KR100436529B1 - 불투명조영제의정제방법 - Google Patents

불투명조영제의정제방법 Download PDF

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Publication number
KR100436529B1
KR100436529B1 KR10-1998-0706478A KR19980706478A KR100436529B1 KR 100436529 B1 KR100436529 B1 KR 100436529B1 KR 19980706478 A KR19980706478 A KR 19980706478A KR 100436529 B1 KR100436529 B1 KR 100436529B1
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KR
South Korea
Prior art keywords
fraction
product
nanofiltration
impurities
solution
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Expired - Lifetime
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KR10-1998-0706478A
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English (en)
Korean (ko)
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KR19990087090A (ko
Inventor
로돌포 피바
카를로 펠리스 비스카르디
마시모 가그나
Original Assignee
브라코 이미징 에스.피.에이.
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Publication of KR19990087090A publication Critical patent/KR19990087090A/ko
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Publication of KR100436529B1 publication Critical patent/KR100436529B1/ko
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027—Nanofiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00—Water conservation; Efficient water supply; Efficient water use
    • Y02A20/124—Water desalination
    • Y02A20/131—Reverse-osmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Drying Of Solid Materials (AREA)
  • Steroid Compounds (AREA)
KR10-1998-0706478A 1996-02-23 1997-02-12 불투명조영제의정제방법 Expired - Lifetime KR100436529B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000339A IT1282674B1 (it) 1996-02-23 1996-02-23 Processo per la purificazione di agenti contrastografici opacizzanti
ITMI96A000339 1996-02-23

Publications (2)

Publication Number Publication Date
KR19990087090A KR19990087090A (ko) 1999-12-15
KR100436529B1 true KR100436529B1 (ko) 2004-12-16

Family

ID=11373370

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0706478A Expired - Lifetime KR100436529B1 (ko) 1996-02-23 1997-02-12 불투명조영제의정제방법

Country Status (15)

Country Link
EP (1) EP0902686B1 (https=)
JP (1) JP4058110B2 (https=)
KR (1) KR100436529B1 (https=)
CN (1) CN1084632C (https=)
AT (1) ATE186844T1 (https=)
AU (1) AU1724397A (https=)
CA (1) CA2247029C (https=)
CZ (1) CZ291744B6 (https=)
DE (2) DE902686T1 (https=)
ES (1) ES2128287T3 (https=)
IN (1) IN190416B (https=)
IT (1) IT1282674B1 (https=)
NO (1) NO313228B1 (https=)
WO (1) WO1997030735A2 (https=)
ZA (1) ZA971459B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
KR20150094639A (ko) * 2012-12-19 2015-08-19 지이 헬스케어 에이에스 X-선 조영제 성분의 정제 방법

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US8420857B2 (en) 2007-08-27 2013-04-16 Mallinckrodt Llc Removal of silica from water soluble compounds by nanofiltration and reverse phase chromatography
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
US9474808B2 (en) 2010-12-21 2016-10-25 Ge Healthcare As Desalination of a composition comprising a contrast agent
GB201120138D0 (en) * 2011-11-22 2012-01-04 Glaxo Group Ltd Novel process
CN105705483B (zh) 2013-11-05 2018-09-04 伯拉考成像股份公司 碘帕醇的制备方法
CN104045580A (zh) * 2014-06-25 2014-09-17 上海华震科技有限公司 一种碘普罗胺脱色纯化工艺
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CN111609649B (zh) 2019-02-25 2022-01-18 Lg电子株式会社 入口冰箱及冰箱
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法
CN111715877B (zh) * 2020-05-22 2022-06-03 深圳市华科创智技术有限公司 一种纳米银线的纯化方法
CN112724035A (zh) * 2021-03-01 2021-04-30 江苏汉邦科技有限公司 一种纯化制备碘佛醇水解物的方法
CN113061099A (zh) * 2021-03-27 2021-07-02 浙江司太立制药股份有限公司 一种高纯度碘造影剂单体的分离纯化方法
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法
EP4534526A1 (en) 2023-10-04 2025-04-09 Bracco Imaging SPA Optimized process for the preparation of iopamidol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110737A1 (de) * 1981-03-16 1982-10-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zum abtrennen und reinigen von wasserloeslichen, nicht-ionischen verbindungen
US5204405A (en) * 1988-11-09 1993-04-20 Nippon Petrochemicals Co., Ltd. Thermoplastic resin composition and method for preparing the same
US5204005A (en) * 1990-02-26 1993-04-20 Mallinckrodt, Inc. Reversed phase chromatographic process
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5160437A (en) * 1991-12-03 1992-11-03 Mallinckrodt Medical, Inc. Purification of crude Ioversol using reverse osmosis
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
IT1275427B (it) * 1995-05-16 1997-08-07 Bracco Spa Processo per la depirogenazione di soluzioni farmaceutiche iniettabili

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
KR20150094639A (ko) * 2012-12-19 2015-08-19 지이 헬스케어 에이에스 X-선 조영제 성분의 정제 방법
KR102180250B1 (ko) * 2012-12-19 2020-11-18 지이 헬스케어 에이에스 X-선 조영제 성분의 정제 방법

Also Published As

Publication number Publication date
NO313228B1 (no) 2002-09-02
KR19990087090A (ko) 1999-12-15
IN190416B (https=) 2003-07-26
HK1018213A1 (en) 1999-12-17
ITMI960339A0 (https=) 1996-02-23
EP0902686A2 (en) 1999-03-24
NO983834D0 (no) 1998-08-20
WO1997030735A2 (en) 1997-08-28
DE69700843T2 (de) 2000-03-16
EP0902686B1 (en) 1999-11-24
WO1997030735A3 (en) 1997-10-23
ITMI960339A1 (it) 1997-08-23
CN1084632C (zh) 2002-05-15
ES2128287T1 (es) 1999-05-16
CZ265198A3 (cs) 1999-07-14
ES2128287T3 (es) 2000-02-16
DE69700843D1 (de) 1999-12-30
NO983834L (no) 1998-10-19
ZA971459B (en) 1998-06-23
JP2000504735A (ja) 2000-04-18
CA2247029C (en) 2007-07-31
DE902686T1 (de) 1999-07-22
CN1211929A (zh) 1999-03-24
CZ291744B6 (cs) 2003-05-14
AU1724397A (en) 1997-09-10
ATE186844T1 (de) 1999-12-15
JP4058110B2 (ja) 2008-03-05
CA2247029A1 (en) 1997-08-28
IT1282674B1 (it) 1998-03-31

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