US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
US4978672A
(en)
|
1986-03-07 |
1990-12-18 |
Ciba-Geigy Corporation |
Alpha-heterocyclc substituted tolunitriles
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
US5013653A
(en)
|
1987-03-20 |
1991-05-07 |
Creative Biomolecules, Inc. |
Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
ATE120761T1
(de)
|
1987-05-21 |
1995-04-15 |
Creative Biomolecules Inc |
Multifunktionelle proteine mit vorbestimmter zielsetzung.
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
ES2059558T3
(es)
|
1987-06-17 |
1994-11-16 |
Sandoz Ag |
Ciclosporins y su uso como productos farmaceuticos.
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
DE68925966T2
(de)
|
1988-12-22 |
1996-08-29 |
Kirin Amgen Inc |
Chemisch modifizierte granulocytenkolonie erregender faktor
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
WO1992010591A1
(en)
|
1990-12-14 |
1992-06-25 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
US20030206899A1
(en)
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
ES2162823T5
(es)
|
1992-08-21 |
2010-08-09 |
Vrije Universiteit Brussel |
Inmunoglobulinas desprovistas de cadenas ligeras.
|
CA2145985C
(en)
|
1992-10-28 |
2003-09-16 |
Napoleone Ferrara |
Vascular endothelial cell growth factor antagonists
|
JPH08511420A
(ja)
|
1993-06-16 |
1996-12-03 |
セルテック・セラピューテイクス・リミテッド |
抗 体
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
CA2196200A1
(en)
|
1994-07-29 |
1996-02-15 |
Michael Joseph Browne |
Novel compounds
|
WO2000073452A2
(en)
|
1999-06-02 |
2000-12-07 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
IL117645A
(en)
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
DE69731289D1
(de)
|
1996-03-18 |
2004-11-25 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
MY129541A
(en)
|
1996-06-25 |
2007-04-30 |
Novartis Ag |
Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
EP1947183B1
(en)
|
1996-08-16 |
2013-07-17 |
Merck Sharp & Dohme Corp. |
Mammalian cell surface antigens; related reagents
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
EP3260468A1
(en)
|
1997-04-07 |
2017-12-27 |
Genentech, Inc. |
Anti-vegf antibodies
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
EP0973804B1
(en)
|
1997-04-07 |
2006-12-27 |
Genentech, Inc. |
Anti-vegf antibodies
|
EP1724282B1
(en)
|
1997-05-21 |
2013-05-15 |
Merck Patent GmbH |
Method for the production of non-immunogenic proteins
|
US6165476A
(en)
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
CO4940418A1
(es)
|
1997-07-18 |
2000-07-24 |
Novartis Ag |
Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
US6503184B1
(en)
|
1997-10-21 |
2003-01-07 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
JP2001520039A
(ja)
|
1997-10-21 |
2001-10-30 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
ヒト腫瘍壊死因子レセプター様タンパク質、tr11,tr11sv1およびtr11sv2
|
US6689607B2
(en)
|
1997-10-21 |
2004-02-10 |
Human Genome Sciences, Inc. |
Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
CA2319236A1
(en)
|
1998-02-09 |
1999-08-12 |
Genentech, Inc. |
Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
CA2325342A1
(en)
|
1998-04-08 |
1999-10-14 |
G.D. Searle & Co. |
Dual avb3 and metastasis-associated receptor ligands
|
AU3657899A
(en)
|
1998-04-20 |
1999-11-08 |
James E. Bailey |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
US7371832B1
(en)
|
1998-07-22 |
2008-05-13 |
Incyte Corporation |
Polynucleotides encoding molecules associated with cell proliferation
|
JP2002522504A
(ja)
|
1998-08-13 |
2002-07-23 |
ジー・ディー・サール・アンド・カンパニー |
多価avb3および転移関連レセプター・リガンド
|
EP1135491A2
(en)
|
1998-12-01 |
2001-09-26 |
Genentech, Inc. |
Methods and compositions for inhibiting neoplastic cell growth
