TW396043B - Method and apparatus for using electroporation mediated delivery of drugs and genes - Google Patents

Method and apparatus for using electroporation mediated delivery of drugs and genes Download PDF

Info

Publication number
TW396043B
TW396043B TW087115609A TW87115609A TW396043B TW 396043 B TW396043 B TW 396043B TW 087115609 A TW087115609 A TW 087115609A TW 87115609 A TW87115609 A TW 87115609A TW 396043 B TW396043 B TW 396043B
Authority
TW
Taiwan
Prior art keywords
electrode
applicator
needle
scope
treatment
Prior art date
Application number
TW087115609A
Other languages
English (en)
Chinese (zh)
Inventor
Gunter A Hofmann
Sukhendu B Dev
Steven C Dimmer
Jeffrey I Levatter
Gurvinder S Nanda
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of TW396043B publication Critical patent/TW396043B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrotherapy Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW087115609A 1997-08-01 1998-09-18 Method and apparatus for using electroporation mediated delivery of drugs and genes TW396043B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/905,240 US6055453A (en) 1997-08-01 1997-08-01 Apparatus for addressing needle array electrodes for electroporation therapy

Publications (1)

Publication Number Publication Date
TW396043B true TW396043B (en) 2000-07-01

Family

ID=25420478

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087115609A TW396043B (en) 1997-08-01 1998-09-18 Method and apparatus for using electroporation mediated delivery of drugs and genes

Country Status (13)

Country Link
US (5) US6055453A (https=)
EP (1) EP0999867B1 (https=)
JP (2) JP2000503586A (https=)
KR (1) KR100756252B1 (https=)
CN (2) CN1768873B (https=)
AT (1) ATE480294T1 (https=)
AU (1) AU734343B2 (https=)
BR (1) BR9806069A (https=)
CA (1) CA2268026C (https=)
DE (1) DE69841888D1 (https=)
RU (1) RU2195332C2 (https=)
TW (1) TW396043B (https=)
WO (1) WO1999006101A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252307B2 (en) 1999-03-22 2012-08-28 Psivida Us, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US8574659B2 (en) 2000-04-26 2013-11-05 Psivida Us, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices

