KR100756252B1 - 일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 - Google Patents
일렉트로포레이션에 의한 약제와 유전자 전달 방법 및 장치 Download PDFInfo
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- KR100756252B1 KR100756252B1 KR1019997002781A KR19997002781A KR100756252B1 KR 100756252 B1 KR100756252 B1 KR 100756252B1 KR 1019997002781 A KR1019997002781 A KR 1019997002781A KR 19997002781 A KR19997002781 A KR 19997002781A KR 100756252 B1 KR100756252 B1 KR 100756252B1
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- Prior art keywords
- electrode
- applicator
- needles
- electroporation
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0502—Skin piercing electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
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- Biophysics (AREA)
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- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrotherapy Devices (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US08/905,240 | 1997-08-01 | ||
| US8/905,240 | 1997-08-01 | ||
| US08/905,240 US6055453A (en) | 1997-08-01 | 1997-08-01 | Apparatus for addressing needle array electrodes for electroporation therapy |
Publications (2)
| Publication Number | Publication Date |
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| KR20000068678A KR20000068678A (ko) | 2000-11-25 |
| KR100756252B1 true KR100756252B1 (ko) | 2007-09-07 |
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| RU (1) | RU2195332C2 (https=) |
| TW (1) | TW396043B (https=) |
| WO (1) | WO1999006101A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017048037A1 (ko) * | 2015-09-17 | 2017-03-23 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
Families Citing this family (402)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602248B1 (en) | 1995-06-07 | 2003-08-05 | Arthro Care Corp. | Methods for repairing damaged intervertebral discs |
| US20050004634A1 (en) * | 1995-06-07 | 2005-01-06 | Arthrocare Corporation | Methods for electrosurgical treatment of spinal tissue |
| US7393351B2 (en) | 1995-06-07 | 2008-07-01 | Arthrocare Corporation | Apparatus and methods for treating cervical inter-vertebral discs |
| DE69733815T2 (de) | 1996-02-15 | 2006-06-08 | Biosense Webster, Inc., Diamond Bar | Sonde zur exkavation |
| US6620155B2 (en) | 1996-07-16 | 2003-09-16 | Arthrocare Corp. | System and methods for electrosurgical tissue contraction within the spine |
| US7357798B2 (en) * | 1996-07-16 | 2008-04-15 | Arthrocare Corporation | Systems and methods for electrosurgical prevention of disc herniations |
| US6726684B1 (en) * | 1996-07-16 | 2004-04-27 | Arthrocare Corporation | Methods for electrosurgical spine surgery |
| US6708066B2 (en) * | 1999-12-10 | 2004-03-16 | Ewa Herbst | Electrochemical treatment of tissues, especially tumors |
| US20060089751A1 (en) * | 1997-01-27 | 2006-04-27 | Ewa Herbst | Electronic delivery systems and methods with feedback |
| IL133708A0 (en) | 1997-06-30 | 2001-04-30 | Rhone Poulence Rorer S A | Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof |
| AU8444798A (en) | 1997-06-30 | 1999-01-25 | Centre National De La Recherche Scientifique | Improved method for transferring nucleic acid into the striped muscle and combination therefor |
| US6778853B1 (en) * | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US7749215B1 (en) | 1998-02-05 | 2010-07-06 | Biosense, Inc. | Intracardiac cell delivery and cell transplantation |
| ES2255155T3 (es) * | 1998-02-05 | 2006-06-16 | Biosense Webster, Inc. | Dispositivo para la administracion intracardiaca de farmacos. |
| US20030113303A1 (en) * | 1998-02-05 | 2003-06-19 | Yitzhack Schwartz | Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances |
| US20030129750A1 (en) * | 1998-02-05 | 2003-07-10 | Yitzhack Schwartz | Homing of donor cells to a target zone in tissue using active therapeutics or substances |
| US6045532A (en) * | 1998-02-20 | 2000-04-04 | Arthrocare Corporation | Systems and methods for electrosurgical treatment of tissue in the brain and spinal cord |
| AU733053C (en) | 1998-02-24 | 2001-11-29 | Boston Scientific Limited | High flow rate dialysis catheters and related methods |
| US6022316A (en) * | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
| AU3973599A (en) | 1998-05-08 | 1999-11-29 | Genetronics, Inc. | Electrically induced vessel vasodilation |
| DE59902949D1 (de) * | 1998-05-29 | 2002-11-07 | Deutsches Ressourcenzentrum Fu | Neues verfahren zum transfer von biologischem material |
| EP1100576B1 (en) * | 1998-06-26 | 2007-08-15 | Genetronics, Inc. | Synergism of photodynamic and electropermeation effects on cell vitality as a novel cytotoxic agent |
| US6697669B2 (en) | 1998-07-13 | 2004-02-24 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| US6532386B2 (en) | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| WO2000056395A1 (en) | 1999-03-25 | 2000-09-28 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| JP4180244B2 (ja) | 1999-04-16 | 2008-11-12 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 内部センサを有する電気的な移動による送出装置系 |
| US6514762B1 (en) | 1999-04-23 | 2003-02-04 | New Mexico State University Technology Transfer Corporation | Delivery of nucleotides by electrochemical release |
| US6221071B1 (en) * | 1999-06-04 | 2001-04-24 | Scimed Life Systems, Inc. | Rapid electrode deployment |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US7074747B1 (en) | 1999-07-01 | 2006-07-11 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| US20050009717A1 (en) * | 1999-07-01 | 2005-01-13 | Lukenbach Elvin R. | Foaming make-up removing cleansing compositions |
| AU5764800A (en) | 1999-07-01 | 2001-01-22 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| US6762158B2 (en) | 1999-07-01 | 2004-07-13 | Johnson & Johnson Consumer Companies, Inc. | Personal care compositions comprising liquid ester mixtures |
| US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6326177B1 (en) | 1999-08-04 | 2001-12-04 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Method and apparatus for intracellular electro-manipulation |
| US6387092B1 (en) * | 1999-09-07 | 2002-05-14 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-used single use devices based on time elapsed from first therapeutic use |
| US6651669B1 (en) | 1999-09-07 | 2003-11-25 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-used single use devices based on cataloging catheter usage |