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
HUP0104865A3
(en)
|
1999-01-15 |
2004-07-28 |
Genentech Inc |
Polypeptide variants with altered effector function
|
AU2600800A
(en)
|
1999-03-08 |
2000-09-28 |
Genentech Inc. |
Promotion or inhibition of angiogenesis and cardiovascularization
|
CA2362427A1
(en)
|
1999-03-08 |
2000-09-14 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
JP2003531811A
(ja)
|
1999-03-08 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
血管形成及び心臓血管新生の促進又は阻害
|
EP2275540B1
(en)
|
1999-04-09 |
2016-03-23 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
ATE376837T1
(de)
|
1999-07-12 |
2007-11-15 |
Genentech Inc |
Stimulierung oder hemmung von angiogenese und herzvaskularisierung mit tumor nekrose faktor ligand/rezeptor homologen
|
DE19932688B4
(de)
|
1999-07-13 |
2009-10-08 |
Scil Proteins Gmbh |
Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
|
GB0018891D0
(en)
|
2000-08-01 |
2000-09-20 |
Novartis Ag |
Organic compounds
|
ES2269366T3
(es)
|
2000-02-11 |
2007-04-01 |
Merck Patent Gmbh |
Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos.
|
EP1276849A4
(en)
|
2000-04-12 |
2004-06-09 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
WO2002057445A1
(en)
|
2000-05-26 |
2002-07-25 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
CA2417185A1
(en)
|
2000-07-25 |
2002-01-31 |
Shui-On Leung |
Multivalent target binding protein
|
GB0020685D0
(en)
|
2000-08-22 |
2000-10-11 |
Novartis Ag |
Organic compounds
|
US20040242847A1
(en)
|
2000-10-20 |
2004-12-02 |
Naoshi Fukushima |
Degraded agonist antibody
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
US20030133936A1
(en)
|
2001-07-12 |
2003-07-17 |
Byrne Michael Chapman |
CD25markers and uses thereof
|
ES2326964T3
(es)
|
2001-10-25 |
2009-10-22 |
Genentech, Inc. |
Composiciones de glicoproteina.
|
IL161156A0
(en)
|
2001-10-30 |
2004-08-31 |
Novartis Ag |
Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
|
AU2003210787B2
(en)
|
2002-02-01 |
2009-04-23 |
Medinol Ltd. |
Phosphorus-containing compounds & uses thereof
|
SG148857A1
(en)
|
2002-03-13 |
2009-01-29 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
US7495090B2
(en)
|
2002-05-23 |
2009-02-24 |
The Regents Of The University Of California |
Nucleic acids encoding chimeric CD154 polypeptides
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
CN1787837A
(zh)
|
2002-11-15 |
2006-06-14 |
希龙公司 |
防止和治疗癌转移以及与癌转移相关的骨质损失的方法
|
AU2003299984A1
(en)
|
2002-12-20 |
2004-07-22 |
Biogen Idec Ma Inc. |
Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
|
JP4511943B2
(ja)
|
2002-12-23 |
2010-07-28 |
ワイス エルエルシー |
Pd−1に対する抗体およびその使用
|
CA2511538C
(en)
|
2002-12-30 |
2013-11-26 |
3M Innovative Properties Company |
Immunostimulatory combinations
|
ES2393483T3
(es)
|
2003-02-11 |
2012-12-21 |
Vernalis (R&D) Limited |
Compuestos de isoxazol como inhibidores de las proteínas de choque térmico
|
US20050008625A1
(en)
|
2003-02-13 |
2005-01-13 |
Kalobios, Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
EP1462114A1
(en)
|
2003-03-28 |
2004-09-29 |
Universiteit Utrecht Holding B.V. |
Methods and means to suppress symptons of an allergic disease by inhibiting the glucocorticoid-induced tumor necrosis factor receptor (GRIT or TNFRSF18)
|
CA2525717A1
(en)
|
2003-05-23 |
2004-12-09 |
Wyeth |
Gitr ligand and gitr ligand-related molecules and antibodies and uses thereof
|
CN1809589A
(zh)
*
|
2003-05-23 |
2006-07-26 |
Wyeth公司 |
Gitr配体和gitr配体相关分子和抗体及其应用
|
DE10324447A1
(de)
|
2003-05-28 |
2004-12-30 |
Scil Proteins Gmbh |
Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
|
MXPA05012723A
(es)
|
2003-05-30 |
2006-02-08 |
Genentech Inc |
Tratamiento con anticuerpos anti-vgf.