Families Citing this family (400)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277112B1 (en) 1996-07-16 2001-08-21 Arthrocare Corporation Methods for electrosurgical spine surgery
US6602248B1 (en) * 1995-06-07 2003-08-05 Arthro Care Corp. Methods for repairing damaged intervertebral discs
US7393351B2 (en) 1995-06-07 2008-07-01 Arthrocare Corporation Apparatus and methods for treating cervical inter-vertebral discs
US20050004634A1 (en) * 1995-06-07 2005-01-06 Arthrocare Corporation Methods for electrosurgical treatment of spinal tissue
WO1997029701A1 (en) 1996-02-15 1997-08-21 Biosense Inc. Catheter based surgery
US6726684B1 (en) * 1996-07-16 2004-04-27 Arthrocare Corporation Methods for electrosurgical spine surgery
US7357798B2 (en) * 1996-07-16 2008-04-15 Arthrocare Corporation Systems and methods for electrosurgical prevention of disc herniations
US20060089751A1 (en) * 1997-01-27 2006-04-27 Ewa Herbst Electronic delivery systems and methods with feedback
US6708066B2 (en) * 1999-12-10 2004-03-16 Ewa Herbst Electrochemical treatment of tissues, especially tumors
HUP0004589A3 (en) 1997-06-30 2003-08-28 Centre Nat Rech Scient Improved method for transferring nucleic acid into the striped muscle and combination therefor
IL133708A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof
WO2003046170A1 (en) * 2001-11-27 2003-06-05 Cellectricon Ab A method for combined parallel agent delivery and electroporation for cell structures and use thereof
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
DE69838526T2 (de) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Gerät zum Freisetzen eines Medikaments im Herzen
US7749215B1 (en) 1998-02-05 2010-07-06 Biosense, Inc. Intracardiac cell delivery and cell transplantation
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US6045532A (en) * 1998-02-20 2000-04-04 Arthrocare Corporation Systems and methods for electrosurgical treatment of tissue in the brain and spinal cord
EP1056501B1 (en) 1998-02-24 2005-11-16 Boston Scientific Limited High flow rate dialysis catheters and related methods
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
AU4368699A (en) * 1998-05-29 1999-12-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. New method for transferring biological material
ATE369877T1 (de) * 1998-06-26 2007-09-15 Genetronics Inc Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
EP1100579B1 (en) 1998-07-13 2015-09-02 Inovio Pharmaceuticals, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
DE69921489T2 (de) 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
WO2000056395A1 (en) 1999-03-25 2000-09-28 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
CA2370349C (en) 1999-04-16 2013-01-29 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6514762B1 (en) 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
US6221071B1 (en) * 1999-06-04 2001-04-24 Scimed Life Systems, Inc. Rapid electrode deployment
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US7074747B1 (en) 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6237604B1 (en) 1999-09-07 2001-05-29 Scimed Life Systems, Inc. Systems and methods for preventing automatic identification of re-used single use devices
US6387092B1 (en) * 1999-09-07 2002-05-14 Scimed Life Systems, Inc. Systems and methods to identify and disable re-used single use devices based on time elapsed from first therapeutic use
US6611793B1 (en) 1999-09-07 2003-08-26 Scimed Life Systems, Inc. Systems and methods to identify and disable re-use single use devices based on detecting environmental changes
US6651669B1 (en) 1999-09-07 2003-11-25 Scimed Life Systems, Inc. Systems and methods to identify and disable re-used single use devices based on cataloging catheter usage
US6587718B2 (en) * 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
US6556869B1 (en) 1999-12-01 2003-04-29 Vertis Neuroscience, Inc. Electrode introducer for a percutaneous electrical therapy system
US6912424B2 (en) * 1999-12-01 2005-06-28 Meagan, Medical, Inc. Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient
US6493592B1 (en) * 1999-12-01 2002-12-10 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode position maintenance
US6560491B1 (en) 1999-12-01 2003-05-06 Vertis Neuroscience, Inc. Percutaneous electrical therapy system providing electrode axial support
US6549797B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Electrode remover for a percutaneous electrical therapy system
US6549810B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode depth control
US6539264B1 (en) 1999-12-01 2003-03-25 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with sharp point protection
US6904324B2 (en) * 1999-12-01 2005-06-07 Meagan Medical, Inc. Method and apparatus for deploying a percutaneous probe
US6622051B1 (en) 1999-12-01 2003-09-16 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode entry angle control
US6522927B1 (en) 1999-12-01 2003-02-18 Vertis Neuroscience, Inc. Electrode assembly for a percutaneous electrical therapy system
US6516226B1 (en) 1999-12-01 2003-02-04 Vertis Neuroscience, Inc. Percutaneous electrical therapy system for minimizing electrode insertion discomfort
US6529776B1 (en) 1999-12-01 2003-03-04 Vertis Neuroscience, Inc. Method and apparatus for repositioning a percutaneous probe
KR100406729B1 (ko) * 2000-02-15 2003-11-21 사회복지법인삼성생명공익재단(삼성서울병원) 생리학적 전기신호에 동조화된 의료기기
US7146210B2 (en) * 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US8447395B2 (en) * 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7089054B2 (en) * 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US6868289B2 (en) * 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7016725B2 (en) * 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7890183B2 (en) * 2000-02-17 2011-02-15 Novocure Ltd. Treating parasites with electric fields