| US6237604B1 (en) | 1999-09-07 | 2001-05-29 | Scimed Life Systems, Inc. | Systems and methods for preventing automatic identification of re-used single use devices |
| US6611793B1 (en) | 1999-09-07 | 2003-08-26 | Scimed Life Systems, Inc. | Systems and methods to identify and disable re-use single use devices based on detecting environmental changes |
| US6587718B2 (en) * | 1999-10-08 | 2003-07-01 | Scimed Life Systems, Inc. | Iontophoretic delivery to heart tissue |
| US6549797B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Electrode remover for a percutaneous electrical therapy system |
| US6529776B1 (en) | 1999-12-01 | 2003-03-04 | Vertis Neuroscience, Inc. | Method and apparatus for repositioning a percutaneous probe |
| US6912424B2 (en) * | 1999-12-01 | 2005-06-28 | Meagan, Medical, Inc. | Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient |
| US6556869B1 (en) | 1999-12-01 | 2003-04-29 | Vertis Neuroscience, Inc. | Electrode introducer for a percutaneous electrical therapy system |
| US6549810B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode depth control |
| US6516226B1 (en) | 1999-12-01 | 2003-02-04 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system for minimizing electrode insertion discomfort |
| US6539264B1 (en) | 1999-12-01 | 2003-03-25 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with sharp point protection |
| US6493592B1 (en) * | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
| US6622051B1 (en) | 1999-12-01 | 2003-09-16 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode entry angle control |
| US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
| US6560491B1 (en) | 1999-12-01 | 2003-05-06 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system providing electrode axial support |
| US6904324B2 (en) * | 1999-12-01 | 2005-06-07 | Meagan Medical, Inc. | Method and apparatus for deploying a percutaneous probe |
| KR100406729B1 (ko) * | 2000-02-15 | 2003-11-21 | 사회복지법인삼성생명공익재단(삼성서울병원) | 생리학적 전기신호에 동조화된 의료기기 |
| US7136699B2 (en) * | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| CN1416466A (zh) | 2000-02-17 | 2003-05-07 | 约朗姆·帕尔蒂 | 破坏正在分裂的细胞的方法和装置 |
| US7146210B2 (en) * | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7016725B2 (en) * | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7805201B2 (en) * | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US7473244B2 (en) * | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| US7588554B2 (en) * | 2000-06-26 | 2009-09-15 | Boston Scientific Scimed, Inc. | Method and apparatus for treating ischemic tissue |
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US6697670B2 (en) * | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| US7118555B2 (en) * | 2000-09-21 | 2006-10-10 | Meagan Medical, Inc. | Method and apparatus for repositioning a percutaneous probe |
| USD480478S1 (en) | 2000-09-28 | 2003-10-07 | Vertis Neuroscience, Inc. | Percutaneous probe applicator |
| US20030158545A1 (en) * | 2000-09-28 | 2003-08-21 | Arthrocare Corporation | Methods and apparatus for treating back pain |
| US6846306B1 (en) * | 2000-10-10 | 2005-01-25 | Cold Spring Harbor Laboratory | Single cell electroporation |
| US6671557B1 (en) | 2000-10-10 | 2003-12-30 | Meagan Medical, Inc. | System and method for providing percutaneous electrical therapy |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| US7108681B2 (en) * | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US6821274B2 (en) | 2001-03-07 | 2004-11-23 | Gendel Ltd. | Ultrasound therapy for selective cell ablation |
| WO2002040093A2 (en) | 2000-11-17 | 2002-05-23 | Gendel Limited | Ablation of cells using combined electric field and ultrasound therapy |
| US20050043726A1 (en) * | 2001-03-07 | 2005-02-24 | Mchale Anthony Patrick | Device II |
| US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US6625486B2 (en) | 2001-04-11 | 2003-09-23 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for intracellular delivery of an agent |
| US8541021B2 (en) * | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| ES2331302T3 (es) | 2001-05-01 | 2009-12-29 | A.V. Topchiev Institute Of Petrochemical Synthesis | Composiciones de hidrogel. |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| EP1390084B1 (en) * | 2001-05-01 | 2011-03-23 | A.V. Topchiev Institute of Petrochemical Synthesis | Two-phase, water-absorbent bioadhesive composition |
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US6733485B1 (en) | 2001-05-25 | 2004-05-11 | Advanced Bionics Corporation | Microstimulator-based electrochemotherapy methods and systems |
| ITTO20010534A1 (it) * | 2001-06-04 | 2002-12-04 | Igea Srl | Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore. |
| US7127284B2 (en) * | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
| US20040204669A1 (en) * | 2001-07-05 | 2004-10-14 | Hofmann Gunter A. | Apparatus for electroporation mediated delivery for drugs and genes |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US7130697B2 (en) * | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
| USRE42016E1 (en) | 2001-08-13 | 2010-12-28 | Angiodynamics, Inc. | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US7713740B2 (en) * | 2001-08-24 | 2010-05-11 | University Of South Florida | Method of using electric fields to facilitate the entry of molecules into cells in vivo |
| US7879610B1 (en) * | 2001-08-24 | 2011-02-01 | University Of South Florida | Electroporation system and method for facilitating entry of molecules into cells in vivo |
| AU2002362310A1 (en) * | 2001-09-14 | 2003-04-01 | Arthrocare Corporation | Methods and apparatus for treating intervertebral discs |
| US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| USD475463S1 (en) | 2001-09-28 | 2003-06-03 | Vertis Neuroscience, Inc. | Control device for delivering electrical therapy |
| DK2308553T3 (da) * | 2001-10-18 | 2014-03-10 | Uroplasty Inc | Elektrisk nervestimulationssystem |
| US8812114B2 (en) | 2001-10-18 | 2014-08-19 | Uroplasty, Inc. | Lead set for nerve stimulator and method of operation thereof |
| FR2831026B1 (fr) * | 2001-10-18 | 2004-05-28 | Commissariat Energie Atomique | Dispositif et procede de traitement par champ electrique pulse d'une substance en ecoulement colonisee par des organismes indesirables |