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
EP1660126A1
(en)
|
2003-07-11 |
2006-05-31 |
Schering Corporation |
Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
US20050069521A1
(en)
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
JP2007509185A
(ja)
|
2003-10-27 |
2007-04-12 |
ノバルティス アクチエンゲゼルシャフト |
βアミロイド産生および/または凝集と関係がある神経障害および血管障害の処置のためのインドリル−ピロールジオン誘導体
|
WO2005055808A2
(en)
|
2003-12-02 |
2005-06-23 |
Genzyme Corporation |
Compositions and methods to diagnose and treat lung cancer
|
DK1704166T3
(en)
|
2004-01-07 |
2015-06-01 |
Novartis Vaccines & Diagnostic |
M-CSF-SPECIFIC MONOCLONAL ANTIBODY AND APPLICATIONS THEREOF
|
AU2005207003C1
(en)
|
2004-01-20 |
2013-06-13 |
Humanigen, Inc. |
Antibody specificity transfer using minimal essential binding determinants
|
AU2005207946A1
(en)
|
2004-01-23 |
2005-08-11 |
Amgen Inc. |
Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
|
CN1980957A
(zh)
|
2004-03-23 |
2007-06-13 |
比奥根艾迪克Ma公司 |
受体偶联剂及其治疗用途
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
DK1761540T3
(en)
|
2004-05-13 |
2016-11-21 |
Icos Corp |
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase DELTA
|
WO2006083289A2
(en)
|
2004-06-04 |
2006-08-10 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
US20060008844A1
(en)
|
2004-06-17 |
2006-01-12 |
Avidia Research Institute |
c-Met kinase binding proteins
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
US20060009360A1
(en)
|
2004-06-25 |
2006-01-12 |
Robert Pifer |
New adjuvant composition
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
US20060099171A1
(en)
|
2004-11-05 |
2006-05-11 |
Masahide Tone |
Mouse glucocorticoid-induced TNF receptor ligand is costimulatory for T cells
|
ES2744149T3
(es)
|
2004-11-16 |
2020-02-21 |
Humanigen Inc |
Intercambio de casetes de la región variable de la inmunoglobulina
|
WO2006074399A2
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
Multispecific binding molecules comprising connecting peptides
|
BRPI0607639B1
(pt)
|
2005-02-08 |
2022-04-05 |
Genzyme Corporation |
Moléculas de anticorpo humano ou fragmento de ligação a antígeno das mesmas que se ligam e neutralizam tgf-beta1, 2 e 3, uso das mesmas e composição farmacêutica
|
EP1866339B8
(en)
|
2005-03-25 |
2021-12-01 |
GITR, Inc. |
Gitr binding molecules and uses therefor
|
EP1885396A2
(en)
|
2005-05-04 |
2008-02-13 |
Quark Pharmaceuticals, Inc. |
Recombinant antibodies against cd55 and cd59 and uses thereof
|
PT1877090E
(pt)
|
2005-05-06 |
2014-04-15 |
Providence Health System |
Proteína de fusão trimérica de imunoglobulina-ox40 e métodos de utilização
|
LT2439273T
(lt)
|
2005-05-09 |
2019-05-10 |
Ono Pharmaceutical Co., Ltd. |
Žmogaus monokloniniai antikūnai prieš programuotos mirties 1(pd-1) baltymą, ir vėžio gydymo būdai, naudojant vien tik anti-pd-1 antikūnus arba derinyje su kitais imunoterapiniais vaistais