US7136699B2 (en) * 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
US7588554B2 (en) * 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US7118555B2 (en) * 2000-09-21 2006-10-10 Meagan Medical, Inc. Method and apparatus for repositioning a percutaneous probe
USD480478S1 (en) 2000-09-28 2003-10-07 Vertis Neuroscience, Inc. Percutaneous probe applicator
US20030158545A1 (en) * 2000-09-28 2003-08-21 Arthrocare Corporation Methods and apparatus for treating back pain
US6671557B1 (en) 2000-10-10 2003-12-30 Meagan Medical, Inc. System and method for providing percutaneous electrical therapy
US6846306B1 (en) * 2000-10-10 2005-01-25 Cold Spring Harbor Laboratory Single cell electroporation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
EP1353723A2 (en) 2000-11-17 2003-10-22 Gendel Limited Ablation of cells using combined electric field and ultrasound therapy
US6821274B2 (en) 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
US20050043726A1 (en) * 2001-03-07 2005-02-24 Mchale Anthony Patrick Device II
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6625486B2 (en) 2001-04-11 2003-09-23 Advanced Cardiovascular Systems, Inc. Method and apparatus for intracellular delivery of an agent
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
AU2002316053A1 (en) * 2001-05-01 2002-11-11 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
WO2002087645A1 (en) 2001-05-01 2002-11-07 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
ITTO20010534A1 (it) * 2001-06-04 2002-12-04 Igea Srl Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore.
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US7130697B2 (en) * 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US7713740B2 (en) * 2001-08-24 2010-05-11 University Of South Florida Method of using electric fields to facilitate the entry of molecules into cells in vivo
US7879610B1 (en) * 2001-08-24 2011-02-01 University Of South Florida Electroporation system and method for facilitating entry of molecules into cells in vivo
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002362310A1 (en) * 2001-09-14 2003-04-01 Arthrocare Corporation Methods and apparatus for treating intervertebral discs
USD475463S1 (en) 2001-09-28 2003-06-03 Vertis Neuroscience, Inc. Control device for delivering electrical therapy
FR2831026B1 (fr) * 2001-10-18 2004-05-28 Commissariat Energie Atomique Dispositif et procede de traitement par champ electrique pulse d'une substance en ecoulement colonisee par des organismes indesirables
US7536226B2 (en) * 2001-10-18 2009-05-19 Uroplasty, Inc. Electro-nerve stimulator system and methods
US8812114B2 (en) 2001-10-18 2014-08-19 Uroplasty, Inc. Lead set for nerve stimulator and method of operation thereof
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
EP1476536B1 (en) * 2002-02-12 2011-07-20 Cellectricon Ab Systems and methods for rapidly changing the solution environment around sensors
CA2476452A1 (en) * 2002-02-15 2003-08-28 Zycos Inc. Electroporation methods for introducing bioactive agents into cells
CA2995944C (en) * 2002-03-07 2023-09-12 Advisys, Inc. Electrode system for facilitating macromolecule introduction
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7697981B2 (en) * 2002-03-22 2010-04-13 The Regents Of The University Of California Method and apparatus for using an electromagnetic field in cellular transplantation
US7218962B2 (en) * 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
DE60322523D1 (de) 2002-04-16 2008-09-11 Cyto Pulse Sciences Inc Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr
US20030204161A1 (en) * 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
DE60324417D1 (de) * 2002-05-23 2008-12-11 Gendel Ltd Ablationsvorrichtung
US10130415B2 (en) * 2002-06-10 2018-11-20 Wisconsin Alumni Research Foundation Circumferential electrode array for tissue ablation
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US20040127893A1 (en) * 2002-12-13 2004-07-01 Arthrocare Corporation Methods for visualizing and treating intervertebral discs
US6997903B2 (en) * 2003-02-10 2006-02-14 Bandula Wijay Local drug delivery catheter
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7794456B2 (en) * 2003-05-13 2010-09-14 Arthrocare Corporation Systems and methods for electrosurgical intervertebral disc replacement
US6969604B1 (en) 2003-06-20 2005-11-29 Yakovenko Sergey A Electroporation chamber
GB0322766D0 (en) * 2003-09-29 2003-10-29 Emcision Ltd Surgical resection device
US7708733B2 (en) * 2003-10-20 2010-05-04 Arthrocare Corporation Electrosurgical method and apparatus for removing tissue within a bone body
US8500713B2 (en) * 2003-10-29 2013-08-06 Medtronic, Inc. Implantable electroporation therapy device and method for using same
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
ES2729378T3 (es) 2003-12-24 2019-11-04 Univ California Ablación de tejido con electroporación irreversible
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
RU2252793C1 (ru) * 2004-02-02 2005-05-27 Карасев Александр Александрович Электродное устройство
FR2867054B1 (fr) 2004-03-04 2006-09-15 Future Medical System Systeme d'endoscopie et connecteur a detecteur de pression destine a un tel systeme
CA2559083C (en) 2004-03-08 2015-06-16 Ichor Medical Systems, Inc. Improved apparatus for electrically mediated delivery of therapeutic agents
CA2560840C (en) * 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
JP4899020B2 (ja) * 2004-03-25 2012-03-21 ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク 組織の予防的処置又は治療に用いるための装置
JP4443278B2 (ja) * 2004-03-26 2010-03-31 テルモ株式会社 拡張体付カテーテル