| CA2468424A1 (en) | 2001-11-27 | 2003-06-05 | Cecilia Farre | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
| US20030170898A1 (en) * | 2001-12-04 | 2003-09-11 | Gundersen Martin A. | Method for intracellular modifications within living cells using pulsed electric fields |
| AU2003205132A1 (en) * | 2002-02-12 | 2003-09-04 | Celectricon AB | Systems and methods for rapidly changing the solution environment around sensors |
| AU2003219805B2 (en) * | 2002-02-15 | 2009-06-04 | Eisai Inc. | Electroporation methods for introducing bioactive agents into cells |
| WO2003076006A2 (en) * | 2002-03-07 | 2003-09-18 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7697981B2 (en) * | 2002-03-22 | 2010-04-13 | The Regents Of The University Of California | Method and apparatus for using an electromagnetic field in cellular transplantation |
| US7218962B2 (en) * | 2002-03-29 | 2007-05-15 | Boston Scientific Scimed, Inc. | Magnetically enhanced injection catheter |
| US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| CN100455328C (zh) * | 2002-04-16 | 2009-01-28 | 塞托·帕尔斯科技公司 | 借助于平移电场和电极极性反转治疗生物体部位的设备 |
| US20030204161A1 (en) * | 2002-04-25 | 2003-10-30 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| AU2003227960B2 (en) * | 2002-05-23 | 2008-10-30 | Gendel Limited | Ablation device |
| US10130415B2 (en) * | 2002-06-10 | 2018-11-20 | Wisconsin Alumni Research Foundation | Circumferential electrode array for tissue ablation |
| US20050070841A1 (en) * | 2002-07-04 | 2005-03-31 | Inovio As | Electroporation device and injection apparatus |
| US7328064B2 (en) * | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| US20040127893A1 (en) * | 2002-12-13 | 2004-07-01 | Arthrocare Corporation | Methods for visualizing and treating intervertebral discs |
| US6997903B2 (en) * | 2003-02-10 | 2006-02-14 | Bandula Wijay | Local drug delivery catheter |
| US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US7794456B2 (en) * | 2003-05-13 | 2010-09-14 | Arthrocare Corporation | Systems and methods for electrosurgical intervertebral disc replacement |
| US6969604B1 (en) | 2003-06-20 | 2005-11-29 | Yakovenko Sergey A | Electroporation chamber |
| GB0322766D0 (en) * | 2003-09-29 | 2003-10-29 | Emcision Ltd | Surgical resection device |
| WO2005039390A2 (en) * | 2003-10-20 | 2005-05-06 | Arthrocare Corporation | Electrosurgical method and apparatus for removing tissue within a bone body |
| US8500713B2 (en) * | 2003-10-29 | 2013-08-06 | Medtronic, Inc. | Implantable electroporation therapy device and method for using same |
| EP1696812B1 (en) * | 2003-12-24 | 2015-07-22 | The Regents of The University of California | Tissue ablation with irreversible electroporation |
| US8298222B2 (en) | 2003-12-24 | 2012-10-30 | The Regents Of The University Of California | Electroporation to deliver chemotherapeutics and enhance tumor regression |
| RU2380092C2 (ru) | 2004-01-30 | 2010-01-27 | Кориум Интернэшнл, Инк. | Быстро растворяющаяся пленка для доставки активного агента |
| RU2252793C1 (ru) * | 2004-02-02 | 2005-05-27 | Карасев Александр Александрович | Электродное устройство |
| FR2867054B1 (fr) | 2004-03-04 | 2006-09-15 | Future Medical System | Systeme d'endoscopie et connecteur a detecteur de pression destine a un tel systeme |
| HUE025052T2 (en) | 2004-03-08 | 2016-01-28 | Ichor Medical Systems Inc | A sharpened device for electrically mediated delivery of medical substances |
| WO2005094526A2 (en) * | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
| EP1727592B1 (en) * | 2004-03-25 | 2017-04-19 | University College Cork-National University of Ireland, Cork | Apparatus for prophylaxis or treatment of tissue |
| JP4443278B2 (ja) * | 2004-03-26 | 2010-03-31 | テルモ株式会社 | 拡張体付カテーテル |
| WO2005096979A1 (en) | 2004-04-01 | 2005-10-20 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
| US20050226991A1 (en) * | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
| JP4929159B2 (ja) | 2004-04-16 | 2012-05-09 | ヌーヴ セラピュティクス、インコーポレイテッド | 画像誘導組織切除を改善するための装置 |
| TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
| FR2880808A1 (fr) | 2005-01-20 | 2006-07-21 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives |
| BRPI0512607A (pt) | 2004-06-24 | 2008-03-25 | Sphergen | dispositivo para a transferência de moléculas para células que utiliza uma força elétrica |
| FR2872056B1 (fr) | 2004-06-24 | 2007-08-10 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques |
| FR2872055B1 (fr) | 2004-06-24 | 2008-02-08 | Yves Leon Scherman | Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede |
| EP1791575B1 (en) * | 2004-08-05 | 2014-10-08 | Corium International, Inc. | Adhesive composition |
| DE602005020504D1 (de) * | 2004-12-07 | 2010-05-20 | Standen Ltd | Vivo über einen längeren zeitraum |
| CA2594231C (en) * | 2004-12-27 | 2016-04-19 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| WO2007012907A2 (en) * | 2005-02-08 | 2007-02-01 | Allen, John | Electric therapy machine |
| US7850645B2 (en) * | 2005-02-11 | 2010-12-14 | Boston Scientific Scimed, Inc. | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power |
| US20080182251A1 (en) * | 2005-03-19 | 2008-07-31 | Luyi Sen | Ultra Low Strength Electric Field Network-Mediated Ex Vivo Gene, Protein and Drug Delivery in Cells |
| US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| CA2612866A1 (en) * | 2005-05-11 | 2006-11-23 | Corium International, Inc. | Permeabilization of biological membranes |
| US8242511B2 (en) * | 2005-06-20 | 2012-08-14 | Nippon Telegraph And Telephone Corporation | Field effect transistor using diamond and process for producing the same |
| US20060293730A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| US20060293731A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating tumors using electroporation |
| US20060293725A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating fatty tissue sites using electroporation |
| US8114070B2 (en) * | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
| US8214221B2 (en) * | 2005-06-30 | 2012-07-03 | Lg Electronics Inc. | Method and apparatus for decoding an audio signal and identifying information included in the audio signal |
| US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
| CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
