KR840006905A - 과립 및 압축된 발포제의 제조방법 및 장치 - Google Patents

과립 및 압축된 발포제의 제조방법 및 장치 Download PDF

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Publication number
KR840006905A
KR840006905A KR1019830006082A KR830006082A KR840006905A KR 840006905 A KR840006905 A KR 840006905A KR 1019830006082 A KR1019830006082 A KR 1019830006082A KR 830006082 A KR830006082 A KR 830006082A KR 840006905 A KR840006905 A KR 840006905A
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KR
South Korea
Prior art keywords
granulation
drying
citric acid
maintain
mixing
Prior art date
Application number
KR1019830006082A
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English (en)
Other versions
KR900007312B1 (ko
Inventor
쟝브루
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쟝브루
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8221476A external-priority patent/FR2537872B1/fr
Priority claimed from FR838319143A external-priority patent/FR2555439B1/fr
Application filed by 쟝브루 filed Critical 쟝브루
Publication of KR840006905A publication Critical patent/KR840006905A/ko
Application granted granted Critical
Publication of KR900007312B1 publication Critical patent/KR900007312B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Glanulating (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용없음

Description

과립 및 압축된 발포제의 제조방법 및 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제2도는 본 발명에 따른 장치의 배치를 도식적으로 나타낸 배치도이다.

Claims (12)

  1. 작용이 단일 장치와 더불어 수행됨을 특징으로 하는 용매의 혼합으로 습윤 처리하고 과립화-건조화 수행되는 농축된 발포제의 제조방법.
  2. 제1항에 있어서, 바닦 유동 성분에 따른 장치가 마지막 건조화에 작동시킴을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서 장치가 과립화-건조화에 작동시킴을 특징으로 하는 방법.
  4. 제1~3항중 어느 한 항에 따라 다음의 작동을 구성함을 특징으로 하는 방법.
    (1) 반응성 선혼합물
    (2) 공기에 의한 바닦의 유동성을 유지하기 위해 용매(습윤)를 1~6% 무개비로 분무화
    (3) 약 60~70°C로 공기를 가열하여 바닦유동성을 지속시켜 건조화.
  5. 제1~4항중 어느 한 항에 따라, 다음의 혼합성분을 특징으로 하는 방법.
    -혼합비등
    -중탄산 나트륨
    -구연산
    -글리코올(필요하다면) 및 용매는 탈광물질화된 물이다.
  6. 제1~4항중 어느 한 항에 따라, 과립화를 위한 혼합물이 다음 식을 특징으로 하는 방법.
    -파라세타몰
    -탄산 제1 나트륨
    -탄산 제1 칼륨
    -소트비롤
    -무수 시트브산
    -아스도르브산 및 용매는 물과 마녹솔 용액이다.
  7. 제1항에 있어서, 특히 상기 언급된 구성장치를 특징으로 하는 방법.
    -혼합방법
    -용매유입방법
    -온도조절방법
    - 진공을 거는 방법 및 진조화는 진공을 거는 장치와 더불어 얻어진다.
  8. 제7항에 있어서, 열 교환 깔데기를 통과한 과립을 재냉각시킴을 특징으로 하는 방법.
  9. 제7항에 있어서, 날이있는 회전판을 작동시켜 일정하게 혼합시키고 진공을 걸어 용매를 일정한 비유로 흡인유입하거나 또는 펌프에 의해 분무화 공급하고 냉각유채를 순환시키거나 또는 이 중의 덮개로 온도를 일정하게 조절시키는 방법을 특징으로 하는 방법.
  10. 제9항에 있어서, 원료분말이 다음과 같음을 특징으로 하는 방법.
    -파라세타몰
    -비타민C
    -중탄산나트륨
    -구연산
    -중탄산칼륨
    -소트비톨
  11. 제7항에 있어서 다음의 제제 성분이 혼합 수행됨을 특징으로 하는 방법.
    -칼슘 카바살레이트
    -리신 카르바메이트
    -구연산
    -방향족
    -PEG(폴리에틸렌글리콜)
    -암모늄 삭카리네이트
    즉, 혼합 및 과립화의 기능을 폐기할 수 있고, 건조, 혼합화-과립화-건조화 기능을 유지할 필요가 없다.
  12. 제1~11항 중 어느 한항에 따른 방법을 수행함을 특징으로 하는 특이한 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830006082A 1982-12-21 1983-12-21 발포과립 및 정제의 제조방법 및 장치 KR900007312B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR8221476 1982-12-21
FR82/21,476 1982-12-21
FR8221476A FR2537872B1 (fr) 1982-12-21 1982-12-21 Procede de fabrication de comprimes effervescents
FR8319143 1983-11-30
FR838319143A FR2555439B1 (fr) 1983-11-30 1983-11-30 Procede et appareillage de fabrication de granules et comprimes effervescents
FR83/19,143 1983-11-30

