JP6839074B2 - 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング - Google Patents
養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング Download PDFInfo
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- JP6839074B2 JP6839074B2 JP2017514849A JP2017514849A JP6839074B2 JP 6839074 B2 JP6839074 B2 JP 6839074B2 JP 2017514849 A JP2017514849 A JP 2017514849A JP 2017514849 A JP2017514849 A JP 2017514849A JP 6839074 B2 JP6839074 B2 JP 6839074B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021020412A JP7627123B2 (ja) | 2014-09-17 | 2021-02-12 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2023007343A JP2023061944A (ja) | 2014-09-17 | 2023-01-20 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2025005441A JP2025081298A (ja) | 2014-09-17 | 2025-01-15 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014086694 | 2014-09-17 | ||
| CNPCT/CN2014/086694 | 2014-09-17 | ||
| CN2014090578 | 2014-11-07 | ||
| CNPCT/CN2014/090578 | 2014-11-07 | ||
| PCT/US2015/050715 WO2016044605A1 (en) | 2014-09-17 | 2015-09-17 | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021020412A Division JP7627123B2 (ja) | 2014-09-17 | 2021-02-12 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534261A JP2017534261A (ja) | 2017-11-24 |
| JP2017534261A5 JP2017534261A5 (Direct) | 2018-11-01 |
| JP6839074B2 true JP6839074B2 (ja) | 2021-03-03 |
Family
ID=54249616
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514849A Active JP6839074B2 (ja) | 2014-09-17 | 2015-09-17 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2021020412A Active JP7627123B2 (ja) | 2014-09-17 | 2021-02-12 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2023007343A Pending JP2023061944A (ja) | 2014-09-17 | 2023-01-20 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2025005441A Pending JP2025081298A (ja) | 2014-09-17 | 2025-01-15 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021020412A Active JP7627123B2 (ja) | 2014-09-17 | 2021-02-12 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2023007343A Pending JP2023061944A (ja) | 2014-09-17 | 2023-01-20 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
| JP2025005441A Pending JP2025081298A (ja) | 2014-09-17 | 2025-01-15 | 養子免疫療法のためのキメラ受容体での細胞毒性細胞のターゲティング |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10577417B2 (Direct) |
| EP (2) | EP3967709A1 (Direct) |
| JP (4) | JP6839074B2 (Direct) |
| KR (4) | KR20210149228A (Direct) |
| CN (2) | CN114621969A (Direct) |
| AU (3) | AU2015317608B2 (Direct) |
| BR (1) | BR112017005390A2 (Direct) |
| CA (1) | CA2961636A1 (Direct) |
| DK (1) | DK3194443T3 (Direct) |
| EA (1) | EA201790624A1 (Direct) |
| ES (1) | ES2891332T3 (Direct) |
| MX (2) | MX2017003645A (Direct) |
| PL (1) | PL3194443T3 (Direct) |
| WO (1) | WO2016044605A1 (Direct) |
Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗-cd123嵌合抗原受體工程化t細胞之初級人類白血病有效靶向 |
| HUE046961T2 (hu) | 2013-02-20 | 2020-04-28 | Univ Pennsylvania | Rák kezelése humanizált EGFRVIII elleni kiméra antigénreceptor alkalmazásával |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| BR112016013187A2 (pt) | 2013-12-19 | 2017-09-26 | Novartis Ag | receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP3097117B1 (en) | 2014-01-21 | 2023-10-04 | Novartis Ag | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| MX395149B (es) | 2014-04-07 | 2025-03-24 | Novartis Ag | Terapias de combinación que comprenden un receptor quimérico de antígeno cd19 para el cáncer. |
| US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| MX2017001011A (es) | 2014-07-21 | 2018-05-28 | Novartis Ag | Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma. |
| AR101829A1 (es) | 2014-07-21 | 2017-01-18 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 |
| TW202140557A (zh) | 2014-08-19 | 2021-11-01 | 瑞士商諾華公司 | 使用cd123嵌合抗原受體治療癌症 |
| KR20210149228A (ko) | 2014-09-17 | 2021-12-08 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| CA2963935A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| EP4036109A3 (en) | 2014-12-29 | 2022-10-12 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法 |
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