| JP5059786B2 (ja) | 2006-02-11 | 2012-10-31 | ジェネトロニクス，インコーポレイティド | 単針生体内エレクトロポレーションのための装置および方法 |
| US20080287857A1 (en) * | 2006-02-11 | 2008-11-20 | Rune Kjeken | Device and method for single-needle in vivo electroporation |
| US20080045880A1 (en) * | 2006-02-11 | 2008-02-21 | Rune Kjeken | Device and method for single-needle in vivo electroporation |
| US7879034B2 (en) * | 2006-03-02 | 2011-02-01 | Arthrocare Corporation | Internally located return electrode electrosurgical apparatus, system and method |
| JP2009528131A (ja) * | 2006-03-03 | 2009-08-06 | ジェネトロニクス，インコーポレイティド | 外科的切除後の組織に残る微視的残余腫瘍の処置方法及び装置 |
| US20070232984A1 (en) * | 2006-03-30 | 2007-10-04 | Michael Lovell | Hand-held electrical stimulation device |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| WO2007117651A2 (en) | 2006-04-07 | 2007-10-18 | University Of South Florida | Passive electric field focus system for in vivo and in vitro applications |
| US7856272B2 (en) * | 2006-04-28 | 2010-12-21 | Flint Hills Scientific, L.L.C. | Implantable interface for a medical device system |
| DK2024006T3 (en) * | 2006-05-18 | 2019-02-04 | Uroplasty Inc | Apparatus for stimulation of a patient's nerve |
| US20090254019A1 (en) * | 2006-06-12 | 2009-10-08 | Karen Julie Gehl | Electrode introducer device |
| US20090281475A1 (en) * | 2006-06-22 | 2009-11-12 | Koninklijke Philips Electronics N.V. | Iontophoretic electrotransport device |
| US20100280494A1 (en) * | 2006-08-08 | 2010-11-04 | Matsuura James E | Catheter and array for anticancer therapy |
| US7674249B2 (en) * | 2006-10-16 | 2010-03-09 | The Regents Of The University Of California | Gels with predetermined conductivity used in electroporation of tissue |
| CA2666501C (en) | 2006-10-17 | 2017-03-21 | Vgx Pharmaceuticals, Inc. | Electroporation devices and methods of using same for electroporation of cells in mammals |
| DK2548438T3 (en) | 2006-11-08 | 2015-10-19 | Veritas Bio LLC | IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL |
| US20080132884A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Systems for treating tissue sites using electroporation |
| US8821446B2 (en) * | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
| DK2167194T3 (en) | 2007-03-06 | 2017-06-19 | Novocure Ltd | TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY |
| US20110135569A1 (en) * | 2007-03-20 | 2011-06-09 | Peak Biosciences Inc. | Method for therapeutic administration of radionucleosides |
| ES2817249T3 (es) | 2007-04-16 | 2021-04-06 | Corium Inc | Matrices de microagujas obtenidas mediante disolución y colada que contienen un principio activo |
| US8470295B2 (en) * | 2007-05-10 | 2013-06-25 | Peak Biosciences, Inc. | Methods of treatment of androgenic steroidal hormone dependent cancer with auger electron-emitting nucleoside analogs |
| US20080312648A1 (en) * | 2007-06-12 | 2008-12-18 | Darion Peterson | Fat removal and sculpting device |
| EP2183024B1 (en) * | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| JP5178132B2 (ja) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | 画像処理システム並びに画像処理方法 |
| EP2211982B1 (en) * | 2007-10-11 | 2016-04-06 | Region Hovedstaden v/Herlev Hospital | An electroporation device for improved electrical field control |
| US20090248012A1 (en) * | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Irreversible electroporation device and method for attenuating neointimal |
| US20100004623A1 (en) * | 2008-03-27 | 2010-01-07 | Angiodynamics, Inc. | Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation |
| CA2720166A1 (en) * | 2008-04-04 | 2009-10-08 | David B. Weiner | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| KR101652767B1 (ko) * | 2008-04-04 | 2016-08-31 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Ｉｌ-28을 이용한 백신 및 면역치료제, 및 그를 사용하는 방법 및 조성물 |
| US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US8992517B2 (en) * | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
| US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
| US9598691B2 (en) | 2008-04-29 | 2017-03-21 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
| US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
| US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
| US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| US8348938B2 (en) * | 2008-05-06 | 2013-01-08 | Old Dominian University Research Foundation | Apparatus, systems and methods for treating a human tissue condition |
| WO2009137800A2 (en) | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
| US8849395B2 (en) | 2008-05-30 | 2014-09-30 | Boston Scientific Scimed, Inc. | Guide catheter having vasomodulating electrodes |
| WO2009155526A2 (en) * | 2008-06-20 | 2009-12-23 | Angiodynamics, Inc. | Device and method for the ablation of fibrin sheath formation on a venous catheter |
| US9681909B2 (en) * | 2008-06-23 | 2017-06-20 | Angiodynamics, Inc. | Treatment devices and methods |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| WO2010083035A2 (en) | 2009-01-14 | 2010-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
| US8753335B2 (en) * | 2009-01-23 | 2014-06-17 | Angiodynamics, Inc. | Therapeutic energy delivery device with rotational mechanism |
| KR100943089B1 (ko) * | 2009-01-23 | 2010-02-18 | 강동환 | 피부처치 장치 |
| WO2010093692A2 (en) * | 2009-02-10 | 2010-08-19 | Hobbs Eamonn P | Irreversible electroporation and tissue regeneration |
| US8632534B2 (en) | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
| WO2010118387A1 (en) * | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| EP2429627B1 (en) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| WO2010129899A1 (en) * | 2009-05-08 | 2010-11-11 | Cellutions, Inc. | Treatment system with a pulse forming network for achieving plasma in tissue |
| USD630321S1 (en) | 2009-05-08 | 2011-01-04 | Angio Dynamics, Inc. | Probe handle |
| WO2010138919A2 (en) | 2009-05-28 | 2010-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| EP2475421B1 (en) * | 2009-09-10 | 2017-08-09 | University College Cork-National University of Ireland, Cork | A device for treating tissue |
| WO2011032179A1 (en) | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
| US20110118732A1 (en) | 2009-11-19 | 2011-05-19 | The Regents Of The University Of California | Controlled irreversible electroporation |
| ES2549190T3 (es) * | 2010-03-01 | 2015-10-23 | Inovio Pharmaceuticals, Inc. | Aplicador y dispositivo de electroporación de múltiples capas de tejido |
| EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| US8979838B2 (en) | 2010-05-24 | 2015-03-17 | Arthrocare Corporation | Symmetric switching electrode method and related system |
| US9289606B2 (en) * | 2010-09-02 | 2016-03-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System for electroporation therapy |
| EP2621522A2 (en) | 2010-09-27 | 2013-08-07 | China Agricultural University | Combined antigen and dna vaccine for preventing and treating autoimmune diseases |
| EP2627274B1 (en) | 2010-10-13 | 2022-12-14 | AngioDynamics, Inc. | System for electrically ablating tissue of a patient |
| WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
| US20120220813A1 (en) * | 2011-01-25 | 2012-08-30 | Sanford Lane | Devices and methods for applying energy to a muscular layer |
| WO2012158132A1 (en) | 2011-05-18 | 2012-11-22 | Eteka Llc | Apparatus for the enhancement of food properties by electroporation or pulsed electric fields |
| CN103717249B (zh) | 2011-06-15 | 2017-03-22 | 克洛恩泰克制药股份公司 | 注射针和装置 |
| WO2012178095A1 (en) * | 2011-06-22 | 2012-12-27 | Ifluidics, Inc. | Electromotive system for high-throughput screening |
| CA2837214C (en) | 2011-06-28 | 2021-06-01 | Inovio Pharmaceuticals, Inc. | A minimally invasive dermal electroporation device |
| US9446112B2 (en) | 2011-07-12 | 2016-09-20 | Philadelphia Health & Education Corporation | Clostridium difficile DNA vaccine |
| CN102334988B (zh) * | 2011-07-28 | 2013-07-03 | 河海大学常州校区 | 手动组合式微电极推进器及制作方法 |
| CN103946952A (zh) | 2011-09-16 | 2014-07-23 | 宾夕法尼亚大学董事会 | 用于治疗癌症的rna改造的t细胞 |
| WO2013044225A1 (en) | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
| US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| CN108095821B (zh) * | 2011-11-08 | 2021-05-25 | 波士顿科学西美德公司 | 孔部肾神经消融 |
| CN103169510B (zh) * | 2011-12-20 | 2016-07-06 | 刘兴鹏 | 用于治疗房颤的化学消融装置 |
| US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
| CN103239734B (zh) | 2012-02-10 | 2016-02-24 | 北京艾棣维欣生物技术有限公司 | 用于预防和/或治疗呼吸道合胞病毒感染的疫苗 |
| EP2817330B1 (en) | 2012-02-22 | 2020-07-08 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| WO2013126729A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
| JP2015524255A (ja) | 2012-07-13 | 2015-08-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法 |
| WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| CN104812401B (zh) | 2012-12-13 | 2017-10-13 | 宾夕法尼亚大学理事会 | Wt1疫苗 |
| EP2934660B1 (en) | 2012-12-21 | 2019-07-17 | Corium, Inc. | Microarray for delivery of therapeutic agent and method of making same |
| EP4094799A1 (en) | 2013-03-12 | 2022-11-30 | Corium, Inc. | Microprojection applicators |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| EP2968119B1 (en) | 2013-03-15 | 2019-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| WO2014160886A2 (en) * | 2013-03-27 | 2014-10-02 | Washington State University | Systems and methods for treating material surfaces |
| US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| WO2014194244A1 (en) | 2013-05-30 | 2014-12-04 | Duke University | Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates |
| US10272144B2 (en) | 2013-07-31 | 2019-04-30 | Bioventures, Llc | Compositions for and methods of treating and preventing targeting tumor associated carbohydrate antigens |
| KR101582988B1 (ko) * | 2013-09-30 | 2016-01-06 | (주)휴먼드림 | 전립선 고주파 치료기 |
| DK3054972T3 (da) | 2013-10-07 | 2019-06-11 | Univ Pennsylvania | Vacciner med interleukin-33 som et adjuvans |
| WO2015070027A1 (en) | 2013-11-07 | 2015-05-14 | University Of Southern California | Use of ikk epsilon inhibitors to activate nfat and t cell response |
| US20160256539A1 (en) | 2013-11-14 | 2016-09-08 | The Trustees Of The University Of Pennsylvania | HIV-1 ENV DNA Vaccine Plus Protein Boost Delivered by EP Expands B- and T-Cell Response and Neutralizing |
| WO2015081155A1 (en) | 2013-11-29 | 2015-06-04 | The Trustees Of The University Of Pennsylvania | Mers-cov vaccine |
| US10835595B2 (en) | 2014-01-06 | 2020-11-17 | The Trustees Of The University Of Pennsylvania | PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy |
| US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
| WO2015112626A1 (en) | 2014-01-21 | 2015-07-30 | June Carl H | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| CN103861202B (zh) | 2014-03-18 | 2016-06-01 | 苏州壹达生物科技有限公司 | 一种利用空心电极针电穿孔给药的装置 |
| US12070601B2 (en) * | 2014-03-28 | 2024-08-27 | Pinnacle Bionics. Inc. | Stimulation system for exercising diaphragm and method of operation thereof |
| AU2015259303B2 (en) | 2014-05-12 | 2021-10-28 | Arena, Christopher B. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| US12114911B2 (en) | 2014-08-28 | 2024-10-15 | Angiodynamics, Inc. | System and method for ablating a tissue site by electroporation with real-time pulse monitoring |
| US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
| KR20230145241A (ko) | 2014-10-01 | 2023-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
| ES2910227T3 (es) | 2014-10-31 | 2022-05-12 | Univ Pennsylvania | Composición y métodos para la estimulación y expansión de células T |
| US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
| CA2964958A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for modified t cells |
| US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
| WO2016123285A1 (en) | 2015-01-29 | 2016-08-04 | The Trustees Of The University Of Pennsylvania | Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy |
| US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
| EP3288471A1 (en) | 2015-05-01 | 2018-03-07 | Inter Science GmbH | Methods, systems, and apparatuses for tissue ablation using pulse shape designs |
| BR112017023692A2 (pt) | 2015-05-01 | 2018-07-17 | The Regents Of The University Of California | moléculas imunoterapêuticas glican-dependentes |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| EA037478B1 (ru) | 2015-08-04 | 2021-04-01 | Дьюк Юниверсити | Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения |
| CN108348551A (zh) | 2015-08-28 | 2018-07-31 | 宾夕法尼亚大学董事会 | 表达嵌合细胞内信号传导分子的细胞的方法和组合物 |
| AU2016335755B2 (en) | 2015-10-07 | 2021-07-01 | Mayo Foundation For Medical Education And Research | Electroporation for obesity or diabetes treatment |