WO2005096979A1 (en) 2004-04-01 2005-10-20 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20050226991A1 (en) * 2004-04-07 2005-10-13 Hossainy Syed F Methods for modifying balloon of a catheter assembly
EP1763321A4 (en) 2004-04-16 2010-02-17 Critical Care Innovations Inc SYSTEMS AND METHOD FOR ENHANCING ABLATION OF IMAGE-GUIDED FABRIC
CA2563817C (en) * 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
FR2872055B1 (fr) 2004-06-24 2008-02-08 Yves Leon Scherman Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
WO2006010837A2 (fr) 2004-06-24 2006-02-02 Sphergen Dispositif our le transfert de molecules aux cellules utilisant une force electrique
MX2007001512A (es) * 2004-08-05 2007-04-20 Corium Int Inc Composicion adhesiva.
ES2344215T3 (es) * 2004-12-07 2010-08-20 Standen Ltd. Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo.
EP3666328B1 (en) * 2004-12-27 2022-04-06 Novocure GmbH Treating a tumor or the like with electric fields at different orientations
WO2007012907A2 (en) * 2005-02-08 2007-02-01 Allen, John Electric therapy machine
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
AU2006226753A1 (en) * 2005-03-19 2006-09-28 The Regents Of The University Of California Ultra low strength electric field network-mediated ex vivo gene, protein and drug delivery in cells
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
WO2006124639A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
EP2400530A3 (en) * 2005-06-20 2012-04-18 Nippon Telegraph And Telephone Corporation Diamond semiconductor element and process for producing the same
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293731A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
CA2613885C (en) * 2005-06-30 2014-05-06 Lg Electronics Inc. Method and apparatus for encoding and decoding an audio signal
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
CN101321555B (zh) 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
CA3063263C (en) 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
US7879034B2 (en) * 2006-03-02 2011-02-01 Arthrocare Corporation Internally located return electrode electrosurgical apparatus, system and method
KR101444471B1 (ko) 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
US20070232984A1 (en) * 2006-03-30 2007-10-04 Michael Lovell Hand-held electrical stimulation device
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
WO2007117651A2 (en) 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
US7856272B2 (en) * 2006-04-28 2010-12-21 Flint Hills Scientific, L.L.C. Implantable interface for a medical device system
US7668598B2 (en) 2006-05-18 2010-02-23 Uroplasty, Inc. Method and apparatus for stimulating a nerve of a patient
DE602007003723D1 (de) * 2006-06-12 2010-01-21 Region Hovedstaden V Herlev Ho Elektrodeneinführeinrichtung
US20090281475A1 (en) * 2006-06-22 2009-11-12 Koninklijke Philips Electronics N.V. Iontophoretic electrotransport device
WO2008020967A2 (en) * 2006-08-08 2008-02-21 Peak Biosciences, Inc. Catheter and array for anticancer therapy
WO2008048620A2 (en) 2006-10-16 2008-04-24 The Regents Of The University Of California Gels with predetermined conductivity used in irreversible electroporation of tissue
ES2993941T3 (en) 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
EP2799547B1 (en) 2006-11-08 2016-12-21 Veritas Bio, LLC In Vivo Delivery of RNA to a Target Cell
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
AU2008209537B2 (en) * 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
US8465533B2 (en) 2007-03-06 2013-06-18 Novocure Limited Treating cancer using electromagnetic fields in combination with photodynamic therapy
WO2008115511A1 (en) * 2007-03-20 2008-09-25 Peak Biosciences, Inc. Method for therapeutic administration of radionucleosides
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
WO2008140808A1 (en) * 2007-05-10 2008-11-20 Peak Biosciences, Inc. Methods for administration of radiotherapeutic agents
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
US20100298759A1 (en) * 2007-10-11 2010-11-25 Region Hovedstaden V/Herlev Hospital electroporation device for improved electrical field control
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US20100004623A1 (en) * 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
KR101589511B1 (ko) * 2008-04-04 2016-02-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 치쿤구니야 바이러스 단백질의 공통 서열, 이를 인코딩하는 핵산 분자, 조성물 및 이를 이용하는 방법
US10071154B2 (en) * 2008-04-04 2018-09-11 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same
CA2722296A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8348938B2 (en) * 2008-05-06 2013-01-08 Old Dominian University Research Foundation Apparatus, systems and methods for treating a human tissue condition
WO2009137800A2 (en) * 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8849395B2 (en) 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
WO2009155526A2 (en) * 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) * 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
CA2751884C (en) 2009-01-14 2018-09-25 Corium International, Inc. Transdermal administration of tamsulosin
KR100943089B1 (ko) * 2009-01-23 2010-02-18 강동환 피부처치 장치
US8753335B2 (en) * 2009-01-23 2014-06-17 Angiodynamics, Inc. Therapeutic energy delivery device with rotational mechanism
US8231603B2 (en) * 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010118387A1 (en) * 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US20100298825A1 (en) * 2009-05-08 2010-11-25 Cellutions, Inc. Treatment System With A Pulse Forming Network For Achieving Plasma In Tissue
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
IE20100567A1 (en) * 2009-09-10 2011-04-27 Univ College Cork Nat Univ Ie A device for treating tissue
CN102821790A (zh) 2009-09-14 2012-12-12 宾夕法尼亚大学托管会 包含IL-15受体α和/或编码IL-15受体α的核酸分子的疫苗和免疫治疗剂,以及其使用方法