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
JP4984160B2
(ja)
|
2005-06-07 |
2012-07-25 |
国立大学法人 東京大学 |
抗体の作製方法
|
CN105330741B
(zh)
|
2005-07-01 |
2023-01-31 |
E.R.施贵宝&圣斯有限责任公司 |
抗程序性死亡配体1(pd-l1)的人单克隆抗体
|
US8211648B2
(en)
|
2005-07-22 |
2012-07-03 |
Kalobios Pharmaceuticals, Inc. |
Secretion of antibodies without signal peptides from bacteria
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
TW200804345A
(en)
|
2005-08-30 |
2008-01-16 |
Novartis Ag |
Substituted benzimidazoles and methods of preparation
|
WO2007044887A2
(en)
|
2005-10-11 |
2007-04-19 |
Transtarget, Inc. |
Method for producing a population of homogenous tetravalent bispecific antibodies
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
TW200732350A
(en)
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
GEP20135924B
(en)
|
2005-12-02 |
2013-10-10 |
The Mount Sinai School Of Medicine Of New York Univ |
Chimeric viruses presenting non-native surface proteins and usage thereof
|
KR101158959B1
(ko)
|
2005-12-13 |
2012-07-09 |
일라이 릴리 앤드 캄파니 |
항-il-17 항체
|
WO2007070660A2
(en)
|
2005-12-13 |
2007-06-21 |
President And Fellows Of Harvard College |
Scaffolds for cell transplantation
|
MY162590A
(en)
|
2005-12-13 |
2017-06-30 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors
|
EP1981969A4
(en)
|
2006-01-19 |
2009-06-03 |
Genzyme Corp |
ANTI-GITRANT ANTIBODIES FOR THE TREATMENT OF CANCER
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
CA2646508A1
(en)
|
2006-03-17 |
2007-09-27 |
Biogen Idec Ma Inc. |
Stabilized polypeptide compositions
|
LT2010528T
(lt)
|
2006-04-19 |
2017-12-27 |
Novartis Ag |
6-o-pakeistieji benzoksazolo junginiai bei csf-1r signalo perdavimo slopinimo būdai
|
UA93548C2
(uk)
|
2006-05-05 |
2011-02-25 |
Айерем Елелсі |
Сполуки та композиції як модулятори хеджхогівського сигнального шляху
|
JP2009539413A
(ja)
|
2006-06-12 |
2009-11-19 |
トゥルビオン・ファーマシューティカルズ・インコーポレーテッド |
エフェクター機能を有する単鎖多価結合タンパク質
|
PE20110224A1
(es)
|
2006-08-02 |
2011-04-05 |
Novartis Ag |
PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO
|
WO2008073160A2
(en)
|
2006-08-17 |
2008-06-19 |
The Trustees Of Columbia University In The City Of New York |
Methods for converting or inducing protective immunity
|
GEP20125612B
(en)
|
2006-08-18 |
2012-08-27 |
Novartis Ag |
Prlr-specific antibody and usage thereof
|
US7767206B2
(en)
|
2006-10-02 |
2010-08-03 |
Amgen Inc. |
Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
|
GB0620894D0
(en)
|
2006-10-20 |
2006-11-29 |
Univ Southampton |
Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
|
JP5572388B2
(ja)
|
2006-11-22 |
2014-08-13 |
インサイト・コーポレイション |
キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン
|
EP2114432B1
(en)
|
2006-12-05 |
2014-07-30 |
Memgen LLC |
Methods of increasing cancer sensitivity to chemotherapeutic agents using chimeric isf35
|
AU2007333394C1
(en)
|
2006-12-08 |
2011-08-18 |
Novartis Ag |
