DE902686T1 - Verfahren zur reinigung opazifierender kontrastmittel - Google Patents

Verfahren zur reinigung opazifierender kontrastmittel

Info

Publication number
DE902686T1
DE902686T1 DE0902686T DE97904423T DE902686T1 DE 902686 T1 DE902686 T1 DE 902686T1 DE 0902686 T DE0902686 T DE 0902686T DE 97904423 T DE97904423 T DE 97904423T DE 902686 T1 DE902686 T1 DE 902686T1
Authority
DE
Germany
Prior art keywords
process according
fraction
nanofiltration
fractions
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0902686T
Other languages
German (de)
English (en)
Inventor
Massimo I-20134 Milano Gagna
Rodolfo I-20134 Milano Piva
Carlo Felice I-20134 Milano Viscardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Publication of DE902686T1 publication Critical patent/DE902686T1/de
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027—Nanofiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00—Water conservation; Efficient water supply; Efficient water use
    • Y02A20/124—Water desalination
    • Y02A20/131—Reverse-osmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Drying Of Solid Materials (AREA)
  • Steroid Compounds (AREA)
DE0902686T 1996-02-23 1997-02-12 Verfahren zur reinigung opazifierender kontrastmittel Pending DE902686T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000339A IT1282674B1 (it) 1996-02-23 1996-02-23 Processo per la purificazione di agenti contrastografici opacizzanti
PCT/EP1997/000639 WO1997030735A2 (en) 1996-02-23 1997-02-12 A process for the purification of opacifying contrast agents

Publications (1)

Publication Number Publication Date
DE902686T1 true DE902686T1 (de) 1999-07-22

Family

ID=11373370

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0902686T Pending DE902686T1 (de) 1996-02-23 1997-02-12 Verfahren zur reinigung opazifierender kontrastmittel
DE69700843T Expired - Lifetime DE69700843T2 (de) 1996-02-23 1997-02-12 Verfahren zur reinigung opazifierender kontrastmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69700843T Expired - Lifetime DE69700843T2 (de) 1996-02-23 1997-02-12 Verfahren zur reinigung opazifierender kontrastmittel

Country Status (15)

Country Link
EP (1) EP0902686B1 (https=)
JP (1) JP4058110B2 (https=)
KR (1) KR100436529B1 (https=)
CN (1) CN1084632C (https=)
AT (1) ATE186844T1 (https=)
AU (1) AU1724397A (https=)
CA (1) CA2247029C (https=)
CZ (1) CZ291744B6 (https=)
DE (2) DE902686T1 (https=)
ES (1) ES2128287T3 (https=)
IN (1) IN190416B (https=)
IT (1) IT1282674B1 (https=)
NO (1) NO313228B1 (https=)
WO (1) WO1997030735A2 (https=)
ZA (1) ZA971459B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
US8420857B2 (en) 2007-08-27 2013-04-16 Mallinckrodt Llc Removal of silica from water soluble compounds by nanofiltration and reverse phase chromatography
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
US9474808B2 (en) 2010-12-21 2016-10-25 Ge Healthcare As Desalination of a composition comprising a contrast agent
GB201120138D0 (en) * 2011-11-22 2012-01-04 Glaxo Group Ltd Novel process
CN104854080B (zh) * 2012-12-19 2018-07-03 通用电气医疗集团股份有限公司 X-射线造影剂的纯化
CN105705483B (zh) 2013-11-05 2018-09-04 伯拉考成像股份公司 碘帕醇的制备方法
CN104045580A (zh) * 2014-06-25 2014-09-17 上海华震科技有限公司 一种碘普罗胺脱色纯化工艺
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CN111609649B (zh) 2019-02-25 2022-01-18 Lg电子株式会社 入口冰箱及冰箱
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法
CN111715877B (zh) * 2020-05-22 2022-06-03 深圳市华科创智技术有限公司 一种纳米银线的纯化方法
CN112724035A (zh) * 2021-03-01 2021-04-30 江苏汉邦科技有限公司 一种纯化制备碘佛醇水解物的方法
CN113061099A (zh) * 2021-03-27 2021-07-02 浙江司太立制药股份有限公司 一种高纯度碘造影剂单体的分离纯化方法
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法
EP4534526A1 (en) 2023-10-04 2025-04-09 Bracco Imaging SPA Optimized process for the preparation of iopamidol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110737A1 (de) * 1981-03-16 1982-10-14 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zum abtrennen und reinigen von wasserloeslichen, nicht-ionischen verbindungen
US5204405A (en) * 1988-11-09 1993-04-20 Nippon Petrochemicals Co., Ltd. Thermoplastic resin composition and method for preparing the same
US5204005A (en) * 1990-02-26 1993-04-20 Mallinckrodt, Inc. Reversed phase chromatographic process
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5160437A (en) * 1991-12-03 1992-11-03 Mallinckrodt Medical, Inc. Purification of crude Ioversol using reverse osmosis
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
IT1275427B (it) * 1995-05-16 1997-08-07 Bracco Spa Processo per la depirogenazione di soluzioni farmaceutiche iniettabili

Also Published As

Publication number Publication date
NO313228B1 (no) 2002-09-02
KR19990087090A (ko) 1999-12-15
IN190416B (https=) 2003-07-26
HK1018213A1 (en) 1999-12-17
ITMI960339A0 (https=) 1996-02-23
EP0902686A2 (en) 1999-03-24
NO983834D0 (no) 1998-08-20
WO1997030735A2 (en) 1997-08-28
DE69700843T2 (de) 2000-03-16
EP0902686B1 (en) 1999-11-24
WO1997030735A3 (en) 1997-10-23
ITMI960339A1 (it) 1997-08-23
CN1084632C (zh) 2002-05-15
ES2128287T1 (es) 1999-05-16
CZ265198A3 (cs) 1999-07-14
ES2128287T3 (es) 2000-02-16
DE69700843D1 (de) 1999-12-30
NO983834L (no) 1998-10-19
ZA971459B (en) 1998-06-23
JP2000504735A (ja) 2000-04-18
CA2247029C (en) 2007-07-31
CN1211929A (zh) 1999-03-24
CZ291744B6 (cs) 2003-05-14
AU1724397A (en) 1997-09-10
KR100436529B1 (ko) 2004-12-16
ATE186844T1 (de) 1999-12-15
JP4058110B2 (ja) 2008-03-05
CA2247029A1 (en) 1997-08-28
IT1282674B1 (it) 1998-03-31

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