywords
eporthilones
analogues
intermediates
synthesis
formula
Prior art date
Application number
PH12012501351A
Other languages
English (en)
Inventor
Samuel J Danishefsky
Rivkin Alexey
Yoshimura Fumihiko
Gabarda Ortega Ana Esther
Cho Young Shin
Chou Ting-Chao
Dong Huajin
Original Assignee
Sloan Kettering Inst Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/402,004 external-priority patent/US6921769B2/en
Priority claimed from US10/435,408 external-priority patent/US7649006B2/en
Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer
Publication of PH12012501351A1 publication Critical patent/PH12012501351A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH12012501351A 2002-08-23 2012-06-29 Synthesis of eporthilones, intermediates thereto, analogues and uses thereof PH12012501351A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US40582302P 2002-08-23 2002-08-23
US40858902P 2002-09-06 2002-09-06
US42312902P 2002-11-01 2002-11-01
US45615903P 2003-03-20 2003-03-20
US10/402,004 US6921769B2 (en) 2002-08-23 2003-03-28 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 US7649006B2 (en) 2002-08-23 2003-05-09 Synthesis of epothilones, intermediates thereto and analogues thereof
US49674103P 2003-08-21 2003-08-21
PCT/US2003/026367 WO2004018478A2 (en) 2002-08-23 2003-08-22 Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Publications (1)

Publication Number Publication Date
PH12012501351A1 true PH12012501351A1 (en) 2014-10-13

Family

ID=31950966

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12012501351A PH12012501351A1 (en) 2002-08-23 2012-06-29 Synthesis of eporthilones, intermediates thereto, analogues and uses thereof

Country Status (18)

Country Link
US (1) US7875638B2 (enExample)
EP (3) EP1506203B1 (enExample)
JP (2) JP4791183B2 (enExample)
KR (1) KR101173510B1 (enExample)
CN (2) CN102532120A (enExample)
AT (2) ATE350383T1 (enExample)
AU (1) AU2003260002B2 (enExample)
CA (1) CA2496477C (enExample)
DE (2) DE60330407D1 (enExample)
DK (2) DK1767535T3 (enExample)
ES (2) ES2336937T3 (enExample)
IL (1) IL167046A (enExample)
MX (1) MXPA05002113A (enExample)
NZ (1) NZ538522A (enExample)
PH (1) PH12012501351A1 (enExample)
PT (2) PT1506203E (enExample)
SI (1) SI1767535T1 (enExample)
WO (1) WO2004018478A2 (enExample)

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