ATE409473T1 - Cyclopropyl und cyclobutyl epothilon analoge - Google Patents
Cyclopropyl und cyclobutyl epothilon analogeInfo
- Publication number
- ATE409473T1 ATE409473T1 AT02767418T AT02767418T ATE409473T1 AT E409473 T1 ATE409473 T1 AT E409473T1 AT 02767418 T AT02767418 T AT 02767418T AT 02767418 T AT02767418 T AT 02767418T AT E409473 T1 ATE409473 T1 AT E409473T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropyl
- cyclobutyl
- epothilone analogue
- compounds
- cyclobutyl epothilone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31469801P | 2001-08-23 | 2001-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409473T1 true ATE409473T1 (de) | 2008-10-15 |
Family
ID=23221047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02767418T ATE409473T1 (de) | 2001-08-23 | 2002-08-22 | Cyclopropyl und cyclobutyl epothilon analoge |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7358266B2 (de) |
| EP (2) | EP2070534A3 (de) |
| JP (2) | JP4176015B2 (de) |
| CN (1) | CN100536841C (de) |
| AT (1) | ATE409473T1 (de) |
| AU (1) | AU2002331171A1 (de) |
| BR (1) | BR0212107A (de) |
| CA (1) | CA2456280A1 (de) |
| DE (1) | DE60229143D1 (de) |
| ES (1) | ES2315399T3 (de) |
| HK (1) | HK1066464A1 (de) |
| PT (1) | PT1420780E (de) |
| WO (1) | WO2003018002A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6242469B1 (en) * | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE60229143D1 (en) * | 2001-08-23 | 2008-11-13 | Novartis Ag | Cyclopropyl und cyclobutyl epothilon analoge |
| WO2004014919A1 (de) * | 2002-08-02 | 2004-02-19 | Novartis Ag | Epothilone derivatives |
| US7384964B2 (en) * | 2002-08-23 | 2008-06-10 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| DE60330407D1 (de) * | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20050171167A1 (en) | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| GB0405898D0 (en) * | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| AU2006336468B2 (en) | 2005-02-11 | 2012-04-12 | University Of Southern California | Method of expressing proteins with disulfide bridges |
| CN101360494A (zh) * | 2005-11-22 | 2009-02-04 | 斯克里普斯研究学院 | 高效埃博霉素的化学合成 |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| JP5115729B2 (ja) * | 2008-06-20 | 2013-01-09 | 信越化学工業株式会社 | トリアルキルシリル基で保護されたアセト酢酸エステル基含有有機ケイ素化合物及びその製造方法 |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| CN116199658A (zh) * | 2022-07-22 | 2023-06-02 | 北京先通国际医药科技股份有限公司 | 一种修饰长链脂肪酸型pet试剂前体的合成方法及其用途 |
| CN115141087B (zh) * | 2022-09-06 | 2023-03-24 | 北京先通国际医药科技股份有限公司 | Pet前体关键中间体的异构体的合成方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| DE19848306A1 (de) * | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
| YU57601A (sh) * | 1999-02-11 | 2005-06-10 | Schering Aktiengesellschaft | Epotilon derivati, postupak za njihovu izradu i njihova farmaceutska primena |
| DE60229143D1 (en) * | 2001-08-23 | 2008-11-13 | Novartis Ag | Cyclopropyl und cyclobutyl epothilon analoge |
-
2002
- 2002-08-22 DE DE60229143T patent/DE60229143D1/de not_active Expired - Fee Related
- 2002-08-22 AT AT02767418T patent/ATE409473T1/de not_active IP Right Cessation
- 2002-08-22 CA CA002456280A patent/CA2456280A1/en not_active Abandoned
- 2002-08-22 WO PCT/EP2002/009407 patent/WO2003018002A2/en active IP Right Grant
- 2002-08-22 CN CNB028164415A patent/CN100536841C/zh not_active Expired - Fee Related