Compounds and compositions as protein kinase inhibitors
|
WO2008140621A2
(en)
|
2006-12-21 |
2008-11-20 |
Mount Sinai School Of Medicine Of New York University |
Transgenic oncolytic viruses and uses thereof
|
JP2008278814A
(ja)
*
|
2007-05-11 |
2008-11-20 |
Igaku Seibutsugaku Kenkyusho:Kk |
アゴニスティック抗ヒトgitr抗体による免疫制御の解除とその応用
|
DK2170959T3
(da)
|
2007-06-18 |
2014-01-13 |
Merck Sharp & Dohme |
Antistoffer mod human programmeret dødsreceptor pd-1
|
US9770535B2
(en)
|
2007-06-21 |
2017-09-26 |
President And Fellows Of Harvard College |
Scaffolds for cell collection or elimination
|
ES2466916T3
(es)
|
2007-06-27 |
2014-06-11 |
Admune Therapeutics Llc |
Complejos de IL-15 e IL-15R alfa y usos de los mismos
|
ES2591281T3
(es)
*
|
2007-07-12 |
2016-11-25 |
Gitr, Inc. |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
JP2010535032A
(ja)
|
2007-07-31 |
2010-11-18 |
メディミューン,エルエルシー |
多重特異性エピトープ結合性タンパク質およびその用途
|
KR20100052545A
(ko)
|
2007-08-28 |
2010-05-19 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Igf―1r의 다중 에피토프에 결합하는 조성물
|
US20090155255A1
(en)
|
2007-09-27 |
2009-06-18 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
BRPI0907718A2
(pt)
|
2008-02-11 |
2017-06-13 |
Curetech Ltd |
método para tratar um tumor, método para melhorar a tolerabilidade a pelo menos um agente quimiterápico, método para aumentar a sobrevida de um indivíduo que tem um tumor, método para reduzir ou prevenir recidiva tumoral, uso de um anticorpo monoclonal humanizado ou seu fragmento e anticorpo monoclonal humanizado ou seu fragmento
|
CN102006891B
(zh)
|
2008-02-13 |
2017-04-26 |
哈佛学院董事会 |
连续的细胞程序化装置
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
US8637542B2
(en)
|
2008-03-14 |
2014-01-28 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
PE20091628A1
(es)
|
2008-03-19 |
2009-11-19 |
Novartis Ag |
Formas cristalinas y dos formas solvatadas de sales de acido lactico de 4-amino-5-fluoro-3-[5-(4-metilpiperazin-1-il)-1h-benzimidazol-2-il]quinolin-2(1h)-ona
|
JP5522405B2
(ja)
|
2008-04-25 |
2014-06-18 |
協和発酵キリン株式会社 |
安定な多価抗体
|
MX2010012718A
(es)
|
2008-05-21 |
2011-04-04 |
Incyte Corp |
Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b ][1,2,4] triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas.
|
CN102036963B
(zh)
|
2008-05-23 |
2013-08-21 |
诺瓦提斯公司 |
作为蛋白酪氨酸激酶抑制剂的喹啉类和喹喔啉类衍生物
|
UY31929A
(es)
|
2008-06-25 |
2010-01-05 |
Irm Llc |
Compuestos y composiciones como inhibidores de cinasa
|
KR20110044992A
(ko)
|
2008-07-02 |
2011-05-03 |
이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 |
TGF-β 길항제 다중-표적 결합 단백질
|
WO2010006086A2
(en)
|
2008-07-08 |
2010-01-14 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
AR072749A1
(es)
|
2008-07-17 |
2010-09-15 |
Novartis Ag |
Anticuerpos contra receptor del factor de la necrosis tumoral (baffr) y composiciones farmaceuticas
|
US20100041663A1
(en)
|
2008-07-18 |
2010-02-18 |
Novartis Ag |
