JPH07100653B2 - 発泡性顆粒及び錠剤の製法及び装置 - Google Patents
発泡性顆粒及び錠剤の製法及び装置Info
- Publication number
- JPH07100653B2 JPH07100653B2 JP59500291A JP50029183A JPH07100653B2 JP H07100653 B2 JPH07100653 B2 JP H07100653B2 JP 59500291 A JP59500291 A JP 59500291A JP 50029183 A JP50029183 A JP 50029183A JP H07100653 B2 JPH07100653 B2 JP H07100653B2
- Authority
- JP
- Japan
- Prior art keywords
- raw material
- solvent
- granulation
- drying
- vacuum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008187 granular material Substances 0.000 title claims description 11
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 238000000034 method Methods 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 23
- 238000001035 drying Methods 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 16
- 238000005469 granulation Methods 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 239000002994 raw material Substances 0.000 claims description 16
- 230000003179 granulation Effects 0.000 claims description 14
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 9
- 230000005484 gravity Effects 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 229960004106 citric acid Drugs 0.000 claims description 4
- 239000007938 effervescent tablet Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 3
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 claims description 3
- 229960005489 paracetamol Drugs 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 2
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 238000010907 mechanical stirring Methods 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- WQNHWIYLCRZRLR-UHFFFAOYSA-N 2-(3-hydroxy-2,5-dioxooxolan-3-yl)acetic acid Chemical compound OC(=O)CC1(O)CC(=O)OC1=O WQNHWIYLCRZRLR-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- YBHYYFYQHRADCQ-UHFFFAOYSA-N 2-aminoacetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound NCC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O YBHYYFYQHRADCQ-UHFFFAOYSA-N 0.000 description 1
- YKXUOESQDCXGIW-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;2-(trimethylazaniumyl)acetate Chemical compound C[N+](C)(C)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC([O-])=O YKXUOESQDCXGIW-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical group OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 229960002609 betaine citrate Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 229960005008 doxylamine succinate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Glanulating (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8221476A FR2537872B1 (fr) | 1982-12-21 | 1982-12-21 | Procede de fabrication de comprimes effervescents |
| FR8319143 | 1983-11-30 | ||
| FR838319143A FR2555439B1 (fr) | 1983-11-30 | 1983-11-30 | Procede et appareillage de fabrication de granules et comprimes effervescents |
| FR8221476 | 1983-11-30 | ||
| PCT/FR1983/000253 WO1984002468A1 (fr) | 1982-12-21 | 1983-12-20 | Procede et appareillages de fabrication de granules et comprimes effervescents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60500534A JPS60500534A (ja) | 1985-04-18 |
| JPH07100653B2 true JPH07100653B2 (ja) | 1995-11-01 |
Family
ID=26223202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59500291A Expired - Lifetime JPH07100653B2 (ja) | 1982-12-21 | 1983-12-20 | 発泡性顆粒及び錠剤の製法及び装置 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US4614648A (OSRAM) |
| EP (1) | EP0162043B1 (OSRAM) |
| JP (1) | JPH07100653B2 (OSRAM) |
| KR (1) | KR900007312B1 (OSRAM) |
| AT (1) | AT394492B (OSRAM) |
| CA (1) | CA1209040A (OSRAM) |
| CH (1) | CH664491A5 (OSRAM) |
| DE (1) | DE3390423C2 (OSRAM) |
| DK (1) | DK163565C (OSRAM) |
| EG (1) | EG17260A (OSRAM) |
| ES (1) | ES528271A0 (OSRAM) |
| GB (1) | GB2146244B (OSRAM) |
| GR (1) | GR81352B (OSRAM) |
| IT (1) | IT1175295B (OSRAM) |
| MA (1) | MA19980A1 (OSRAM) |
| NL (1) | NL193488C (OSRAM) |
| PT (1) | PT77864B (OSRAM) |
| SE (1) | SE457416B (OSRAM) |
| WO (1) | WO1984002468A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1209040A (fr) * | 1982-12-21 | 1986-08-05 | Jean Bru | Procede de fabrication de granules et comprimes effervescents |
| US4904478A (en) * | 1983-08-11 | 1990-02-27 | Mission Pharmacal Company | Slow-release sodium fluoride tablet and method for treatment of osteoporosis |
| DE3440288C2 (de) * | 1984-11-05 | 1987-03-12 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung |
| US4772467A (en) * | 1985-02-19 | 1988-09-20 | Board Of Regents, U T Systems | Osteoporosis inhibition by dietary calcium supplementation |