| WO2017070196A1 (en) * | 2015-10-21 | 2017-04-27 | The Methodist Hospital System | Cellular vectors for delivery of therapeutics |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| WO2017112826A2 (en) | 2015-12-21 | 2017-06-29 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| BR112018013242B1 (pt) * | 2015-12-28 | 2023-10-10 | Inovio Pharmaceuticals, Inc | Dispositivo de eletroporação com gerador de sinal melhorado |
| MX394498B (es) | 2015-12-30 | 2025-03-24 | Inovio Pharmaceuticals Inc | Dispositivo de electroporacion con arreglo de agujas extraible con sistema de bloqueo. |
| EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
| AU2017241925B2 (en) | 2016-03-28 | 2022-01-13 | Ichor Medical Systems, Inc. | Method and apparatus for delivery of therapeutic agents |
| US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| KR102624967B1 (ko) | 2016-04-29 | 2024-01-16 | 이노비오 파마수티컬즈, 인크. | 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도 |
| WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| EP3474760B1 (en) | 2016-06-27 | 2023-01-11 | Galvanize Therapeutics, Inc. | Generator and a catheter with an electrode for treating a lung passageway |
| US10233419B2 (en) | 2016-06-30 | 2019-03-19 | Zymergen Inc. | Apparatuses and methods for electroporation |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| WO2018053201A1 (en) | 2016-09-14 | 2018-03-22 | Duke University | Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs |
| JP2020500150A (ja) | 2016-09-23 | 2020-01-09 | デューク ユニバーシティ | 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド |
| US10613005B2 (en) | 2016-10-31 | 2020-04-07 | Agilent Technologies, Inc. | Deparaffinization of tissue by electric field generation and ionization |
| US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
| US10376495B2 (en) | 2016-11-23 | 2019-08-13 | University Of South Florida | Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF) |
| CA3045958A1 (en) | 2016-12-22 | 2018-06-28 | Ohio State Innovation Foundation | Interpentrating microstructures for nanochannel-based cargo delivery |
| WO2018132732A1 (en) | 2017-01-12 | 2018-07-19 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| CN107212920A (zh) * | 2017-01-23 | 2017-09-29 | 杭州安杰思医学科技有限公司 | 内窥镜用处理装置、内窥镜、及扩展支架 |
| US10813935B2 (en) | 2017-02-23 | 2020-10-27 | Transgenex Nanobiotech, Inc. | Methods and compositions for treating drug resistance in cancer |
| WO2018156989A1 (en) | 2017-02-24 | 2018-08-30 | University Of South Florida | The hsp90 activator aha1 drives production of pathological tau aggregates |
| US10272052B2 (en) | 2017-02-24 | 2019-04-30 | University Of South Florida | Compositions and methods for the treatment of tauopathies |
| US11827705B2 (en) | 2017-03-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Methods to protect transplanted tissue from rejection |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| SE541651C2 (en) * | 2017-07-28 | 2019-11-19 | Scandinavian Chemotech Ab | An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal |
| US10850095B2 (en) | 2017-08-08 | 2020-12-01 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US11590345B2 (en) | 2017-08-08 | 2023-02-28 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US10857347B2 (en) * | 2017-09-19 | 2020-12-08 | Pulse Biosciences, Inc. | Treatment instrument and high-voltage connectors for robotic surgical system |
| US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
| DK3731771T3 (da) | 2017-12-26 | 2023-08-28 | Galvanize Therapeutics Inc | V462033dk00 |
| EP3684399A1 (en) | 2017-12-29 | 2020-07-29 | Cellectis | Method for improving production of car t cells |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| US12390262B2 (en) | 2018-03-13 | 2025-08-19 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
| US11525759B2 (en) | 2018-04-24 | 2022-12-13 | Agilent Technologies, Inc. | Deparaffinization of tissue utilizing electric field |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| SG11202010395XA (en) | 2018-05-02 | 2020-11-27 | Oncosec Medical Inc | Electroporation systems, methods, and apparatus |
| CN112839671A (zh) | 2018-05-17 | 2021-05-25 | 明尼苏达大学董事会 | 抗药性免疫细胞及其使用方法 |
| US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
| US12497611B2 (en) | 2018-08-17 | 2025-12-16 | Yale University | Compositions and methods for high-throughput activation screening to boost T cell effector function |
| US12594347B2 (en) | 2018-09-07 | 2026-04-07 | Duke University | Nanoparticulate drug delivery systems |
| US20220170097A1 (en) | 2018-10-29 | 2022-06-02 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
| US12226148B2 (en) * | 2018-11-05 | 2025-02-18 | Region Hovedstaden V/Herlev Hospital | Electrode assembly for improved electric field distribution |
| TWI850282B (zh) | 2018-11-27 | 2024-08-01 | 香港商弘年發展有限公司 | 用於治療癌症之質體建構體和使用方法 |
| US20220054827A1 (en) * | 2018-12-13 | 2022-02-24 | Newsouth Innovations Pty Limited | Method and system for controlling molecular electrotransfer |
| US11071860B2 (en) * | 2019-02-06 | 2021-07-27 | Oncosec Medical Incorporated | Systems and methods for detecting fault conditions in electroporation therapy |
| US11571569B2 (en) | 2019-02-15 | 2023-02-07 | Pulse Biosciences, Inc. | High-voltage catheters for sub-microsecond pulsing |
| US12534714B2 (en) | 2019-03-18 | 2026-01-27 | The Broad Institute, Inc. | Type VII CRISPR proteins and systems |
| JP7654557B2 (ja) | 2019-03-27 | 2025-04-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法 |
| JP2022536885A (ja) | 2019-04-08 | 2022-08-22 | パテル、ウダヤン | バイパス通路を備えたカテーテル上の膨張可能バルーン |
| CN118203401A (zh) | 2019-04-18 | 2024-06-18 | 盖能适治疗股份有限公司 | 用于治疗异常组织的装置、系统和方法 |
| US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| EP3998973A4 (en) | 2019-07-16 | 2023-07-26 | Galvanize Therapeutics, Inc. | TREATMENT OF THE REPRODUCTIVE TRACT WITH PULSED ELECTRIC FIELDS |
| US12214189B2 (en) | 2019-07-24 | 2025-02-04 | Virginia Tech Intellectual Properties, Inc. | Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies |
| JP2022545794A (ja) * | 2019-08-30 | 2022-10-31 | ノボキュア ゲーエムベーハー | 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加 |
| WO2021074695A1 (en) | 2019-10-16 | 2021-04-22 | Avacta Life Sciences Limited | PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES. |
| CN114786605A (zh) | 2019-10-21 | 2022-07-22 | 英杜基奈克斯公司 | 用于十二指肠脉冲电场治疗的装置、系统和方法 |