Organic Compounds as Smo Inhibitors
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
WO2010020675A1
(en)
|
2008-08-22 |
2010-02-25 |
Novartis Ag |
Pyrrolopyrimidine compounds as cdk inhibitors
|
US20110159023A1
(en)
|
2008-08-25 |
2011-06-30 |
Solomon Langermann |
Pd-1 antagonists and methods for treating infectious disease
|
NZ591130A
(en)
|
2008-08-25 |
2012-09-28 |
Amplimmune Inc |
Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof
|
PT2344474E
(pt)
|
2008-09-02 |
2015-12-28 |
Novartis Ag |
Derivados de picolinamida como inibidores de cinase
|
WO2010028798A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Multivalent antibodies
|
UA104147C2
(uk)
|
2008-09-10 |
2014-01-10 |
Новартис Аг |
Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
|
CN102149820B
(zh)
|
2008-09-12 |
2014-07-23 |
国立大学法人三重大学 |
能够表达外源gitr配体的细胞
|
CA2738429C
(en)
|
2008-09-26 |
2016-10-25 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
AU2009319048B2
(en)
|
2008-11-28 |
2014-01-30 |
Novartis Ag |
Pharmaceutical combination comprising a Hsp 90 inhibitor and a mTOR inhibitor
|
SI2376535T1
(sl)
|
2008-12-09 |
2017-07-31 |
F. Hoffmann-La Roche Ag |
Protitelesa anti-pd-l1 in njihova uporaba za izboljšanje funkcije celic t
|
WO2010071880A1
(en)
*
|
2008-12-19 |
2010-06-24 |
University Of Miami |
Tnfr25 agonists to enhance immune responses to vaccines
|
WO2010091262A1
(en)
|
2009-02-05 |
2010-08-12 |
Mount Sinai School Of Medicine Of New York University |
Chimeric newcastle disease viruses and uses thereof
|
JP5844159B2
(ja)
|
2009-02-09 |
2016-01-13 |
ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille |
Pd−1抗体およびpd−l1抗体ならびにその使用
|
UA103918C2
(en)
|
2009-03-02 |
2013-12-10 |
Айерем Элелси |
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
US8703132B2
(en)
|
2009-06-18 |
2014-04-22 |
Hoffmann-La Roche, Inc. |
Bispecific, tetravalent antigen binding proteins
|
DK2445903T3
(da)
|
2009-06-26 |
2014-06-23 |
Novartis Ag |
1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer
|
JO3002B1
(ar)
|
2009-08-28 |
2016-09-05 |
Irm Llc |
مركبات و تركيبات كمثبطات كيناز بروتين
|
LT3023438T
(lt)
*
|
2009-09-03 |
2020-05-11 |
Merck Sharp & Dohme Corp. |
Anti-gitr antikūnai
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
JP2013512251A
(ja)
|
2009-11-24 |
2013-04-11 |
アンプリミューン、インコーポレーテッド |
Pd−l1/pd−l2の同時阻害
|
BR112012013736A2
(pt)
|
2009-12-07 |
2018-08-14 |
Univ Leland Stanford Junior |
processo para intesificação de terapia com anticorpos antitumor
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
SI2519543T1
(sl)
|
2009-12-29 |
2016-08-31 |
Emergent Product Development Seattle, Llc |
Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
CA3083324A1
(en)
|
2010-03-05 |
2011-09-09 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
TR201807750T4
(tr)
|
2010-06-11 |
2018-06-21 |
Kyowa Hakko Kirin Co Ltd |
Anti-TIM-3 antikoru.