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
EP2542299B1 (en) * 2010-03-01 2015-07-15 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8979838B2 (en) 2010-05-24 2015-03-17 Arthrocare Corporation Symmetric switching electrode method and related system
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
CN103200959A (zh) 2010-09-27 2013-07-10 中国农业大学 预防和治疗自身免疫性疾病的联合抗原和dna疫苗
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US20120220813A1 (en) * 2011-01-25 2012-08-30 Sanford Lane Devices and methods for applying energy to a muscular layer
WO2012158132A1 (en) 2011-05-18 2012-11-22 Eteka Llc Apparatus for the enhancement of food properties by electroporation or pulsed electric fields
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
WO2012178095A1 (en) * 2011-06-22 2012-12-27 Ifluidics, Inc. Electromotive system for high-throughput screening
KR102081868B1 (ko) * 2011-06-28 2020-02-26 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치
US9446112B2 (en) 2011-07-12 2016-09-20 Philadelphia Health & Education Corporation Clostridium difficile DNA vaccine
CN102334988B (zh) * 2011-07-28 2013-07-03 河海大学常州校区 手动组合式微电极推进器及制作方法
WO2013040557A2 (en) 2011-09-16 2013-03-21 The Trustees Of The University Of Pennsylvania Rna engineered t cells for the treatment of cancer
US9708384B2 (en) 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
CN104023662B (zh) * 2011-11-08 2018-02-09 波士顿科学西美德公司 孔部肾神经消融
CN103169510B (zh) * 2011-12-20 2016-07-06 刘兴鹏 用于治疗房颤的化学消融装置
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
CA3205751A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
MX2014010185A (es) 2012-02-22 2014-11-14 Univ Pennsylvania Uso de dominio de señalizacion cd2 en receptores de antigeno quimericos de segunda generacion.
KR20150029714A (ko) 2012-07-13 2015-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강
WO2014055442A2 (en) 2012-10-01 2014-04-10 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
US9598489B2 (en) 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
CA2888648C (en) 2012-12-13 2021-06-08 The Trustees Of The University Of Pennsylvania Wt1 vaccine
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
CA3130120A1 (en) 2013-03-12 2014-10-09 Corium, Inc. Microprojection applicators
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
JP6689187B2 (ja) 2013-03-15 2020-04-28 コリウム， インコーポレイテッド 複数の衝突微小突起アプリケータおよび使用方法
RU2711567C2 (ru) 2013-03-15 2020-01-17 Кориум, ИНК. Микрочип для доставки лекарственного средства и способы его использования
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2014160886A2 (en) * 2013-03-27 2014-10-02 Washington State University Systems and methods for treating material surfaces
WO2014194244A1 (en) 2013-05-30 2014-12-04 Duke University Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
AU2014296038B2 (en) 2013-07-31 2020-09-10 Bioventures, Llc. Compositions for and methods of treating and preventing cancer targeting tumor associated carbohydrate antigens
KR101582988B1 (ko) * 2013-09-30 2016-01-06 (주)휴먼드림 전립선 고주파 치료기
WO2015054012A1 (en) 2013-10-07 2015-04-16 The Trustees Of The University Of Pennsylvania Vaccines with interleukin-33 as an adjuvant
US10370664B2 (en) 2013-11-07 2019-08-06 University Of Southern California Use of IKK epsilon inhibitors to activate NFAT and T cell response
KR20220061285A (ko) 2013-11-14 2022-05-12 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 HIV-1 EnV DNA 백신과 단백질 부스터
KR20160091350A (ko) 2013-11-29 2016-08-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신
KR20220062143A (ko) 2014-01-06 2022-05-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
CN103861202B (zh) * 2014-03-18 2016-06-01 苏州壹达生物科技有限公司 一种利用空心电极针电穿孔给药的装置
US12070601B2 (en) * 2014-03-28 2024-08-27 Pinnacle Bionics. Inc. Stimulation system for exercising diaphragm and method of operation thereof
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
AU2015323944B2 (en) 2014-10-01 2018-11-29 Inovio Pharmaceuticals, Inc. Vaccines having an antigen and interleukin-21 as an adjuvant
CN107106609A (zh) 2014-10-31 2017-08-29 宾夕法尼亚大学董事会 刺激和扩展t细胞的组合物和方法
JP7372728B2 (ja) 2014-10-31 2023-11-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改変ｔ細胞に関する方法および組成物
WO2016069282A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Altering gene expression in modified t cells and uses thereof
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CA2974956A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
US10828353B2 (en) 2015-01-31 2020-11-10 The Trustees Of The University Of Pennsylvania Compositions and methods for T cell delivery of therapeutic molecules
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
US10925972B2 (en) 2015-05-01 2021-02-23 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
EP3288471A1 (en) 2015-05-01 2018-03-07 Inter Science GmbH Methods, systems, and apparatuses for tissue ablation using pulse shape designs
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6882782B2 (ja) 2015-08-04 2021-06-02 デューク ユニバーシティ 遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
US11649435B2 (en) 2015-08-28 2023-05-16 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
WO2017070196A1 (en) * 2015-10-21 2017-04-27 The Methodist Hospital System Cellular vectors for delivery of therapeutics
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017112825A2 (en) 2015-12-21 2017-06-29 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
HUE060331T2 (hu) * 2015-12-28 2023-02-28 Inovio Pharmaceuticals Inc Elektroporációs készülék javított jelgenerátorral
IL300102B2 (en) 2015-12-30 2025-07-01 Inovio Pharmaceuticals Inc Electroporation device with detachable needle array with lock-out system
US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