- 2002-08-22 EP EP08165542A patent/EP2070534A3/de not_active Withdrawn
- 2002-08-22 PT PT02767418T patent/PT1420780E/pt unknown
- 2002-08-22 ES ES02767418T patent/ES2315399T3/es not_active Expired - Lifetime
- 2002-08-22 JP JP2003522522A patent/JP4176015B2/ja not_active Expired - Fee Related
- 2002-08-22 EP EP02767418A patent/EP1420780B1/de not_active Expired - Lifetime
- 2002-08-22 AU AU2002331171A patent/AU2002331171A1/en not_active Abandoned
- 2002-08-22 BR BR0212107-7A patent/BR0212107A/pt not_active IP Right Cessation
- 2002-08-23 US US10/227,073 patent/US7358266B2/en not_active Expired - Fee Related
-
2004
- 2004-11-25 HK HK04109321.7A patent/HK1066464A1/xx not_active IP Right Cessation
-
2008
- 2008-07-15 JP JP2008183765A patent/JP2009007367A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005501107A (ja) | 2005-01-13 |
| DE60229143D1 (en) | 2008-11-13 |
| US20040039026A1 (en) | 2004-02-26 |
| WO2003018002A3 (en) | 2003-09-04 |
| JP4176015B2 (ja) | 2008-11-05 |
| EP1420780A2 (de) | 2004-05-26 |
| JP2009007367A (ja) | 2009-01-15 |
| WO2003018002A2 (en) | 2003-03-06 |
| CN100536841C (zh) | 2009-09-09 |
| BR0212107A (pt) | 2004-08-24 |
| US7358266B2 (en) | 2008-04-15 |
| AU2002331171A1 (en) | 2003-03-10 |
| EP2070534A3 (de) | 2009-08-26 |
| EP2070534A2 (de) | 2009-06-17 |
| HK1066464A1 (en) | 2005-03-24 |
| ES2315399T3 (es) | 2009-04-01 |
| EP1420780B1 (de) | 2008-10-01 |
| PT1420780E (pt) | 2008-12-29 |
| CN1545411A (zh) | 2004-11-10 |
| CA2456280A1 (en) | 2003-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE409473T1 (de) | Cyclopropyl und cyclobutyl epothilon analoge | |
| ATE450534T1 (de) | Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung | |
| DK1814846T3 (da) | 11beta-HSD1-inhibitorer | |
| WO2004026863A8 (en) | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors | |
| NO20051209L (no) | Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk anvendelse derav samt intermediater for samme | |
| NO20021448D0 (no) | Nye tiazolo (4,5-D)-pyrimidinforbindelser | |
| HK1071129A1 (en) | Novel compounds | |
| PL1613304T3 (pl) | Inhibitory DPP-IV | |
| DE60110415D1 (de) | Neue Pyrazin-Derivate oder Salze davon, pharmazeutische Zusammensetzungen, die die Derivate oder deren Salze enthalten und Intermediäre zur Herstellung der Derivate | |
| DE60234345D1 (de) | Verbindungen mit taxol-verstärkender wirkung | |
| MXPA04000755A (es) | Nuevos compuestos. | |
| MXPA04005099A (es) | Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento. | |
| DE60004217D1 (de) | Sulphostinanaloga und verfahren zur herstellung von sulphostin und analoga davon | |
| GB0114004D0 (en) | Chemical compounds | |
| SI1483251T1 (sl) | C cian epotilonski derivati | |
| SE0101038D0 (sv) | Novel compounds | |
| DE69332636D1 (de) | Antidepressiv und gegen die Parkinsonsche Krankheit wirkende Verbindungen | |
| DK0516069T3 (da) | Leukotrien B4-antagonister | |
| ATE275558T1 (de) | 4-arylpiperidinderivate zur behandlung von pruritus | |
| WO2005056000A3 (fr) | Substance neuroactive et utilisations d'une telle substance | |
| TH61672A (th) | อนุพันธ์ไทอีโนไพริดีน การผลิตและการใช้สารเหล่านี้ | |
| TH68162A (th) | อิมิดาโซควิโนลีนซึ่งถูกแทนที่ด้วยซัลโฟนามิโดอีเทอร์ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1420780 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |