ES2128287T3 - Procedimiento para la purificacion de agentes de contraste opacificadores. - Google Patents

Procedimiento para la purificacion de agentes de contraste opacificadores.

Info

Publication number
ES2128287T3
ES2128287T3 ES97904423T ES97904423T ES2128287T3 ES 2128287 T3 ES2128287 T3 ES 2128287T3 ES 97904423 T ES97904423 T ES 97904423T ES 97904423 T ES97904423 T ES 97904423T ES 2128287 T3 ES2128287 T3 ES 2128287T3
Authority
ES
Spain
Prior art keywords
opacifying
purification
procedure
contrast agents
referred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97904423T
Other languages
English (en)
Other versions
ES2128287T1 (es
Inventor
Rodolfo Piva
Carlo Felice Viscardi
Massimo Gagna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of ES2128287T1 publication Critical patent/ES2128287T1/es
Application granted granted Critical
Publication of ES2128287T3 publication Critical patent/ES2128287T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027—Nanofiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00—Water conservation; Efficient water supply; Efficient water use
    • Y02A20/124—Water desalination
    • Y02A20/131—Reverse-osmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Drying Of Solid Materials (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A AGENTES CONTRASTOGRAFICOS OPACIFICANTES QUE COMPRENDE TECNICAS CROMATOGRAFICAS Y DE NANOFILTRACION COMBINADAS, LA SEPARACION CROMATOGRAFICA SUBSECUENTE DE LA SOLUCION DE PRODUCTO BRUTO Y UNA FASE DE NANOFILTRACION, CON UNA DESIONIZACION FINAL SOBRE RESINAS DE INTERCAMBIO IONICO.
ES97904423T 1996-02-23 1997-02-12 Procedimiento para la purificacion de agentes de contraste opacificadores. Expired - Lifetime ES2128287T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000339A IT1282674B1 (it) 1996-02-23 1996-02-23 Processo per la purificazione di agenti contrastografici opacizzanti

Publications (2)

Publication Number Publication Date
ES2128287T1 ES2128287T1 (es) 1999-05-16
ES2128287T3 true ES2128287T3 (es) 2000-02-16

Family

ID=11373370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97904423T Expired - Lifetime ES2128287T3 (es) 1996-02-23 1997-02-12 Procedimiento para la purificacion de agentes de contraste opacificadores.

Country Status (16)

Country Link
EP (1) EP0902686B1 (es)
JP (1) JP4058110B2 (es)
KR (1) KR100436529B1 (es)
CN (1) CN1084632C (es)
AT (1) ATE186844T1 (es)
AU (1) AU1724397A (es)
CA (1) CA2247029C (es)
CZ (1) CZ291744B6 (es)
DE (2) DE902686T1 (es)
ES (1) ES2128287T3 (es)
HK (1) HK1018213A1 (es)
IN (1) IN190416B (es)
IT (1) IT1282674B1 (es)
NO (1) NO313228B1 (es)
WO (1) WO1997030735A2 (es)
ZA (1) ZA971459B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
WO2009029464A1 (en) * 2007-08-27 2009-03-05 Mallinckrodt Inc. Removal of silica from water soluble compounds by nanofiltration and reverse phase chromatography
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
ES2680019T3 (es) * 2010-12-21 2018-09-03 Ge Healthcare As Desalinización de una composición que comprende un agente de contraste
GB201120138D0 (en) * 2011-11-22 2012-01-04 Glaxo Group Ltd Novel process
CN104854080B (zh) * 2012-12-19 2018-07-03 通用电气医疗集团股份有限公司 X-射线造影剂的纯化
KR102265049B1 (ko) 2013-11-05 2021-06-16 브라코 이미징 에스.피.에이. 이오파미돌의 제조 방법
CN104045580A (zh) * 2014-06-25 2014-09-17 上海华震科技有限公司 一种碘普罗胺脱色纯化工艺
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CN111609649B (zh) 2019-02-25 2022-01-18 Lg电子株式会社 入口冰箱及冰箱
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法
CN111715877B (zh) * 2020-05-22 2022-06-03 深圳市华科创智技术有限公司 一种纳米银线的纯化方法
CN112724035A (zh) * 2021-03-01 2021-04-30 江苏汉邦科技有限公司 一种纯化制备碘佛醇水解物的方法
CN113061099A (zh) * 2021-03-27 2021-07-02 浙江司太立制药股份有限公司 一种高纯度碘造影剂单体的分离纯化方法
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110737A1 (de) * 1981-03-16 1982-10-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zum abtrennen und reinigen von wasserloeslichen, nicht-ionischen verbindungen
US5204405A (en) * 1988-11-09 1993-04-20 Nippon Petrochemicals Co., Ltd. Thermoplastic resin composition and method for preparing the same
US5204005A (en) * 1990-02-26 1993-04-20 Mallinckrodt, Inc. Reversed phase chromatographic process
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5160437A (en) * 1991-12-03 1992-11-03 Mallinckrodt Medical, Inc. Purification of crude Ioversol using reverse osmosis
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
IT1275427B (it) * 1995-05-16 1997-08-07 Bracco Spa Processo per la depirogenazione di soluzioni farmaceutiche iniettabili

Also Published As

Publication number Publication date
ATE186844T1 (de) 1999-12-15
NO983834D0 (no) 1998-08-20
ES2128287T1 (es) 1999-05-16
CN1084632C (zh) 2002-05-15
CZ265198A3 (cs) 1999-07-14
DE69700843D1 (de) 1999-12-30
WO1997030735A2 (en) 1997-08-28
ZA971459B (en) 1998-06-23
CA2247029A1 (en) 1997-08-28
WO1997030735A3 (en) 1997-10-23
CA2247029C (en) 2007-07-31
DE902686T1 (de) 1999-07-22
ITMI960339A0 (es) 1996-02-23
NO313228B1 (no) 2002-09-02
IN190416B (es) 2003-07-26
JP4058110B2 (ja) 2008-03-05
CZ291744B6 (cs) 2003-05-14
ITMI960339A1 (it) 1997-08-23
DE69700843T2 (de) 2000-03-16
KR19990087090A (ko) 1999-12-15
CN1211929A (zh) 1999-03-24
AU1724397A (en) 1997-09-10
KR100436529B1 (ko) 2004-12-16
EP0902686A2 (en) 1999-03-24
NO983834L (no) 1998-10-19
EP0902686B1 (en) 1999-11-24
JP2000504735A (ja) 2000-04-18
HK1018213A1 (en) 1999-12-17
IT1282674B1 (it) 1998-03-31

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