EP3436139B1 (en) 2016-03-28 2025-04-30 PapiVax Biotech, Inc. METHOD AND APPARATUS FOR ADMINISTERING THERAPEUTIC AGENTS
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
KR102624967B1 (ko) 2016-04-29 2024-01-16 이노비오 파마수티컬즈, 인크. 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
JP7287888B2 (ja) 2016-06-27 2023-06-06 ギャラリー，インコーポレイテッド ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
RU2019110848A (ru) 2016-09-14 2020-10-15 Дьюк Юниверсити Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
EP3515928B1 (en) 2016-09-23 2026-01-28 Duke University Unstructured non-repetitive polypeptides having lcst behavior
US10613005B2 (en) 2016-10-31 2020-04-07 Agilent Technologies, Inc. Deparaffinization of tissue by electric field generation and ionization
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US10376495B2 (en) 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
EP3558265B1 (en) 2016-12-22 2025-04-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based cargo delivery
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
CN107212920A (zh) * 2017-01-23 2017-09-29 杭州安杰思医学科技有限公司 内窥镜用处理装置、内窥镜、及扩展支架
US10813935B2 (en) 2017-02-23 2020-10-27 Transgenex Nanobiotech, Inc. Methods and compositions for treating drug resistance in cancer
US10272052B2 (en) 2017-02-24 2019-04-30 University Of South Florida Compositions and methods for the treatment of tauopathies
WO2018156989A1 (en) 2017-02-24 2018-08-30 University Of South Florida The hsp90 activator aha1 drives production of pathological tau aggregates
JP7618192B2 (ja) 2017-03-28 2025-01-21 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 移植された組織を拒絶反応から保護するための方法
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SE541651C2 (en) * 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
US10850095B2 (en) 2017-08-08 2020-12-01 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
US11590345B2 (en) 2017-08-08 2023-02-28 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
US10857347B2 (en) 2017-09-19 2020-12-08 Pulse Biosciences, Inc. Treatment instrument and high-voltage connectors for robotic surgical system
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
DK4218641T3 (da) 2017-12-26 2025-08-18 Galvanize Therapeutics Inc Optimering af energilevering til forskellige anvendelser
AU2018396083B2 (en) 2017-12-29 2025-09-25 Cellectis Method for improving production of CAR T cells
US12296018B2 (en) 2018-01-26 2025-05-13 Duke University Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11525759B2 (en) 2018-04-24 2022-12-13 Agilent Technologies, Inc. Deparaffinization of tissue utilizing electric field
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
AU2019263465A1 (en) 2018-05-02 2020-12-24 Grand Decade Developments Limited Electroporation systems, methods, and apparatus
AU2019269601A1 (en) 2018-05-17 2020-11-26 Regents Of The University Of Minnesota Drug-resistant immune cells and methods of use thereof
EP3829622A4 (en) 2018-08-02 2022-05-11 Duke University DOUBLE AGONIST FUSION PROTEINS
WO2020037142A1 (en) 2018-08-17 2020-02-20 Yale University Compositions and methods for high-throughput activation screening to boost t cell effector function
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
WO2020094622A1 (en) * 2018-11-05 2020-05-14 Region Hovedstaden V/Herlev Hospital An electrode assembly for improved electric field distribution
TWI850282B (zh) 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
US20220054827A1 (en) * 2018-12-13 2022-02-24 Newsouth Innovations Pty Limited Method and system for controlling molecular electrotransfer
US11071860B2 (en) * 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US11571569B2 (en) 2019-02-15 2023-02-07 Pulse Biosciences, Inc. High-voltage catheters for sub-microsecond pulsing
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
JP7654557B2 (ja) 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法
WO2020209961A1 (en) 2019-04-08 2020-10-15 Udayan Patel Inflatable balloon over catheter with bypass passageway
JP7551648B2 (ja) 2019-04-18 2024-09-17 ガルヴァナイズ セラピューティクス，インコーポレイテッド 異常組織を治療するための器械、及びシステム、
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
AU2020314830B2 (en) 2019-07-16 2026-01-22 Galvanize Therapeutics, Inc. Treatment of the reproductive tract with pulsed electric fields
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
CN114364433A (zh) 2019-08-30 2022-04-15 诺沃库勒有限责任公司 向颈部输送肿瘤治疗场（TTFields）
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
EP4048179A1 (en) 2019-10-21 2022-08-31 Endogenex, Inc. Devices, systems, and methods for pulsed electric field treatment of the duodenum
EP4048796B1 (en) 2019-10-23 2025-08-27 Yale University Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy
CN110946642A (zh) * 2019-12-13 2020-04-03 天津市鹰泰利安康医疗科技有限责任公司 一种高频双极性不可恢复电穿孔系统
CN115867349A (zh) 2020-02-25 2023-03-28 艾诺奥医药品有限公司 针对冠状病毒的疫苗和使用方法
EP4114860A1 (en) 2020-03-06 2023-01-11 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
PH12022553102A1 (en) 2020-05-14 2023-11-20 Inovio Pharmaceuticals Inc Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
EP4165183A1 (en) 2020-06-12 2023-04-19 University of Rochester Encoding and expression of ace-trnas
CN116133679A (zh) 2020-06-30 2023-05-16 门德斯有限公司 白血病衍生细胞在卵巢癌疫苗中的用途
WO2022056490A1 (en) 2020-09-14 2022-03-17 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
WO2022097068A1 (en) 2020-11-05 2022-05-12 Dcprime B.V. Use of tumor-independent antigens in immunotherapies
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
AU2022211682A1 (en) 2021-01-22 2023-08-03 Mendus B.V. Methods of tumor vaccination
EP4301782A1 (en) 2021-03-05 2024-01-10 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
KR20230157388A (ko) 2021-03-12 2023-11-16 멘두스 비.브이. 백신접종의 방법 및 cd47 차단의 용도
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
