SG11202010395XA - Electroporation systems, methods, and apparatus - Google Patents
Electroporation systems, methods, and apparatusInfo
- Publication number
- SG11202010395XA SG11202010395XA SG11202010395XA SG11202010395XA SG11202010395XA SG 11202010395X A SG11202010395X A SG 11202010395XA SG 11202010395X A SG11202010395X A SG 11202010395XA SG 11202010395X A SG11202010395X A SG 11202010395XA SG 11202010395X A SG11202010395X A SG 11202010395XA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- electroporation systems
- electroporation
- systems
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3476—Powered trocars, e.g. electrosurgical cutting, lasers, powered knives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/30—Surgical robots
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0507—Electrodes for the digestive system
- A61N1/0509—Stomach and intestinal electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00166—Multiple lumina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00875—Resistance or impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
- A61B2018/143—Needle multiple needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862665553P | 2018-05-02 | 2018-05-02 | |
US201862742684P | 2018-10-08 | 2018-10-08 | |
US201862745699P | 2018-10-15 | 2018-10-15 | |
US201862755001P | 2018-11-02 | 2018-11-02 | |
US201962824011P | 2019-03-26 | 2019-03-26 | |
PCT/US2019/030437 WO2019213421A1 (en) | 2018-05-02 | 2019-05-02 | Electroporation systems, methods, and apparatus |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202010395XA true SG11202010395XA (en) | 2020-11-27 |
Family
ID=68384469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202010395XA SG11202010395XA (en) | 2018-05-02 | 2019-05-02 | Electroporation systems, methods, and apparatus |
Country Status (12)
Country | Link |
---|---|
US (2) | US20190336757A1 (en) |
EP (1) | EP3787665A4 (en) |
JP (1) | JP2021523763A (en) |
KR (1) | KR20210018228A (en) |
CN (1) | CN112236192A (en) |
AU (1) | AU2019263465A1 (en) |
BR (1) | BR112020021981A2 (en) |
CA (1) | CA3098615A1 (en) |
IL (1) | IL278210A (en) |
MX (1) | MX2020011618A (en) |
SG (1) | SG11202010395XA (en) |
WO (1) | WO2019213421A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115737104A (en) | 2015-03-31 | 2023-03-07 | 昂科赛克医疗公司 | Systems and methods for improved tissue sensing-based electroporation |
US11071860B2 (en) * | 2019-02-06 | 2021-07-27 | Oncosec Medical Incorporated | Systems and methods for detecting fault conditions in electroporation therapy |
US11069282B2 (en) | 2019-08-15 | 2021-07-20 | Samsung Display Co., Ltd. | Correlated double sampling pixel sensing front end |
US11087656B2 (en) * | 2019-08-15 | 2021-08-10 | Samsung Display Co., Ltd. | Fully differential front end for sensing |
US11250780B2 (en) | 2019-08-15 | 2022-02-15 | Samsung Display Co., Ltd. | Estimation of pixel compensation coefficients by adaptation |
US11081064B1 (en) | 2020-01-13 | 2021-08-03 | Samsung Display Co., Ltd. | Reference signal generation by reusing the driver circuit |
WO2021158685A1 (en) * | 2020-02-04 | 2021-08-12 | Oncosec Medical Incorporated | Hemostatic combination therapy with low voltage electroporation |
US11257416B2 (en) | 2020-02-14 | 2022-02-22 | Samsung Display Co., Ltd. | Voltage mode pre-emphasis with floating phase |
IL299110A (en) * | 2020-06-19 | 2023-02-01 | Oncosec Medical Inc | Methods of determining responsiveness to cancer immunotherapy |
US20230256236A1 (en) * | 2020-06-24 | 2023-08-17 | Oncosec Medical Incorporated | Transformable needle for electroporation |
KR102490645B1 (en) * | 2020-07-16 | 2023-01-25 | 고려대학교 산학협력단 | System and Method for Planning Electric Fields Therapy based on Absorbed Energy |
MX2023001255A (en) * | 2020-07-29 | 2023-05-15 | Oncosec Medical Inc | Combination therapy for treatment of cancer. |
WO2022038535A1 (en) * | 2020-08-20 | 2022-02-24 | Cochlear Limited | Electroporation shield for implantable electrodes |
US20220096151A1 (en) * | 2020-09-30 | 2022-03-31 | Boston Scientific Scimed Inc. | Pretreatment waveform for irreversible electroporation |
US11719738B2 (en) | 2020-10-15 | 2023-08-08 | Samsung Display Co., Ltd. | Two-domain two-stage sensing front-end circuits and systems |
KR102277440B1 (en) | 2020-12-07 | 2021-07-14 | (주)더스탠다드 | Method for detecting electroporated area using ttc on potato model |
US20220370128A1 (en) | 2021-05-18 | 2022-11-24 | Biosense Webster (Israel) Ltd. | Efficiency of ire ablation procedure by applying stress signal to target tissue |
KR102326448B1 (en) * | 2021-06-29 | 2021-11-15 | (주)더스탠다드 | Irreversible electroporation system monitoring output high voltage stably |
WO2023277488A1 (en) * | 2021-06-29 | 2023-01-05 | (주)더스탠다드 | Irreversible electroporation system and pulse applying method thereof |
WO2023064934A1 (en) * | 2021-10-15 | 2023-04-20 | Intergalactic Therapeutics, Inc. | Respiratory delivery of therapeutic agents |
KR102410404B1 (en) | 2021-12-17 | 2022-06-22 | (주)딥인사이트 | Smart mirror using under display camera |
CN115050254B (en) * | 2022-07-11 | 2023-10-13 | 暨南大学附属第一医院(广州华侨医院) | Minimally invasive surgical exercise model for removing Rake cyst |
CN114983551B (en) * | 2022-07-12 | 2022-10-25 | 深圳迈微医疗科技有限公司 | Tissue ablation device and electrochemical impedance measuring device |
EP4342515A1 (en) | 2022-09-23 | 2024-03-27 | IGEA S.p.A. | Improved electroporation device |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5704908A (en) * | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
US7456012B2 (en) * | 1997-11-06 | 2008-11-25 | Cellectricon Ab | Method and apparatus for spatially confined electroporation |
JP2004041434A (en) * | 2002-07-11 | 2004-02-12 | Kiyohito Ishida | Electroporation apparatus |
US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
EP2432412A2 (en) * | 2009-05-20 | 2012-03-28 | Herlev Hospital | Electroporation device with improved tip and electrode support |
ES2776949T3 (en) * | 2009-08-31 | 2020-08-03 | Applied Med Resources | Multifunctional Surgical Access System |
WO2014207077A1 (en) * | 2013-06-26 | 2014-12-31 | Atropos Limited | An inflatable pneumoperitoneum device |
US9020605B2 (en) | 2012-10-25 | 2015-04-28 | Oncosec Medical Incorporated | Electroporation device |
US9536205B2 (en) * | 2013-01-24 | 2017-01-03 | Nec Corporation | Adaptive control of hybrid ultracapacitor-battery storage system for photovoltaic output smoothing |
US10368850B2 (en) * | 2014-06-18 | 2019-08-06 | Siemens Medical Solutions Usa, Inc. | System and method for real-time ultrasound guided prostate needle biopsies using a compliant robotic arm |
KR20230162993A (en) * | 2014-11-13 | 2023-11-29 | 어플라이드 메디컬 리소시스 코포레이션 | Systems and methods for tissue removal |
CA2973390A1 (en) * | 2015-01-09 | 2016-07-14 | Oncosec Medical Incorporated | Method for the treatment of malignancies |
US20180044429A1 (en) * | 2015-03-09 | 2018-02-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
CN115737104A (en) * | 2015-03-31 | 2023-03-07 | 昂科赛克医疗公司 | Systems and methods for improved tissue sensing-based electroporation |
WO2018057943A1 (en) * | 2016-09-23 | 2018-03-29 | Oncosec Medical Incorporated | Modulating responses to checkpoint inhibitor therapy |
-
2019
- 2019-05-02 AU AU2019263465A patent/AU2019263465A1/en active Pending
- 2019-05-02 SG SG11202010395XA patent/SG11202010395XA/en unknown
- 2019-05-02 WO PCT/US2019/030437 patent/WO2019213421A1/en unknown
- 2019-05-02 CA CA3098615A patent/CA3098615A1/en active Pending
- 2019-05-02 EP EP19796326.7A patent/EP3787665A4/en active Pending
- 2019-05-02 CN CN201980038156.XA patent/CN112236192A/en active Pending
- 2019-05-02 MX MX2020011618A patent/MX2020011618A/en unknown
- 2019-05-02 BR BR112020021981-9A patent/BR112020021981A2/en unknown
- 2019-05-02 KR KR1020207033381A patent/KR20210018228A/en unknown
- 2019-05-02 US US16/401,811 patent/US20190336757A1/en not_active Abandoned
- 2019-05-02 JP JP2020560398A patent/JP2021523763A/en active Pending
-
2020
- 2020-06-22 US US16/907,891 patent/US20200316376A1/en active Pending
- 2020-10-21 IL IL278210A patent/IL278210A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20190336757A1 (en) | 2019-11-07 |
MX2020011618A (en) | 2021-02-16 |
CN112236192A (en) | 2021-01-15 |
EP3787665A1 (en) | 2021-03-10 |
EP3787665A4 (en) | 2022-02-16 |
US20200316376A1 (en) | 2020-10-08 |
AU2019263465A1 (en) | 2020-12-24 |
BR112020021981A2 (en) | 2021-01-26 |
IL278210A (en) | 2020-11-30 |
KR20210018228A (en) | 2021-02-17 |
CA3098615A1 (en) | 2019-11-07 |
WO2019213421A1 (en) | 2019-11-07 |
JP2021523763A (en) | 2021-09-09 |
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