JP7291396B2 - 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 - Google Patents

融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 Download PDF

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JP7291396B2
JP7291396B2 JP2019527363A JP2019527363A JP7291396B2 JP 7291396 B2 JP7291396 B2 JP 7291396B2 JP 2019527363 A JP2019527363 A JP 2019527363A JP 2019527363 A JP2019527363 A JP 2019527363A JP 7291396 B2 JP7291396 B2 JP 7291396B2
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ボーエルレ，パトリック
ホフマイスター，ロバート
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ティーシーアール２ セラピューティクス インク．
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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JP2019527363A 2016-11-22 2017-11-22 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 Active JP7291396B2 (ja)

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JP2023087484A JP2023109968A (ja) 2016-11-22 2023-05-29 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法

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US201662425535P 2016-11-22 2016-11-22
US201662425407P 2016-11-22 2016-11-22
US62/425,535 2016-11-22
US62/425,407 2016-11-22
US201662425884P 2016-11-23 2016-11-23
US201662425697P 2016-11-23 2016-11-23
US62/425,884 2016-11-23
US62/425,697 2016-11-23
PCT/US2017/063137 WO2018098365A2 (en) 2016-11-22 2017-11-22 Compositions and methods for tcr reprogramming using fusion proteins

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JP2019536452A5 JP2019536452A5 (OSRAM) 2020-12-24
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US (1) US11851491B2 (OSRAM)
EP (1) EP3544996A2 (OSRAM)
JP (2) JP7291396B2 (OSRAM)
CN (1) CN110177803A (OSRAM)
AU (1) AU2017363311A1 (OSRAM)
CA (1) CA3044593A1 (OSRAM)
WO (1) WO2018098365A2 (OSRAM)

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BR112019007100A2 (pt) 2016-10-07 2019-06-25 Tcr2 Therapeutics Inc composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
IL268554B2 (en) 2017-02-08 2025-03-01 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CA3235295C (en) 2017-02-20 2024-11-19 Dragonfly Therapeutics, Inc. Proteins binding her2, nkg2d and cd16
IL270138B2 (en) 2017-04-26 2025-08-01 Eureka Therapeutics Inc Structures that specifically recognize glypican 3 and their uses
CN110741016A (zh) 2017-04-26 2020-01-31 优瑞科生物技术公司 嵌合抗体/t-细胞受体构筑体及其用途
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
US11884733B2 (en) 2018-02-08 2024-01-30 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the NKG2D receptor
US12384847B2 (en) 2018-02-08 2025-08-12 Dragonfly Therapeutics, Inc. Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen
KR20200144093A (ko) 2018-02-17 2020-12-28 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 막 단백질 전달을 위한 조성물 및 방법
US12215157B2 (en) 2018-02-20 2025-02-04 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use
AU2019231792A1 (en) * 2018-03-09 2020-10-22 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
WO2019178362A1 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
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AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
US20210315933A1 (en) * 2018-07-26 2021-10-14 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using target specific fusion proteins
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