| US4851221A (en) * | 1985-02-19 | 1989-07-25 | Mission Pharmacal Company | Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid |
| GB2174004B (en) * | 1985-04-23 | 1988-11-30 | American Cyanamid Co | Pharmaceutical tablet preparations |
| IT1209667B (it) * | 1985-11-12 | 1989-08-30 | Zambon Spa | Composizione effeverscente adattivita' analgesica. |
| US4814177A (en) * | 1986-03-18 | 1989-03-21 | Board Of Regents, University Of Texas System | Ultradense and more soluble and bioavailable preparations of calcium citrate |
| ES2040733T3 (es) * | 1986-12-20 | 1993-11-01 | Boehringer Mannheim Gmbh | Medicamentos que contienen clodronato y procedimiento para su preparacion. |
| CA2009326C (en) * | 1989-05-09 | 1998-01-27 | Lawrence J. Daher | Aqueous granulation solution and a method of tablet granulation |
| US5348745A (en) * | 1989-05-09 | 1994-09-20 | Miles Inc. | Aqueous granulation solution and a method of tablet granulation |
| US5317044A (en) * | 1989-05-16 | 1994-05-31 | J. M. Huber Corporation | Endothermic blowing agents for surface migration of components in foamed products, compositions and applications |
| US5137655A (en) * | 1989-05-16 | 1992-08-11 | J. M. Huber Corporation | High temperature endothermic blowing agents compositions and applications |
| US5009810A (en) * | 1989-05-16 | 1991-04-23 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
| US5252618A (en) * | 1989-05-16 | 1993-10-12 | J. M. Huber Corporation | Endothermic blowing agents for strengthening weld lines in molded thermoplastic resins and products |
| US5302455A (en) * | 1989-05-16 | 1994-04-12 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
| US5250224A (en) * | 1989-05-16 | 1993-10-05 | J. M. Huber Corporation | Foamed products containing endothermic blowing agents and processes |
| US5009809A (en) * | 1989-05-16 | 1991-04-23 | J. M. Huber Corporation | High temperature endothermic blowing agents compositions and applications |
| USRE35368E (en) * | 1989-05-16 | 1996-10-29 | J. M. Huber Corporation | Endothermic blowing agents for surface migration of components in foamed products, compositions and applications |
| USRE35447E (en) * | 1989-05-16 | 1997-02-11 | J. M. Huber Corporation | Endothermic blowing agents for strengthening weld lines in molded thermoplastic resins and products |
| US5106534A (en) * | 1989-05-16 | 1992-04-21 | J. M. Huber Corporation | Endothermic blowing agents compositions and applications |
| US5252213A (en) * | 1989-06-20 | 1993-10-12 | University Of Washington | Dry dialysate composition |
| US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
| US5234963A (en) * | 1992-05-13 | 1993-08-10 | Gaia Research | Production of encapsulated chemical foaming concentrates |
| US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| EP0673644A1 (en) * | 1994-03-18 | 1995-09-27 | E-PHARMA TRENTO S.p.A. | Process and plant for preparation of effervescent granules |
| DE19734431A1 (de) * | 1997-08-08 | 1999-02-11 | Glatt Process Technology Gmbh | Verfahren und Vorrichtung zum Aufarbeiten einer Lösung oder Feststoffsuspension enthaltend thermisch labile Komponenten |
| US5997901A (en) | 1998-10-22 | 1999-12-07 | Mills; Robert G. | Method of manufacturing scented molded products |
| DE19931708A1 (de) * | 1999-07-08 | 2001-01-18 | Bayer Ag | Verfahren zur Herstellung schnell zerfallender, fester pharmazeutischer Zubereitungen |
| FR2796841B1 (fr) * | 1999-07-28 | 2003-08-15 | Lipha | Nouveau procede de production de melanges effervescents et les comprimes qui en resultent |
| ES2174734B1 (es) * | 2000-11-03 | 2003-10-01 | Belmac S A Lab | Nueva formulacion galenica de paracetamol dispersable y soluble, procedimiento para su preparacion y aplicaciones. |
| RU2257891C1 (ru) * | 2003-12-31 | 2005-08-10 | ООО "Фармстандарт-Фитофарм-НН" | Способ получения композиции в форме шипучих таблеток |
| WO2006085677A1 (en) * | 2005-02-09 | 2006-08-17 | Shinagawa Machinery Works Co., Ltd | Kneading and granulating machine |
| US7568297B2 (en) * | 2006-04-10 | 2009-08-04 | Woodhaven Capital Corp. | Grain drying aeration system |
| JP5467751B2 (ja) * | 2008-09-29 | 2014-04-09 | 小林製薬株式会社 | タンパク質凝固作用が抑制されてなるアミノ酸含有固体組成物 |
| WO2013081567A1 (en) * | 2011-12-02 | 2013-06-06 | Mahmut Bilgic | Effervescent antipsychotic formulations |
| CA2961445C (en) | 2014-09-17 | 2019-03-26 | Babu Padmanabhan | Effervescent composition and method of making it |