| WO2021108050A2 (en) | 2019-10-23 | 2021-06-03 | Yale University | Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy |
| CN110946642A (zh) * | 2019-12-13 | 2020-04-03 | 天津市鹰泰利安康医疗科技有限责任公司 | 一种高频双极性不可恢复电穿孔系统 |
| JP2023511780A (ja) | 2020-02-25 | 2023-03-22 | イノビオ ファーマシューティカルズ，インコーポレイティド | コロナウイルスに対するワクチンおよび使用方法 |
| JP2023516080A (ja) | 2020-03-06 | 2023-04-17 | ジーオー セラピューティクス，インコーポレイテッド | 抗グリコｃｄ４４抗体およびその使用 |
| US20210322471A1 (en) | 2020-03-27 | 2021-10-21 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
| BR112022022719A2 (pt) | 2020-05-14 | 2023-02-14 | Inovio Pharmaceuticals Inc | Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| CA3181680A1 (en) | 2020-06-12 | 2021-12-16 | University Of Rochester | Encoding and expression of ace-trnas |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| EP4210832A1 (en) | 2020-09-14 | 2023-07-19 | Vor Biopharma, Inc. | Chimeric antigen receptors for treatment of cancer |
| CA3196677A1 (en) | 2020-11-05 | 2022-05-12 | Erik Hans MANTING | Use of tumor-independent antigens in immunotherapies |
| US12485279B2 (en) | 2020-11-25 | 2025-12-02 | Virginia Tech Intellectual Properties, Inc. | Methods for modulating temporal infrastructure of pulsed electric fields |
| JP2024506249A (ja) | 2021-01-22 | 2024-02-13 | メンドゥス・ベスローテン・フェンノートシャップ | 腫瘍ワクチン接種の方法 |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| CA3212351A1 (en) | 2021-03-12 | 2022-09-15 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| CA3223587A1 (en) * | 2021-06-30 | 2023-01-05 | Paul Fisher | Side-port injection devices for use with electroporation, and related systems and methods |
| EP4376877A2 (en) | 2021-07-29 | 2024-06-05 | Vor Biopharma Inc. | Chimeric antigen receptors for treatment of cancer |
| WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
| US20250101126A1 (en) | 2021-08-05 | 2025-03-27 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
| IL310808A (en) | 2021-08-13 | 2024-04-01 | Inovio Pharmaceuticals Inc | Combination therapy to treat brain cancer |
| CN118354789A (zh) | 2021-09-03 | 2024-07-16 | Go医疗股份有限公司 | 抗糖-cMET抗体及其用途 |
| EP4396232A1 (en) | 2021-09-03 | 2024-07-10 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
| US20240409638A1 (en) | 2021-10-07 | 2024-12-12 | Avacta Life Sciences Limited | Serum half-life extended pd-l1 binding polypeptides |
| EP4413038A1 (en) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
| AU2023215397A1 (en) | 2022-02-07 | 2024-08-22 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression. |
| CN119213021A (zh) | 2022-02-10 | 2024-12-27 | 艾菲赛尔治疗株式会社 | 与CD40L特异性结合的Stefin A蛋白变体及其用途 |
| US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
| AU2023378712A1 (en) | 2022-11-07 | 2025-05-01 | Pinetree Therapeutics, Inc. | Combination therapy comprising bispecific antibodies comprising an nrp1 binding domain |
| EP4634373A1 (en) | 2022-12-16 | 2025-10-22 | University of Rochester | Repairment of barrier dysfunction in esophagus |
| WO2024236547A1 (en) | 2023-05-18 | 2024-11-21 | Inceptor Bio, Llc | Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof |
| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| WO2025101685A1 (en) | 2023-11-09 | 2025-05-15 | University Of Rochester | Suppression of nonsense mutations using anticodon engineered (ace)-trnas |
| WO2026030209A1 (en) | 2024-07-29 | 2026-02-05 | University Of Rochester | Use of decoding trnas to boost protein expression or function |
| WO2026047626A1 (en) | 2024-08-30 | 2026-03-05 | Inceptor Bio, Llc | Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674267A (en) * | 1993-03-30 | 1997-10-07 | Centre National De La Recherche Scientifique | Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE863111C (de) | 1951-07-03 | 1953-01-15 | Walter Hallegger | Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung |
| DE2800039C2 (de) | 1978-01-02 | 1984-06-20 | Horst Dr.Med. 6700 Ludwigshafen Kief | Akupunkturgerät |
| US5421819A (en) * | 1992-08-12 | 1995-06-06 | Vidamed, Inc. | Medical probe device |
| US5370675A (en) * | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
| US4712559A (en) * | 1985-06-28 | 1987-12-15 | Bsd Medical Corporation | Local current capacitive field applicator for interstitial array |
| US4931046A (en) * | 1987-05-15 | 1990-06-05 | Newman Martin H | Iontophoresis drug delivery system |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| DE68925030T2 (de) * | 1988-01-21 | 1996-07-25 | Massachusetts Inst Technology | Molekültransport durch gewebe mit der verwendung von elektroporation. |
| US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| US5749847A (en) | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| US4860752A (en) * | 1988-02-18 | 1989-08-29 | Bsd Medical Corporation | Invasive microwave array with destructive and coherent phase |
| EP0346513A1 (de) | 1988-06-15 | 1989-12-20 | Etama Ag | Anordnung zur Elektrotherapie |
| ES2012944A6 (es) | 1989-01-09 | 1990-04-16 | Tomas Justribo Jose Ramon | Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales. |
| CS275292B2 (en) | 1989-02-22 | 1992-02-19 | Cvut Fakulta Elektrotechnick | Private rehabilitation apparatus with ion transcutaneous acceleration |
| US6001617A (en) | 1989-06-07 | 1999-12-14 | Queen's University At Kingston | Electroporation device and method of use |
| US5215088A (en) | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| DE4000893A1 (de) | 1990-01-15 | 1991-07-18 | Bosch Gmbh Robert | Mehrkanaliges geraet zur elektrostimulation |
| US5620481A (en) * | 1991-07-05 | 1997-04-15 | Desai; Jawahar M. | Device for multi-phase radio-frequency ablation |
| US5328451A (en) | 1991-08-15 | 1994-07-12 | Board Of Regents, The University Of Texas System | Iontophoretic device and method for killing bacteria and other microbes |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US5425752A (en) | 1991-11-25 | 1995-06-20 | Vu'nguyen; Dung D. | Method of direct electrical myostimulation using acupuncture needles |
| US5545130A (en) * | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
| US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
| US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
| US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
| US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5688233A (en) * | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