JP2024523615A (ja) * 2021-06-30 2024-06-28 イノビオ ファーマシューティカルズ，インコーポレイティド 電気穿孔とともに使用するためのサイドポート注射デバイス、並びに関連するシステム及び方法
US20250082755A1 (en) 2021-07-29 2025-03-13 Vor Biopharma Inc. Chimeric antigen receptors for treatment of cancer
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
JP2024531915A (ja) 2021-08-05 2024-09-03 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｍｕｃ抗体およびその使用
IL310808A (en) 2021-08-13 2024-04-01 Inovio Pharmaceuticals Inc Combination therapy to treat brain cancer
CA3230934A1 (en) 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses
AU2022339819A1 (en) 2021-09-03 2024-04-11 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
CA3243439A1 (en) 2022-02-07 2023-08-10 University Of Rochester SEQUENCES OPTIMIZED FOR ENHANCED DNA EXPRESSION AND/OR NONSENSE MUTATION DELETION
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
JP2025537200A (ja) 2022-11-07 2025-11-14 パインツリー・セラピューティクス・インコーポレイテッド Ｎｒｐ１結合ドメインを含む二重特異性抗体を含む、組み合わせ治療
EP4634373A1 (en) 2022-12-16 2025-10-22 University of Rochester Repairment of barrier dysfunction in esophagus
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function
WO2026047626A1 (en) 2024-08-30 2026-03-05 Inceptor Bio, Llc Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE863111C (de) 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
DE2800039C2 (de) 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US5421819A (en) * 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US4712559A (en) * 1985-06-28 1987-12-15 Bsd Medical Corporation Local current capacitive field applicator for interstitial array
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
EP0398960B1 (en) * 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US5547467A (en) 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US4860752A (en) * 1988-02-18 1989-08-29 Bsd Medical Corporation Invasive microwave array with destructive and coherent phase
EP0346513A1 (de) 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
ES2012944A6 (es) 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US6001617A (en) 1989-06-07 1999-12-14 Queen's University At Kingston Electroporation device and method of use
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
DE4000893A1 (de) 1990-01-15 1991-07-18 Bosch Gmbh Robert Mehrkanaliges geraet zur elektrostimulation
US5620481A (en) * 1991-07-05 1997-04-15 Desai; Jawahar M. Device for multi-phase radio-frequency ablation
US5328451A (en) 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5425752A (en) 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US5545130A (en) * 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5514131A (en) 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
AU685086B2 (en) * 1993-02-02 1998-01-15 Vidamed, Inc. Transurethral needle ablation device
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
WO1994027670A1 (en) 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
US5551426A (en) * 1993-07-14 1996-09-03 Hummel; John D. Intracardiac ablation and mapping catheter
US5536267A (en) * 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5814599A (en) 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5571083A (en) * 1994-02-18 1996-11-05 Lemelson; Jerome H. Method and system for cell transplantation
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5728094A (en) * 1996-02-23 1998-03-17 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5786454A (en) 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
US5645526A (en) * 1994-09-30 1997-07-08 Becton Dickinson And Company Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch
US5720921A (en) 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5868740A (en) 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5780052A (en) 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5789213A (en) 1995-05-11 1998-08-04 Health Research Inc. Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5980517A (en) 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
AU6855796A (en) 1995-08-29 1997-03-19 Cbr Laboratories, Inc. In vivo electroporation of cells
US5688232A (en) * 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
WO1997047355A1 (en) 1996-06-12 1997-12-18 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
GB2314274A (en) * 1996-06-20 1997-12-24 Gyrus Medical Ltd Electrode construction for an electrosurgical instrument
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5874268A (en) 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
US5908753A (en) 1996-10-04 1999-06-01 Merck & Co., Inc. Transformation of Candida albicans by electroporation
US5845646A (en) * 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
JP2001520537A (ja) 1997-04-03 2001-10-30 エレクトロフェクト・アクティーゼルスカブ 医薬品と核酸の骨格筋への導入方法
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5879891A (en) 1997-09-17 1999-03-09 Merck & Co., Inc. Transformation of saccharomyces cerevisiae by electroporation
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
NZ507185A (en) 1998-04-14 2002-09-27 Gmp Drug Delivery Inc Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6040184A (en) 1998-10-09 2000-03-21 Stratagene Method for more efficient electroporation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252307B2 (en) 1999-03-22 2012-08-28 Psivida Us, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US8574659B2 (en) 2000-04-26 2013-11-05 Psivida Us, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US8574613B2 (en) 2000-04-26 2013-11-05 Psivida Us, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US9192579B2 (en) 2000-04-26 2015-11-24 Psivida Us, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US9849085B2 (en) 2000-04-26 2017-12-26 Psivida Us Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices

Also Published As

Publication number Publication date
EP0999867A1 (en) 2000-05-17
CA2268026A1 (en) 1999-02-11
CN1768873A (zh) 2006-05-10
KR20000068678A (ko) 2000-11-25
JP2002291910A (ja) 2002-10-08
RU2195332C2 (ru) 2002-12-27
ATE480294T1 (de) 2010-09-15
US6014584A (en) 2000-01-11
AU8682398A (en) 1999-02-22
DE69841888D1 (de) 2010-10-21
CN1248923A (zh) 2000-03-29
JP4180285B2 (ja) 2008-11-12
CN1217717C (zh) 2005-09-07
US6055453A (en) 2000-04-25
KR100756252B1 (ko) 2007-09-07
BR9806069A (pt) 2000-01-25
CA2268026C (en) 2003-07-29
EP0999867B1 (en) 2010-09-08
US6181964B1 (en) 2001-01-30
AU734343B2 (en) 2001-06-14
US6233482B1 (en) 2001-05-15
CN1768873B (zh) 2011-04-13
US6068650A (en) 2000-05-30
WO1999006101A1 (en) 1999-02-11
JP2000503586A (ja) 2000-03-28
HK1027049A1 (en) 2001-01-05
EP0999867A4 (en) 2008-03-26

Similar Documents

Publication Publication Date Title
TW396043B (en) Method and apparatus for using electroporation mediated delivery of drugs and genes
TW542732B (en) Electroporation device
US6216034B1 (en) Method of programming an array of needle electrodes for electroporation therapy of tissue
US8014854B2 (en) Method and device for treating abnormal tissue growth with electrical therapy
Miura et al. The role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro‐and chemoreceptors
JP4050331B2 (ja) 接続電極テンプレートを有する電気穿孔装置
US8024048B2 (en) Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) Implantable device and method for the electrical treatment of cancer
US20050222646A1 (en) Method and device for treating cancer with modified output electrical therapy
US20040204669A1 (en) Apparatus for electroporation mediated delivery for drugs and genes
TW483769B (en) Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
JP2001506172A (ja) 作用物質のイオン導入法による送達のための針
Lugnani et al. Iontophoresis of drugs in the bladder wall: equipment and preliminary studies
WO2020233604A1 (zh) 电场发生装置及其用途以及使待透皮物质进入目标对象的方法
Hua General Anesthetics Activate a Central Pain-Suppression Circuit in the Amygdala

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent
MM4A Annulment or lapse of patent due to non-payment of fees