|
AU2011275749C1
(en)
|
2010-07-09 |
2015-09-17 |
Aduro Biotech Holdings, Europe B.V. |
Agonistic antibody to CD27
|
US20120014947A1
(en)
*
|
2010-07-16 |
2012-01-19 |
The University Of Chicago |
Methods and compositions to reduce liver damage associated with conditions or therapies that affect the immune system
|
CU24094B1
(es)
|
2010-08-20 |
2015-04-29 |
Novartis Ag |
Anticuerpos para el receptor 3 del factor de crecimiento epidérmico(her3)
|
NZ629913A
(en)
|
2010-08-23 |
2016-01-29 |
Univ Texas |
Anti-ox40 antibodies and methods of using the same
|
RU2013110876A
(ru)
|
2010-08-24 |
2014-09-27 |
Рош Гликарт Аг |
Активируемые биспецифические антитела
|
WO2012025530A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
PT2918607T
(pt)
|
2010-09-21 |
2018-01-11 |
Altor Bioscience Corp |
Moléculas de fusão de il-15 multiméricas solúveis e métodos de produção e utilização das mesmas
|
PT2624873T
(pt)
|
2010-10-06 |
2020-03-04 |
Harvard College |
Hidrogéis injectáveis formadores de poros para terapias celulares à base de materiais
|
WO2012088461A2
(en)
|
2010-12-23 |
2012-06-28 |
Biogen Idec Inc. |
Linker peptides and polypeptides comprising same
|
ES2878089T3
(es)
|
2011-04-28 |
2021-11-18 |
Harvard College |
Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva
|
CN103842383B
(zh)
|
2011-05-16 |
2017-11-03 |
健能隆医药技术(上海)有限公司 |
多特异性fab融合蛋白及其使用方法
|
EP2714073B1
(en)
|
2011-06-03 |
2021-03-10 |
President and Fellows of Harvard College |
In situ antigen-generating cancer vaccine
|
SG10201902706VA
(en)
|
2011-06-03 |
2019-04-29 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
EP3626739A1
(en)
|
2011-06-24 |
2020-03-25 |
Stephen D. Gillies |
Light chain immunoglobulin fusion proteins and methods of use thereof
|
WO2013039954A1
(en)
*
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anti-gitr antibodies
|
US20130071403A1
(en)
|
2011-09-20 |
2013-03-21 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
WO2013049254A1
(en)
|
2011-09-26 |
2013-04-04 |
Jn Biosciences Llc |
Hybrid constant regions
|
US9382319B2
(en)
|
2011-09-26 |
2016-07-05 |
Jn Biosciences Llc |
Hybrid constant regions
|
RU2019133467A
(ru)
|
2011-10-11 |
2020-07-06 |
МЕДИММЬЮН, ЭлЭлСи |
Cd40l-специфичные каркасные структуры, происходящие из tn3, и способы их применения
|
KR101981873B1
(ko)
|
2011-11-28 |
2019-05-23 |
메르크 파텐트 게엠베하 |
항-pd-l1 항체 및 그의 용도
|
CN109125718A
(zh)
|
2012-01-13 |
2019-01-04 |
哈佛学院董事会 |
在结构聚合装置中tlr激动剂的控制传递
|
JO3357B1
(ar)
|
2012-01-26 |
2019-03-13 |
Novartis Ag |
مركبات إيميدازوبيروليدينون
|
UY34632A
(es)
|
2012-02-24 |
2013-05-31 |
Novartis Ag |
Compuestos de oxazolidin- 2- ona y usos de los mismos
|
US20150086584A1
(en)
|
2012-03-22 |
2015-03-26 |
University Of Miami |
Multi-specific binding agents
|
US9649305B2
(en)
|
2012-03-29 |
2017-05-16 |
Advanced Cancer Therapeutics, Llc |
PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic
|
ES2773895T3
(es)
|
2012-04-16 |
2020-07-15 |
Harvard College |
Composiciones de sílice mesoporosa para modular las respuestas inmunitarias
|
JP2015514421A
(ja)
|
2012-04-17 |
2015-05-21 |
ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォーコマーシャライゼーションThe University Of Washington Through Its Center For Commercialization |
