JP7834866B2 - Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用 - Google Patents

Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用

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Publication number
JP7834866B2
JP7834866B2 JP2024534736A JP2024534736A JP7834866B2 JP 7834866 B2 JP7834866 B2 JP 7834866B2 JP 2024534736 A JP2024534736 A JP 2024534736A JP 2024534736 A JP2024534736 A JP 2024534736A JP 7834866 B2 JP7834866 B2 JP 7834866B2
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ncbi gene
international publication
pharmaceutically acceptable
alkyl
compound
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JP2024545193A (ja
JP2024545193A5 (enExample
Inventor
ピーター エー． ブロムグレン，
ジミン ドゥ，
ムソン キム，
リアノン トーマス－トラン，
マイケル ティー． トゥデスコ，
チャンドラセカール ベンカタラマニ，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
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Priority to JP2025108392A priority Critical patent/JP2025129253A/ja
Publication of JP2024545193A5 publication Critical patent/JP2024545193A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2024534736A 2021-12-22 2022-12-20 Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用 Active JP7834866B2 (ja)

Priority Applications (1)

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JP2025108392A JP2025129253A (ja) 2021-12-22 2025-06-26 Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用

Applications Claiming Priority (3)

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US202163292650P 2021-12-22 2021-12-22
US63/292,650 2021-12-22
PCT/US2022/082058 WO2023122615A1 (en) 2021-12-22 2022-12-20 Ikaros zinc finger family degraders and uses thereof

Related Child Applications (1)

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JP2024545193A JP2024545193A (ja) 2024-12-05
JP2024545193A5 JP2024545193A5 (enExample) 2025-07-07
JP7834866B2 true JP7834866B2 (ja) 2026-03-24

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JP2025108392A Pending JP2025129253A (ja) 2021-12-22 2025-06-26 Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用

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Country Status (14)

Country Link
US (1) US12122764B2 (enExample)
EP (2) EP4452415B1 (enExample)
JP (2) JP7834866B2 (enExample)
KR (1) KR20240125012A (enExample)
CN (1) CN118488948A (enExample)
AR (1) AR128075A1 (enExample)
AU (1) AU2022417491B2 (enExample)
CA (1) CA3237577A1 (enExample)
ES (1) ES3072039T3 (enExample)
PL (1) PL4452415T3 (enExample)
PT (1) PT4452415T (enExample)
SI (1) SI4452415T1 (enExample)
TW (1) TWI834442B (enExample)
WO (1) WO2023122615A1 (enExample)

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CA3217792A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc Cdk2 degraders and uses thereof
EP4644382A4 (en) * 2022-12-27 2026-04-01 Gluetacs Therapeutics Shanghai Co Ltd ISOINDOLINONE SKELETON-BASED COMPOUND WITH SULFUR/OXYGEN SUBSTITUTED GLUTARIMIDE AND ITS USE
IL330075A (en) * 2023-12-19 2026-08-01 Bristol Myers Squibb Co Compounds for lowering WEE1 levels and uses thereof

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