Publications (2)

Publication Number Publication Date
KR840006905A true KR840006905A (ko) 1984-12-04
KR900007312B1 KR900007312B1 (ko) 1990-10-08

Family

ID=26223202

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006082A KR900007312B1 (ko) 1982-12-21 1983-12-21 발포과립 및 정제의 제조방법 및 장치

Country Status (19)

Country Link
US (2) US4614648A (ko)
EP (1) EP0162043B1 (ko)
JP (1) JPH07100653B2 (ko)
KR (1) KR900007312B1 (ko)
AT (1) AT394492B (ko)
CA (1) CA1209040A (ko)
CH (1) CH664491A5 (ko)
DE (1) DE3390423C2 (ko)
DK (1) DK163565C (ko)
EG (1) EG17260A (ko)
ES (1) ES528271A0 (ko)
GB (1) GB2146244B (ko)
GR (1) GR81352B (ko)
IT (1) IT1175295B (ko)
MA (1) MA19980A1 (ko)
NL (1) NL193488C (ko)
PT (1) PT77864B (ko)
SE (1) SE457416B (ko)
WO (1) WO1984002468A1 (ko)

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FR2796841B1 (fr) * 1999-07-28 2003-08-15 Lipha Nouveau procede de production de melanges effervescents et les comprimes qui en resultent
ES2174734B1 (es) * 2000-11-03 2003-10-01 Belmac S A Lab Nueva formulacion galenica de paracetamol dispersable y soluble, procedimiento para su preparacion y aplicaciones.
ATE400356T1 (de) * 2005-02-09 2008-07-15 Shinagawa Machinery Works Co L Knet- und granuliermaschine
JP5467751B2 (ja) * 2008-09-29 2014-04-09 小林製薬株式会社 タンパク質凝固作用が抑制されてなるアミノ酸含有固体組成物
WO2013081567A1 (en) * 2011-12-02 2013-06-06 Mahmut Bilgic Effervescent antipsychotic formulations
AU2015316552C1 (en) 2014-09-17 2018-08-23 Steerlife India Private Limited Effervescent composition and method of making it
US11219594B2 (en) 2015-12-12 2022-01-11 Steerlife India Private Limited Effervescent compositions of metformin and processes for preparation thereof
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Also Published As

Publication number Publication date
GB2146244B (en) 1987-01-28
US4614648A (en) 1986-09-30
CA1209040A (fr) 1986-08-05
DK163565C (da) 1992-09-07
GB8427318D0 (en) 1984-12-05
PT77864B (fr) 1986-03-25
IT1175295B (it) 1987-07-01
EP0162043B1 (fr) 1989-12-13
GR81352B (ko) 1984-12-11
KR900007312B1 (ko) 1990-10-08
SE8404142L (sv) 1984-08-20
USRE33086E (en) 1989-10-10
ATA908083A (de) 1991-10-15
JPH07100653B2 (ja) 1995-11-01
PT77864A (fr) 1984-01-01
NL193488B (nl) 1999-08-02
MA19980A1 (fr) 1984-07-01
WO1984002468A1 (fr) 1984-07-05
DK163565B (da) 1992-03-16
IT8368331A0 (it) 1983-12-21
ES8603753A1 (es) 1986-01-01
ES528271A0 (es) 1986-01-01
SE8404142D0 (sv) 1984-08-20
AT394492B (de) 1992-04-10
NL193488C (nl) 1999-12-03
DK397984D0 (da) 1984-08-20
EG17260A (fr) 1995-12-31
GB2146244A (en) 1985-04-17
JPS60500534A (ja) 1985-04-18
DE3390423C2 (de) 1996-08-14
DE3390423T1 (de) 1985-01-24
CH664491A5 (fr) 1988-03-15
NL8320404A (nl) 1985-04-01
DK397984A (da) 1984-08-20
EP0162043A1 (fr) 1985-11-27
SE457416B (sv) 1988-12-27

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