JP6731403B2 - 免疫応答およびがん治療の増強に使用するための組成物および方法 - Google Patents

免疫応答およびがん治療の増強に使用するための組成物および方法 Download PDF

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JP6731403B2
JP6731403B2 JP2017519278A JP2017519278A JP6731403B2 JP 6731403 B2 JP6731403 B2 JP 6731403B2 JP 2017519278 A JP2017519278 A JP 2017519278A JP 2017519278 A JP2017519278 A JP 2017519278A JP 6731403 B2 JP6731403 B2 JP 6731403B2
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seq
amino acid
acid sequence
antibody
cancer
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JP2017535257A (ja
JP2017535257A5 (enExample
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ブログドン，ジェニファー
シポレッタ，ダニエラ
ドラノフ，グレン
エー． ニー，デボラ
エー． ニー，デボラ
ワン，フェイ
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/515—Complete light chain, i.e. VL + CL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/74—Inducing cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/75—Agonist effect on antigen
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017519278A 2014-10-08 2015-10-08 免疫応答およびがん治療の増強に使用するための組成物および方法 Expired - Fee Related JP6731403B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462061644P 2014-10-08 2014-10-08
US62/061,644 2014-10-08
US201562198673P 2015-07-29 2015-07-29
US62/198,673 2015-07-29
US201562220764P 2015-09-18 2015-09-18
US62/220,764 2015-09-18
PCT/US2015/054775 WO2016057846A1 (en) 2014-10-08 2015-10-08 Compositions and methods of use for augmented immune response and cancer therapy

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JP2017535257A JP2017535257A (ja) 2017-11-30
JP2017535257A5 JP2017535257A5 (enExample) 2018-11-08
JP6731403B2 true JP6731403B2 (ja) 2020-07-29

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US (3) US20170306038A1 (enExample)
EP (2) EP3204419A1 (enExample)
JP (1) JP6731403B2 (enExample)
KR (1) KR20170065029A (enExample)
CN (1) CN107001476B (enExample)
AU (2) AU2015330771B2 (enExample)
BR (1) BR112017007093A2 (enExample)
CA (1) CA2964146A1 (enExample)
CL (2) CL2017000836A1 (enExample)
CO (1) CO2017003408A2 (enExample)
CR (1) CR20170138A (enExample)
CU (1) CU24437B1 (enExample)
EA (1) EA036467B1 (enExample)
EC (1) ECSP17027870A (enExample)
IL (1) IL251435A0 (enExample)
MA (1) MA41044A (enExample)
MX (1) MX379426B (enExample)
PE (1) PE20171654A1 (enExample)
PH (1) PH12017500634A1 (enExample)
SG (1) SG11201702596YA (enExample)
TN (1) TN2017000120A1 (enExample)
WO (2) WO2016057846A1 (enExample)

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AU2019200346B2 (en) 2020-07-30
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CN107001476A (zh) 2017-08-01
BR112017007093A2 (pt) 2018-03-06
CN107001476B (zh) 2021-08-24
CR20170138A (es) 2017-08-21
CU20170045A7 (es) 2017-09-06
WO2016057841A1 (en) 2016-04-14
US20170306038A1 (en) 2017-10-26
WO2016057846A1 (en) 2016-04-14
SG11201702596YA (en) 2017-04-27
US20170306037A1 (en) 2017-10-26
KR20170065029A (ko) 2017-06-12
AU2015330771A1 (en) 2017-04-20
MA41044A (fr) 2017-08-15
US10662247B2 (en) 2020-05-26
MX379426B (es) 2025-03-10
PH12017500634A1 (en) 2017-09-25
CL2018001369A1 (es) 2018-07-27
CA2964146A1 (en) 2016-04-14
MX2017004669A (es) 2017-06-19
IL251435A0 (en) 2017-05-29
EP3204419A1 (en) 2017-08-16
CU24437B1 (es) 2019-09-04
CO2017003408A2 (es) 2017-07-11
PE20171654A1 (es) 2017-11-13
AU2015330771B2 (en) 2018-10-18
EA036467B1 (ru) 2020-11-13

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