| US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| JPH08506259A (ja) | 1993-02-02 | 1996-07-09 | ヴィーダメッド インコーポレイテッド | 経尿道ニードル切除装置および方法 |
| US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| WO1994027670A1 (en) | 1993-06-02 | 1994-12-08 | Cardiac Pathways Corporation | Catheter having tip with fixation means |
| US5551426A (en) * | 1993-07-14 | 1996-09-03 | Hummel; John D. | Intracardiac ablation and mapping catheter |
| US5536267A (en) * | 1993-11-08 | 1996-07-16 | Zomed International | Multiple electrode ablation apparatus |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US5571083A (en) * | 1994-02-18 | 1996-11-05 | Lemelson; Jerome H. | Method and system for cell transplantation |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5807308A (en) * | 1996-02-23 | 1998-09-15 | Somnus Medical Technologies, Inc. | Method and apparatus for treatment of air way obstructions |
| US5786454A (en) | 1994-09-16 | 1998-07-28 | Washington University School Of Medicine | Modified SH2 domains |
| US5645526A (en) * | 1994-09-30 | 1997-07-08 | Becton Dickinson And Company | Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| US5868740A (en) | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
| US5810762A (en) * | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5780052A (en) | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5789213A (en) | 1995-05-11 | 1998-08-04 | Health Research Inc. | Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
| US6002961A (en) | 1995-07-25 | 1999-12-14 | Massachusetts Institute Of Technology | Transdermal protein delivery using low-frequency sonophoresis |
| US5983131A (en) | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| US5980517A (en) | 1995-08-15 | 1999-11-09 | Rita Medical Systems, Inc. | Cell necrosis apparatus |
| AU6855796A (en) | 1995-08-29 | 1997-03-19 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
| US5688232A (en) * | 1995-09-28 | 1997-11-18 | Becton Dickinson And Company | Iontophoretic drug delivery device having an improved controller |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| WO1997047355A1 (en) | 1996-06-12 | 1997-12-18 | Alza Corporation | Reduction of skin sensitization in electrotransport drug delivery |
| GB2314274A (en) * | 1996-06-20 | 1997-12-24 | Gyrus Medical Ltd | Electrode construction for an electrosurgical instrument |
| US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US5874268A (en) | 1996-09-23 | 1999-02-23 | Duke University | Method of introducing exogenous compounds into cells by electroporation and apparatus for same |
| US5908753A (en) | 1996-10-04 | 1999-06-01 | Merck & Co., Inc. | Transformation of Candida albicans by electroporation |
| US5845646A (en) | 1996-11-05 | 1998-12-08 | Lemelson; Jerome | System and method for treating select tissue in a living being |
| CA2285056C (en) | 1997-04-03 | 2004-12-14 | Iacob Mathiesen | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US5879891A (en) | 1997-09-17 | 1999-03-09 | Merck & Co., Inc. | Transformation of saccharomyces cerevisiae by electroporation |
| TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
| US6022316A (en) | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
| AU742057B2 (en) | 1998-04-14 | 2001-12-13 | Gmp Drug Delivery, Inc. | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| US6040184A (en) | 1998-10-09 | 2000-03-21 | Stratagene | Method for more efficient electroporation |
-
1997
- 1997-08-01 US US08/905,240 patent/US6055453A/en not_active Expired - Lifetime
-
1998
- 1998-07-31 AT AT98938256T patent/ATE480294T1/de not_active IP Right Cessation
- 1998-07-31 CN CN2005100847339A patent/CN1768873B/zh not_active Expired - Lifetime
- 1998-07-31 EP EP98938256A patent/EP0999867B1/en not_active Expired - Lifetime
- 1998-07-31 WO PCT/US1998/016042 patent/WO1999006101A1/en not_active Ceased
- 1998-07-31 AU AU86823/98A patent/AU734343B2/en not_active Expired
- 1998-07-31 DE DE69841888T patent/DE69841888D1/de not_active Expired - Lifetime
- 1998-07-31 KR KR1019997002781A patent/KR100756252B1/ko not_active Expired - Lifetime
- 1998-07-31 RU RU99109111/14A patent/RU2195332C2/ru not_active IP Right Cessation
- 1998-07-31 BR BR9806069-4A patent/BR9806069A/pt not_active Application Discontinuation
- 1998-07-31 JP JP11511309A patent/JP2000503586A/ja active Pending
- 1998-07-31 CN CN988014610A patent/CN1217717C/zh not_active Expired - Lifetime
- 1998-07-31 CA CA002268026A patent/CA2268026C/en not_active Expired - Lifetime
- 1998-09-18 TW TW087115609A patent/TW396043B/zh not_active IP Right Cessation
- 1998-11-09 US US09/189,070 patent/US6068650A/en not_active Expired - Lifetime
- 1998-11-09 US US09/189,360 patent/US6181964B1/en not_active Expired - Lifetime
- 1998-11-09 US US09/189,062 patent/US6233482B1/en not_active Expired - Lifetime
-
1999
- 1999-01-08 US US09/227,416 patent/US6014584A/en not_active Expired - Lifetime
-
2002
- 2002-03-04 JP JP2002057679A patent/JP4180285B2/ja not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674267A (en) * | 1993-03-30 | 1997-10-07 | Centre National De La Recherche Scientifique | Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017048037A1 (ko) * | 2015-09-17 | 2017-03-23 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
| KR101788301B1 (ko) * | 2015-09-17 | 2017-10-20 | 주식회사 엘림텍 | 전기천공장치 및 그 제어방법 |
Also Published As
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| US6181964B1 (en) | 2001-01-30 |
| TW396043B (en) | 2000-07-01 |
| CN1768873B (zh) | 2011-04-13 |
| CN1248923A (zh) | 2000-03-29 |
| JP2000503586A (ja) | 2000-03-28 |
| BR9806069A (pt) | 2000-01-25 |
| EP0999867A1 (en) | 2000-05-17 |
| AU734343B2 (en) | 2001-06-14 |
| CN1768873A (zh) | 2006-05-10 |
| US6014584A (en) | 2000-01-11 |
| AU8682398A (en) | 1999-02-22 |
| US6055453A (en) | 2000-04-25 |
| KR20000068678A (ko) | 2000-11-25 |
| JP2002291910A (ja) | 2002-10-08 |
| EP0999867A4 (en) | 2008-03-26 |
| HK1027049A1 (en) | 2001-01-05 |
| US6068650A (en) | 2000-05-30 |
| WO1999006101A1 (en) | 1999-02-11 |
| CA2268026A1 (en) | 1999-02-11 |
| DE69841888D1 (de) | 2010-10-21 |
| CN1217717C (zh) | 2005-09-07 |
| US6233482B1 (en) | 2001-05-15 |
| ATE480294T1 (de) | 2010-09-15 |
| RU2195332C2 (ru) | 2002-12-27 |
| CA2268026C (en) | 2003-07-29 |
| EP0999867B1 (en) | 2010-09-08 |
| JP4180285B2 (ja) | 2008-11-12 |
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