Hlaクラスiiタンパク質の発現能を有するhlaクラスii欠損細胞、hlaクラスi欠損細胞、及びその使用
|
CA2871715A1
(en)
|
2012-05-15 |
2013-11-21 |
Novartis Ag |
Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
|
CA2871332A1
(en)
|
2012-05-15 |
2013-11-21 |
Novartis Ag |
Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
|
US9315489B2
(en)
|
2012-05-15 |
2016-04-19 |
Novartis Ag |
Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
|
DK2861579T5
(da)
|
2012-05-15 |
2022-10-24 |
Novartis Ag |
Benzamidderivater til at hæmme aktiviteten af ABL1, ABL2 og BCR-ABL1
|
JO3300B1
(ar)
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
KR101566539B1
(ko)
|
2012-06-08 |
2015-11-05 |
국립암센터 |
신규한 Th2 세포 전환용 에피토프 및 이의 용도
|
AR091649A1
(es)
|
2012-07-02 |
2015-02-18 |
Bristol Myers Squibb Co |
Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
|
CN112587658A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
CN104684928A
(zh)
|
2012-08-02 |
2015-06-03 |
Jn生物科学有限责任公司 |
通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白
|
TWI472974B
(zh)
|
2012-09-06 |
2015-02-11 |
Au Optronics Corp |
多類物體觸控點偵測方法
|
JP6359019B2
(ja)
|
2012-10-24 |
2018-07-18 |
ノバルティス アーゲー |
IL−15Rα型、IL−15Rα型を発現する細胞、ならびにIL−15RαおよびIL−15/IL−15Rα複合体の治療上の使用
|
CN104994850A
(zh)
|
2012-11-08 |
2015-10-21 |
诺华股份有限公司 |
包含b-raf抑制剂和组蛋白脱乙酰基酶抑制剂的药物组合以及其在治疗增生性疾病中的用途
|
CA2891938A1
(en)
|
2012-11-28 |
2014-06-05 |
Novartis Ag |
Combination therapy
|
RS58528B1
(sr)
|
2012-12-03 |
2019-04-30 |
Bristol Myers Squibb Co |
Poboljšanje anti-kancerske aktivnosti imunomodulatornih fc fuzionih proteina
|
EP2948475A2
(en)
|
2013-01-23 |
2015-12-02 |
AbbVie Inc. |
Methods and compositions for modulating an immune response
|
SI2953969T1
(sl)
|
2013-02-08 |
2020-01-31 |
Novartis Ag |
Protitelesa proti-IL-17A in njihova uporaba v zdravljenju avtoimunskih in vnetnih motenj
|
US9498532B2
(en)
|
2013-03-13 |
2016-11-22 |
Novartis Ag |
Antibody drug conjugates
|
NZ711946A
(en)
|
2013-03-14 |
2020-05-29 |
Icahn School Med Mount Sinai |
Newcastle disease viruses and uses thereof
|
ES2665619T3
(es)
|
2013-03-14 |
2018-04-26 |
Novartis Ag |
3-Pirimidin-4-il-oxazolidin-2-onas como inhibidores de IDH mutante
|
US9242969B2
(en)
|
2013-03-14 |
2016-01-26 |
Novartis Ag |
Biaryl amide compounds as kinase inhibitors
|
EP3421495A3
(en)
|
2013-03-15 |
2019-05-15 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
CN105188373B
(zh)
|
2013-05-18 |
2017-09-22 |
艾杜罗生物科技公司 |
抑制“干扰素基因刺激蛋白”依赖性信号传导的组合物和方法
|
AU2014268836B2
(en)
|
2013-05-18 |
2018-08-02 |
Aduro Biotech, Inc. |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
|
AR097306A1
(es)
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
CN105658646B
(zh)
|
2013-11-01 |
2018-11-27 |
诺华股份有限公司 |
作为激酶抑制剂的氨基杂芳基苯甲酰胺
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
GB201322583D0
(en)
|
2013-12-19 |
2014-02-05 |
Alligator Bioscience Ab |
Antibodies
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
CN106103484B
(zh)
|
2014-03-14 |
2021-08-20 |
诺华股份有限公司 |
针对lag-3的抗体分子及其用途
|
EA037006B1
(ru)
|
2014-06-06 |
2021-01-26 |
Бристол-Майерс Сквибб Компани |
Антитела к индуцируемому глюкокортикоидами рецептору фактора некроза опухолей (gitr) и их применения
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|