| WO2017098481A1 (en) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| DE102016218135A1 (de) | 2016-09-21 | 2018-03-22 | Robert Bosch Gmbh | Produktionsmodul zum Herstellen fester Arzneiformen |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2999293A (en) | 1957-09-12 | 1961-09-12 | Warner Lambert Pharmaceutical | Process of granulating effervescent materials |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2497057A (en) * | 1950-02-07 | Toilet bowl -gleanee | ||
| US2463962A (en) * | 1947-05-17 | 1949-03-08 | Fearn Lab Inc | Product for producing effervescing carbonated beverages |
| DE1060093B (de) * | 1957-04-26 | 1959-06-25 | Ciba Geigy | Neue Methode zur Herstellung eines Tablettengranulates |
| US2877159A (en) * | 1957-04-26 | 1959-03-10 | Ciba Pharm Prod Inc | Method for preparing tablet granulations |
| US2985562A (en) * | 1958-03-27 | 1961-05-23 | Warner Lambert Pharmaceutical | Effervescent compositions |
| US3401216A (en) * | 1964-01-09 | 1968-09-10 | Bristol Myers Co | Methods for preparing pharmaceutical compositions |
| US3480185A (en) * | 1966-06-20 | 1969-11-25 | Johnson & Johnson | Charged effervescing agent and medicament dispensing metering valve-actuated aerosol container producing a dose of medicament and carbonation in water |
| FR2092893B1 (OSRAM) * | 1970-06-29 | 1973-07-13 | Bru Jean | |
| FR2132521A1 (en) * | 1971-04-06 | 1972-11-24 | Sofrader Sa | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
| FR2154323A1 (en) * | 1971-09-29 | 1973-05-11 | Sofrader Sa | Effervescent tablets prdn - by controlled drying in effervescent granule formation |
| GB1359614A (en) * | 1971-04-06 | 1974-07-10 | Dev Et De Rech Soc Fr De | Method for the manufacture of effervescent tablets |
| US3903255A (en) * | 1971-05-17 | 1975-09-02 | Rohm & Haas | Effervescent potassium chloride tablet |
| DE2218729B1 (de) * | 1972-04-18 | 1974-03-21 | Barmag Barmer Maschinenfabrik Ag, 5600 Wuppertal | Vorrichtung zum mischen und granulieren |
| US4093710A (en) * | 1976-07-07 | 1978-06-06 | Sandoz, Inc. | Rapid dissolving effervescent granules |
| US4153678A (en) * | 1978-07-17 | 1979-05-08 | American Cyanamid Company | Levamisole effervescent tablets |
| DE2842822C3 (de) * | 1978-09-30 | 1982-05-19 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneistoffzubereitungen schwerlöslicher Arzneistoffe in Form von Brausegranulaten |
| AU528310B2 (en) * | 1978-11-16 | 1983-04-21 | Beecham Group Plc | Composition of paracetamol and metoclopramide |
| US4267164A (en) * | 1980-01-31 | 1981-05-12 | Block Drug Company Inc. | Effervescent stannous fluoride tablet |
| AT372299B (de) * | 1980-12-15 | 1983-09-26 | Gergely Gerhard | Vorrichtung zur herstellung von gewuenschtenfalls zu brausetabletten verarbeitbaren brausegranulaten |
| EP0076340B1 (de) * | 1981-10-06 | 1984-08-15 | Gerhard Dr. Gergely | Verfahren zur Herstellung von gewünschtenfalls zu Brausetabletten verarbeitbaren Brausegranulaten |
| CA1209040A (fr) * | 1982-12-21 | 1986-08-05 | Jean Bru | Procede de fabrication de granules et comprimes effervescents |
-
1983
- 1983-12-19 CA CA000443701A patent/CA1209040A/fr not_active Expired
- 1983-12-20 WO PCT/FR1983/000253 patent/WO1984002468A1/fr not_active Ceased
- 1983-12-20 EP EP84900064A patent/EP0162043B1/fr not_active Expired
- 1983-12-20 CH CH4062/84A patent/CH664491A5/fr not_active IP Right Cessation
- 1983-12-20 DE DE3390423T patent/DE3390423C2/de not_active Expired - Lifetime
- 1983-12-20 PT PT77864A patent/PT77864B/pt unknown
- 1983-12-20 AT AT0908083A patent/AT394492B/de not_active IP Right Cessation
- 1983-12-20 GR GR73291A patent/GR81352B/el unknown
- 1983-12-20 JP JP59500291A patent/JPH07100653B2/ja not_active Expired - Lifetime
- 1983-12-20 US US06/643,980 patent/US4614648A/en not_active Ceased
- 1983-12-20 GB GB08427318A patent/GB2146244B/en not_active Expired
- 1983-12-20 NL NL8320404A patent/NL193488C/nl not_active IP Right Cessation
- 1983-12-21 ES ES528271A patent/ES528271A0/es active Granted
- 1983-12-21 MA MA20201A patent/MA19980A1/fr unknown
- 1983-12-21 EG EG79483A patent/EG17260A/xx active
- 1983-12-21 IT IT68331/83A patent/IT1175295B/it active
- 1983-12-21 KR KR1019830006082A patent/KR900007312B1/ko not_active Expired
-
1984
- 1984-08-20 DK DK397984A patent/DK163565C/da not_active IP Right Cessation
- 1984-08-20 SE SE8404142A patent/SE457416B/sv not_active IP Right Cessation
-
1987
- 1987-07-10 US US07/071,991 patent/USRE33086E/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2999293A (en) | 1957-09-12 | 1961-09-12 | Warner Lambert Pharmaceutical | Process of granulating effervescent materials |
Non-Patent Citations (1)
| Title |
|---|
| 大塚・林編「粉体を中心とした製剤学」（昭５１−３−２５）廣川書店Ｐ．１０３ |
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